Weitere ähnliche Inhalte Ähnlich wie Manufacturing Process Optimization Using Statistical Modeling 2015 Ähnlich wie Manufacturing Process Optimization Using Statistical Modeling 2015 (20) 2. 2
Though rare, if applied early in a company’s lifecycle during tech
transfer or early in commercialization, process optimization can
unlock key business drivers such as cycle time or yield to
accelerate profitability.
Discoverant’s powerful suite of tools and analytics can enable
small up and coming Biotech companies to immediately drive cost
down while improving quality. The margin effect can be very
dramatic.
This presentation details the business case for implementing
Discoverant to achieve business driven results both for the
company and the market you serve.
Abstract
3. Agenda
• Discoverant and your manufacturing value stream
• Three Steps to turn data into information
1. Gather Data Brute force data gathering, formatting & analysis
2. Analyze Data Mind the gap … holes in your limited analysis
3. Optimize Process Drowning in a sea of data
• The Discoverant value proposition
• Bang for the buck & what Discoverant eliminates
3
4. New Manufacturing Data Collection Landscape
Eng
Maint
HISTLIMSERP CAPA MES
Paper Records
Raw
Materials
Process
Step 1
Process
Step 2
Process
Step 3
Process
Steps…
Final
Product
MS EXCELBIOVIA Discoverant
5. Step One: Gather Data
• Straightforward right?
– Which data?
– How much data?
– What timeframe?
– What format?
– Nominal versus discrete? (What’s that even mean?!?!)
• From Paper-based to spreadsheet to complex
equipment systems – gathering data is not
straightforward…
5
6. Useful Information Starts with Useful Data…
6
Lot No. Response 1 Response 2 Parameter 1 Parameter 2 Parameter 2 LC RATIO Parameter 3 Parameter 3 LC RATIO Parameter 4 Parameter 4 LC RATIO Parameter 5 Parameter 5 LC RATIO Parameter 6 Parameter 6 LC RATIO Parameter 7 Parameter 7 LC RATIO Parameter 8 Parameter 8 LC RATIO Parameter 9 Parameter 9 LC RATIO
Parameter
10
Parameter
10 LC RATIO
Parameter
11
Parameter
11 LC RATIO
Parameter
12
Parameter
12
14-2225 23.8 65 29.01 23.26 0.164590999 0.040687801 52.27 89.05 0.630130201 137.96 0.155591645 683.71 0.771089908 65.01 0.073318446 0.41 191.79 266.68 6 5 36 72 75 139 4.918776978 0 14.3 0.62 13.3 0.63 910.7 404.6 27.84 532.9 22.96
14-2191 25.2 67 28.81 22.32 0.144204678 0.041930482 51.13 103.65 0.669660163 136.03 0.153813971 680.42 0.769375155 67.93 0.076810873 0.45 194.33 260 9 7 40 67 72 138 4.93057971 1 14.7 0.65 13.1 0.64 910.2 404.5 27.85 529.6 22.95
14-2194 27.3 69 28.39 22.06 0.148302521 0.042554622 50.46 98.3 0.660840336 147.76 0.161887962 688.46 0.754286591 76.51 0.083825447 0.44 183.11 253.31 11 6 39 70 104 139 4.95294964 1 14.8 0.6 13.2 0.6 910 404.5 27.83 529.3 22.95
14-2192 25.1 70 28.88 22.15 0.145954138 0.044346336 51.03 100.73 0.663745387 133.07 0.15135006 678.9 0.772161689 67.25 0.076488251 0.45 198.11 257.32 13 5 39 69 71 138 4.919565217 1 15.2 0.67 13 0.66 910.9 405.2 27.89 529.5 22.95
14-2135 25.3 71 28.63 22.44 0.142061281 0.039187136 51.07 106.89 0.676690301 139.71 0.157412624 684.11 0.770793429 63.72 0.071793947 0.41 180.5 250.7 14 5 42 67 75 140 4.8865 1 15.5 0.66 13.3 0.67 910.1 404.5 27.85 529.8 22.96
14-2200 25.8 71 29.02 22.35 0.155046826 0.046271245 51.37 92.78 0.643635102 146.82 0.162748163 687.63 0.76222939 67.68 0.075022447 0.45 179.91 250.82 11 5 35 69 102 141 4.876808511 0 15.3 0.67 13 0.67 910 406.4 27.86 530.3 22.95
14-2227 25.5 71 28.73 22.27 0.147249405 0.042713568 51 100.24 0.662787622 142.7 0.158193468 684.5 0.758818704 74.86 0.082987828 0.43 192.03 254.28 4 5 34 70 77 140 4.889285714 1 14.7 0.65 13.2 0.65 910.4 404.8 27.84 529.2 22.95
14-2180 25.1 72 28.1 22.31 0.15056013 0.039074099 50.41 97.77 0.659805642 138.66 0.156718695 680.35 0.768956904 65.76 0.074324401 0.42 195.71 256.16 20 6 39 71 74 138 4.930072464 1 14.7 0.65 13.2 0.65 914.3 406.8 27.86 530 22.95
14-2182 25.3 72 28.66 22.13 0.145229033 0.042853393 50.79 101.59 0.666688542 138.54 0.157503411 675.59 0.76806503 65.47 0.07443156 0.44 191.38 256.73 20 6 39 70 71 138 4.89557971 1 14.9 0.65 13.2 0.65 910.2 404.6 27.83 529.1 22.95
14-2202 25.5 72 29.11 22.39 0.144191139 0.043276662 51.5 103.78 0.668341061 140.68 0.158090508 680.88 0.765145471 68.31 0.076764022 0.43 200.92 258.01 9 5 35 68 79 137 4.969927007 0 14.5 0.64 13.2 0.64 919 404.5 27.88 529.5 22.96
14-2171 25.6 73 28.57 22.01 0.140603041 0.041906222 50.6 105.96 0.676887696 133.28 0.150293189 683.02 0.770207488 70.5 0.079499323 0.45 196.55 256.62 13 5 40 72 69 141 4.844113475 1 14.6 0.65 13.2 0.65 910.1 404.6 27.84 529.2 22.95
14-2189 25.3 73 29.09 22.02 0.149116273 0.047877023 51.11 96.56 0.653890431 140.03 0.15734415 680.48 0.764618635 69.45 0.078037215 0.45 200.46 262.36 18 5 37 70 72 138 4.931014493 1 14.6 0.63 13.4 0.64 913.2 404.5 27.96 529 22.95
14-2199 25.7 73 29.22 21.99 0.138887134 0.045664119 51.21 107.12 0.676561612 149.05 0.164182721 685.42 0.755009198 73.36 0.080808081 0.43 195.09 258.84 11 5 36 71 106 139 4.931079137 0 14.7 0.65 13.2 0.65 910.3 404.6 27.86 529.8 22.94
14-2201 26.2 73 29.15 22.31 0.147670109 0.045274027 51.45 99.62 0.659385756 139.57 0.157474896 678.48 0.765519576 68.25 0.077005529 0.45 192.52 252.56 6 5 36 68 83 139 4.881151079 0 15.2 0.67 13 0.66 910.3 405.4 27.84 529.3 22.97
14-2211 25.4 73 28.76 22.32 0.145189618 0.041891628 51.11 102.65 0.667729135 138.37 0.154701877 683.94 0.764665765 72.12 0.080632358 0.44 200.35 259.33 5 5 36 70 81 136 5.028970588 1 14.7 0.64 13.3 0.64 910.8 404.5 27.84 529.5 22.95
14-2215 25.8 73 29.02 22.3 0.155650171 0.046904446 51.32 91.95 0.641795212 144.43 0.160810119 681.73 0.759046474 71.98 0.080143407 0.44 197.84 257.93 5 6 35 70 83 138 4.940072464 0 14.6 0.63 13.1 0.62 910.9 404.6 27.84 529.4 22.96
14-2107 25.8 74 27.82 21.96 0.140724127 0.037552067 49.8 106.27 0.68099968 135.79 0.153754699 682.13 0.772374202 65.24 0.073871099 0.43 181.27 241.78 28 5 41 67 76 141 4.837801418 1 15.8 0.7 13 0.68 910.4 404.6 27.88 530.1 22.97
