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Vipin Kumar.pptx

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Vipin Kumar.pptx

  1. 1. Hematopoeisis Name-Vipin Kumar Group-216
  2. 2. Haemopoiesis: Stages in the development of blood cells
  3. 3. HEMATOPOIESIS • Mature blood cells have a relatively short life span • Must be continusly replaced by stem cells • Stem cells produce in HEMATOPOIETIC ORGAN
  4. 4. HEMATOPOIESIS ERYTHROPOESIS: Formation of the erythrocytes (RBCs red blood cells) LEUKOPOESIS: Formation of the white blood cells GRANULOPOESIS:Formation of the granulocytes (neuthrophil, eosinophil, and basophil THROMBOPOESIS: Formation of the platelets
  5. 5. Hematopoesis loation Hematopoesis occour in primary and secondary organs: primary organs include:Bone marrow and thymus secondary organs include:spleen,lymphatic system and tonsils THYMUS: Glandular lymphatic organ near the heart where T lymphocytes mature well developed at birth and increase in size until puberty when it starts to decrease in size.
  6. 6. PRENATAL HEMOPOIESIS • Subdivide into four phases : – Mesoblastic : • begin after 2 weeks after conception at yolk sac • Mesenchymal cells aggregate into blood islands – Hepatic • Begins at 6 weeks until end of gestation • Nucleated erythrocyte • Appear of leucocyte (8th week) – Splenic • Begin at second trimester until end of gestation – Myeloid • Begin at the end of second trimester • Hemopoiesis at bone marrow
  7. 7. POSTNATAL HEMOPOIESIS • Hemopoiesis almost exclusively in BONE MARROW • Stem cells undergo – multiple cells divisions – and differentiation • Replace the cells that leave the blood stream, die or destroy
  8. 8. Haematopoiesis during foetal life and infancy Blood cell production begins at 14–20 days in the foetal sac and this is the site of haematopoiesis for about 2 months. The liver and spleen become the main sites of blood cell production during the second trimester of pregnancy and foetal bone marrow in the third trimester. At birth, haematopoiesis is confined to the bone marrow. During infancy and up to about 4 years of age, almost all the bones of the body contain blood cell producing red marrow. Haematopoiesis during adult life By about 25 years of age, the main sites of haematopoiesis are the vertebrae, ribs, sternum, skull bones, pelvis and sacrum, and the proximal ends of the femur and humerus. At these sites about half the marrow is red active cell producing marrow and the remainder, non-cell producing yellow fatty marrow. Other bone marrow cavities in the body contain nonhaematopoietic fatty marrow. In certain blood disorders, e.g. chronic dyserythropoietic and haemolytic anaemias and myelofibrosis, blood cell production can resume in the liver and spleen (extramedullary haematopoiesis) and the fatty marrow in some bones can become replaced by haematopoietic marrow.
  9. 9. HEMOPOIETIC GROWTH FACTORS Table 10-6 Gartner colour text histology • Regulated the hemopoiesis • Produce by spesific cells • Acts on spesific stem cells, progenitor cells, and precursor cells • The route to deliver growth factor : – Via blood stream – Secrete near the hemopoietic cells – Direct cell-cell contact • Induced rapid mitosis or and differentiation • Most ot them are glycoproteins

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