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INTRODUCTION TO
SKELETAL IMAGING
Muhammad Bin Zulfiqar
PGR II SIMS/SHL
New Radiology Department
Overview of Skeletal system
•Total

bones
•Skull bones
•Ear bones
•Throat Bone
•Thorax
•Vertebral column
•Shoulder girdle
•Upper limb
•Pelvis
•Lower Limb

206
22
6
1
25
24
4
60
4
60
Imaging Modalities for Skeletal
System
•Plain Radiographs(main focus)
•Nuclear Scintigraphy
•Contrast Examination
•Ultrasound
•Computed Tomography
•Magnetic Resonance Imaging
Major Diseases of Bone










Trauma
Congenital
Infections
Tumors
Metabolic, Endocrine, Nutritional
Bone Dysplasia
Inflammatory Diseases(R.A.)
Associated soft tissues abnormalities
Skeletal Anatomy and Physiology
Skeletal Development
Intramembranous Ossification
 Enchondral Ossification


Bone Structure


Epiphysis – ZPC – Metaphysis
– Diaphysis



Cortex – Medulla – Periosteum
– Endosteum

Bone Metabolism


Bone mineral - Hormones
Anatomy
Anatomy
Anatomy
Approach to skeletal imaging
Preliminary Analysis
• Clinical data

• Number of lesions
• Symmetry of lesions
• Determination of Systems Involved
Analysis of The Lesions
Skeletal Location

Position Within Bone
Site of Origin

Shape
Size

Margination
Cortical Integrity
Analysis of The Lesions
Behavior of Lesions
• Osteolytic Lesions
• Osteoblastic Lesions
• Mixed Lesions
 Matrix
 Periosteal Response
• Solid Response
• Laminated Response
• Spiculated Response
• Codmans’ Triangle
Radiologic Predictor Variables
Supplementary Analysis
 Other imaging Procedures
 Laboratory Examination
 Biopsy
 Soft Tissue Changes

TRAUMA
Fracture and Dislocation
The radiographs should be made
 Include at least one joint
 Preferably two joints
 Two position AP – LAT
TRAUMA
Time intervals between Radiographic Study
 Initial Diagnostic study
 Post reduction and post immobilization
 One or Two weeks later, if position has
changed
 After approximately six eight weeks for
Primary callus
 After each plaster cast or traction change
 Before final discharge of patient
TRAUMA
Types of Fracture
 Closed fracture
 Does not break the skin or communicate
with the outside environment
 Simple fracture
 Open fractur
 Penetrates the skin over fracture site
 Compound fracture
TRAUMA
Comminuted

fracture
 Two or more bony fragments have separated
 Non Comminuted fracture
 Penetrates completely through the bone
 Avulsion fracture
 Tearing away of a portion of the bone
 Impaction fracture
 Bone is driven into its adjacent segment
TRAUMA


Incomplete Fracture
 Broken only one side of the bone
 Greenstick (Hickory Stick) fracture
 Torus (Buckling) fracture

Fracture Orientation
 Oblique fracture
 Commonly occurs in the shaft of long
tubular bone
 45 to the long axis of the bone
Fractur
Fracture
TRAUMA
Spiral fracture
 Torsion, coupled with axial compression
and angulation
 Transverse fracture
 Run at a right angle to the lonh axis
 Uncommon through healthy bone
 Pathologic fracture

Fracture
TRAUMA
Spatial Relationships of Fracture
 Alignment
 Position of the distal fragment in relation
to the proximal fragment
 Apposition
 Closeness of the bony contact at the
fracture site
 If the ends are pulled referred to as
Distraction
Fracture
TRAUMA
Rotation
 Twisting forces on a fractured bone along
its longitudinal axis
Traumatic Articular Lesions
 Subluxation
 Dislocation
 Diastasis
Epiphyseal Fractures
 Salter-Harris Classification