14-2164 26 74 28.61 22.28 0.147696387 0.041962214 50.9 99.96 0.662645012 138.12 0.155535286 684.79 0.771133858 65.12 0.073330856 0.44 185.2 250.03 18 5 39 69 73 140 4.891357143 0 15.5 0.68 13.4 0.69 910 404.5 27.82 529.7 22.95
14-2179 25.3 74 28.3 22.31 0.149240752 0.04006957 50.61 98.88 0.661448926 138 0.153509016 684.73 0.761682815 76.24 0.084808169 0.43 194.23 255.07 17 5 37 71 73 139 4.926115108 1 14.8 0.64 13.4 0.65 910.9 404.6 27.89 529.8 22.94
14-2181 25.7 74 28.3 22.12 0.144123013 0.040265833 50.46 103.06 0.671488142 137.24 0.155961635 676.42 0.768694032 66.3 0.075344334 0.43 186.96 250.59 16 5 38 73 68 139 4.866330935 1 15.1 0.67 13.3 0.67 910 404.4 27.84 529.9 22.95
14-2188 26 74 28.82 21.94 0.148735679 0.046640906 50.76 96.75 0.655887736 134.13 0.148735862 685.96 0.760656465 81.71 0.090607674 0.44 199.13 253.54 22 5 37 70 72 140 4.899714286 1 15.1 0.65 13.1 0.65 910.1 405.5 27.84 529.9 22.95
14-2193 25.7 74 28.42 22.24 0.140911107 0.039156054 50.66 107.17 0.679021732 138.23 0.155606588 683.71 0.769657672 66.39 0.07473574 0.45 188.5 252.41 7 6 40 69 72 140 4.883642857 1 15.4 0.67 13.3 0.68 910 404.5 27.88 529 22.95
14-2193 25.7 74 28.42 22.24 0.140911107 0.039156054 50.66 107.17 0.679021732 138.23 0.155606588 683.71 0.769657672 66.39 0.07473574 0.45 188.5 252.41 7 6 40 69 72 140 4.883642857 1 15.4 0.67 13.3 0.68 910 404.5 27.88 529 22.95
14-2204 26 74 29.11 22.23 0.149919072 0.046398705 51.35 96.94 0.653763151 141.73 0.158984598 678.14 0.760698621 71.6 0.08031678 0.44 195.14 250.79 6 5 33 71 81 139 4.878705036 0 15.4 0.67 13.3 0.68 911 404 27.82 531.1 22.93
14-2206 25.4 74 29.11 22.16 0.146183785 0.045847351 51.27 100.32 0.661785078 140.74 0.156781927 682.13 0.759881027 74.81 0.083337047 0.44 198.29 259.12 4 6 35 71 81 132 5.167651515 0 14.7 0.65 13.2 0.65 910 404 27.85 530.8 22.95
14-2210 26.1 74 29.34 22.01 0.144926582 0.048264963 51.35 100.52 0.661881873 139.32 0.155390484 685.46 0.764527426 71.8 0.08008209 0.43 195.01 255.1 6 5 34 71 81 139 4.931366906 0 15 0.66 13.3 0.67 910.3 404.5 27.89 529.4 22.96
14-2214 24.8 74 29.01 22.79 0.144496576 0.039436977 51.79 105.92 0.671569871 143.66 0.159010914 684.09 0.757189029 75.71 0.083800058 0.44 193.03 261.13 4 6 36 68 83 139 4.921510791 1 14.2 0.63 13.3 0.63 911.1 405 27.82 529.3 22.93
14-2069 25.7 75 28.45 21.86 0.154149919 0.04647063 50.31 91.5 0.645229532 141.37 0.158985605 677.04 0.761403509 70.79 0.079610886 0.4 185.28 253.79 3 5 37 71 77 138 4.906086957 1 14.9 0.64 13.2 0.64 910 404.5 27.85 529.4 22.95
14-2122 25.8 75 29.36 22.05 0.141837129 0.047021742 51.41 104.05 0.669304001 138.23 0.153392887 682.03 0.756844033 80.89 0.089763081 0.43 195.08 250.61 17 5 40 70 74 130 5.246384615 1 15.5 0.68 13.5 0.69 910.1 404.9 27.88 530.4 22.95
14-2124 26.3 75 28.48 22.03 0.144288708 0.042245219 50.5 102.17 0.669177364 143.92 0.159570694 680.1 0.75405801 77.9 0.086371297 0.42 182.01 248.87 21 4 42 68 78 136 5.000735294 1 15.9 0.7 13.3 0.7 910.3 404 27.84 530.2 22.96
14-2128 26.3 75 28.8 21.87 0.150340276 0.047638688 50.57 94.8 0.651680759 135.11 0.150842916 681.57 0.760935581 79.02 0.088221503 0.43 181.71 245.1 14 5 39 68 75 140 4.868357143 1 15.4 0.68 13.3 0.68 910 404.6 27.84 529.5 22.95
14-2183 25.5 75 28.83 21.98 0.144624293 0.04507172 50.81 101.17 0.665679695 137.14 0.155186656 684.03 0.774043521 62.54 0.070769823 0.44 181.9 252.01 20 5 38 71 73 140 4.885928571 1 15.2 0.66 13.3 0.67 910.7 405.2 27.84 529.4 22.95
14-2184 25.6 75 28.66 21.94 0.142829243 0.043747152 50.6 103.01 0.670594362 138.88 0.156611561 684.82 0.772254674 63.08 0.071133765 0.44 179.29 251 17 5 38 70 73 140 4.891571429 1 15.1 0.65 13.2 0.65 910.2 407 27.91 530.2 22.96
14-2195 25.9 75 28.91 22.05 0.146074859 0.045445512 50.96 99.99 0.66240477 144.11 0.160270027 682.59 0.759133423 72.47 0.08059655 0.44 198.09 257.72 10 5 41 68 103 139 4.910719424 1 14.7 0.65 13.36 0.66 910 405.2 27.84 530 22.98
14-2203 25.9 75 29.42 22.14 0.14696316 0.04832393 51.56 99.09 0.657749751 142.77 0.159314847 681.48 0.760453049 71.9 0.080232104 0.42 204.74 257.33 7 4 36 72 79 117 5.824615385 0 15.1 0.66 13.4 0.67 916.3 404.3 27.84 529.7 22.97
14-2207 25.6 75 29.19 22.58 0.149893787 0.043879448 51.47 98.87 0.656332979 138.86 0.155043434 680.31 0.759596704 76.45 0.085359862 0.44 193.78 255.72 5 5 33 70 81 139 4.894316547 1 14.7 0.65 13.4 0.66 910.5 404.6 27.84 530.6 22.95
14-2212 25.8 75 29.25 22.23 0.148407771 0.046865612 51.46 98.31 0.656318846 141.54 0.157762743 680.82 0.758852837 74.81 0.08338442 0.45 193.47 254.42 6 6 35 70 81 138 4.933478261 0 15 0.67 13.2 0.68 910 404.5 27.85 529.8 22.95
14-2213 25.5 75 29.11 22.26 0.148617973 0.045733743 51.29 98.41 0.657030311 142.72 0.159269716 681.76 0.760816436 71.61 0.079913848 0.43 200.15 258.44 5 5 35 71 82 139 4.904748201 0 14.4 0.64 13.4 0.65 910 404.5 27.82 529.3 22.95
14-2216 26.2 75 29.2 22.28 0.146965699 0.045646438 51.48 100.12 0.660422164 147.68 0.163605344 679.01 0.752232291 75.97 0.084162365 0.43 193.63 254.24 6 6 34 70 85 138 4.920362319 1 14.6 0.64 13.3 0.64 910 404.6 27.84 530.5 22.95
14-2223 26 75 29.11 22.08 0.149664475 0.047651325 51.19 96.34 0.653019725 140.61 0.157237909 681.31 0.761878669 72.33 0.080883422 0.43 196.58 255.45 2 6 36 69 77 138 4.937028986 0 15 0.66 13.3 0.66 910.7 404.8 27.96 529.8 22.96
14-2100 25.7 76 28.61 22.3 0.156217163 0.044203152 50.89 91.84 0.643362522 134.66 0.150323733 682.97 0.762413485 78.17 0.087262782 0.43 185.64 249.6 3 5 39 71 75 140 4.878357143 1 14.8 0.66 13.4 0.66 910 404.5 27.83 529.4 22.97
14-2127 26.4 76 29.19 21.88 0.151429165 0.050591736 51.07 93.42 0.646549934 138.28 0.161696953 648.81 0.758682383 68.09 0.079620665 0.43 181.84 244.19 12 5 39 71 74 140 4.634357143 1 16.1 0.7 13.2 0.7 910.2 404.6 27.81 530.3 22.95
14-2129 26.6 76 29.35 21.86 0.147682746 0.05060127 51.21 96.81 0.654033239 133.18 0.150925863 681.55 0.772364634 67.69 0.076709503 0.42 187.98 244.55 17 5 41 71 71 139 4.90323741 1 15.9 0.68 13.3 0.69 910 404.5 27.85 529.5 22.95
