Inflammatory Bowel Diseases: World Market Report 2009-2024

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Inflammatory Bowel Diseases: World Market Report 2009-2024
Published on February 2009

Report Summary

This brand new in-depth market analysis examines the current and future prospects of the inflammatory bowel diseases (IBD) market.
The world market for intestinal anti-inflammatories was worth over $2400 million in 2008, and had grown at 9% over the previous
year. The value of other types of drugs used to treat IBD, including immunosuppressants and monoclonal antibodies, approached
$12000m. It is predicted the market for intestinal anti-inflammatories and IBD drugs to continue expanding, based on rising disease
rates and evolving diagnostic methods. Currently, IBD is under-diagnosed, especially in developing countries. As governments and
health services address chronic illnesses like IBD, this market will expand into previously untreated regions. Continuing studies and
surveys indicate that IBD is spreading globally, and has an especially high prevalence rate in India. In addition, the Latin American
countries experienced 14% sales growth last year, and are set to account for an increasingly large share of the world market in years
to come.

This report ' Inflammatory Bowel Diseases: World Market 2009-2024 - discusses and analyses the major drug categories used in the
treatment of IBD. This report forecasts the top brand-name and generic drugs used for IBD, including monoclonal antibody therapies.
How much of an impact will monoclonal antibodies have on sales of other IBD-related therapies, for example' You should know and
ths report will tell you.

This report also analyses the major markets worldwide, discussing the principal national markets in detail, in addition to the world
market. Through this report, you will discover how the leading markets will perform in the future, and how the relative values of each
region will change over time. The US was the largest market in 2008, but will it retain its leading market share until 2024' How will the
European market share compare with the Asian market share in 2014, 2019 and 2024'

Drug types analysed and forecasted in this report ' Inflammatory Bowel Diseases: World Market 2009-2024 - include:

' Aminosalicylate acid / 5-ASA

' Corticosteroids

' Immunomodulators

' Antibiotics

Inflammatory Bowel Diseases: World Market Report 2009-2024 Page 1/11


' Biologic therapies

' Monoclonal antibodies.

' Includes unique primary material unavailable elsewhere

This report covers disease and therapy distinctions between the two major types of IBD: Crohn's disease and ulcerative colitis. It
discusses these diseases and addresses aetiological theories that impact upon treatment. We provide the information you need to
assess the future of those diseases and of the relevant markets. Sources consulted include industrial databases, commercial
information, published economic research and market-specific interviews with experts in the IBD field. The result is a comprehensive
market- and industry-based report with detailed analyses and informed opinion that you will not find anywhere else.

In particular, Inflammatory Bowel Diseases: The World Market 2009-2024 focuses on the following essential aspects of that
market:

' Forecast of the overall world IBD market from 2009 to 2024

' Forecasts of the current leading drugs' sales from 2009 to 2024

' Assessments of pipeline developments

' Analyses of short- and long-term drivers in the market

' Analyses of how disease theories impact upon treatment procedures

' Sales forecasts for the leading regional markets from 2009 to 2024, including discussions of specific country markets

' Discussion of the importance of generics in the IBD market

' Discussion of why the market contains so many types of drugs, and what that means for future developments

' Assessments of opportunities and threats in the IBD market worldwide

' Analyses of the impact monoclonal antibodies will have on the IBD market, present and future.

Why you should buy this report:

' To receive a comprehensive assessment of the complex IBD market, including the various types of therapies



' To receive a comprehensive analysis of the sales prospects for existing and new IBD drugs from 2009 to 2024

' To discover which types of therapies are most likely to succeed over the short- and long-term, and why each will succeed

' For a thorough assessment of the current and future market at global and regional levels

' To find out where the market is heading, both technologically and commercially

' For a logical analysis of the multifaceted treatment options for IBD, including market drivers and restraints.

The global IBD market is highly complex, with multiple drugs being used simultaneously and/or sequentially for therapy. The market
can therefore accept a large number of drugs, but the market is already fairly saturated, with several similar drugs on the market.
What does such saturation mean for the futures of existing drugs' What does this mean for the pipeline' If, as the author's report
interviewees say, IBD current drugs are less efficacious than they could be, what then are the promising future treatments that could
fill therapeutic gaps' This report covers those important matters, amongst others.

As inflammatory bowel disease rates continue to rise, as too public awareness spreads and more-thorough diagnostic procedures
expand the number of patients, the demand for IBD drugs will increase. What drugs and which companies will meet these therapeutic
needs successfully in the future' Can new and future therapies compete successfully with established treatments'

This report answers those and other important questions, to enable you to take advantage of this expanding market.

