1. MEDICINAL CHEMISTRY -III (BP601T)
Multiple Choice Questions
1) The term chemotherapy is used for…
a. Treatment of CVS disease
b. Treatment of CNS disease
c. Treatment of disease caused by infective organism
d. d. Treatment of respiratory disease
Ans. – c
2) Who is regarded as father of chemotherapy?
a. Paul Ehrlich
b. Alexander Fleming
c. Gerhard Domagk
d. None of the above
Ans. – a
3) Which is (are) the narrow spectrum antibiotic(s)?
a. Penicillin
b. Streptomycin
c. Erythromycin
d. All of the above
Ans. – d
4) Which is narrow spectrum antibiotic?
a. Gentamycin
b. Penicillin G
c. Chloramphenicol
d. Aminoglycoside antibiotic
Ans. – c
5) Which is the synthetic antibiotic?
a. Cephalothin
b. Chloramphenicol
c. Tetracycline
d. Penicillin G
Ans. – b
6) Which antibiotic is bacterial cell wall synthesis inhibitor?
a. Cephalosporins
b. Macrolide antibiotics
c. Amino glycoside antibiotic
d. All of the above
Ans. – a
7) Which antibiotic interfere in functioning of cytoplasmic membrane?
a. Polymixins
b. Amphotericin B
c. Nystatin
d. All of the above
Ans. – d
2. 8) Which antibiotic is protein synthesis inhibitor?
a. Penicillin
b. Cephalosporin
c. Erythromycin
d. Rifampin
Ans. – c
9) Which antibiotic interfere with nucleic acid biosynthesis?
a. Lincomycin
b. Rifampin
c. Tetracycline
d. Streptomycin
Ans. – b
10) Penicillin was discovered by scientist…
a. Paul Ehrlich
b. Alexander Fleming
c. Gerhard Domagk
d. None of the above
Ans. – b
11) Which heterocyclic ring is present in the chemical structure of penicillin?
a. Thiazolidine
b. Pyrrolidine
c. Pyrazolidine
d. Thiazole
Ans. – a
12) Which basic ring is present in penicillins?
a. Cepham ring
b. Penam ring
c. Cephem ring
d. None of the above
Ans. – b
13) Different penicillins are derivatives of….
a. 6-nitro penicillanic acid
b. 7-amino penicillanic acid
c. 6-amino penicillanic acid
d. 7-nitro penicillanic acid
Ans. – c
14) Penicillins are degraded by
a. Acid
b. Alkali
c. Penicillinase
d. All of the above
Ans. – c
15) On acid degradation, penicillin is converted in to
a. Penicilloic acid
b. Penillic acid
c. Penilloic acid
3. d. Penicillamine
Ans. – b
16) On alkali degradation, penicillin is converted in to .
a. Penicilloic acid
b. Penillic acid
c. Penilloic acid
d. Penicillamine
Ans. – a
17) Identify the given structure of penicillin.
a. Penicillin V
b. Penicillin G
c. Methicillin
d. Cloxacillin
Ans. – b
18) Which penicillin is a penicillinase susceptible?
a. Methicillin
b. Cloxacillin
c. Oxacillin
d. Phenoxy methyl penicillin
Ans. – d
19) Penicillin V is also known as
a. Phenoxy methyl penicillin
b. Benzyl penicillin
c. Cloxacillin
d. Carbenicillin
Ans. – a
20) Penicillin G is also known as
a. Benzyl penicillin
b. Natural penicillin
c. Both (a) & (b)
d. None of the above
Ans. – c
21) Identify the structure of penicillin.
a. Ampicillin
b. Methicillin
c. Cloxacillin
d. Oxacillin
Ans. – b
22) Identify the chemical class of the given penicillin.
a. Amino penicillin
b. Carboxy penicillin
c. Ureido penicillin
d. None of the above
Ans. – a
4. 23) Which is the extended spectrum penicillin?
a. Cloxacillin
b. Ticarcillin
c. Penicillin G
d. Penicillin V
Ans. – b
24) Identify the given structure of penicillin
a. Carbenicillin
b. Ampicillin
c. Cloxacillin
d. Bacampicillin
Ans. – c
25) Identify the chemical class of given penicillin
a. Amino penicillin
b. Carboxy penicillin
c. Ureido penicillin
d. None of the above
Ans. – b
26) Identify the given structure of penicillin
a. Ampicillin
b. Oxacillin
c. Ticarcillin
d. Amoxicillin
Ans. – d
27) Which is not the extended spectrum penicillin
a. Azlocillin
b. Ticarcillin
c. Oxacillin
d. Carbenicillin
Ans. – c
28) Identify the given structure of penicillin.
a. Piperacillin
b. Azlocillin
c. Mezlocillin
d. Ampicillin
Ans. – a
29) Give the chemical class of the given penicillin.
a. Amino penicillin
b. Carboxy penicillin
c. Ureido penicillin
d. None of the above
Ans. – c
30) Which is the beta lactamase inhibitor?
a. Clavulanic acid
b. Salbactam
c. Tazobactam
5. d. All of the above
Ans. – d
31) Penicillins interfere with synthesis of .
a. Bacterial cell wall
b. Bacterial protein
c. Nucleic acid
d. All of the above
Ans. – a
32) Penicillins inhibit bacterial cell wall by inhibiting enzyme .
a. Penicillinase
b. Transpeptidase
c. Lactamase
d. Amidase
Ans. – b
33) In penicillins, beta lactam ring is fused with
a. Thiazolidine
b. Piperidine
c. Pyrrolidine
d. Pyrimidine
Ans. – a
34) Penicillin can be derived from .
a. Penicillium notatum
b. Penicillium crysogenum
c. Both (a) & (b)
d. None of the above
Ans. – c
35) Primarily penicillins are effective against strains of
a. Gram negative bacteria
b. Gram positive bacteria
c. Both (a) & (b)
d. None of the above
Ans. – b
36) The stability of benzyl penicillin can be increased by substitution of at alpha position of
amide function.
a. Electron donating group
b. Electron withdrawing group
c. Electron releasing group
d. None of the above
Ans. – b
37) Which of the following statements about penicillin is false?
a. Ticarcillin is resistant to beta lactamase
b. Penicillins are bacteriostatic in effect
c. Penicillin V is available in oral, i.v. and i.m. route
d. All of the above
Ans. – b
6. 38) Which of the following penicillin drugs is a prodrug?
a. Ticarcillin
b. Bacampicillin
c. Ampicillin
d. Carbenicillin
Ans. – b
39) Which does not describe Penicillins?
a. Bactericidal
b. Inhibit cell wall synthesis
c. Broad spectrum
d. Cause bacteria to die from cell lysis
Ans. – c
40) Which is not a penicillinase resistant penicillin?
a. Ampicillin
b. Amoxicillin
c. Penicillin G
d. Penicillin V
Ans. – c