14-2132 26.1 76 28.96 21.82 0.136853989 0.044781736 50.79 108.66 0.681510286 135.9 0.151977723 682.32 0.763042238 75.99 0.084980038 0.42 175.92 242.13 19 5 43 67 74 140 4.873714286 1 16.2 0.7 13.2 0.7 910 404.5 27.83 529.4 22.95
14-2140 26 76 28.95 22.12 0.140133038 0.043268926 51.07 106.78 0.676464998 134.9 0.152111406 682.84 0.769961098 69.11 0.077927496 0.42 183.57 250.33 20 5 40 69 73 140 4.877428571 1 15.6 0.68 13.3 0.68 910 404.3 27.85 529 22.99
14-2156 25.6 76 28.78 22.18 0.14687769 0.043705715 50.95 100.05 0.662538905 139.89 0.157994601 679.56 0.767508838 65.96 0.074496561 0.41 196.08 254.14 18 5 38 71 72 139 4.888920863 1 14.7 0.65 13.2 0.65 910 408 27.8 529.9 22.95
14-2159 25.9 76 29.09 22.24 0.146133123 0.045009528 51.32 100.86 0.662724226 141.17 0.158832133 682.07 0.767405491 65.56 0.073762376 0.44 180.39 250.03 20 5 38 68 76 141 4.837375887 1 15.5 0.68 13.3 0.69 910.4 405.1 27.95 529.3 22.96
14-2196 25.5 76 28.88 22.07 0.141022364 0.043514377 50.94 105.55 0.674440895 144.54 0.161176654 679.32 0.757510203 72.92 0.081313143 0.44 197.85 257.77 11 7 41 69 104 138 4.922608696 1 14.4 0.64 13.2 0.64 910.2 404.7 27.85 529.9 22.95
14-2217 26.5 76 29.2 22.35 0.148870978 0.045627123 51.55 98.58 0.65663092 142.51 0.159934908 684.51 0.768206049 64.03 0.071859043 0.44 192.91 254.82 3 6 36 69 81 138 4.960217391 0 14.9 0.65 13.3 0.65 910.6 405.8 27.82 529.4 22.99
14-2070 26.2 77 28.45 21.69 0.152456597 0.047515288 50.14 92.13 0.647571519 135.4 0.152075027 684.97 0.769326669 69.98 0.078598304 0.42 186.21 250.28 3 5 39 71 74 141 4.857943262 1 15.4 0.68 13.3 0.68 910.3 404.5 27.84 532.4 22.95
14-2071 25.5 77 28.27 21.81 0.145633013 0.043135684 50.08 99.68 0.665598291 138.37 0.154973904 681.65 0.763445557 72.84 0.081580539 0.43 186.86 252.9 3 5 38 69 75 140 4.868928571 1 14.6 0.64 13.2 0.64 912.5 404.6 27.84 529.4 23.01
14-2089 26.3 77 28.59 21.93 0.13843823 0.0420428 50.52 107.89 0.68108074 137.1 0.152572363 681.79 0.758733126 79.7 0.08869451 0.4 187.85 247.45 3 5 40 69 74 139 4.904964029 1 15 0.66 13.4 0.67 910 404.5 27.88 529.3 22.95
14-2096 26.1 77 29.07 22.05 0.152142414 0.048437177 51.12 93.81 0.647277996 137.75 0.15312361 681.53 0.757592263 80.32 0.089284126 0.41 180.79 248.3 2 5 40 70 74 138 4.938623188 1 15.5 0.68 13.2 0.68 911.4 406.6 27.85 529.7 22.95
14-2097 26.2 77 28.56 21.85 0.143109772 0.043948127 50.42 102.27 0.669832329 138.57 0.155570774 683.6 0.767469014 68.55 0.076960212 0.43 184.51 252.1 3 5 41 67 77 139 4.917985612 1 15.4 0.67 13.2 0.67 910.2 404.5 27.84 529.3 22.96
14-2101 25.8 77 29.22 21.94 0.146647951 0.048659849 51.16 98.45 0.658044248 134.46 0.14986124 683.66 0.761967389 79.11 0.088171372 0.43 191.78 247.27 3 5 39 73 74 139 4.918417266 1 15.1 0.66 13.3 0.67 910 404.5 27.82 529.4 22.95
14-2105 25.6 77 28.57 22.42 0.151282051 0.041497976 50.98 97.21 0.655937922 133.63 0.150562228 680.57 0.766804876 73.34 0.082632895 0.43 187.49 248.6 3 5 40 72 70 139 4.89618705 1 15.1 0.67 13.2 0.66 910 404.5 27.82 530.3 22.95
14-2108 26 77 28.77 21.94 0.139602952 0.043458895 50.71 106.45 0.6773352 139.91 0.151655737 682.38 0.739667227 100.26 0.108677036 0.44 190.4 251.82 33 5 38 70 75 138 4.944782609 1 15.1 0.65 13.1 0.65 910 404.5 27.87 529.5 22.94
14-2118 25.5 77 29.07 22.05 0.136540962 0.043470184 51.12 110.37 0.683447892 133.48 0.149013129 682.43 0.761844691 79.85 0.089142181 0.41 186.6 248.68 25 6 43 69 73 140 4.8745 1 14.9 0.65 13.2 0.65 910 404.6 27.84 529.7 22.95
14-2119 25.5 77 28.56 22.06 0.140841474 0.041499074 50.62 106.01 0.676817979 126.99 0.144020414 680.85 0.772157641 73.91 0.083821945 0.44 190.48 249.54 24 6 40 72 70 140 4.863214286 1 15.3 0.67 13.2 0.66 912 404.6 27.84 530 22.95
14-2121 25.9 77 28.57 21.92 0.152021638 0.046119703 50.49 93.7 0.649837021 136.6 0.153378022 685.37 0.769551206 68.64 0.077070772 0.42 191.68 248.23 19 5 38 70 74 140 4.8955 1 15.9 0.7 13 0.69 910.4 404.8 27.8 530 22.96
14-2130 26.9 77 29.14 21.94 0.148745763 0.048813559 51.11 96.42 0.653694915 130.94 0.146138393 691.55 0.771819196 73.51 0.082042411 0.41 187.17 247.11 23 6 41 68 75 134 5.160820896 1 15.8 0.7 13 0.69 910 404.5 27.84 529.3 22.95
14-2139 26.2 77 29.23 21.67 0.135683426 0.047335796 50.9 108.81 0.681297351 140.23 0.155300346 680.39 0.753510676 82.34 0.091188978 0.43 195.45 249.36 21 5 42 71 74 139 4.894892086 1 15.2 0.67 13.3 0.68 910 404.5 27.85 529.5 22.99
14-2141 26.3 77 28.68 22.44 0.148727466 0.04135737 51.12 99.76 0.661187699 137.64 0.15382896 679.47 0.759387992 77.65 0.086783048 0.43 187.64 251.01 16 5 43 69 74 135 5.033111111 1 15.6 0.68 13.2 0.68 910 404.7 27.82 529.3 22.96
14-2147 25.1 77 28.76 22.2 0.142161885 0.042008197 50.97 105.2 0.673668033 140.02 0.154385578 686.69 0.75714207 80.24 0.088472352 0.45 189.19 261.33 16 5 38 70 71 137 5.012335766 1 14.5 0.64 13.3 0.65 910 405 27.84 529.6 22.95
14-2150 25.4 77 28.78 21.75 0.148170856 0.047891546 50.53 96.26 0.655766742 143.03 0.159906536 682.14 0.762627731 69.29 0.077465734 0.46 201.04 262.06 15 5 39 71 74 138 4.943043478 1 14.6 0.65 13.2 0.65 910.5 404.6 27.85 530.4 22.97
14-2158 26 77 28.81 22.23 0.147697827 0.043718025 51.08 99.47 0.66088632 136.03 0.153347537 680.88 0.767560621 70.16 0.079091842 0.43 197.24 255.79 17 5 39 72 70 127 5.361259843 0 15.7 0.69 13.2 0.68 911 405 27.94 533 22.95
14-2160 25.8 77 28.51 21.73 0.143688422 0.044832375 50.23 100.99 0.667790782 138.59 0.155554807 683.64 0.767324399 68.71 0.077120794 0.42 186.59 250.01 22 5 40 68 73 139 4.918273381 0 15.4 0.68 13.4 0.69 911.4 404.8 27.84 529.4 22.95
14-2168 26 77 28.91 21.8 0.145410886 0.047425293 50.71 99.21 0.661752935 142.84 0.157628727 682.64 0.753316118 80.7 0.089055155 0.43 190.19 249.94 16 5 36 71 74 140 4.876 1 15 0.64 13.2 0.64 910.3 404.7 27.81 531.1 22.94
14-2185 25.7 77 27.83 22.06 0.145456943 0.038045628 49.92 101.77 0.671040485 145.24 0.163352528 679.67 0.764429998 64.21 0.072217473 0.45 186.39 252.67 27 6 39 69 75 140 4.854785714 1 15.3 0.66 13.3 0.66 917.2 405.9 27.84 534.2 22.95
