1. CNS Tumors

2. Classification
-
Gliomas
o
Astrocytoma
•
•
o
o
-
Medulloblastoma
Other parenchymal tumors
o
o
-
Central neurocytoma
Ganglioglioma
Dysembryoplastic neuroepithelial tumor
Poorly Differentiated Neoplasms
o
-
Oligodendroglioma
Ependymoma
Neuronal Tumors
o
o
o
-
Fibrillary
Pilocytic
Primary CNS lymphoma
Germ cell tumors
Meningioma
Shwannoma
Metastatic tumors

3. Which Tumor ?
35 year old man complained of headache for the
past 2 years , he also been having weakness in
his left upper limb , he came to the neurologist
because he had a seizure yesterday. MRI was
performed ; mass in his cerebral hemisphere.
he started chemotherapy and radiotherapy as
resection was not feasible , 11 months later he
passed away .

4. Which Tumor ?
A mother brings her 5 year old son to the
neurologist, he has been having tremors and
was ataxic. MRI is shown . The tumor was
resected. Histologic features of it : GFAP +ve
Rosenthal fibers.
Source :http://emedicine.medscape.com/article/985927-workup#a0720

5. Glioblastoma

6. Glioblastoma

7. BRAIN TUMORS
•
Gross: Cyst filled with gelatinous material, and mural nodule. Micro: Cells with
long, hair-like processes, Rosenthal fibers. GFAP positive
Pilocytic astrocytoma, grade I / IV

8. WHO grading (biologic behavior) Astrocytomas (I - IV)
Pilocytic (I / IV)
Well-differentiated (II / IV)
Anaplastic (III / IV)
Glioblastoma (IV / IV)

9. Oligodendroglioma G II

10. Ependymoma G II

11. Medulloblastoma
A
C
B

12. Meningioma G I

13. Schwannoma G I