The document discusses the role of Ayurvedic drugs in immunomodulation. It begins with introducing the topic and scope of immunomodulation. Next, it describes the Ayurvedic concept of immunomodulation and compares it to the modern scientific understanding. It then discusses specific Ayurvedic drugs and formulations that have immunomodulatory properties, including Agastya Haritaki Rasayana yoga. Studies investigating the immunomodulatory effects of ingredients like Pippali and Haritaki are summarized. The document concludes by outlining the probable mode of action of the Ayurvedic drugs in modulating the immune system.

1. ROLE OF AYURVEDIC DRUGS
IN IMMUNOMODULATION
HOD & Guide
Dr Ravi.R.Chavan
Dept of RS&BK
Asst. Professor
TGAMC, Ballari.
PRESENTER
DR.PRIYANKA.PATIL
3RD YEAR P.G. SCHOLAR

2. CONTENTS
• Introduction
• Scope
• Ayurvedic concept of immunomodulation
• Ayurveda and Covid19
• Yoga/Formulation
• List of references
• Method of preparation
• Properties
• Mode of action
• Discussion
• conclusion
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3. Introduction
Most potent tool
•Immunomodulators are considered now as one
of the most potent tools in the management of
health and disease by modern medicine.
A subject of scientific
investigation.
•. The modulation of immune response by using
Ayurvedic medications as a possible therapeutic
measure has now become a subject of scientific
investigation.
Bringing the Modern concept closer to
the Ayurveda
•The recent understanding of Circadian rhythms, seasonal
variatons, different psychological states on immune system, neuro
- endocrine – immune axis or the influence of exercise are
unfolding many such concepts which are bringing the modern
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4. Scope
•Currently Gradual decrease in immunity
• Many new diseases are emerging like Covid19
•Neither effective antiviral drugs nor effective vaccines
•Prevention is the best strategy
•Boost immunity by Rasayana Chikitsa (Immunomodulatory therapy).
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5. Concept of Immunomodulation
•Definition
•: An Immunomodulator can be defined as a substance which can influence any constituent or function of the
immune system in specific or non specific manner including both innate or adaptive arms of immune response.
• Concept
•The concept in modern scientific understanding would mean enhancement of immune responsiveness of an
organism against a pathogen by nonspecifically activating the immune system
•Classification
• 1. Immuno adjuvants
• 2. Immunostimulants
• 3. Immunosuppresants
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6. Concept of Immunomodulation in ayurveda
•Definition
•Vyadikshamatwa
•‘Balam hyalam doshaharam nigrahaya doshanam’.
•Charaka has also described bala as factor that destroys the doshas and disease causing factor.
• Ayurveda details the concept of immunomodulation by the term “Rasayana”. The use of formulation for
improving overall resistance of the body against common infection.
•Concept
•Acharya chakrapanidatta explains “Vyadhibala Viroditwa” ” i.e. antagonistic to the strength and virulence of
disease
•“Vyadhi utpadana pratibandhakatwa” i.e. the capacity to inhibit and bind the causes of disease.
•Therapeutic strategy in ayurvedic medicine is to enhance the body’s overall natural resistance to the disease
causing agent rather than directly neutralising the agent itself.
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7. RASAYANA MODE OF
ACTION
Ayurveda describes a number of drugs which posseses immunomodulatory effect are haritaki, pippali, tulasi, guduchi,
amalaka, aswagandha, punarnava & shilajatu etc. Rasayana like Chyavanprasha, Agastya Haritaki, Pippali Rasayana are used.
Rasayana working on Respiratory system are best for Prevention of Coronavirus and boosting immune system. Rasayana
Chikitsa can be effective in the Prevention as well as reducing symptoms of COVID-19. One of such formulation is discussed
next.
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8. YOGA - AGATSYA HARITAKI RASAYANA.
Introduction
• Agastya Haritaki Rasayana is an Avaleha
preparation, propounded by Sage Agastya used in the
pranavaha srotovikaras like kasa, shwasa,
vishamajvara.most of the ingredients of formulation
are having properties of Tikta madhura rasa, laghu
ruksha teekshna guna, katu vipaka and ushna veerya
and having kaphavata shamaka properties.
• Posseses the qualities of rasayana. used as nimittika
rasayana. as this yoga indicated in disease like Kasa
(cough), Shwasa (asthma), Pratishay a (running or
stuffy nose), Vishamajvara, which are similar to
Coronavirus. .
