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Digestion of Lipids

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Biochemistry - Digestion of Lipids

Veröffentlicht in: Gesundheit & Medizin
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Digestion of Lipids

  1. 1. V.S.Rashmi Priyem ULTRA’s BEST Dental Science College
  2. 2. DIGESTIONOF LIPIDS •Digestion In Stomach •Lingual Lipase •Gastric Lipase •Digestion In Intestines •Emulsification •Bile Salts •Factors •Lipolytic Enzymes In Intestines •DigestionOfTriglycerides • Pancreatic Lipase •Isomerase •Cholesterol Ester •Co-lipase Rashmi Priyem Saravanan
  3. 3.  The Major Dietary Lipids are  Triacyl Glycerol  Cholesterol  Phospholipids  Average Normal Indian Diet contains about 20-30 g of Lipids per Day Rashmi Priyem Saravanan
  4. 4.  The Lingual Lipase from the Mouth enters Stomach along with the food  It has an Optimum pH of 2.5-5  The Enzyme continues to be Active in the Stomach  Acts on Short ChainTriglycerides (SCT)  SCTs are present in Milk, Butter and Ghee  The action of Lingual Lipase is observed to be More Significant in the Newborn Infants Rashmi Priyem Saravanan
  5. 5.  Gastric Lipase is Acid Stable, with an Optimum pH around 5.4  Secreted by Chief ells, the Secretion is Stimulated by Gastrin Rashmi Priyem Saravanan
  6. 6.  Emulsification is a Prerequisite for Digestion of Lipids  The Lipids are Dispersed into Smaller Droplets-  SurfaceTension is Reduced  Surface Area of Droplets is Increased  This Process is Favoured by:  1. Bile Salts (DetergentAction)  2. Peristalsis (Mechanical Mixing)  3. Phospholipids Rashmi Priyem Saravanan
  7. 7.  The Bile Salts present in the Bile (Sodium glycocholate and Sodium taurocholate)  Lower SurfaceTension  EmulsifyThe Fat Droplets.  The Emulsification IncreasesThe Surface Area of the particles for EnhancedActivity of Enzymes. Rashmi Priyem Saravanan
  8. 8.  1. Pancreatic lipase with Co-lipase  2. Cholesterol esterase  3. PhospholipaseA2. Rashmi Priyem Saravanan
  9. 9.  The Bile (pH 7.7) entering the Duodenum serves to Neutralise the AcidChyme from the Stomach and provides a pH Favorable for the action of Pancreatic Enzymes. Rashmi Priyem Saravanan
  10. 10. Rashmi Priyem Saravanan
  11. 11.  1. Pancreatic Lipase can easily Hydrolyse the FattyAcids Esterified to the 1st and 3rd Carbon Atoms of Glycerol forming 2- Monoacylglycerol andTwo Molecules of Fatty Acid Rashmi Priyem Saravanan
  12. 12.  2.Then an Isomerase Shifts the Ester Bond from Position 2 to 1  The Bond in the 1st Position is then Hydrolysed by the Lipase to form Free Glycerol and Fatty acid Rashmi Priyem Saravanan
  13. 13.  3. Cholesterol Ester may be Hydrolysed to Free Cholesterol and FattyAcid  The action of PhospholipaseA2 produces Lysophospholipid and a FattyAcid Rashmi Priyem Saravanan
  14. 14.  The Co-lipase is secreted by the Pancreas as an InactiveZymogen  It is activated byTrypsin Rashmi Priyem Saravanan

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