Salter - Harris
Dislocation
TRAUMA
Fracture Healing
 Main steps in fracture healing

Formation of hematoma

Organization of hematoma

Formation of fibrous callus

Replacement of fibrous callus by
primary bany callus

Absorption primary bany callus
Transformation to secondary bony callus

Remodeling
TRAUMA
Complication of Fractures
 Immediate complication
 Arterial injury
 Compartment syndrome
 Gas gangrene
 Fat embolism syndrome
 Thromboembolism
TRAUMA


Intermediate complication
 Osteomyelitis
 Myositis ossificans
 Synostosis
 Delayed union



Delayed complication
 Osteonecrosis
 Osteoporosis
 Non union – Mal union
Myositis Ossificans
INFECTION
Suppurative Osteomyelitis


General Consideration
 Systemic or Local infections
 Immunosuppresed patients, alcoholics,
newborns, and drug addicts are predisposed
 Antibiotics have significatly reduced the
sepsis-related mortality
INFECTION


Etiology
 Staphylococcus aureus causes 90%
 Pathway for the spread
 Hematogenous
 Contiguous
 Direct Implantation
 Postoperative
INFECTION


Radiologic Features
 Bone scan are the earliest means of
diagnosis
 Radiographic latent period for plain film
 10 days for extremities
 21 days for spine
 Soft tissue alteration : elevated fat planes,
obliterated fat planes, increased density.
INFECTION


Bone changes :
 Moth-eaten bone destruction
Usually metaphyseal in origin
 Periosteal new bone formation
Solid – Laminated – Codman’s Triangle
 Sequestrum
 Involucrum
 Joint space destruction (ankylosis)
0steomyelitis
Osteomyelitis
INFECTION
Septic Arthritis
 General consideration
 Single joint involvement in the rule
 Most common route is hematogenous
or direct traumatic implantation
 Etiology
 Most frequently is Staphylococcus Aureus
INFECTION


Radiologic Features
 The knee and hip are the most common
sites
 Joint effusion leads to distortion of the
fat folds
 Positive Walden storm's sign
 Rapid loss of joint space
 Bony ankylosis
INFECTION
Nonsuppurative osteomyelitis
(tuberculosis)
 General Consideration
 Found in patients such as prepubertal
children, debilitated geriatric, silicosis,
AIDS sufferers, Lymphoma patients,
Alcoholics, corticosteroid and drug abusers
INFECTION


Etiology
 Mycobacterium tuberculosis
 Two mode of spread
 Inhalation
 Ingestion
INFECTION


Radiologic Features
 Spinal tuberculosis is most common at L-I
 Early sign for spine are :
 Lytic endplate destruction
 loss of disc height
 Anterior “ gouge defect “
 Paraspinal swelling
INFECTION
Advanced sign for spinal involvement are:
 Vertebral body collapse
 Gibbus formation and obliteration of the
disc
 Tubercular arthritis is common in the hip and
knee
 Uniform joint space narrowing, early destruction
of the subchondral cortex, “moth-eaten” bone
destruction and juxtaarticular osteoporosis are
the cardinal sign of tubercular arthritis

Tuberculosis
Tuberculosis
TUMORS AND TUMORLIKE
PROCESSES
METASTATIC BONE TUMORS
PRIMARY MALIGNANT BONE TUMORS
 Multiple myeloma
 Osteosarcoma
 Ewing’s Sarcoma
PRIMARY QUASIMALIGNANT BONE
TUMOR
 Giant Cell Tumor
TUMORS
PRIMARY BENIGN BONE TUMORS
 Osteochondroma
 Osteoma
 Bone island
 Osteoid osteoma
 Simple bone cyst
 Aneurysmal bone cyst
TUMORS
Metastatic Bone Tumors
 General Consideration
 The most common malignant tumors
 CNS tumors and basal cell Ca rarely
 Life threatening complication
 Incidence
 70% are metastatic, 30% are primary
 In females 70% from breast Ca
In males 60% from prostate Ca
TUMORS


