Ventilator-associated pneumonia (VAP) occurs in about 13 out of every 1,000 ventilator days and is a leading cause of death from hospital-acquired infections. VAP results from aspiration of oropharyngeal secretions in most cases as the endotracheal tube provides a pathway to the lungs. Preventing VAP focuses on reducing bacterial load in the oropharynx through techniques like oral chlorhexidine rinses and subglottic secretion drainage, as well as following bundles to minimize ventilator circuit changes and maximize oral hygiene.