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Failure to Thrive
Pamudith Karunaratne
Medical Undergraduate
Faculty of Medical Sciences
University of Sri Jayewardenepura
https://orcid.org/0000-0001-9306-2267
https://www.linkedin.com/in/pamudith-karunaratne/
Welcome!!
Failure to Thrive
FTT Contents
1
2
3
4
5
What is failure to thrive?
Diagnosis
Etiology
Management
Diagnostic Evaluation
What is
failure to thrive?
What is failure to thrive?
Children with
very low weight for age or height
and those who do not maintain an
appropriate growth pattern may
have failure to thrive (FTT),
also known as
weight faltering.
FTT Progression
Weight Height OFC Cognitive skills Immune function
FTT Epidemiology
Failure to thrive is seen in
all around the globe but more
prevalent in children of lower
socioeconomic status and is
associated with lower parental
education levels.
48%
52%
Underweight 21.1%
< 5 years
Diagnosis
Diagnosis
Recognition
Recognition
Weight and Height must be accurately obtained and
charted on an Appropriate reference scale
Specialized growth charts
(Turner syndrome or trisomy 21)
Below the 5th percentile
for Sex and Corrected age
95 90 75 50 25 10 5
weight for age or weight
for length/height falls
by Two Major Percentiles
(percentile markers 95, 90, 75, 50, 25, 10, and 5)
95 90 75 50 25 10 5
Etiology
FTT Causes
Inadequate
Caloric Intake
Inadequate
Nutrient
Absorption
Increased
Metabolism
FTT Causes Inadequate Caloric Intake
Inadequate breast milk supply
Incorrect formula preparation
feeding difficulties
(e.g. cleft lip or palate)
Poor feeding habits
Neglect or abuse
Poor oral neuromotor
coordination
Toxin-induced gastrointestinal upset
(e.g. anorexia, constipation, or abdominal pain)
GORD
FTT Causes Nutrient Malabsorption
Celiac disease
Chronic gastrointestinal conditions
(e.g. irritable bowel syndrome), infections
Pancreatic cholestatic
conditions
Anemia, iron deficiency
Milk protein allergy
Inborn errors of metabolismCystic fibrosis
Biliary atresia
FTT Causes Increased Metabolism
Renal failure
Chronic infection
(e.g. human immunodeficiency virus infection, AIDS, tuberculosis)
Inflammatory conditions
(e.g., asthma, inflammatory
bowel disease)
Hyperthyroidism
Congenital heart disease
Chronic lung disease
of prematurity
Malignancy
FTT Risk Factors
• Congenital anomalies
(e.g. cerebral palsy, autism,
trisomy 21)
• Developmental delay
• Gastroesophageal reflux
• Low birth weight (< 2,500 g )
• Poor oral health, dental caries
• Prematurity (< 37 weeks'
gestation)
Medical conditions
• Family stressors
• abuse or violence (perpetrator
or victim)
• Poor parenting skills
• Postpartum depression
• Poverty
• Social isolation of a caretaker
• Substance abuse
• Unusual health and nutritional
beliefs (e.g., restricted diets)
Psychosocial issues
Diagnostic Evaluation
FTT History
COMPONENT EXAMPLES
Diet History
A complete diet history should be taken for entire normal
day including Time, Type and the Amount.