Radiologic Features
 Technetium bone scan
 80% of all metastases are located in the
central or axial skeleton
- Spine and Pelvis being a most common
 Alteration in bone density and architecture
 75% osteolytic, moth eaten or permeative
 15% osteoblastic
 Periosteal response is rare
Metastatic
TUMORS
Primary Malignant Bone Tumors
 Multiple Myeloma
 Bone scan are cold
 Gross Osteoporosis may be the only early
sign
 Punched out lesions
 Vertebra plana or wrinkled vertebra
 Preservation of pedicles
Multiple Myeloma
Multiple Myeloma
TUMORS


Osteosarcoma
 75% of cases occurs in the 10 to 25 age
 Metaphysis of the distal femur, proximal
humerus are the most common sites
 Permeative or ivory medullary lesion in
metaphysis of a long tubular bone
 A sunburst or sunray periosteal response
 Cortical disruption with soft tissue mass
formation
 Sclerotic – Lytic – Mixed lesion
Osteosarcoma
Osteosarcoma
TUMORS


Ewing’s Sarcoma
 Most cases occur in the 10 – 25 age range
 May mimic infection
 Diaphyseal permeative lesion
 Femur, tibia and fibula
 Onion skin periosteal response
 Most common primary malignant bone
tumor to metastasize to bone
Ewing’s Sarcoma
TUMORS
Primary quasimalignant bone tumor
 Giant cell Tumor
 Osteoclastoma
 20-40 years is the usual age range
 Distal femur, proximal tibia
distal radius, proximal humerus
 Metaphysis and extend to subarticular
 Radiolucent, eccentric
 Soap Bubble appearance
Giant Cell Tumor
TUMOR
Primary Benign Bone Tumors
 Osteochondroma
 Painless and hard mass near a joint
 Humerus, tibia, femur, ribs
 Two types : - sessile
- pedunculated
 Coat hanger exostose – cauliflower mass
 The cortex and spongiosa blend
imperceptibly
Osteochondroma
TUMOR


Osteoma
 A rise in membranous bones
 Sinuses – frontal, ethmoid
Mandible
Skull bones
 Homogenously opaque
Osteoma

TUMOR


Bone Island
 Epiphyseal, metaphyseal
 Medullary
 Round – oval : Long axis oriented
Smooth or radiating border
Opaque
Normal adjacent cortex
May change size
TUMOR


Osteoid osteoma
 Consists a nidus, that usually 1 cm or less
 Target calcification
 Most common location is in the cortex
 Radiolucent nidus surrounded by perifocal
reactive sclerosis
Osteoid Osteoma
TUMOR
Simple Bone Cyst
 Expansile radiolucent
 Proximal humerus, femur, calcaneus
 No periosteal reaction
 Pathologic fracture
 Aneurysmal Bone Cyst
 Some lesion may reach 8 – 10 cm
 Cortical ballooning “ blown out app”

Aneurysmal Bone Cyst
Aneurysmal Bone Cyst
ARTHRITIC DISORDERS
Degenerative Disorders
 Degenerative Joint Disease
 etc
Inflammatory Disorders
 Rheumatoid Arthritis
 etc
Metabolic Disorders
 Gout
 etc
ARTHRITIC


Degenerative Joint Disease
Osteoarthritis – Osteoarthrosis
 Asymmetric distribution
 Non uniform loss of the joint space
 Osteophytes
 Subchondral sclerosis
 Subchondral cyst
 Loose bodies
 Subluxation
Osteoarthrosis
ARTHRITIC
 Rheumatoid Arthritis

Generalized Connective tissue disorder
 Highest incidence among the 40 – 50 year
 Symmetric peripheral joint pain and swelling
 Early : - Soft tissue swelling
Marginal erosions
Osteoporosis - Periostitis
Loss of joint space
Late : - Ankylosis
Deformities