Table of Content

Table of Contents

1 Executive Summary
1.1 Inflammatory Bowel Diseases (IBD) Market Trajectory
1.1.1 Prediction for the IBD Market
1.1.2 Prevalence Rates Rising Worldwide
1.2 Aims, Scope and Format of the Report
1.2.1 Chapter Outline
1.3 Complexities of the IBD Market: Assessing Multiple Drug Categories
1.4 Research Methods

2 What Is Inflammatory Bowel Disease'
2.1 Definition and Diagnosis
2.2 Signs, Symptoms and Secondary Conditions
2.2.1 Bleeding Ulcers, Fistulae, Bowel Perforations, Toxic Megacolon
2.2.2 Pyoderma Gangrenosum
2.2.3 Primary Sclerosing Cholangitis
2.2.4 Malnutrition, Poor Nutrient Absorption and Stunting
2.3 Ulcerative Colitis



2.4 Crohn's Disease
2.5 Indeterminate Colitis: Distinguishing Crohn's Disease from Ulcerative Colitis
2.6 Causes / Aetiology of Inflammatory Bowel Disease
2.7 Prevalence
2.8 Socioeconomic Costs
2.8.1 The Individual Cost of IBD

3 Autoimmune Disorders
3.1 Brief Overview of the Immune System
3.2 What are Autoimmune Diseases / Disorders'
3.3 What Causes Autoimmune Disorders'
3.4 Why are Autoimmune Diseases Spreading in Developed Countries, but Not in Developing Countries'
3.4.1 The Hygiene Hypothesis
3.5 What Inflammation is and Why Inflammation is Dangerous
3.5.1 What is Inflamed in Inflammatory Bowel Disease'
3.5.2 The Costs and Consequences of Non-Treatment

4 Treatments for Inflammatory Bowel Diseases
4.1 The Goals of IBD Treatment
4.1.1 Producing Remission
4.1.2 Maintaining Remission
4.2 Drug Categories and their Mechanisms of Action
4.2.1 Aminosalicylates / 5-ASA / Mesalazine / Mesalamine
4.2.2 Corticosteroids
4.2.3 Immunomodulators
4.2.4 Antibiotics
4.2.5 Biologic Therapies / Monoclonal Antibodies
4.3 Surgical Treatments
4.3.1 Surgery for Ulcerative Colitis
4.3.2 Surgery for Crohn's Disease
4.4 The Leading Alternative Treatments: Hygiene Theory, Helminthic Therapy and Faecal Bacteriotherapy
4.4.1 Helminthic Therapy
4.4.2 Faecal / Fecal Bacteriotherapy / Human Probiotic Infusions (HPI)
4.4.3 Smoking

5 World IBD Market: Market Projection, Top Drug Projections
5.1 World Inflammatory Bowel Diseases Market, 2009-2024
5.1.1 The 5 Types of IBD Drugs
5.1.2 Other Drugs Cross-Indicated for IBD: Accounting for Monoclonal Antibodies
5.2 Lialda: Easier to Use, Growing in Significance
5.2.1 Unique Selling Point: Lialda is Lactose-Free
5.2.2 Lialda's Downside
5.3 Asacol
5.4 Entocort
5.4.1 Steroid Side Effects and Entocort EC
5.5 Pentasa
5.5.1 Excellent Safety Profile Assisting Pentasa's Sales



5.6 Salofalk
5.6.1 Salofalk Once-Daily
5.6.2 Salofalk and China Medical Sales Agreement
5.7 Budenofalk: 22% growth last year
5.7.1 Sales to be Boosted by New Sales Deal with Salix
5.8 Colazal: Losing Ground
5.9 Monoclonal Antibodies Forecasts
5.10 Remicade
5.10.1 Label Expansion Assisting Remicade's Sales
5.11 Humira
5.11.1 Label Expansion Behind Humira's Growth
5.11.2 Registered for Crohn's in US and EU; In Phase III for Crohn's in Japan
5.12 Cimzia
5.12.1 Challenged by the Committee for Medicinal Products for Human Use
5.13 Tysabri
5.13.1 Still Under Scrutiny for Liver Toxicity