Environment Regular feeding routine at home and day care
Family eating patterns
Cultural or religious food restrictions; immigrant families
may be unfamiliar with the nutritional quality of local
foods
Preparation of food
Formula mixing technique, frequency of feedings, use of
baby foods and table foods
Resources
Use of Women, Infants, and Children program, social w
orkers, and home health visits; access to food supplies
Feeding history
FTT History
COMPONENT EXAMPLES
Gastrointestinal conditions
Celiac disease, inflammatory bowel disease,
cystic fibrosis
Parental childhood nutrition Parental malnourishment
Parental height, parental age
at puberty
Genetic short stature, constitutional growth delay
Psychiatric illness, substance
abuse
Affecting caretaker function
Family medical history
FTT History
COMPONENT EXAMPLES
Living conditions
Safety and comfort, ability of parents to provide
appropriate nutrition
Parent-child relationship Poor parenting skills, lack of attachment
Primary caregivers Parents, family members, foster family
Stressors Financial and emotional support for child and family
Social history
FTT Examination
FINDING POTENTIAL UNDERLYING CAUSES
Dysmorphic appearance
Genetic abnormality, undiagnosed syndro
me
Edema Renal, liver disease
Hair color/texture change Zinc deficiency
Heart murmur Anatomic cardiac defect
Hepatomegaly Infection, chronic illness, malnutrition
FTT Examination
FINDING POTENTIAL UNDERLYING CAUSES
Mental status change Cerebral palsy, poor social bonding
Poor parent-child interaction Depression, social stress
Rash, skin changes, bruising
Human immunodeficiency virus infection,
cow's milk allergy, abuse
Respiratory compromise Cystic fibrosis
Wasting Cerebral palsy, cancer
Management
Management
• The goal of treatment is to establish optimal
growth velocity while supporting the family in
the plan of care.
• Treating the underline cause while correcting
Lactation, Introducing formula feeding,
nutrient-rich, healthy food choices, ideally
provided in three meals and three snacks per
day.
• If usual treatment is insufficient, support from
additional health care professionals, such as
a dietitian, dentist etc.
FTT Management
AGE
(MONTHS)
MEDIAN WEIGHT GAIN
(GRAMS PER DAY)
0 to 3 26 to 31
3 to 6 17 to 18
6 to 9 12 to 13
9 to 12 9
12 and older 7 to 9
Normal Median Weight Gain in Children
Information from Malks-Jjumba L. Failure to thrive. The University of British Columbia. Learn pediatrics. February 2011.
http://learn.pediatrics.ubc.ca/body-systems/gastrointestinal/failure-to-thrive/. Accessed April 20, 2016.
Catch-up growth will occur when the child gains at two to three times
the average rate per age
FTT Management
Method for calculating catch-up calorie needs
Get the target ideal weight for the age
and height.
Recommended dietary allowance is
the target ideal weight multiplied by
the DRI for age (see chart above).
AGE KCAL / KG / DAY
0 to 6 months 108
6 to 12 months 98
1 to 3 years 102
Dietary Reference Intake A 10-month-old boy with failure to thrive has
a weight of 7 kg and height of 72 cm.
72 cm corresponds to the 50th percentile for
height for a 9-month-old boy
target ideal weight can be determined by
finding the corresponding weight at the 50th
percentile, which is about 8.8 kg
In this case recommended dietary allowance
is : 8.8 kg × 98 kcal per kg per day
= 862 kcal per day
FTT Prevention
 Routine health surveillance visits in early childhood
 Counsel and educate families on nutrition.
 Risk factors for FTT can also be identified and addressed.
References
1. Homan GJ. Failure to Thrive: A Practical Guide. Am Fam Physician. 2016 Aug 15;94(4)
:295-9. [PubMed]
https://www.aafp.org/afp/2016/0815/p295.html
2. Smith AE, Gossman WG. Failure To Thrive. [Updated 2018 Oct 27]. In: StatPearls [Inte
rnet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK459287/#!po=78.5714
3. CDC Growth Charts
https://www.cdc.gov/growthcharts/data/set1clinical/set1color.pdf
4. Factors associated with growth faltering in Sri Lankan infants
https://jpgim.sljol.info/articles/10.4038/jpgim.8074/galley/5964/download/
Thank you

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Failure To Thrive by Pamudith Karunaratne

  • 1. pamudithkarunaratne@gmail.com Failure to Thrive Pamudith Karunaratne Medical Undergraduate Faculty of Medical Sciences University of Sri Jayewardenepura https://orcid.org/0000-0001-9306-2267 https://www.linkedin.com/in/pamudith-karunaratne/
  • 3. FTT Contents 1 2 3 4 5 What is failure to thrive? Diagnosis Etiology Management Diagnostic Evaluation
  • 5. What is failure to thrive? Children with very low weight for age or height and those who do not maintain an appropriate growth pattern may have failure to thrive (FTT), also known as weight faltering.
