Acetate mevalonate pathway

1. GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE
AND TECHNOLOGY
TOPIC: ACETATE MEVALONATE PATHWAY AND DIFFERENT SECONDARY METABOLITES OBTAINED
FROM IT
5th semester, Section- B
Presented by:
Souvik Dutta (18601919067)
Kaenat Faiz (18601919068)
Kirtisha Chowdhury (18601919069)

2. CONTENT
• INTRODUCTION
• ACETATE MEVALONATE PATHWAY
• SECONDARY METABOLITES OBTAINED FROM THE PATHWAY
• CAROTENOIDS
• PHARMACOLOGY AND DISEASE
• CONCLUSION
• REFERENCE

3. INTRODUCTION[1]
• Metabolic pathway for secondary metabolites production.
• Biosynthetic pathway for isoprenoid derivative.
• Acetyl CoA is the precursor of this pathway.
• Mevalonic acid is major intermediate of this pathway.
• Terpenoids and steroids can be formed with the help of this pathway.

4. ACETATE MEVALONATE PATHWAY[1,2]
Hydroxymethylglut
arate- CoA
Mevalonate
2NADPH
5-Phosphomevalonate
ATP
5-Pyrophosphomevalonate
ATP
ATP
-CO2
Isopentenyl pyrophosphate
Dimethylallyl
pyrophosphate
Geranyl pyrophosphate
Farnesyl pyrophosphate
+ Isopentenyl
pyrophosphate

5. SECONDARY METABOLITES OBTAINED FROM THE INTERMEDIATE
PRODUCTS OF ACETATE MEVALONATE PATHWAY [2]
C10PP
Geranyl Pyrophosphate
C15PP
Farnesnyl Pyrophosphate
C20PP
C30PP
Squalene
Triterpenes Steroids
×2
Phytol
Gibberelin
Carotenoids
Gutta
×2
Isopentenyl
pyrophosphate
Isopentenyl
pyrophosphate
Monoterpenes (C10)
Sesquiterpenes (C15)

6. 2
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CAROTENOIDS[1]
• C40 compound, tetraterpenoids
• Lipid soluble, polyene pigment
• Classification of caratenoid on the basis of source:
 Phytocaratenoids
 Zoocaratenoids
• Classification of caratenoid chemically:
 Carotene
 Carotenoid

7. PHARMACOLOGY [1]
Drugs that target mevalonate pathway
1.Statins
2.Biophosphates
DISEASES[1]
1.Mevalonate kinase deficiency
a.Mevalonic acidura
b.HIDS

8. CONCLUSION[1,2]
Acetate mevalonate patway is the basic metabolism pathway which is useful for the biosynthesis of
various secondary metabolites like hemiterpenes, sesquiterpenes, caratenois, squalene, steroids, etc. The
mevalonate pathway begins with acetyle-CoA and ends with the production of Isopentenyl
pyrophosphate (IPP)and Dimethylally pyrophosphate (DMAPP) which are used to make isoprenoids, a
diverse class of over 30,000 biomolecules such as cholerestrol , Vitamin K, and all steroid hormones.

9. REFERENCE
1. Dr. Shukla P, Dr. Alok S, Dr. Shukla P, Pharmacognosy and Phytochemistry Semester-5, Nirali
Prakashan, New Delhi. Page no.-1.8-1.9, 10.1-10.3
2. Shah B.N., Seth A.K. Textbook of Pharmacognosy and Phytochemistry. 1st ed. New Delhi :
Elsevier India Pvt. Ltd; 2010. Page no.146-147

10. THANK YOU
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