Rheumatoid Arthritis
Rheumatoid Arthritis
ARTHRITIS
Gout

Disorder of purin metabolism
 Deposits of Sodium monourate crystals
into cartilage, synovium, periarticular
and subcutaneous tissues
 Dense soft tissue Tophi, preservation
of joint space, Bone erosions (marginal
periarticular) “overhanging margin sign”
 Metatarsophalangeal joint

Gout
QUESTIONS
THANK YOU

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Introduction to skeletal imaging

  • 1. INTRODUCTION TO SKELETAL IMAGING Muhammad Bin Zulfiqar PGR II SIMS/SHL New Radiology Department
  • 2. Overview of Skeletal system •Total bones •Skull bones •Ear bones •Throat Bone •Thorax •Vertebral column •Shoulder girdle •Upper limb •Pelvis •Lower Limb 206 22 6 1 25 24 4 60 4 60
  • 3.
  • 4. Imaging Modalities for Skeletal System •Plain Radiographs(main focus) •Nuclear Scintigraphy •Contrast Examination •Ultrasound •Computed Tomography •Magnetic Resonance Imaging
  • 5. Major Diseases of Bone         Trauma Congenital Infections Tumors Metabolic, Endocrine, Nutritional Bone Dysplasia Inflammatory Diseases(R.A.) Associated soft tissues abnormalities
  • 6. Skeletal Anatomy and Physiology Skeletal Development Intramembranous Ossification  Enchondral Ossification  Bone Structure  Epiphysis – ZPC – Metaphysis – Diaphysis  Cortex – Medulla – Periosteum – Endosteum Bone Metabolism  Bone mineral - Hormones
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  • 14. Approach to skeletal imaging Preliminary Analysis • Clinical data • Number of lesions • Symmetry of lesions • Determination of Systems Involved
  • 15. Analysis of The Lesions Skeletal Location Position Within Bone Site of Origin Shape Size Margination Cortical Integrity
  • 16. Analysis of The Lesions Behavior of Lesions • Osteolytic Lesions • Osteoblastic Lesions • Mixed Lesions  Matrix  Periosteal Response • Solid Response • Laminated Response • Spiculated Response • Codmans’ Triangle
  • 17. Radiologic Predictor Variables Supplementary Analysis  Other imaging Procedures  Laboratory Examination  Biopsy  Soft Tissue Changes 
  • 18. TRAUMA Fracture and Dislocation The radiographs should be made  Include at least one joint  Preferably two joints  Two position AP – LAT
  • 19. TRAUMA Time intervals between Radiographic Study  Initial Diagnostic study  Post reduction and post immobilization  One or Two weeks later, if position has changed  After approximately six eight weeks for Primary callus  After each plaster cast or traction change  Before final discharge of patient
  • 20. TRAUMA Types of Fracture  Closed fracture  Does not break the skin or communicate with the outside environment  Simple fracture  Open fractur  Penetrates the skin over fracture site  Compound fracture
  • 21. TRAUMA Comminuted fracture  Two or more bony fragments have separated  Non Comminuted fracture  Penetrates completely through the bone  Avulsion fracture  Tearing away of a portion of the bone  Impaction fracture  Bone is driven into its adjacent segment
  • 22. TRAUMA  Incomplete Fracture  Broken only one side of the bone  Greenstick (Hickory Stick) fracture  Torus (Buckling) fracture Fracture Orientation  Oblique fracture  Commonly occurs in the shaft of long tubular bone  45 to the long axis of the bone
  • 25. TRAUMA Spiral fracture  Torsion, coupled with axial compression and angulation  Transverse fracture  Run at a right angle to the lonh axis  Uncommon through healthy bone  Pathologic fracture 
