Glycyrrhiza glabra is another important medicinal plant that exhibits great medicinal properties and uses. lets see what are these.....

1. Better understanding
of
Biological activities
of
Glycyrrhiza glabra
….in last 20 years

2. Presented by
Dr. Sudhakar Kokate
Director PPRC, India

4. Description
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5. 1. Family: Leguminosae
2. Distribution: England, France, Germany,
USA, Italy, India, Russia, Spain
3. Origin: Greece
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6. 4. Meaning: Glycyrrhiza – sweet root
glabra – smooth
5. Etyology: also known as Liquorice plant
6. Flowers: Purplish blue colour
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7. 5. Underground portion: branches of long
roots + thin rhizomes (stolons)
6. Propagation: by rhizome cuttings
7. For drug prep: dried unpeeled roots &
stolons are used
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8. Chemicals
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9. 1. Glycyrrhizin (2 – 14%) – triterpenoid
saponin
2. Major constituent: Glycyrrhizinic acid
3. Glabranin A & B
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10. 4. Glycyrrbetol
5. Glabrolide
6. Isoglabrolide
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11. 7. Flavones: liquirtin, isoliquertin,
rhamnoliquirtin
8. Isoflavones
9. Neoliquiritin
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12. 10. Formononetin
11. Glabrone
12. Hispaglaridin A & B
13. Coumarins: herniarin, umbelliferone
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13. 14. Triterpene sterols: onocerin,
betaamyrin, stigmasterol
15. Sugars: glucose, sucrose
16. Asparagine
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14. 17. Starch
18. Protein
19. Glycyramarin
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15. Biological activities
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16. 1. Anti-HIV
2. Anti-hepatitis
3. Anti-tumour effect
4. Anti-diabetic
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17. 5. Anti-carcinogenic
6. Anti-inflammatory
7. Anti-allergic
8. Anti-thrombin
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18. 9. Hepato-protective
10.Immuno-modulatory
11.Anti-viral
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19. Utility
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20. 1. Used as demulcent & expectorant
2. Liquid extract used in cough mixtures
3. Liquid extract used as flavouring agent
in nauseous medicines
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21. 4. Used as a substitute for corticosteroids
5. For peptic ulcers
6. Used in skin diseases
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22. 7. Commercially liquorice added to
chewing gum, chocolate candy,
cigarettes smoking mixture &
chewing tobacco
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23. Side effects
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24. Glycyrrhetic acid, the metabolite of
Glycyrrhizin can inhibit 11-
betahydroxy steroid dehydrogenase in
kidney & thereby cause
pseudoaldosteronism resulting in
hypertension, hypokalemic myopathy,
arrythmia & cardiac arrest
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25. Hence
the use of this drug
needs
CAUTION !!
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26. Thank you !!