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9. List of references
• Bhaishajya ratnavali kasachikitsa 15/173-178
• Chakradatta 11/64-66
• Astanga hridaya chi.3/125-128
• Charaka samhita chi.18/57-62
दशमूल िं स्वयिंगुप्तिं शिंखपुल्पिं शलि ब तिं। हलस्िलपप्पल्य़पतमतगगलपप्पल मू लित्रकतन्॥
भतलगगपुष्करमू िंि लिप तिंशिं यवतढकम्। हररिलकशििं िैव ज े पन्ितढके पिेि्॥
यवैलस्वन्नेेः कषतयिं ििं पूििं िच्ितभयतशिम्। पिेि् गुडिु तिं दत्वत कुडवन्ि प्रथक् घ्रुितन्॥
िै ति् सलपप्प ीिुर्तगि् लसध्दे शीिे ि मतलशशकति्। ल ह्यदेकतिं लशवतिं लनत्यमिेः खतदेि् रसतयनम्॥
ििल पल ििं हन्यति् वर्तगयुब वर्गनम्। पन्िकतसतन् क्षयिं श्वतसिं लहशकतन्ि लवषमज्वरतन्॥
हन्यतत्थत ग्रीण्यशोह्रद्रोगतरुलिपीनसतन्। अगस्त्यलवलहििं ध्न्यलमदिं श्रेष्टिं रसतयनम्||
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10. •Ingredients
•Kwatha dravyas
•Dashamoola – 20pala
•Kapikacchu- 2pala
•Shankhapuspi – 2pala
•Shati – 2pala
•Bala – 2pala
•Gajapippali – 2pala
•Apamarga – 2pala
•Chitrakamula – 2pala
•Bharangi – 2pala
•Pushkaramoola – 2pala
•Yava – 1 adhak
•Haritaki – 100 Nos
•Jala – 5 adhaka
•Paka dravyas
•Guda - 1kudava
•Ghrita - 1kudava
•Taila - 1kudava
•Prakshepa dravyas
•Pippali churna - 1kudava
•Madhu - 1kudava
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11. Method of preparation & Dose
•Prepare the decoction of the kwatha dravyas till yava is cooked & strain the decoction.
•Fry the haritaki fruits in ghrita and taila and then cook in the decoction mixed with jaggery.
•Cook till siddhi laxana of the avaleha obtained.
•On completion add pippalichurna and madhu.
Dose : 6-12gms
Indication: kasa, ksaya, shwasa, vishamajvara,
grahani, arsha, aruchi, pinasa
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12. Properties of drugs
Name Rasa Guna Veerya Vipaka Karma
Bilva Tikta,
kashaya
Laghu, Ruksha Usna Katu Kaphapittahara
Krimigna
Agnimata Tikta, Katu
Kashaya, Madhura
Ruksha
Laghu
Usna Katu Kapha Vatahara
Sothahara
Dipana.
Syonaka Madhura, Tikta,
Kashaya
Laghu
Ruksha
Usna Katu Kapha Vatahara
Dipana, Grahi.
Kasmari Tikta, kashaya Guru Usna Katu Dipana, Pacana.
Patala Tikta, Kashaya Laghu Usna Katu Hrudya. Kanthya
Bala Madhura Guru Sita Madhura Brumhaniya
Salaparni Madhura, Tikta Guru Usna Madhura Balya
Prusniparni Madhura, Tikta Laghu Usna Madhura Balya
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13. Mudgaparni Madhura Laghu
Ruksha
Sita Madhura Tridoshahara
Jivaniya
Masaparni Madhura
Tikta
Laghu
Snigdha
Sita Madhura Vatapittahara
Balya, Jivaniya.
Pippali Katu Laghu
Snigdha
Usna Madhura Vata kaphahara
Vrsya, Dipana
Rasayana.
Svadamstra Madhura Guru
Snigdha
Sita Madhura Vata pittahara
Mutrala, Rasayana.
Bruhati Katu, Tikta Laghu Ruksha Usna Katu Kapha Vatahara
Sukra recaka.
Kantakari Katu Tikta Laghu Ruksha
Tiksna
Usna Katu Kapha vatahara
Dipanapacana
Kapikacchu Madhura,tikta Guru snigda Sheeta Madhura Vatahara
Shankhapushpi Katu tikta Sara Sheeta Katu Tridosha shamana
Shati Katu Tikta
Kashaya
Laghu
Tiksna
Usna Katu Kaphavatahra Grahi
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14. Apamarga Katu tikta Tikshna sara ushna katu Kaphavatahara
Chitraka moola Katu Laghu ruksha Ushna Katu Kaphavatahara
Bharangi Katu tikta Laghu ruksha Ushna Katu Kaphavatahara
Pushkara moola Tikta
Katu
Laghu
Tiksna
Usna Katu Kaphavatahara
Dipana.
Yava Madhura Ruksha Sheeta Katu Vatakaphahara
Haritaki Panca Rasa Laghu
Ruksha
Usna Madhura Tridoshahara
Anulomana
Guda Madhura Laghu snigdha Sheeta Madhura Vatapittahara
Ghrita Madhura Guru snigdha Sheeta Madhura Vata pittahara
Taila Madhura
Kashaya
Guru snigdha Usna Madhura Vatahara
Balya, Deepana
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15. Probable mode of action
•Ushna veerya & Laghu ruksha guna
•Tikta katu & madhura rasa
•Katu vipaka
•Kaphavatahrut
Guna
•Laghu guna is
Lekhana,
Tikshna guna
is Sodhana &
Kaphavatahr
ut. Ruksha
guna does
Soshana & is
Kaphahara
Veerya
• Agnimaha
bhoota
dominant
,contribute
to
Pachana,
Liquificati
on of
Kapha,
potent
Vatakaph
a samaka
& helps in
reversing
the
pathophys
iology of
swasa
roga.
