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St Thomas University
School of Science, Technology
 & Engineering Management

      Medicinal Plants
            And
   Cancer Research at STU

                     Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Science Building




Carnival Cruise Lines Science & Technology Building




                                     Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Medicinal Plants
Why medicinal plants & cancer research ???




                                    Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Medicinal Plants

             Laboratory of Biochemical and Biomedical Research
                     Created in 2004, New Mexico, USA




Biomembrane Structure, Interaction   New Medicinal Agents against Diseases
   and Signal Transduction



                                              - Native American Medicine man
    Ligusticum porteri                        - Ketowa Indian (Cherokee Nation)
    & Anemopsis californica
                                              - Folk medicine with local plants




                                                 Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Importance of Medicinal Plants

           Medicine man recommended two medicinal plants:
  Ligusticum porteri (Osha) and Anemopsis californica (Yerba Mansa)




• Common names:                        • Common names: Lizard Tail, Swamp
Loveroot, Porter’s Lovage, Osha,          Root, Yerba Mansa
Chuchupate, and Wild Parsley
• Location:                            • Common Location:
In the West, Canada to Mexico             Wet, swampy areas
Especially the Rocky Mountain region

                                                 Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Importance of Medicinal Plants




Willow tree           Salicin                      Acetyl-salicylic acid


                             “Miracle drug”
                    - pain/fever reducer
                    - blood thinner against strokes
                    - acts against cancer
                    - acts against Alzheimer




                                          Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Importance of Medicinal Plants




Pacific Yew tree                      Paclitaxel/Taxol


             Used in Cancer Chemotherapy
 - Discovered in 1967, due to a plant screening by the NCI
 - In 2000, 1.6 billion US$



                                          Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Importance of Medicinal Plants




                 Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Importance of Medicinal Plants


     Flower




            Leaf




     Root




                   Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
USDA-FS and STU




Ardesia crenata       Pyrus calleryana




                       Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
Interdisciplinary!


                     Dried and ground plants                   Freeze-Dry

                      Leafs/roots/flowers

                                                                                   Biological activity testing
Harvest/Voucher specimen                       Extraction



                           Fractionation


Structure identification

                               Activity

                                                    Antibacterial                          Anticancer
                                                    Antifungal
                                                                Wim F.A. Steelant, CE, Ph.D., April 12th , 2012

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Medicinal Plants and Cancer Research at St. Thomas University

  • 1. St Thomas University School of Science, Technology & Engineering Management Medicinal Plants And Cancer Research at STU Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 2. Science Building Carnival Cruise Lines Science & Technology Building Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 3. Medicinal Plants Why medicinal plants & cancer research ??? Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 4. Medicinal Plants Laboratory of Biochemical and Biomedical Research Created in 2004, New Mexico, USA Biomembrane Structure, Interaction New Medicinal Agents against Diseases and Signal Transduction - Native American Medicine man Ligusticum porteri - Ketowa Indian (Cherokee Nation) & Anemopsis californica - Folk medicine with local plants Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 5. Importance of Medicinal Plants Medicine man recommended two medicinal plants: Ligusticum porteri (Osha) and Anemopsis californica (Yerba Mansa) • Common names: • Common names: Lizard Tail, Swamp Loveroot, Porter’s Lovage, Osha, Root, Yerba Mansa Chuchupate, and Wild Parsley • Location: • Common Location: In the West, Canada to Mexico Wet, swampy areas Especially the Rocky Mountain region Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 6. Importance of Medicinal Plants Willow tree Salicin Acetyl-salicylic acid “Miracle drug” - pain/fever reducer - blood thinner against strokes - acts against cancer - acts against Alzheimer Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 7. Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 8. Importance of Medicinal Plants Pacific Yew tree Paclitaxel/Taxol Used in Cancer Chemotherapy - Discovered in 1967, due to a plant screening by the NCI - In 2000, 1.6 billion US$ Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 9. Importance of Medicinal Plants Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 10. Importance of Medicinal Plants Flower Leaf Root Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 11. USDA-FS and STU Ardesia crenata Pyrus calleryana Wim F.A. Steelant, CE, Ph.D., April 12th , 2012
  • 12. Interdisciplinary! Dried and ground plants Freeze-Dry Leafs/roots/flowers Biological activity testing Harvest/Voucher specimen Extraction Fractionation Structure identification Activity Antibacterial Anticancer Antifungal Wim F.A. Steelant, CE, Ph.D., April 12th , 2012