14-2197 25.7 77 28.78 21.94 0.141311349 0.044055133 50.72 104.54 0.673322169 145.04 0.161750438 680.77 0.759203292 70.88 0.07904627 0.45 208.4 261.47 7 6 40 70 106 133 5.118571429 1 14.6 0.65 13.3 0.65 911.4 404.5 27.83 529.7 22.94
14-2205 25.4 77 28.89 22.43 0.147662936 0.042527979 51.32 100.58 0.662146149 143.88 0.161892117 677.69 0.762528974 67.17 0.075578909 0.44 196.46 254.75 5 5 34 71 80 139 4.875467626 0 14.9 0.66 13.3 0.66 915.5 405 27.83 530.9 22.95
14-2209 24.9 77 29.41 22.28 0.14359371 0.045952565 51.69 103.47 0.666860015 139.44 0.155179897 680.03 0.756791346 79.1 0.088028757 0.45 203.51 257.11 4 5 34 70 79 139 4.892302158 1 14.1 0.62 13.3 0.62 912 404.5 27.84 529.3 22.95
14-2218 25.5 77 29.41 22.54 0.154383562 0.047054795 51.95 94.05 0.644178082 146.88 0.161901193 686.97 0.75722537 73.37 0.080873438 0.44 194.93 261.98 5 5 35 70 84 140 4.906928571 0 13.9 0.61 13.3 0.62 911 404.6 27.82 529.4 22.95
14-2047 26.3 78 28.57 21.99 0.146776131 0.04391937 50.56 99.26 0.662528367 136.56 0.15479834 683.59 0.774887211 62.03 0.070314448 0.4 185.72 249.75 2 5 42 70 73 139 4.917913669 1 15.2 0.66 13.2 0.66 911.7 404.5 27.84 529.5 22.95
14-2073 25.8 78 28.52 21.59 0.138326499 0.044400308 50.11 105.97 0.678946694 137.61 0.153146736 683.74 0.760937065 77.2 0.085916198 0.42 186.58 249.53 3 6 41 70 77 140 4.883857143 1 14.7 0.65 13.3 0.65 910.1 404.5 27.82 529.2 22.92
14-2090 26.4 78 29.11 21.58 0.146047645 0.050961018 50.7 97.07 0.656943692 134.68 0.150151623 680.52 0.75869604 81.76 0.091152337 0.41 183.98 242.71 4 4 39 70 76 139 4.895827338 1 15.3 0.67 13.4 0.67 910 404.5 27.84 529.4 22.95
14-2098 26.8 78 28.55 21.94 0.154703145 0.046608377 50.49 91.33 0.643985334 136.29 0.151892386 681.68 0.75971826 79.31 0.088389354 0.43 175.65 241.7 3 5 39 73 74 140 4.869142857 1 15.4 0.66 13.3 0.66 910 404.5 27.82 529.3 22.94
14-2106 25.5 78 28.59 21.88 0.145246946 0.044543282 50.5 100.17 0.664962825 138.52 0.155565289 679.77 0.763417675 72.14 0.081017037 0.42 183.85 250.55 11 5 40 72 75 133 5.111052632 1 15.1 0.67 13.3 0.67 910 404.5 27.9 529.3 22.95
14-2110 26 78 29.08 21.69 0.138851546 0.047308111 50.77 105.44 0.674988797 137.32 0.153204213 682.78 0.761759193 76.22 0.085036594 0.43 186.06 251.1 19 5 38 71 74 138 4.947681159 1 15 0.68 13.3 0.68 910.4 404.5 27.84 530 22.96
14-2113 26 78 29.29 21.95 0.140327324 0.046924946 51.24 105.18 0.672420407 133.33 0.149299024 688.18 0.77060378 71.53 0.080097196 0.41 190.01 248.24 21 5 41 68 74 142 4.846338028 1 15.9 0.69 13.4 0.7 910 404.5 27.84 530.3 22.95
14-2116 27.1 78 28.4 21.9 0.143202773 0.042503106 50.29 102.63 0.671091349 129.5 0.146763829 683.98 0.775162347 68.89 0.078073824 0.39 173.19 238.57 27 5 38 70 74 137 4.992554745 1 16.3 0.72 13.1 0.72 910 404.5 27.86 530.1 22.95
14-2117 25.9 78 29.1 21.98 0.145293496 0.047065045 51.08 100.2 0.662347964 133.26 0.149050399 681.27 0.761995839 79.53 0.088953761 0.42 185.92 249.43 15 5 42 68 75 140 4.866214286 1 15.4 0.67 13.3 0.67 910 282.6 27.83 529.3 22.95
14-2123 26.5 78 28.87 22.09 0.142121855 0.043620923 50.95 104.47 0.672135366 130.1 0.147992265 679.62 0.773086111 69.38 0.078921624 0.42 187.96 252.15 28 7 39 69 73 139 4.889352518 1 16 0.69 13.4 0.7 913.4 405.9 27.85 529.7 22.97
14-2125 26.2 78 28.66 21.95 0.144436402 0.044153451 50.61 101.36 0.666973745 138.81 0.153848712 682.71 0.756674979 80.73 0.089476309 0.44 188.1 247.58 19 5 39 71 73 141 4.841914894 1 15.2 0.65 13.4 0.66 910.1 404.6 27.84 529.3 22.95
14-2131 26.1 78 28.92 22.01 0.145732636 0.0457525 50.96 100.1 0.662782229 140.36 0.157144616 682.51 0.764126334 70.32 0.07872905 0.42 180.13 246.89 27 5 40 71 74 140 4.875071429 1 15.9 0.7 13 0.69 910.3 404.5 27.84 529.2 22.95
14-2134 26.4 78 28.01 22.44 0.148197068 0.036785101 50.46 100.97 0.666820763 133.21 0.149744823 680.94 0.765462353 75.43 0.084792824 0.43 186.15 249.75 18 6 40 71 72 139 4.898848921 1 15.6 0.68 13.3 0.68 910 404.5 27.84 529.3 22.95
14-2143 26.4 78 28.71 21.84 0.146596859 0.046113572 50.55 98.43 0.66069271 135.14 0.151878533 682.14 0.766630329 72.51 0.081491138 0.43 188.74 247.19 23 4 40 73 74 138 4.943043478 1 15.7 0.69 13.1 0.68 911.6 404.5 27.86 530.8 22.95
14-2172 26.2 78 28.61 21.13 0.140203039 0.049631743 49.68 100.97 0.669962179 148.53 0.165458009 681.6 0.759282158 67.56 0.075259834 0.45 188.54 250.1 12 7 37 71 76 140 4.868571429 1 15.3 0.67 13.3 0.68 911.6 405.2 27.93 531.4 22.95
14-2173 26.1 78 28.63 22.01 0.143724696 0.043228418 50.64 102.5 0.669322189 137.29 0.154581485 681.38 0.767198865 69.47 0.07821965 0.45 189.89 250 16 5 40 70 71 139 4.902014388 0 15 0.66 13.4 0.66 910.2 405.9 27.84 529.8 22.95
14-2198 25.5 78 28.51 21.73 0.144914972 0.045215072 50.24 99.71 0.664954985 141.59 0.159548815 681.96 0.768457586 63.89 0.0719936 0.44 197.58 259.07 10 5 38 71 104 134 5.089253731 0 14.3 0.64 13.4 0.65 910.1 404.7 27.85 529.3 22.95
14-2208 26 78 29.43 22.29 0.147313462 0.047187892 51.73 99.59 0.658185183 144.16 0.160243656 682.55 0.758700799 72.92 0.081055545 0.44 188.81 252.9 4 4 33 71 80 138 4.946014493 0 15.1 0.67 13.4 0.68 912 404.9 27.84 529.3 22.95
14-2026 25.3 79 29.36 21.98 0.148253069 0.049777418 51.31 96.92 0.653716444 129.6 0.147167369 680.43 0.772662753 70.6 0.080169878 0.41 182.01 254.41 2 5 41 68 73 138 4.930652174 1 14.2 0.62 13.2 0.62 911.1 404.5 27.84 529.3 22.95
14-2031 25.7 79 28.87 22.09 0.146417445 0.044939352 50.96 99.91 0.662225757 136.83 0.153329822 681.91 0.764138998 73.65 0.08253118 0.41 189.63 249 9 5 41 71 73 141 4.836241135 1 14.5 0.64 13.3 0.64 910 404.5 27.85 529.8 22.95
14-2036 26.2 79 28.67 21.76 0.139290744 0.044232493 50.43 105.79 0.67718602 135.48 0.152799865 682.4 0.769638527 68.77 0.077561608 0.43 183.66 246.35 5 5 39 71 73 139 4.909352518 1 15 0.66 13.1 0.66 911.2 406.2 27.6 530 22.96
14-2068 26.1 79 28.58 21.88 0.137913646 0.042231327 50.46 108.19 0.68194138 141.55 0.157962281 682.27 0.761377078 72.28 0.080660641 0.4 189.35 252.93 5 5 43 68 77 140 4.873357143 1 14.6 0.64 13.4 0.64 915 404.7 27.86 529.1 22.98
