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Lower-body fat loss is not associated with elevations in diabetes and cardiovascular disease risk factors
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4. Abdominal and Lower Body Fat Loss and Changes in Health Risk: Longitudinal Observations From: Fujioka et al. 1991, Ross et al. 2000 Δ Health Risk Abdominal Fat Loss Δ Health Risk Lower Body Fat Loss Good Bad ?
5. Objective During weight loss, is the reduction of lower body fat for a given amount of abdominal (visceral and subcutaneous) fat reduction associated with an exacerbation in cardiometabolic profile? Janiszewski et al. Diabetologia (2008) 51:1475-1482
10. Effects of Treatment: Anthropometric Body Weight (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * * Significantly different from baseline (P < 0.05) Waist Circumference (cm) Men Women * *
11. Effects of Treatment: Abdominal AT Visceral AT (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * * Significantly different from baseline (P < 0.05)
12. Effects of Treatment: Lower Body AT Lower body SAT (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * * Significantly different from baseline (P < 0.05)
13. Effects of Treatment: Cardiometabolic Risk Factors OGTT Glucose AUC (mmol/L •2Hr ) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * Significantly different from baseline (P < 0.05) * Triglycerides (mmol/L) Men Women * * LDL-cholesterol (mmol/L) Men Women * * Fasting Insulin (pmol/L) Men Women * *
14. Abdominal AT Loss and Changes in Cardiometabolic Risk Abdominal Fat Loss Controlled for: age, gender, treatment group, and change in VO 2 max Janiszewski et al. Diabetologia (2008) 51:1475-1482 Δ Glucose Δ OGTT glucose Δ OGTT insulin Δ Cholesterol Δ LDL-C Good β = 0.21 to 0.24, p < 0.05
15. Abdominal AT Loss and Changes in Cardiometabolic Risk Abdominal Fat Loss Good Controlled for: age, gender, treatment group, and change in VO 2 max + Δ lower body SAT β = 0.19 to 0.24, p < 0.05 Δ OGTT glucose Δ Cholesterol Δ LDL-C Janiszewski et al. Diabetologia (2008) 51:1475-1482 =
16. Lower Body AT Loss and Changes in Cardiometabolic Risk Janiszewski et al. Diabetologia (2008) 51:1475-1482 Δ Health Risk Lower Body Fat Loss Bad ?
17. Lower Body AT Loss and Changes in Cardiometabolic Risk Δ OGTT Insulin AUC Lower Body SAT Loss Good Controlled for: age, gender, treatment group, and change in VO 2 max β = 0.23, p < 0.05 Janiszewski et al. Diabetologia (2008) 51:1475-1482
18. Lower Body AT Loss and Changes in Cardiometabolic Risk Δ Cardiometabolic Risk Factors Lower Body SAT Loss Controlled for: age, gender, treatment group, and change in VO 2 max + Δ in abdominal VAT and SAT = β = -0.07 to 0.19, p > 0.05 Not Bad Janiszewski et al. Diabetologia (2008) 51:1475-1482