6 Crucial Pipeline Developments: New Drug Targets, Innovative Delivery Technologies, and Cutting-Edge Treatments
6.1 Traficet-EN
6.2 Alicaforsen: Approved for Pouchitis, Cancelled for Crohn's, Under Assessment for UC
6.3 Rifaxamin
6.4 Myoconda: Is this the Cure for IBD'
6.5 Bupropion (Wellbutrin)
6.6 Abatacept (Orencia)
6.7 Polyketals: Technology to Deliver Drugs to Internal Inflammation
6.8 Extracorporeal Photopheresis (Light Therapy Outside of the Body): Uvadex (Methoxsalen)
6.9 A New Monoclonal Antibody Indicated for Crohn's Disease: Ustekinumab (Stelara)
6.10 Interleukins: Promising New Drug Targets (with a Table of Pipeline Interleukin Drugs)
6.11 Stem Cells: Prochymal by Osiris Therapeutics

7 Leading Companies
7.1 Procter & Gamble: 27% of the IBD Market
7.2 Ferring: Drug Originator and Innovator, but Limited Late-stage Pipeline
7.3 Shire
7.3.1 Lialda's Success and its Potential
7.3.2 Shire's Share of Pentasa
7.4 Dr. Falk
7.5 Prometheus Laboratories: Significance through IBD Drugs and Tests
7.5.1 Prometheus's Diagnostic and Genetic Analysis Tests: Frontiers of IBD Treatment
7.5.2 Serology Retrospective Results
7.5.3 Prometheus and Monoclonal Antibodies
7.6 Salix: Losing Colazal, Gaining US License to Budenofalk
7.7 Cosmo Pharmaceuticals / Cosmo Technologies: Watch this Company!
7.7.1 MMX Revenues

8 World Markets by Region
8.1 Changing Regional Market Share



8.2 North America: Slower Growth, Market Share in 2024 Compared with 2009
8.3 Europe: Retaining Market Share in the Long Term'
8.3.1 United Kingdom
8.3.2 Germany
8.3.3 Poland: Increasing in Market Relevance
8.4 Africa, Asia, Australasia: Growing Markets
8.4.1 The Incidence and Prevalence of IBD in Asia
8.4.2 Japan
8.4.3 Australia
8.4.4 China
8.4.5 India
8.5 Latin America

9 Strengths, Weaknesses, Opportunities and Threats of the IBD Market
9.1 Strengths
9.1.1 Monoclonal Antibodies: a Threat to Intestinal Anti-Inflammatories'
9.2 Weaknesses
9.2.1 Genotyping: A Dead End'
9.3 Opportunities
9.4 Threats
9.4.1 Cures and/or Vaccines'
9.4.2 Market Saturation
9.4.3 The World Economic Climate - Will this Limit Uptake of New IBD Drugs in a Nearly-Saturated Market'

10 Interviews with Relevant Key Opinion Leaders
10.1 Interview with Marco Greco, Chairman of the European Federation of Crohn's and Ulcerative Colitis Associations (EFCCA).
10.1.1 Public Awareness
10.1.2 Differences Between European Countries
10.1.3 Drug Companies' Involvement in Awareness Campaigns
10.1.4 Unmet Medical Needs
10.2 Interview with Dr. Alan Fraser, Associate Professor of Medicine, University of Auckland, Director for Clinical Examinations at
Auckland Hospital.
10.2.1 Autoimmunity vs. Infection Theories
10.2.2 Monoclonal Antibodies
10.2.3 Genotyping
10.2.4 Remaining Therapeutic Gaps
10.2.5 Future Treatments
10.3 Interview with Professor Thomas Borody, MD, PhD, Director of the Centre for Digestive Diseases (Sydney), and Executive
Director and Chief Medical Officer of Giaconda Limited
10.3.1 Mycobacterium avium paratuberculosis (MAP) Infection and IBD Aetiology
10.3.2 IBD and HIV/AIDS
10.3.3 Monoclonal Antibodies and Immunosuppressant Treatments
10.3.4 Potential Cure(s)
10.3.5 Remicade and MAP
10.3.6 Genotyping
10.3.7 Crohn's vs. Colitis
10.3.8 Future Therapies
10.3.9 Potential and Future of Myconda



11 Conclusions
11.1 IBD Market Sales Forcasts
11.2 The Market will be Stimulated by New Delivery Technologies and New Drug Targets
11.3 Many Drugs and Generics on the Market, but Poor Disease Management Means High Potential Drug Uptake
11.4 The IBD Market - Will Sales Growth Continue Steadily from 2009 to 2024'