14-2077 26 79 28.67 21.83 0.14407339 0.045142555 50.49 101.02 0.666710665 126.62 0.143272571 678.98 0.768276814 78.17 0.088450615 0.4 178.74 248.9 3 5 41 67 73 140 4.849857143 1 14.8 0.65 13.2 0.65 910.7 404.2 27.83 529.7 22.95
14-2091 26.9 79 28.61 21.7 0.150038028 0.047777086 50.27 94.32 0.652146857 133.21 0.151172292 681.4 0.773281282 66.57 0.075546426 0.4 191.03 250.97 3 5 38 71 71 139 4.902158273 0 15.2 0.67 13.2 0.67 910.2 404.5 27.95 529.4 23.01
14-2094 26.7 79 29.34 21.66 0.141596391 0.050205923 51 101.97 0.666601294 135.76 0.154053901 680.96 0.772720567 64.53 0.073225532 0.42 187.88 246.95 3 5 41 71 72 139 4.898992806 0 15.5 0.67 13.4 0.68 910.1 405.3 27.84 529.6 22.95
14-2099 26.2 79 28.67 21.71 0.145363241 0.046601942 50.43 98.97 0.662671577 134.67 0.151580298 682.27 0.76794156 71.5 0.080478141 0.43 185.22 246.45 4 5 40 71 74 136 5.016691176 1 15.6 0.68 13.1 0.68 910 404.5 27.84 529.3 22.96
14-2109 26.1 79 28.87 21.96 0.147858874 0.04652572 50.82 97.69 0.657756531 129.44 0.146430309 680.71 0.77006007 73.82 0.083509621 0.42 185.8 247.24 19 6 39 71 74 138 4.932681159 1 15.4 0.68 13.4 0.68 910.1 404.5 27.85 529.3 22.96
14-2126 26.8 79 28.83 22.02 0.150894264 0.04666621 50.85 95.08 0.651545261 132.85 0.149676649 682.75 0.769226436 71.98 0.081096915 0.42 186.04 244.93 21 5 40 72 73 140 4.876785714 1 15.7 0.69 13.2 0.68 910.1 404.5 27.84 529.2 22.95
14-2144 26.5 79 29.09 21.81 0.142353632 0.047516481 50.88 102.31 0.667776255 131.82 0.147408443 682.3 0.762985742 80.13 0.089605815 0.44 184.95 246.49 27 5 40 70 73 138 4.944202899 1 15.5 0.68 13.3 0.68 910.9 404.6 27.83 529.4 22.95
14-2154 25.9 79 28.86 22.18 0.151678862 0.045681461 51.04 95.19 0.650960815 141.68 0.15842027 679.73 0.760043832 72.92 0.081535898 0.44 191.89 254.45 17 6 37 71 73 139 4.890143885 1 14.9 0.67 13.1 0.66 910 404.6 27.86 529.1 22.98
14-2178 25.4 79 28.61 22.06 0.143042407 0.042471794 50.67 103.55 0.671443393 140.78 0.157087225 683.56 0.762740044 71.85 0.080172731 0.46 190.48 256.42 17 6 38 67 73 140 4.882571429 1 14.5 0.64 13.3 0.64 910.7 405.4 27.84 529.6 22.95
14-2224 26.4 79 29.18 22.15 0.144149421 0.045750358 51.33 102.33 0.6659508 142.63 0.159284821 680.76 0.760251943 72.05 0.080463236 0.41 191.18 249.89 4 7 37 68 77 143 4.760559441 0 15 0.67 13.2 0.67 911.3 405.5 27.88 530.3 22.95
14-2029 25.5 80 28.57 21.85 0.147177691 0.045264718 50.42 98.04 0.6603799 140.08 0.158702105 678.95 0.769208982 63.63 0.072088913 0.41 179.35 247.73 11 5 41 69 75 139 4.884532374 1 14.7 0.63 13.4 0.64 910.6 404.8 27.84 529.4 22.94
14-2048 26.2 80 28.9 22 0.138888889 0.043560606 50.88 107.5 0.678661616 137.19 0.154964419 679.88 0.767965661 68.23 0.07706992 0.43 186.25 249.36 2 5 40 70 72 139 4.891223022 1 14.9 0.65 13.2 0.65 911.1 404.4 27.88 528.9 22.95
14-2072 26.2 80 28.53 21.38 0.143953676 0.048141664 49.91 98.61 0.663950983 149.33 0.165570844 680.97 0.75503099 71.61 0.079398166 0.43 186.28 250.81 3 5 41 70 78 140 4.864071429 1 14.6 0.64 13.3 0.64 910 404.5 27.88 529.3 22.93
14-2079 26.2 80 28.33 21.76 0.147056836 0.044400892 50.09 97.88 0.661485436 132.53 0.149582393 685.2 0.773363431 68.27 0.077054176 0.42 182.96 251.53 4 5 42 69 76 139 4.929496403 1 15.2 0.66 13.1 0.65 913.4 404.8 27.84 529.8 22.95
14-2084 26.6 80 28.73 22.5 0.142884359 0.039563091 51.23 106.24 0.674668191 137.26 0.154936732 679.31 0.766793467 69.34 0.078269802 0.42 179.77 248.16 2 5 42 70 75 140 4.852214286 1 15.2 0.66 13.1 0.66 912.2 809.8 27.84 530.1 22.96
14-2088 26.7 80 28.81 21.85 0.14640847 0.046636291 50.66 98.58 0.66054677 135.68 0.152341601 679.89 0.763380978 75.06 0.084277422 0.42 191.5 249.72 4 5 39 70 74 139 4.891294964 1 15.1 0.66 13.2 0.66 910.1 404.5 27.85 529.3 22.95
14-2093 26.4 80 29.13 21.91 0.14788067 0.048731102 51.02 97.12 0.655507559 132.09 0.148399056 679.03 0.762869341 78.98 0.088731603 0.43 186.73 252.26 3 4 41 72 74 156 4.35275641 1 15.2 0.67 13.2 0.66 918.1 404.7 27.85 530.1 22.95
14-2112 26.5 80 27.18 22.09 0.148794288 0.034285329 49.27 99.19 0.668126095 138.96 0.154957848 679.16 0.757348677 78.64 0.087693474 0.42 188.16 249.62 13 5 41 70 74 138 4.921449275 1 15.6 0.7 13.1 0.69 910.2 404.6 27.85 530.4 23.07
14-2114 25.9 80 28.88 22.07 0.145474919 0.044888274 50.95 100.76 0.664161888 140.41 0.155384394 681.69 0.754390624 81.53 0.090224981 0.41 183.05 245.79 19 5 41 70 77 141 4.834680851 1 15.4 0.67 13.2 0.67 910.1 404.5 27.83 529.4 22.95
14-2115 26.1 80 28.62 22.09 0.145549186 0.043025631 50.71 101.06 0.665875997 135.55 0.152125606 681.09 0.764376459 74.4 0.083497935 0.4 183.19 245.65 21 5 42 71 74 140 4.864928571 1 15.9 0.69 13.3 0.69 910 404.5 27.82 530.1 22.95
14-2133 26.6 80 28.25 21.52 0.134525223 0.042070388 49.78 110.2 0.688879165 138.94 0.15388364 685.08 0.758763526 78.87 0.087352834 0.42 177.51 242.55 24 5 42 69 76 141 4.858723404 1 15.9 0.68 13.4 0.68 910.1 404.5 27.84 529.5 22.95
14-2138 26 80 28.79 21.54 0.138958777 0.046771176 50.33 104.68 0.67531127 135.1 0.153162447 682.09 0.7732833 64.88 0.073554253 0.4 194.83 253.63 25 5 41 71 73 140 4.872071429 1 15.4 0.68 13.2 0.68 911.3 404.5 27.84 529.3 22.97
14-2152 25.9 80 28.52 21.92 0.141364633 0.042564169 50.44 104.62 0.674706565 142.96 0.15984436 681.87 0.762402585 69.54 0.077753055 0.43 184.51 253.81 18 5 39 69 72 140 4.8705 1 15 0.67 13.2 0.67 910.1 404.5 27.83 529.9 22.92
14-2155 25.5 80 28.84 22.09 0.150272109 0.045918367 50.93 96.07 0.653537415 147.65 0.164179602 682.4 0.758795534 69.27 0.077024863 0.44 192.65 252.7 21 7 37 70 76 140 4.874285714 0 14.7 0.65 13.4 0.66 910.2 404.8 27.87 530.3 22.95
14-2220 25.7 80 28.89 22.24 0.151829601 0.045398689 51.16 95.35 0.650942108 144.31 0.160344444 688.07 0.764522222 67.62 0.075133333 0.44 180.89 251.22 6 4 37 71 83 146 4.712808219 0 13.4 0.58 13.4 0.58 912 404.9 27.84 530.3 22.95
14-2222 28.2 80 28.78 22.06 0.14810339 0.045115811 50.84 98.11 0.658677409 140.47 0.154999669 688.57 0.759792995 77.22 0.085207336 0.43 188.93 252.8 4 5 36 69 80 139 4.953741007 0 13.8 0.55 13.3 0.56 913.7 405.5 27.84 530.6 22.95
