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Inorganic ppt.pptx

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Inorganic ppt.pptx

  1. 1. The medicinal therapeutic potential of metal coordination complexes Presented by Riyansha Verma (38) Sanya Gulati(41)
  2. 2. ABSTRACT In the present survey paper, we have collected the developmental history of utilization of transition metal complexes as drugs to treat several human diseases like diabetes, and neurological disorders. With the help of relevant literature medicinal use of transition metal complexes is discussed. The paper integrates all such discoveries relevant to the Metal-based co- ordination compounds that have been used throughout the history of human medicine to treat various chronic diseases. The structural characteristics of NSAID complexes with copper(II) or zinc(II) previously reported are presented in this paper. We also outlined chalcone based metal coordination complexes as suitable bioactive agents.
  3. 3. Chalconemetalcomplexesasanticanceragents • Chalcone based metal complexes are used as effective antiproliferative drugs. • These are used as effective alternative therapy as bacterias have developed resistance against drugs therefore,drugs based on metal coordination complexes have been widely used and worked upon. • For instance it has been found that, Pd(II)-tetracycline combination has sixteen times the potency of tetracycline against resistant E.coli bacteria. • The emergence of chloroquine resistance necessitates the new effective antiparasitic agents. For this, the gold and ruthenium complexes of chloroquine and clotrimazole have been prepared and evaluated against Plasmodium.
  4. 4. Nonplatinum based complexes forcancer treatment The idea of substituting alternative metal ions for platinum has been investigated in attempt to develop novel complexes with minimal systemic toxicity and activity against malignancies resistant to cisplatin. •Ruthenium complexes Ruthenium(II) forms either penta- or hexa-coordinated complexes, while ruthenium(III) only hexa-coordinated ones. Both of them show antitumor activity, but Ru(III) is probably in vivo first reduced to Ru(II) acting rather as a prodrug. A prodrug is an inactive form of a drug which have little or no pharmacological activity which gets activated by enzymatic or chemical reactions. • For instance, Ru(ii) complex [Ru(biphenyl)(en)Cl]PF6 binds DNA either by intercalation through the aromatic ligand or by covalent binding with the metal ion. Ru(III) complexes is the [Ru(HIn)2Cl4](H2In) which reacts with DNA and induces apoptosis.
  5. 5. Gold and Titanium coordi- nation complexes as anticancer agent Auranofin is a gold coordination complex which is used to treat rheumatoid arthritis. Auranofin is a thioredoxin reductase (TR) inhibitor made up of Au(I) and a phosphine ligand. The inhibition of TR induces mitochondria-dependent apoptosis. Au(III) complexes have also been widely explored as its chemistry is comparable to that of Pt(ii) .Au(III) is isoelectronic with Pt(II) and forms square planar complexes. Titanocene dichloride, a titanium coordination complex showing anti-tumor activity. The titanocene dichloride, binds DNA via the phosphate backbone, inducing apoptosis

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