2. Tips to be Covered
Introduction
Results
Discussions
Conclusions
References
3. Introduction
Aedes aegypti – transmit Dengue virus.
Infected blood meal from infected mosquito.
Mosquito immune system.
Infection with the virus result and control.
Limit infection with the virus.
Role of mosquito’s natural microbial flora.(2)
4. Results
Global transcriptome to dengue
physiological of Aedes aegypti to systemic using genome-wide
transcriptional profiling approach.
Functional classification of different genes in dengue-infected midgut
and carcass.
Immune responses to dengue infection
Putative Immune genes regulate by virus infection in carcass and midgut
tissues
Immune functions such as PRRs, signaling modulation, transduction,
effector systems and apoptosis.(2)
5. Con’t
Toll pathway involved anti-dengue defense
Tested of Caspar and Cactus gene in midgut.
Infection of mosquitoes with dengue virus induces Toll pathway then
exerts an anti-dengue effect.
Dengue infection influences
mosquito’s endogenous bacterial flora (2)
6. Discussion
Ae.aegypti mosquito responses to dengue.
Activation of Toll pathway.
Support future experiments to defense against
dengue virus infection in Ae.aegypti.(2)
7. Conclusion
Role of Toll pathway to dengue virus in
Ae.aegypti.
Mosquito’s natural micro biota role’s in
modulating dengue virus infection.(2)
8. Reference
1. Aedes [Internet]. Wikipedia. 2016 [cited 31 May
2016]. Available from:
https://en.wikipedia.org/wiki/Aedes
2. Xi Z, Ramirez J, Dimopoulos G. The Aedes aegypti
Toll Pathway Controls Dengue Virus Infection.
PLoS Pathogens. 2008;4(7):e1000098.