14-2025 25.9 81 28.96 21.96 0.150441872 0.047955059 50.91 95.05 0.651161198 138.33 0.15637046 684.09 0.773306354 62.21 0.070323186 0.43 188.29 250.04 3 5 38 70 74 141 4.851702128 1 14.9 0.64 13.4 0.66 910.7 404.7 27.88 530.8 22.96
14-2027 25.8 81 28.85 21.89 0.145245836 0.046181408 50.75 99.97 0.663326919 141.76 0.158857873 690.76 0.774073535 59.85 0.067068593 0.43 184.96 250.49 12 5 42 69 74 143 4.83048951 1 14.6 0.65 13.2 0.64 910 404.7 27.84 529.7 22.96
14-2028 25.3 81 28.62 22.06 0.149549183 0.044471561 50.69 96.83 0.656430073 135.26 0.154431073 680.22 0.776630968 60.38 0.068937958 0.41 185.53 249.6 7 5 41 70 74 140 4.858714286 1 14.6 0.63 13.3 0.64 911.1 405.6 27.83 529.5 22.95
14-2035 25.9 81 28.62 21.81 0.138037975 0.043101266 50.45 107.57 0.680822785 136.81 0.154157324 682.48 0.769017544 68.18 0.076825132 0.43 185.54 250.21 6 5 41 67 74 145 4.706758621 1 14.7 0.65 13.4 0.66 910.7 405 27.81 529.3 22.92
14-2049 26.4 81 29.37 22.09 0.139377879 0.045933497 51.45 107.03 0.675310745 137.97 0.154858913 681.58 0.765012234 71.39 0.080128853 0.41 177.38 250.53 2 5 42 68 73 140 4.868428571 1 14.9 0.64 13.1 0.63 915.5 404.5 27.84 529.6 22.95
14-2085 26.8 81 28.62 21.7 0.153432794 0.048928799 50.3 91.11 0.644205614 134.79 0.153153051 681.88 0.774775594 63.43 0.072071356 0.42 177.7 246.18 3 5 38 72 74 140 4.870571429 1 15.3 0.67 13.5 0.68 910.2 404.6 27.84 529.3 22.96
14-2102 26.6 81 28.01 21.98 0.138517772 0.038001008 49.98 108.69 0.684963448 138.31 0.153984035 682.52 0.759866846 77.38 0.086149119 0.43 190.1 248.19 3 9 42 71 75 136 5.018529412 1 15.4 0.68 136 0.67 910 404.5 27.85 529.3 22.96
14-2111 26 81 28.19 22.09 0.152797953 0.042194093 50.28 94.29 0.652210002 135.03 0.15005334 682.33 0.758245544 82.52 0.091701116 0.43 174.58 242.97 16 5 38 70 77 141 4.839219858 1 15.5 0.68 13.2 0.68 910.2 404.3 27.83 529.3 22.93
14-2120 25.4 81 28.88 22.16 0.145321005 0.044068464 51.03 101.45 0.665289527 136.26 0.152354756 684.75 0.765631289 73.35 0.082013954 0.43 185.32 247.96 23 5 41 67 73 141 4.856382979 1 15 0.66 13.2 0.65 910.2 404.5 27.86 530.2 23.14
14-2136 26.1 81 28.47 21.98 0.14598831 0.043105739 50.46 100.11 0.664917641 140.98 0.157038786 681.07 0.758649498 75.69 0.084311716 0.41 190.16 251.74 19 5 40 70 76 139 4.899784173 1 15.5 0.65 13.1 0.65 910.6 404.7 27.83 529.5 22.96
14-2142 26.2 81 28.36 21.85 0.142745149 0.042529562 50.21 102.86 0.67198014 130.8 0.147845057 682.05 0.770930587 71.86 0.081224356 0.43 190.68 253.26 20 5 39 69 75 139 4.906834532 1 15.4 0.65 13.4 0.66 910.1 404.6 27.84 529.3 22.95
14-2146 26.2 81 28.58 22.09 0.148564127 0.043647858 50.67 98.02 0.659223889 138.31 0.153689731 682.86 0.758792351 78.76 0.087517918 0.43 196.2 253 16 5 39 70 75 138 4.94826087 1 15 0.67 13.1 0.67 910.1 404.6 27.84 529.6 22.95
14-2157 25.9 81 28.63 21.94 0.144389602 0.044027641 50.57 101.38 0.667193156 141.37 0.158018868 682.53 0.762910221 70.74 0.079070911 0.43 192.75 252.09 16 5 40 70 73 135 5.055777778 1 15.4 0.67 13.1 0.67 910 404.6 27.83 529.2 22.95
14-2167 25.8 81 27.65 22.08 0.14977615 0.037783204 49.73 97.69 0.662664496 136.45 0.153228523 679.97 0.763582257 74.08 0.08318922 0.43 196.57 253.1 9 6 37 72 70 139 4.891870504 1 14.6 0.65 13.3 0.65 911.2 404.5 27.83 529.4 22.97
14-2170 25.7 81 28.41 22.11 0.150254842 0.042813456 50.52 96.63 0.65667686 138.2 0.156591695 682.73 0.773587899 61.62 0.069820407 0.43 191.87 252.03 22 5 40 69 73 140 4.876642857 0 15.1 0.66 13.3 0.67 910 404.5 27.83 529.7 22.98
14-2186 26.2 81 29.03 22.05 0.144580683 0.045767491 51.13 101.43 0.665071143 137.8 0.155169696 681.85 0.767797221 68.41 0.077033083 0.46 181.83 246.26 24 5 38 69 72 139 4.905395683 1 15.5 0.68 13.4 0.69 910.1 405.1 27.83 529.4 22.95
14-2187 25.6 81 27.97 22.01 0.143893828 0.038964435 49.97 102.98 0.673247908 141.42 0.158916732 681.82 0.766175975 66.66 0.074907293 0.46 191.14 253.71 20 7 27 69 74 139 4.905179856 0 15 0.66 13.3 0.66 910 404.5 27.84 531 22.95
14-2221 25.6 81 29.1 22.15 0.152045579 0.047707304 51.25 94.43 0.648201538 137.66 0.156243616 677.34 0.768778517 66.06 0.074977868 0.43 182.43 249.01 6 5 32 70 81 139 4.87294964 0 13.9 0.61 13.3 0.61 910 404.5 27.84 531.1 22.95
14-2046 25.9 82 28.9 22 0.155279503 0.048701299 50.9 90.78 0.640739695 131.1 0.149608006 681.83 0.778087163 63.36 0.072304831 0.4 185.77 250.26 3 5 39 71 73 140 4.870214286 0 15 0.65 13.3 0.65 910.2 404.7 27.83 530.2 22.96
14-2057 26.1 82 28.73 21.98 0.151013397 0.046375816 50.71 94.84 0.651597389 133.51 0.151128569 681.83 0.771807294 68.08 0.077064137 0.4 186.89 249.59 3 5 37 71 73 140 4.870214286 1 14.7 0.64 13.2 0.64 910.9 404.4 27.73 529.9 22.94
14-2074 26.6 82 28.82 21.62 0.149495229 0.049785645 50.44 94.18 0.651223897 139.95 0.157631529 682.8 0.76906615 65.08 0.073302321 0.43 182.46 246.48 2 6 38 71 75 140 4.877142857 0 15.6 0.68 13.3 0.68 910 406 27.98 529.5 22.88
14-2080 27.3 82 28.72 21.78 0.139776665 0.04453857 50.5 105.32 0.675908099 129.15 0.144782126 682.49 0.765097586 80.39 0.090120287 0.42 176.95 242.29 3 5 42 69 73 160 4.2655625 1 15.1 0.67 13.4 0.68 910 404.2 28.08 529.5 22.83
14-2087 26.6 82 28.25 21.64 0.144247434 0.044060792 49.88 100.13 0.667444341 134.14 0.149363086 683.64 0.761223944 80.3 0.08941297 0.42 182.84 246.88 3 5 42 71 74 140 4.883142857 1 15 0.67 13.3 0.67 910.3 404 27.84 529.3 22.92
14-2092 26.7 82 28.6 22.06 0.15110624 0.044797589 50.66 95.33 0.652989931 138.22 0.154771236 681.53 0.763140215 73.31 0.082088549 0.44 182.56 245.4 3 5 41 70 74 140 4.868071429 1 15.5 0.68 13.5 0.69 910 404.9 27.83 530.8 22.95
14-2103 26.3 82 28.5 21.87 0.142633536 0.04324007 50.37 102.96 0.671492859 135.66 0.151230714 682.24 0.760545795 79.14 0.088223491 0.44 178.27 243.15 2 5 41 68 76 139 4.908201439 1 15.4 0.67 13.3 0.68 910.2 404.7 27.8 529.6 22.94
14-2104 25.8 82 28.32 21.96 0.144616398 0.041883438 50.28 101.57 0.668883767 131.3 0.148581516 680.87 0.770485125 71.52 0.080933359 0.42 185.25 246.85 2 5 42 67 74 138 4.93384058 1 15.2 0.67 13.3 0.67 911.5 404.6 27.82 532.2 22.95