List of Tables

Table 3.1 The Most Common Autoimmune Disorders, by Type
Table 4.1 IBD Drugs by Type, Chemical Name and Brand Name
Table 5.1 World Intestinal Anti-Inflammatories Sales Forecasts, 2009-2024
Table 5.2 Lialda Sales Forecast, 2009-2024
Table 5.3 Asacol Sales Forecast, 2009-2024
Table 5.4 Entocort Sales Forecast, 2009-2024
Table 5.5 Pentasa Sales Forecast, 2009-2024
Table 5.6 Salofalk Sales Forecast, 2009-2024
Table 5.7 Budenofalk Sales Forecast, 2009-2024
Table 5.8 Colazal Sales Forecast, 2009-2024
Table 5.9 Autoimmune-Indicated Monoclonal Antibodies Forecasts, 2009-2024
Table 5.10 Remicade Sales Forecast, 2009-2024
Table 5.11 Humira Sales Forecast, 2009-2024
Table 5.12 Cimzia Sales Forecast, 2009-2024
Table 5.13 Tysabri Sales Forecast, 2009-2024
Table 6.1 Interleukin-targeted Drugs Pipeline, by Phase and Company, 2008
Table 8.1 World Intestinal Anti-Inflammatories Sales Forecasts, 2009-2024
Table 8.2 World Market Sales Forecasts by Region, 2009-2024
Table 8.3 North America Sales Forecast, 2009-2024
Table 8.4 Europe Sales Forecast, 2009-2024
Table 8.5 Africa, Asia, Australasia Sales Forecast, 2009-2024
Table 8.6 Latin America Sales Forecast, 2009-2024
Table 9.1 Strengths and Weaknesses in the IBD Market
Table 9.2 Opportunities and Threats in the IBD Market
List of Figures
Figure 2.1 Direct and Indirect Medical Costs of IBD in 4 Countries
Figure 5.1 World Intestinal Anti-Inflammatories Market Projection, 2009-2024
Figure 5.2 IBD Market Breakdown by Drug Type, 2008
Figure 5.3 Top-Selling IBD Drugs, 2008
Figure 5.4 Sales Forecasts of Top-Selling IBD Drugs, 2009-2024
Figure 5.5 Lialda Sales Forecast, 2009-2024
Figure 5.6 Asacol Sales Forecast, 2009-2024
Figure 5.7 Entocort Sales Forecast, 2009-2024
Figure 5.8 Pentasa Sales Forecast, 2009-2024
Figure 5.9 Salofalk Sales Forecast, 2009-2023
Figure 5.10 Budenofalk Sales Forecast, 2009-2024
Figure 5.11 Colazal Sales Forecast, 2009-2024
Figure 5.12 Autoimmune-indicated Monoclonal Antibodies Forecast
Figure 5.13 Remicade Sales Forecast, 2009-2024
Figure 5.14 Humira Sales Forecast, 2009-2024



Figure 5.15 Cimzia Sales Forecast, 2009-2024
Figure 5.16 Tysabri Sales Forecast, 2009-2024
Figure 7.1 Top IBD Companies, 2008
Figure 8.1 World Intestinal Anti-Inflammatories Sales Forecast, 2009-2024
Figure 8.2 Regional Sales Forecasts, 2009-2024
Figure 8.3 Market Share by World Region, 2014 Projection
Figure 8.4 Market Share by World Region, 2024 Projection
Figure 8.5 North America Sales Forecast, 2009-2024
Figure 8.6 Europe Sales Forecast, 2009-2024
Figure 8.7 Africa, Asia, Australasia Sales Forecast, 2009-2024
Figure 8.8 Latin America Sales Forecast, 2009-2024

Companies Listed

Abbott
Alaven Pharm
Amgen
AstraZeneca
Atlantic Healthcare
Biogen Idec
Biovail
Biovitrum
Bristol-Myers Squibb
Center for Digestive Diseases (Sydney)
Centocor
ChemoCentryx
Committee for Medicinal Products for Human Use (CHMP)
Conaris Research Institute AG
Cosmo Pharmaceuticals, S.p.A.
Cosmo Technologies, Ltd.
Crohn's and Colitis Foundation of America (CCFA)
Dong A
Dr. Falk Pharma
Elan (Ireland)
European Federation of Crohn's and Colitis Associations (EFCCA)
European Medicines Agency (EMEA)
Faes Farma
Ferring
Food and Drug Administration (FDA)
Genmat
Genzyme
Giaconda
Giuliani
GlaxoSmithKline
Isis Pharmaceuticals
Johnson & Johnson
Medarex
Merck



Novartis
Osiris Therapeutics
Pediatric Inflammatory Bowel Disease Center at Cedars-Sinai Medical Center in Los Angeles
Pfizer
Probiotic Therapy Research Center, Sydney
Procter & Gamble
Prometheus Laboratories
Salix
Santarus
Santen
Schering-Plough
Shire
Stanford University
Synergen
Therakos
University of Washington
Wyeth
ZymoGenetics



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