  • 27. TRAUMA Spatial Relationships of Fracture  Alignment  Position of the distal fragment in relation to the proximal fragment  Apposition  Closeness of the bony contact at the fracture site  If the ends are pulled referred to as Distraction
  • 29. TRAUMA Rotation  Twisting forces on a fractured bone along its longitudinal axis Traumatic Articular Lesions  Subluxation  Dislocation  Diastasis Epiphyseal Fractures  Salter-Harris Classification 
  • 32. TRAUMA Fracture Healing  Main steps in fracture healing  Formation of hematoma  Organization of hematoma  Formation of fibrous callus  Replacement of fibrous callus by primary bany callus  Absorption primary bany callus Transformation to secondary bony callus  Remodeling
  • 33. TRAUMA Complication of Fractures  Immediate complication  Arterial injury  Compartment syndrome  Gas gangrene  Fat embolism syndrome  Thromboembolism
  • 34. TRAUMA  Intermediate complication  Osteomyelitis  Myositis ossificans  Synostosis  Delayed union  Delayed complication  Osteonecrosis  Osteoporosis  Non union – Mal union
  • 36. INFECTION Suppurative Osteomyelitis  General Consideration  Systemic or Local infections  Immunosuppresed patients, alcoholics, newborns, and drug addicts are predisposed  Antibiotics have significatly reduced the sepsis-related mortality
  • 37. INFECTION  Etiology  Staphylococcus aureus causes 90%  Pathway for the spread  Hematogenous  Contiguous  Direct Implantation  Postoperative
  • 38. INFECTION  Radiologic Features  Bone scan are the earliest means of diagnosis  Radiographic latent period for plain film  10 days for extremities  21 days for spine  Soft tissue alteration : elevated fat planes, obliterated fat planes, increased density.
  • 39. INFECTION  Bone changes :  Moth-eaten bone destruction Usually metaphyseal in origin  Periosteal new bone formation Solid – Laminated – Codman’s Triangle  Sequestrum  Involucrum  Joint space destruction (ankylosis)
  • 42. INFECTION Septic Arthritis  General consideration  Single joint involvement in the rule  Most common route is hematogenous or direct traumatic implantation  Etiology  Most frequently is Staphylococcus Aureus
  • 43. INFECTION  Radiologic Features  The knee and hip are the most common sites  Joint effusion leads to distortion of the fat folds  Positive Walden storm's sign  Rapid loss of joint space  Bony ankylosis
  • 44. INFECTION Nonsuppurative osteomyelitis (tuberculosis)  General Consideration  Found in patients such as prepubertal children, debilitated geriatric, silicosis, AIDS sufferers, Lymphoma patients, Alcoholics, corticosteroid and drug abusers
  • 45. INFECTION  Etiology  Mycobacterium tuberculosis  Two mode of spread  Inhalation  Ingestion
  • 46. INFECTION  Radiologic Features  Spinal tuberculosis is most common at L-I  Early sign for spine are :  Lytic endplate destruction  loss of disc height  Anterior “ gouge defect “  Paraspinal swelling
  • 47. INFECTION Advanced sign for spinal involvement are:  Vertebral body collapse  Gibbus formation and obliteration of the disc  Tubercular arthritis is common in the hip and knee  Uniform joint space narrowing, early destruction of the subchondral cortex, “moth-eaten” bone destruction and juxtaarticular osteoporosis are the cardinal sign of tubercular arthritis 
  • 50. TUMORS AND TUMORLIKE PROCESSES METASTATIC BONE TUMORS PRIMARY MALIGNANT BONE TUMORS  Multiple myeloma  Osteosarcoma  Ewing’s Sarcoma PRIMARY QUASIMALIGNANT BONE TUMOR  Giant Cell Tumor
  • 51. TUMORS PRIMARY BENIGN BONE TUMORS  Osteochondroma  Osteoma  Bone island  Osteoid osteoma  Simple bone cyst  Aneurysmal bone cyst