14-2148 25.5 82 28.37 22.09 0.147374741 0.041897391 50.46 99.43 0.663353126 141.5 0.158044051 680.72 0.760309163 73.1 0.081646786 0.43 200.65 261.38 20 5 38 69 73 138 4.932753623 1 14.6 0.64 13.2 0.64 910 404.8 27.84 530.2 22.95
14-2161 26.4 82 28.96 22 0.141306442 0.04470422 50.96 104.73 0.672682895 145.24 0.160631733 683.18 0.755579641 75.76 0.083788626 0.44 185.91 247.43 16 5 38 68 77 139 4.914964029 1 15.5 0.67 13.3 0.67 910.8 404.4 27.81 529.5 22.95
14-2169 25.4 82 28.6 22.8 0.147191737 0.037443512 51.4 103.5 0.668173015 139.36 0.15719007 681.46 0.76864771 65.75 0.074162221 0.45 190.16 254.09 15 6 39 68 74 139 4.902589928 0 14.7 0.64 13.2 0.63 911 404.6 27.84 529.5 22.95
14-2033 26.2 83 28.99 21.95 0.145143159 0.04655161 50.94 100.29 0.663162071 138.24 0.154876874 682.85 0.765029465 71.49 0.080093661 0.41 188.99 249.23 9 5 41 70 72 141 4.842907801 1 14.7 0.64 13.2 0.63 910.2 404.8 27.83 530.5 22.93
14-2040 26.1 83 28.73 21.89 0.149470809 0.04670536 50.61 95.83 0.654353022 138.69 0.156145506 688.76 0.775447248 60.76 0.068407246 0.41 180.64 243.36 6 5 37 72 74 141 4.884822695 0 14.7 0.66 13.5 0.67 910.8 404.6 27.81 529.3 22.75
14-2043 26.2 83 28.83 21.54 0.143361065 0.048519135 50.38 99.88 0.664758735 128.34 0.145347059 682.11 0.772500255 72.54 0.082152686 0.43 186.17 250.83 3 5 38 71 74 140 4.872214286 1 14.6 0.63 13.4 0.64 910.7 404.6 27.84 529.5 22.91
14-2044 26.1 83 28.4 21.91 0.149444103 0.044267103 50.31 96.3 0.65684469 151.19 0.169275382 680.46 0.761856778 61.51 0.06886784 0.43 185.61 251.38 7 6 39 70 84 135 5.040444444 0 15.3 0.66 13.3 0.67 910.1 404.2 27.85 529.2 22.85
14-2056 26.1 83 29.14 21.92 0.150725435 0.049645878 51.04 94.37 0.648903252 139.1 0.157983804 679.89 0.772189853 61.48 0.069826343 0.4 184.49 254.17 3 6 38 70 77 145 4.688896552 1 14.4 0.63 13.3 0.63 912 404.6 27.83 529.4 22.89
14-2060 27 83 29.06 21.9 0.14431631 0.047182867 50.96 100.79 0.664184514 133.61 0.152241289 681.3 0.776304095 62.71 0.071454616 0.4 187.17 247.53 3 5 40 71 73 140 4.866428571 0 15.3 0.67 13.2 0.68 910.1 404.5 27.84 529.6 22.95
14-2061 26.3 83 28.59 21.64 0.143131159 0.045968649 50.24 100.96 0.667769032 135.72 0.152306138 677.83 0.760666592 77.55 0.08702727 0.42 185 252.31 3 5 40 68 76 137 4.947664234 1 14.7 0.65 13.3 0.65 910.4 406 27.89 529.1 22.94
14-2078 26.5 83 29.33 21.3 0.14458322 0.054507195 50.63 96.69 0.656326364 140.18 0.156713248 679.94 0.760134153 74.38 0.083152599 0.41 185.89 248.73 3 5 39 71 76 140 4.856714286 1 15.3 0.67 13.5 0.68 910 404.8 27.84 529.6 22.95
14-2137 26.3 83 28.88 21.79 0.142083985 0.04623109 50.66 102.69 0.669600939 132.58 0.14814401 680.57 0.760464389 81.79 0.091391602 0.43 184.25 248.58 17 5 40 70 75 140 4.861214286 1 15.2 0.66 13.4 0.66 910.4 404.5 27.84 529.4 22.95
14-2153 25.7 83 28.74 22.09 0.146136544 0.04399312 50.84 100.33 0.663733792 146.1 0.162968912 681.09 0.759729612 69.3 0.077301476 0.43 198.46 258 20 5 38 67 75 138 4.935434783 0 14.8 0.66 13.3 0.67 910.6 404.6 27.83 530.1 22.95
14-2174 25.4 83 29.08 22.07 0.146868969 0.046649364 51.16 99.12 0.659612697 138.72 0.156761705 681.9 0.770586839 64.29 0.072651456 0.44 195.85 257.18 18 5 36 68 74 139 4.905755396 1 14.8 0.64 13.4 0.65 912.6 405.1 27.84 529.8 22.95
14-2176 26.4 83 28.97 21.9 0.141390664 0.045645297 50.88 104.02 0.671573375 135.02 0.152926119 683.84 0.77452968 64.05 0.0725442 0.43 186.22 250.85 24 5 39 68 72 140 4.884571429 1 15.1 0.66 13.4 0.67 915.6 404.5 27.85 534.2 22.95
14-2045 26 84 28.88 21.92 0.140756437 0.044692737 50.8 104.93 0.673794388 138.17 0.155365898 681.12 0.765888544 70.03 0.078745558 0.43 179.84 249.35 6 5 42 71 75 140 4.865142857 1 14.9 0.65 13.3 0.66 910.1 404.7 27.84 529.9 22.96
14-2050 26.7 84 28.62 21.74 0.142885311 0.045218534 50.36 101.79 0.669010845 129.86 0.148147303 685.93 0.78252487 60.77 0.069327827 0.44 177.99 246.66 2 5 41 67 73 141 4.864751773 1 15.1 0.66 13.3 0.66 914 404.9 27.84 530.5 22.95
14-2059 26.4 84 28.88 21.85 0.153279551 0.049316029 50.73 91.82 0.644124868 130.61 0.149394917 680.58 0.778464072 63.07 0.072141011 0.41 176.98 247.12 3 5 40 70 74 140 4.861285714 1 15.3 0.68 13.5 0.67 911.6 404.5 27.84 529.9 22.93
14-2076 26.4 84 28.64 21.9 0.139206712 0.042842614 50.54 106.78 0.678743961 138.91 0.154877913 684.06 0.762693723 73.93 0.082428364 0.42 187.31 247.67 2 4 41 68 78 124 5.516612903 1 15.6 0.7 13.2 0.7 910.2 405.6 27.83 531.5 22.97
14-2151 26.4 84 28.71 22.07 0.144295521 0.04341288 50.77 102.17 0.667996077 136.46 0.153714447 679.56 0.765485779 71.73 0.080799775 0.41 191.71 257.36 19 6 38 69 73 137 4.960291971 1 15.1 0.67 13.2 0.67 911.2 404.9 27.84 529 22.95
14-2034 26 85 28.86 21.92 0.140135533 0.044367728 50.77 105.64 0.675361207 134.77 0.151493351 684.07 0.768954935 70.77 0.079551714 0.42 189.62 253.3 7 5 41 70 72 140 4.886214286 1 14.5 0.63 13.2 0.62 913.6 404.6 27.8 530 22.94
14-2086 27.1 85 28.63 21.44 0.136075146 0.045633409 50.07 107.49 0.682216299 136.64 0.153127206 684.37 0.766947206 71.32 0.079925588 0.4 184.32 248.37 3 5 43 67 77 140 4.888357143 1 15.1 0.66 13.5 0.68 910.2 404.5 27.86 529.5 22.91
14-2149 26.2 85 29.09 21.74 0.147359859 0.049820376 50.83 96.7 0.655459906 134.94 0.152641879 683.55 0.773220366 65.54 0.074137756 0.42 203.29 258.39 24 5 38 69 71 138 4.95326087 0 14.5 0.56 13.5 0.57 910.9 405.6 27.85 529.6 22.95
14-2165 26 85 28.74 21.94 0.144923707 0.044917102 50.7 100.71 0.665235485 140.14 0.158468462 680.6 0.769613497 63.6 0.071918041 0.44 188.37 247.41 16 5 36 69 73 140 4.861428571 0 15.7 0.67 13.4 0.68 912.3 408.2 27.81 529.7 22.94
14-2166 25.7 85 28.99 21.92 0.14472468 0.046678991 50.91 100.55 0.663871649 134.66 0.151986456 679.05 0.766422122 72.29 0.081591422 0.44 191.46 255.99 15 5 38 70 71 138 4.920652174 1 14.7 0.66 13.2 0.65 913.8 404.5 27.87 529.6 22.95
Manually intensive & time intensive to gather the data
Manually intensive & time intensive to format the data for analysis
It can take armies & weeks to create insights… and it may be too late
7. Step Two: Analyze Data
• Time to hire a consultant…
– Or an Operational Excellence person
– Or statistician?