  • 6. FTT Progression Weight Height OFC Cognitive skills Immune function
  • 7. FTT Epidemiology Failure to thrive is seen in all around the globe but more prevalent in children of lower socioeconomic status and is associated with lower parental education levels. 48% 52% Underweight 21.1% < 5 years
  • 10. Recognition Weight and Height must be accurately obtained and charted on an Appropriate reference scale Specialized growth charts (Turner syndrome or trisomy 21)
  • 11. Below the 5th percentile for Sex and Corrected age 95 90 75 50 25 10 5
  • 12. weight for age or weight for length/height falls by Two Major Percentiles (percentile markers 95, 90, 75, 50, 25, 10, and 5) 95 90 75 50 25 10 5
  • 15. FTT Causes Inadequate Caloric Intake Inadequate breast milk supply Incorrect formula preparation feeding difficulties (e.g. cleft lip or palate) Poor feeding habits Neglect or abuse Poor oral neuromotor coordination Toxin-induced gastrointestinal upset (e.g. anorexia, constipation, or abdominal pain) GORD
  • 16. FTT Causes Nutrient Malabsorption Celiac disease Chronic gastrointestinal conditions (e.g. irritable bowel syndrome), infections Pancreatic cholestatic conditions Anemia, iron deficiency Milk protein allergy Inborn errors of metabolismCystic fibrosis Biliary atresia
  • 17. FTT Causes Increased Metabolism Renal failure Chronic infection (e.g. human immunodeficiency virus infection, AIDS, tuberculosis) Inflammatory conditions (e.g., asthma, inflammatory bowel disease) Hyperthyroidism Congenital heart disease Chronic lung disease of prematurity Malignancy
  • 18. FTT Risk Factors • Congenital anomalies (e.g. cerebral palsy, autism, trisomy 21) • Developmental delay • Gastroesophageal reflux • Low birth weight (< 2,500 g ) • Poor oral health, dental caries • Prematurity (< 37 weeks' gestation) Medical conditions • Family stressors • abuse or violence (perpetrator or victim) • Poor parenting skills • Postpartum depression • Poverty • Social isolation of a caretaker • Substance abuse • Unusual health and nutritional beliefs (e.g., restricted diets) Psychosocial issues
  • 20. FTT History COMPONENT EXAMPLES Diet History A complete diet history should be taken for entire normal day including Time, Type and the Amount. Environment Regular feeding routine at home and day care Family eating patterns Cultural or religious food restrictions; immigrant families may be unfamiliar with the nutritional quality of local foods Preparation of food Formula mixing technique, frequency of feedings, use of baby foods and table foods Resources Use of Women, Infants, and Children program, social w orkers, and home health visits; access to food supplies Feeding history
  • 21. FTT History COMPONENT EXAMPLES Gastrointestinal conditions Celiac disease, inflammatory bowel disease, cystic fibrosis Parental childhood nutrition Parental malnourishment Parental height, parental age at puberty Genetic short stature, constitutional growth delay Psychiatric illness, substance abuse Affecting caretaker function Family medical history
  • 22. FTT History COMPONENT EXAMPLES Living conditions Safety and comfort, ability of parents to provide appropriate nutrition Parent-child relationship Poor parenting skills, lack of attachment Primary caregivers Parents, family members, foster family Stressors Financial and emotional support for child and family Social history
  • 23. FTT Examination FINDING POTENTIAL UNDERLYING CAUSES Dysmorphic appearance Genetic abnormality, undiagnosed syndro me Edema Renal, liver disease Hair color/texture change Zinc deficiency Heart murmur Anatomic cardiac defect Hepatomegaly Infection, chronic illness, malnutrition
  • 24. FTT Examination FINDING POTENTIAL UNDERLYING CAUSES Mental status change Cerebral palsy, poor social bonding Poor parent-child interaction Depression, social stress Rash, skin changes, bruising Human immunodeficiency virus infection, cow's milk allergy, abuse Respiratory compromise Cystic fibrosis Wasting Cerebral palsy, cancer
  • 26. Management • The goal of treatment is to establish optimal growth velocity while supporting the family in the plan of care. • Treating the underline cause while correcting Lactation, Introducing formula feeding, nutrient-rich, healthy food choices, ideally provided in three meals and three snacks per day. • If usual treatment is insufficient, support from additional health care professionals, such as a dietitian, dentist etc.
