2. INTRODUCTION
ā¦ Patients can now swallow pill-sized, disposable
cameras
ā¦ This new esophageal capsule endoscope is a
smooth plastic capsule about the size of a large
vitamin pill that has tiny video cameras at each
end.
ā¦ The pill takes about 2,600 color pictures, which
are transmitted to a recording device worn by the
patient.
ā¦ The disposable capsule is passed naturally,
usually within 24 hours.
3. EVOLUTION
ā¦ The technology available to doctors has evolved
dramatically over the past 40 years.
ā¦ Basic endoscopy was introduced in the late 1960s,
and about 20 years later, ultrasound was added,
enabling us to look at internal GI structures as
never before.
ā¦ Now, with EUS, we can determine the extent to
which tumors in the esophagus, stomach,
pancreas, or rectum have spread in a less invasive
way.
ā¦ One technology that has been available for about
30 years is Endoscopic Retrograde Cholangio
pancreatography (ERCP).
4. USES OF ERCP:
ā¢ ERCP's is used to place stents within bile ducts,
remove difficult bile duct stones, and obtain
biopsy samples.
ā¢ Used in motility treatment.
ā¢ Motility is the movement of food from one
place to another along the digestive tract.
5. ASSOCIATED TECHNOLOGIES
ā¢ Passive capsule observation endoscopes
ā¢
ā¢
ā¢
ā¢
ā¢
ā¢
ļ compact low-power consumption imaging
technology.
ļ compact low-power consumption wireless
transmission technology.
Capsule guidance system
Wireless power supply system
Drug delivery system
Body fluid sampling technology
Self-propelled capsule
Ultrasound capsule
6. TECHNOLOGY
ā¦ Ultra-Low-Power Wireless Technology is Used
in Swallowable Camera Capsule.
ā¦ improvement of the signal-to-noise ratio (SNR)
in CMOS detectors,
ā¦ development of white LEDs, and development
of application-specific integrated circuits
(ASICs).
ā¦ CMOS detectors have active pixel resolutions
that provide comparable performance to CCDs,
while drawing less power than CCDs
7. EXAMPLES
ā¢ Mrs.Judy Shuhala, a retired school teacher,
had Gastritis,an inflammation of the stomach
lining.
ā¢ Mr.Norman Cullen, a 76-year-old Bay Area
resident, Suffering from an undetected GI
bleed.
8. MARKET VIEW
ā¦ 01 August 2001Physicians and patients in the
European Union, the United States of America,
Australia, and Israel will now be able to benefit
from a new medical technology .
ā¦ The Israeli company Given Imaging Ltd., which
manufactures the diagnostic system, has
received official approval to market the video
capsule to physicians within European Union
countries.
9. ā¦ the United States Food and Drug Administration
(FDA) cleared the marketing of the cameracapsule in the U.S.
ā¦ The system is also currently being used in
clinical trials in Belgium, France, Germany, Italy,
and Spain.
ā¦ The Given system will be available to doctors in
selected markets within 90 days of placing an
order.
11. ā¦ The M2A capsule consists of a microchip camera,
light emitting diodes that act as flash, an antenna,
two 1.5 V silver oxide batteries and Zarlink's RF
transmitter chip .
ā¦ The RF transmitter chip is manufactured in
0.35Āµm CMOS technology
ā¦ It re-quires a voltage of 2.6 to 3.2 V and transmits
on a 403, 432 or 434 MHz carrier
ā¦ This allows a data rate of 2,700 kbit/s over a distance of 1 m while having a power consumption of
5.2 MW.
12. ā¦ All this is run by two ultra low-power silver
oxide batteries that will operate for 6-8 hours.
ā¦ weighs 3.5 grams and can display a 140Ā° field of
view of the patients insides at 1:8 magnification.
ā¦ This information is then transmitted via an array
of sensors secured to the abdomen, to the Data
Recorder affixed to a belt worn around the
patient's waist.
13. ā¦ The silver oxide batteries in the capsule power
the CMOS detector, as well as the LEDs and
transmitter.
ā¦ white-light LEDs are important because
pathologists distinguish diseased tissue by color.
