gene editing therapy gene therapy newer treatments scd sickle cell anemia sickle cell disease fcm ferric carboxymaltose iron deficiency anemia anemia in malignancy rituximab in all acute lymphoblastic leukemia b cell all rituximab romiplostim thrombocytopenia sickle cell thalassemia vte testing guidelines hypercoagulable states thrombophilia testing septic shock qsofa sofa score code sepsis sepsis-3 neutropnic sepsis sepsis covid guidelines for thromboprophylaxis cac covid associated coagulopathy central venous catheter central venous access device cvc cvad handwash
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