– Or bioinformatics?
– Or???
• Turning seas of data into drinkable information is both
art and science. It helps if you have end to end
process understanding… not many do
7
8. Process Modeling Using Minitab®
Release Test A = 341 + 3.32 PP1 + 1.04 PP2 - 1.44 PP3
- 3.38 PP4 + 1.07 PP5 - 0.218 PP6+ 7.6 PP7 + 0.79 PP8
- 0.094 PP10 - 0.164 PP11 - 7.2 PP12 - 0.098 PP13
+ 0.083 PP14 + 0.22 PP15 - 3.82 PP16 - 0.68 PP17
+ 0.348 PP18 + 1.19 PP18 - 1.75 PP19 - 2.40 PP20
- 8.31 PP21+ 4.30 PP22 - 0.011 PP23 - 0.641 PP24
- 0.153 PP25 - 7.3 PP27 - 0.42 PP28 + 0.065 PP29
- 0.67 PP30
8
That’s looks complicated… so it must be awesome! And worth it.. Right?
9. This looks promising! But now what???
9
The model appears to follow quite nicely with the actual results… but there are gaps
10. Step Three: “Optimizing” Your Process…
• Questions should abound at this point
– What does the analysis mean?
– Did I use the right data?
– Did I use enough data?
– Which are the most important?
• The most common pitfall in process optimization is
not having the right level of predictive capability – in
other words Root Cause.
10
11. Manually Gathered Data Is Often Limiting…
11
MRP
Raw Material
Purchase
BOM item
Supplier
Lead Time
Agreed Delivery
Date
Order Size
Unit of Measure
Price
MRP
Raw Material
Receipt
Received Date
Quantity
Received
C of A (Multiple
Parameters)
Supplier Lot #
Expiry Date
XL Spreadsheet
Raw Material
Test Results
(Multiple
parameters)
Weighing and
Dispensing
MRP
BOM item
(multiple)
Lot kit
Weight
Volume
Raw Material
Combo 1
Historian Batch Record
Supplier lot #
and amount
for each:
RAW 1
RAW 2
RAW 3
RAW4
RAW5
AWFI
(amount)
Solvent amount
Mixing time
Temperature
Pressure
Tank Weight
Raw Material
Combo 2
Historian
Amount of AWFI
Mixing time
Pressure
Tank Weight
Batch Record
Supplier lot #
and amount
for RAW 6
Mixing Step 1
Historian
Historian
Raw Material
Combo 3
RAW 7 lot #
and the
amount
RAW 8 lot #
and the
amount
AWFI amount
Temperature
Batch Record
Mixing Step 2
Historian
Time
Pressure
Mixing Speed
Ramp time
Total Mixing time
Conductivity
Temperature
Filtration Step
Batch Record Log Book
Lot #
Number
of uses
Concentration
Step 1
Conductivity
Dilution Transfer time
Buffer Exchange qty
Buffer Exchange transfer time
Buffer exchange flow rate
Temperature
Pressure
Historian
Finished Product
Transfer
Historian
Bulk volume
Temperature
Pressure
Finished Product
Hold
Saline amount
Lot #
Batch record
Inspection Sampling
Saline added
Lot #
Batch record
QC Release
XL Spreadsheet
Tank farm hold
Log Book
Tank ID
Lot #
Time
Temperature
Filling
XL Spreadsheet
Packaging& Labeling
Paper based
record
P&L Loss
Total Cartons
XL Spreadsheet
Initial Bulk
concentration
XL Spreadsheet
Final Bulk
concentration
Amount of AWFI
Pressure
Combo 1 transfer time
Combo 1 transfer amount
Combo 2 transfer time
Combo 2 transfer amount
Mixing Speed
Ramp time
Total mix time
Conductivity
Temperature
Release Test 1
Release Test 2
Release Test 3
Release Test 4
Release Test 5
Release Test 6
Release Test 7
Release Test 8
Release Test 9
Release Test 10
Release Test 11
Release Test 12
Release Test 13
Release Test 14
Lot #
Bulk Date
Fill Date
Hold Time
Fill Time
Tank ID
Theoretical Yield
Total vials filled
Filled vials to inspection
Acceptable Inspected vials
Vials to Inventory
Line Loss
Purge loss
Split Loss
Crimp Reject
Weight Check Loss
Other reject
Low/High reject
Dark
Light
Fiber
The previous data set
represented less than
15% of the total
possible parameters
measured
As a result the model
can only explain
~59% of the results..
Good but not great.
12. The Discoverant Value Proposition
• Time savings in data gathering, formatting & analysis
– What’s the cost to have operators, scientists & engineers
data hunting versus producing, discovering & designing?
• In our case, with over 200 hundred parameters it equates to
approximately 3 full time headcount (fully burdened)
• Material savings in avoiding lost production batches
– What’s the cost to throw materials away during production
or reject finished goods lots at QC weeks after?
• In our case anywhere from $20K to $500K depending on where in
the process the scrap occurred
12
13. 3rd Party
LIMSELN
Accelrys
EBRLES PRIMR
DATAACCESS&AGGREGATION
NexusInvisionModules
External DatabasesBIOVIA Product Suite
Accelrys
LIMS
Historian 3rd Party
EBR/MES ERP
Data
Ware-
house
Tabular Data
Process/Product
Monitoring
Investigational
Analysis
Stability
Analysis
SPC
Feature
Extraction
REPORTING&COLLABORATION
Quantitative
Analysis
Chromatography
/Phase Analysis
Dynamic Mapping Engine
CONTEXTUALIZATION
DIRECT CONNECTS
BIOVIA Discoverant Activities
14. Discoverant Harmonizes Four Important Tools
1. It acts as a data warehouse
– Content aggregation from disparate systems
2. It becomes your prime report generator
– Dashboards and standard/custom reports for multiple org levels
3. It performs statistical analysis and modeling*
– Process Optimization want to maximize yield, at optimal
concentration without losing lots later to OOS test results? I do!
4. Manufacturing monitoring during the production
process
– Course corrections in real time to avoid in-process scrap
14
*Multiple Linear Regression Modeling using derived parameter functionality
15. Summary: Discoverant offers powerful capability.
• Automated and preformatted data gathering
• Customizable report generation
• Advanced statistical analysis to enable root cause
identification and optimization faster and with less
resources
• Parametric release? Stay tuned
15
