Sherrington coined the term "synapse" and observed that neurons communicate chemically at junctions between neurons called synapses. He discovered the concepts of temporal and spatial summation - that repeated or multiple stimuli can have cumulative effects. Neurotransmitters are chemicals released at synapses that allow communication between neurons. They bind to receptors on the post-synaptic neuron and can have excitatory or inhibitory effects. Drugs can influence synapses by altering neurotransmitter synthesis, release, reuptake or receptor binding.