1. Phylogenetic Analysis in the
Genetic Epidemiology of SARS-CoV-
2: Insights from Multiple Studies
Presented by:
Darakhshan Irfan

2. Introduction
• SARS-CoV-2 a novel coronavirus was first identified in
December 2019 in Wuhan, Hubei Province, China.
• Genetic Epidemiology is the study of contribution of
genetic factor in health or disease in family and
population and how genes interplay with
environmental factors
• Phylogenetic analysis is a key tool in genetic
epidemiology that allows researchers to reconstruct
the evolutionary relationships among different SARS-
CoV-2 strains and track the spread of the virus

3. Problem Statement
• SARS-CoV-2 has spread globally, leading to a
pandemic
• Which resulted in millions of infections and
deaths worldwide, significantly impacting
healthcare systems, economies, and daily life.
• it's crucial to understand its transmission
dynamics and genetic diversity in controlling
its spread and developing effective
interventions.

4. Objectives
• To examine the genetic diversity, evolutionary
relationship, and transmission of virus.
• This study may aid in controlling viral spread.
It emphasizes how important phylogenetics is
for understanding the genetic epidemiology of
SARS-CoV-2 and how it could influence clinical
and public health decisions.

5. Methodology
• Data Collection
• Sample Preparation
• Next Generation Sequencing
• Data Analysis
• Phylogenetic Analysis

6. Results

9. Conclusions
• In conclusion, the studies highlight the important
role that phylogenetic analysis plays in the
genetic epidemiology of SARS-CoV-2.
• Phylogenetic analysis can provide valuable
insights into the transmission dynamics and
spread of SARS-CoV-2, including the identification
of local transmission clusters and the tracking of
viral evolution over time and complementing
traditional epidemiological methods