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The FermiCloud Project has been operating an Infrastructure-as-a-Service private Cloud using OpenNebula since the fall of 2010. FermiCloud has made significant contributions in X.509-based authentication and authorization, accounting, fabric deployment and high-availability cloud infrastructure. Our current program of work, carried out jointly with KISTI, focuses on interoperability and federation with the goal of running scientific cloud-based workflows across multiple clouds. I will identify some of the technical challenges that remain to be solved in widespread cloud deployment, as well as lessons that we have learned from grid computing and applied to the cloud environment.