Rasa &
Vipaka
•Katu rasa
combats
the Kapha,
clears the
obstruction
in the
Srotas and
does
Sodhana
•Tikta rasa -
Lekhana
and Kanta-
sodhana
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16. Study conducted on pippali….
Author Title Drug Result
DeeptiBisht et al
“A Clinical study to
evaluate the efficacy
of PippaliRasayana
in certain
Respiratory
disorders”
(Gr-I)(N=15): Pippali
Rasayana prepared from
Palash Kshara bhavit
Pippali for 45 days(Gr-
II)(N=12): On respective
allopathic drug treatment
PippaliRasayana helps in increasing Hb% and reduction
in ESR also showed improvement in frequency and
duration of exacerbation. Hence it is very much effective
in the management of Respiratory diseases as an adjuvant
E S Sunila & G
Kuttan
Immunomodulatory
and antitumor
activity of Piper
longum Linn. and
piperine
alcoholic extract of Piper
longum (10
mg/dose/animal) as well
as piperine (1.14
mg/dose/animal)
Administration could inhibit the solid tumor development
in mice induced with DLA cells and increase the life span
of mice bearing Ehrlich ascites carcinoma tumor to 37.3
and 58.8%, respectively.
• increased the total WBC count to 142.8 and 138.9%,
respectively, in Balb/c mice.
•The number of plaque forming cells also enhanced
significantly by the administration of the extract
(100.3%) and piperine (71.4%) on 5th day after
immunization.
•Bone marrow cellularity and alpha-esterase positive
cells were also increased by the administration of Piper
longum extract and piperine.
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17. Study conducted on haritaki
Author Topic Drug Result
Pranoti
Belapurkar
Pragya
Goyal, and Pre
eti Tiwari
Imunomodulatory
Effects
of Triphala and its
Individual
Constituents: A
Review
the model animals were
pretreated with 500 mg/kg of
aqueous extract orally and
challenged with 50 000 CFU
of S. typhimurium.
• The animals showed 3×103/mm3 increase in WBC
count and 4% increase in lymphocyte count as
compared to saline treated control animals
• 102% increase in lymphocyte proliferation and
28.87% increase in foot pad thickness as compared to
the infected control in DTH test.
• study concluded that the extract shows its protective
effect through its immunomodulatory activity in mice
against typhoid
Reshma r
parekar et al
Experimental
evaluation of
analgesic, anti-
inflammatory and
anti-platelet
potential
of Dashamoola
Wistar albino rats (180-200 g)
and Swiss albino mice (20-25 g)
of either sex were divided
randomly into five groups:
Distilled water, aspirin
(500mg/kg in rats; 722.2 mg/kg
in mice), Dashamoolarishta (1.8
mL/kg in rats
Dashamoolarishta and its combination with aspirin
showed significantly (P < 0.01) less number of writhes.
It showed significant (P < 0.001) anti-inflammatory
activity by paw edema reduction in rats
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18. Discussion
❑ Rasayana/Immunomodulator helps to improve digestion and metabolism as well as
microcirculations, thus allowing to obtain the best qualities of all Dhatus.
❑ Rasayana acts on seven Dhatus which further improves the Oja which is responsible for
producing good immune power in the body. This Oja gives immunity to the body by
nonspecific way mediated through neutrophils and monocytes and by specific way
mediated by B lymphocytes which acts against the virus and bacterial pathogens.
❑ Humoral mediated by B lymphocytes become plasma cells and produces immunoglobin
which destroys antigens.
❑ Same as Agatsya haritaki rasayana Majority of Rasayana drugs works on numerous organs
by improving their functions by acquiring Vyadhikshamatva through its appetizer,
digestive, cognition enhancement, antioxidant, adaptogenic and immunomodulators.
Kantakari, Pushkarmool, Haritaki, Pippali, Tulsi, & Brihati are effective in Pranavaha
Strododushti & for strengthening due to their antipyretic, antiallergic, immunomodulatory,
anti-inflammatory and analgesic properties.
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19. Conclusion
• Rasayanas are effective in enhancing immunity of the body.
Agastya haritaki Rasayana working on Respiratory system helps
in strengthening function of Respiratory organs as well as
reducing symptoms of Respiratory disorders. Immunity plays an
important role in Prevention of diseases. So, it can be concluded
that Rasayana Chikitsa can be effective in the Prevention as well
as reducing symptoms of COVID-19.
• Agastya Haritaki Rasayana; a popular Avaleha kalpana, works
at various levels including Dhatus, Agni & Srotas, improving the
Vyadikshmatva of the body. Rasayana as immunomodulator
herbs are perhaps the only drug that can be taken securely for
long period, even in a healthy state, without any specific
contradictions.
• Health is defined as a “state of complete physical, mental and
social well-being and not merely an absence of disease or
infirmity to lead a socially and economically productive life”.
Ayurveda can be used effectively in the management of immune-
compromised conditions like acquired immune deficiency
syndrome (AIDS), Tuberculosis and malignancy. The Rasayana
therapy makes it easily possible with its remarkable benefits on
immunity, health, longevity, regeneration of cells and tissues in
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