ā¦ The developers provided a novel optical design
that uses a wide-angle lens over the imager, and
manages to integrate both the LEDs and imager
under one dome while handling stray light and
reflections.
15. UTILITIES
ā¦ Eliminates Procrastination
ā¦ Views the Entire GI Tract
ā¦ Traditional endoscopy can view only the upper GI
tract.
ā¦ Earliest Cancer Detection
ā¦ Advances Treatment of Irritable Bowel Capsule
endoscopy
16. APPLICATION DOMAIN
ā¦ Capsule Endoscopy :
Patient has to swallow a vitamin pill
sized video capsule as an endoscope.
Capsule Endoscopy helps the doctor to determine
the cause for:~
ā¦ Recurrent abdominal pain
ā¦
Diarrhea
ā¦
Bleeding
ā¦
Anemia
17. ā¦ It is useful to detect small bowel tumors
ā¦ Patients who are on medications for joint
pains etc.
ā¦ Inflammatory bowel diseases
ā¦ Irritable bowel
ā¦ To monitor the therapeutic effects
18. How should the patient prepare himself or herself
for the study?
ā¦ Patient will be given written instructions the day
before.
ā¦ An empty stomach allows better visualization (10
hrs before the examination).
ā¦ The doctor will inform the time of fasting.
ā¦ If the patient is on medications inform the doctor.
ā¦ Cardiac patients have to inform about pace
makers & other devices.
ā¦ Patient can eat ,4 hrs after ingestion of the
capsule.
19. RESEARCH AND DEVELOPMENT
SCOPE
ā¢ The torpedo-shaped capsule can provide more
than five hours of real-color images.
ā¢ The patient need not be in a hospital or clinic
during this time
ā¢ The images are transmitted from the capsule using
UHF signals to an antenna array attached to the
patient (much like an ECG test).
20. ā¦ The data indicate where in the abdomen the
capsule was at the time.
ā¦ These promote greater efficiency in medical
institutions and help improve quality of life for
the patients.
ā¦ Gastrointestinal endoscopes are now recognized
as the only medical devices that can
simultaneously perform observations, diagnoses
(tissue extraction), and treatment.
21. CONVERGENCE OF TECHNOLOGY
The different technologies used are:
ā¢ Telemedicine.
ā¢ Electronics.
ā¢ Information Technology.
22. MATHEMATICAL SUPPORT
ā¦ In an FDA-organized trial conducted in New York, the
ā¦ Given Imaging Diagnostic System 12 patients, or 60
percent
ā¦ push enterosc
ā¦ opy 7 of 20 patients, or 35 percent.
In total, 14 lesions were detected
ā¦ The Given Imaging Diagnostic System 12 of the 14
lesions, or 86 percent,
ā¦ push enteroscopy 7 out of 14, or 50 percent.
ā¦ The FDA also noted that the Given system was able to
identify sources of bleeding in five cases which were
beyond the reach of the traditional enteroscope.
24. CONCLUSION
ā¦ Endoscopy is the most common diagnostic tool
for GI problems; however, the endoscope is not
long enough to view the entire small intestine.
ā¦ If the patientās problem lies further down the
intestinal tract, itās more difficult for the
physician to diagnose and treat.
ā¦ Now amazing new technologyāa wireless,
allowable video capsuleā allows physicians to
capture images of the small intestine with no pain
to the patient.
25. ā¦ The capsuleās greatest benefit is its ability to
survey the entire GI tract, possibly eliminating
the need for further diagnostic studies.
ā¦ the Given system is user-friendly and painless,
allowing patients to return to work on the same
day of ingestion
ā¦ it increases accuracy when compared to some
other endoscopic devices.
ā¦ this product may also offer cost savings by
reducing the number of diagnostic tests
required to obtain an accurate diagnosis.
26. FUTURE OF TECHNOLOGY
ā¦ At this time, the capsule is not a replacement for
colonoscopy.
ā¦ Photodynamic therapy is one of the new
treatments that will soon be available to patients
with certain types of Barrett's esophagus or GI
tumors.
ā¦ hotodynamic therapy uses lasers to destroy the
precancerous esophagus cells (identified by a
photosensitive chemical marker), but leaves
normal cells alone.