  • 52. TUMORS Metastatic Bone Tumors  General Consideration  The most common malignant tumors  CNS tumors and basal cell Ca rarely  Life threatening complication  Incidence  70% are metastatic, 30% are primary  In females 70% from breast Ca In males 60% from prostate Ca
  • 53. TUMORS  Radiologic Features  Technetium bone scan  80% of all metastases are located in the central or axial skeleton - Spine and Pelvis being a most common  Alteration in bone density and architecture  75% osteolytic, moth eaten or permeative  15% osteoblastic  Periosteal response is rare
  • 55. TUMORS Primary Malignant Bone Tumors  Multiple Myeloma  Bone scan are cold  Gross Osteoporosis may be the only early sign  Punched out lesions  Vertebra plana or wrinkled vertebra  Preservation of pedicles
  • 58. TUMORS  Osteosarcoma  75% of cases occurs in the 10 to 25 age  Metaphysis of the distal femur, proximal humerus are the most common sites  Permeative or ivory medullary lesion in metaphysis of a long tubular bone  A sunburst or sunray periosteal response  Cortical disruption with soft tissue mass formation  Sclerotic – Lytic – Mixed lesion
  • 61. TUMORS  Ewing’s Sarcoma  Most cases occur in the 10 – 25 age range  May mimic infection  Diaphyseal permeative lesion  Femur, tibia and fibula  Onion skin periosteal response  Most common primary malignant bone tumor to metastasize to bone
  • 63. TUMORS Primary quasimalignant bone tumor  Giant cell Tumor  Osteoclastoma  20-40 years is the usual age range  Distal femur, proximal tibia distal radius, proximal humerus  Metaphysis and extend to subarticular  Radiolucent, eccentric  Soap Bubble appearance
  • 65. TUMOR Primary Benign Bone Tumors  Osteochondroma  Painless and hard mass near a joint  Humerus, tibia, femur, ribs  Two types : - sessile - pedunculated  Coat hanger exostose – cauliflower mass  The cortex and spongiosa blend imperceptibly
  • 67. TUMOR  Osteoma  A rise in membranous bones  Sinuses – frontal, ethmoid Mandible Skull bones  Homogenously opaque
  • 69. TUMOR  Bone Island  Epiphyseal, metaphyseal  Medullary  Round – oval : Long axis oriented Smooth or radiating border Opaque Normal adjacent cortex May change size
  • 70. TUMOR  Osteoid osteoma  Consists a nidus, that usually 1 cm or less  Target calcification  Most common location is in the cortex  Radiolucent nidus surrounded by perifocal reactive sclerosis
  • 72. TUMOR Simple Bone Cyst  Expansile radiolucent  Proximal humerus, femur, calcaneus  No periosteal reaction  Pathologic fracture  Aneurysmal Bone Cyst  Some lesion may reach 8 – 10 cm  Cortical ballooning “ blown out app” 
  • 75. ARTHRITIC DISORDERS Degenerative Disorders  Degenerative Joint Disease  etc Inflammatory Disorders  Rheumatoid Arthritis  etc Metabolic Disorders  Gout  etc
  • 76. ARTHRITIC  Degenerative Joint Disease Osteoarthritis – Osteoarthrosis  Asymmetric distribution  Non uniform loss of the joint space  Osteophytes  Subchondral sclerosis  Subchondral cyst  Loose bodies  Subluxation
  • 78. ARTHRITIC  Rheumatoid Arthritis Generalized Connective tissue disorder  Highest incidence among the 40 – 50 year  Symmetric peripheral joint pain and swelling  Early : - Soft tissue swelling Marginal erosions Osteoporosis - Periostitis Loss of joint space Late : - Ankylosis Deformities 
  • 81. ARTHRITIS Gout Disorder of purin metabolism  Deposits of Sodium monourate crystals into cartilage, synovium, periarticular and subcutaneous tissues  Dense soft tissue Tophi, preservation of joint space, Bone erosions (marginal periarticular) “overhanging margin sign”  Metatarsophalangeal joint 
  • 82. Gout