Anaemia is a condition in which you don't have enough healthy red blood cells to carry adequate oxygen to the body's tissues. Having anaemia may make you feel tired and weak. There are many forms of anaemia, each with its own cause. Anaemia can be temporary or long term, and it can range from mild to severe. A hematinic is a nutrient required for the formation of blood cells in the process of hematopoiesis. The main hematinics are iron, B12, and folate. Deficiency in hematinics can lead to anaemia. In cases of hematinic deficiency, hematinics can be administered as medicines, in order to increase the haemoglobin content of the blood. Erythropoietin (EPO) is a hormone that stimulates erythropoiesis, which can also be given as a medicine to increase the haemoglobin content of the blood, but EPO is not classified as a hematinic as it is not considered a nutrient, but a hormone. Hematinics includes drugs like Iron formulations (Ferrous sulfate, iron dextran, etc.,), Folic acid, Vitamin B12 and Erythropoietin. In this video, I've explained Iron formulations. In the next video, I'll be talking about Folic acid and Vitamin B12.

1. HAEMATINICS
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2. DEFINATION HAEMATINIC:- These are the
substance which are used for formation of
blood & used for treatment of anemia.
EXAMPLE:- Iron , folic acid , vitamin B12
CAUSE OF ANEMIA:-
- Production & destruction of RBC due to
- Blood loss
- Impaired RBC formation
- Increased destruction of RBC
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3. IRON
DISTRIBUTION IN OUR BODY:-
- Total body content in on adult is 2.5-5 gm
it is more in man.
- It is distributed to hemoglobin = 62%
Iron store as territin &
Haemosiderin 25%
myoglobin
parenchymal iron.
- Iron stored only ferric form with =apoteritin.
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4. DAILY REQUIREMENT:-
Adult male = 0.5-1 mg
Adult female = 1-2 mg
Infants = 60 ug/ kg
Children = 20 ug/kg
Pregnancy = 3-5 mg
SOURCE:-
- Rich:- liver, egg , dry , dry fruits , yeast
- Medium:- meat , chicken fish
- Poor :- milk
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5. IRON ABSORPTION :-From intestine
- By two forms
Haeme(35%) Inorganic iron(5%)
better absorption Ferric iron which need
to be converted into
ferrous before
absorption.
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6. FACTOR IMPAIRING ABSORPTION:-
-Alkalis(decrease solubility
&reduction ) = complex formation
- phosphate(egg yolk)
- phylates (Maizet wheat)
- tetracycline( insoluble coml.)
TRANSPORT,UTILIZATION,STORAGE &
EXCRETION
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7. - In body
free iron ferric iron
complexed acidic glycoprotein transferring
transported to erythropietic & other cells
iron dissociate from complex at acidic PH
of intracellular vesicles.
- Released iron is utilized for synthesis of
hemoglobin.
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8. STORAGE:- In RE cells in liver , spleen , bone
marrow, hepatocytes & myocytes as feritin &
haemosiderin.
IRON PREPARATION :-
1) ORAL IRON :-
- Preferred route of administration.(skin,urin)
- Dissociable ferrous salts are inexpensive have
high iron content & better absorbed than ferric
salts.
SIDE EFFECT :- GI irritation, nausea, vomiting ,
constipation , heart born , metallic test.
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9. PREPARTION :- Ferrous sulfate
Ferrous gluconate
Ferrous fumarate
Colloidal ferrous hydrate
2) PARENTRAL IRON :-
INDICATION:-
- Oral iron is not tolerated.
- Failure compliance to oral iron.
- non – compliance to oral iron.
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10. PREPARTION:- iron dextrin
iron sorbital – citric acid complex
ROUTE:- IM & IV
- But more suitable route is IM.
SIDE EFFECT:- Fever , headache , joint pain
chest pain
USE:- Iron deficiency anemia.
Metaloblactic anemia.
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11. Thank you
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