2. An abnormal protein present in the blood.
Form precipitate at low temp.(0-4 deg.)
Dissolve again when blood is heated.
Clump & Blocking blood vessels.
caused local ischaemia.
(toes & fingers become gangrenous)
3.
4. 1. Skin lesion:-develops purplish or
reddish skin lesions on legs & hands.
2. Joint pain:-R.A are more common.
3. Peripheral neuropathy:- can damaged
the nerves causing numbness and
other problems.
5. Classified into 3 groups based on Ig & rheumatoid
factor activity.
Type 1- is a monoclonal antibody that
doesn’t have rheumatoid factor activity.
eg:-Lymphoma
Type 2- is monoclonal that have
presence of rheumatoid factor.
Type 3- is polyclonal antibody with
rheumatoid factor.
6. Type 2 & type 3 are Mixed with both IgG, & IgM.
Most commonly with recurrent lower extremities
purpura, glomerulonephritis, & peripheral
neuropathy.
7. Rheumatoid factor is a sensitive test for
cryoglobulinemia.
Other routine tests include measuring blood levels
of rheumatoid factor activity, complement C4, other
complement components, and hepatitic C antigen.
Biopsies of skin lesions and, where indicated, kidney
or other tissues can help in determining the nature
of the vascular disease.
8. Advice to avoid or protect their extremities from
exposure to Cold.
Drug used are prime risk factor because more than
90% of cases are associated with hepatitis C
infection.
Prednisone, cylcophosphoamide should be
administered.