  • 27. FTT Management AGE (MONTHS) MEDIAN WEIGHT GAIN (GRAMS PER DAY) 0 to 3 26 to 31 3 to 6 17 to 18 6 to 9 12 to 13 9 to 12 9 12 and older 7 to 9 Normal Median Weight Gain in Children Information from Malks-Jjumba L. Failure to thrive. The University of British Columbia. Learn pediatrics. February 2011. http://learn.pediatrics.ubc.ca/body-systems/gastrointestinal/failure-to-thrive/. Accessed April 20, 2016. Catch-up growth will occur when the child gains at two to three times the average rate per age
  • 28. FTT Management Method for calculating catch-up calorie needs Get the target ideal weight for the age and height. Recommended dietary allowance is the target ideal weight multiplied by the DRI for age (see chart above). AGE KCAL / KG / DAY 0 to 6 months 108 6 to 12 months 98 1 to 3 years 102 Dietary Reference Intake A 10-month-old boy with failure to thrive has a weight of 7 kg and height of 72 cm. 72 cm corresponds to the 50th percentile for height for a 9-month-old boy target ideal weight can be determined by finding the corresponding weight at the 50th percentile, which is about 8.8 kg In this case recommended dietary allowance is : 8.8 kg × 98 kcal per kg per day = 862 kcal per day
  • 29. FTT Prevention  Routine health surveillance visits in early childhood  Counsel and educate families on nutrition.  Risk factors for FTT can also be identified and addressed.
  • 30. References 1. Homan GJ. Failure to Thrive: A Practical Guide. Am Fam Physician. 2016 Aug 15;94(4) :295-9. [PubMed] https://www.aafp.org/afp/2016/0815/p295.html 2. Smith AE, Gossman WG. Failure To Thrive. [Updated 2018 Oct 27]. In: StatPearls [Inte rnet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK459287/#!po=78.5714 3. CDC Growth Charts https://www.cdc.gov/growthcharts/data/set1clinical/set1color.pdf 4. Factors associated with growth faltering in Sri Lankan infants https://jpgim.sljol.info/articles/10.4038/jpgim.8074/galley/5964/download/

Editor's Notes

  1. If confirmed by repeated valid measurements, FTT should prompt a search for causes of undernutrition, including neglect, family food insecurity, and underlying medical conditions. Inadequate caloric intake is the most common cause of FTT, but inadequate nutrient absorption or increased metabolism is also possible.
  2. Difficulty attaining or maintaining appropriate weight is the first indication of FTT, and sustained undernutrition can impede appropriate height, head circumference, and the development of cognitive skills or immune function in extreme cases. Early identification and management of the issues causing undernutrition are critical.
  3. The term FTT should be used as a clinical finding and not as a diagnosis.
  4. Recognition depends on reliable and valid measurements over time; therefore, serial measurements of weight and height must be accurately obtained and charted on an appropriate reference scale (growth chart) Specialized growth charts can be used in addition to these standard charts for supplemental data collection in children born prematurely or with specific diagnoses, such as Turner syndrome or trisomy 21
  5. Although there is no consensus on the definition of childhood FTT, the term is often used for infants and children with weight below the 5th percentile for sex and corrected age
  6. sustained decrease in growth velocity, in which weight for age or weight for length/height falls by two major percentiles (percentile markers 95, 90, 75, 50, 25, 10, and 5) over time.15
  7. *—Low birth weight is a major predictor of need for future referral for failure to thrive. 5 †—Poverty is the most significant psychosocial risk facto
  8. Information from Food and Agriculture Organization of the United Nations. Energy requirements of infants from birth to 12 months. http://www.fao.org/docrep/007/y5686e/y5686e05.htm. Accessed April 26, 2016.