1.
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Emerging Cancer Vaccines: Market Forecasts, New Developments and Pipeline
Analysis, 3rd Edition
November 1, 2008
It is the general consensus of scientists that cancer vaccines will become a reality.
Overall the cancer treatment market continues to grow and this demand sets the stage
for vaccine products.
There are several promising vaccines: the propholactic Gardasil has created a pathway
for new vaccine products. M-Vax, Ocon-Vax in late stage development and are
preparing for regulatory review in the United States, Europe, Canada, or other
international regions. Many of the products with potential approval status over the
coming years are already in Phase III development, have orphan drug status, SPA
status, or Fast Track status. This provides a promising future for many of these
products. Additionally, some products in international regions have been granted
compassionate use status which is significant in evaluating need on a patient-by-patient
basis. In this report, Kalorama Information provides a realistic estimate of the cancer
vaccine for the near term for the following products:
• Melonoma Vaccines
• Lung Cancer Vaccines
• Prostate Cancer Vaccines
• Cervical Cancer Vaccines
• Brain Cancer Vaccines
• Colon/Rectal Cancer Vaccines
• Breast Cancer Vaccines
• Lymphoma Vaccines
• Ovarian Cancer Vaccines
• Leukemia Vaccines
• Bladder Cancer Vaccines
As part of its exhaustive research and analysis, this report provides:
• Forecasts for Future Revenues from Cancer Vaccines
• Cancer Epidemiology

2. • Reviews of Products in the Pipeline
• Detailed Profiles of 13 Companies Operating in the Cancer Vaccine Market
• Directory of Related Companies
Some of the issues discussed in this report important for anyone operating in this
market include:
• Introduction
• Early Detection and Screening
• Monoclonal Antibodies and Therapeutic Vaccines
• Political and Social Pressure
• Insurance and Reimbursement Issues
• Personalized Medicine
• Pharmacogenomics
• Vaccine Strategies
• New Genetic Technique
• Future Growth in Vaccines
As part of its detailed coverage of developments in cancer vaccines..the following
companies are profiled in this report:
• Antigenics, Inc.
• Avax Technologies, Inc.
• Biovest International, Inc.
• Cell Genesys, Inc.
• Dendreon Corporation
• Genitope Corporation
• GlaxoSmithKline plc
• Merck & Company, Inc.
• Northwest Biotherapeutics, Inc.
• NovaRx
• Oncothyreon
• Vaccinogen
• Vical, Inc.
Table of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
Introduction
Scope and Methodology

3. Size and Growth of the Market
Issues and Trends Affecting Market
Leading Competitors
CHAPTER TWO: INTRODUCTION
Introduction
History and Growth of the Cancer Treatment Market
Types of Vaccines
Antigen/Adjuvant Vaccines
Whole Cell Tumor Vaccines
Dendritic Cell (DC) Vaccines
Viral Vectors and DNA Vaccines
Idiotype Vaccines
Types of Therapeutic Vaccines
Patient-Specific Vaccines
Prostate Specific Antigen
Sialyl Tn
Heat Shock Proteins
Ganglioside Molecules
Carcinoembryonic Antigen (CEA)
MART-1
Tyrosinase
Adjuvants
Industry Structure
Demographics and Statistics
Growing and Aging Population
Life Expectancy and Cancer

4. CHAPTER THREE: CERVICAL CANCER VACCINES
Overview
Description of Vaccines on the Market
Gardasil/Silgard
Cervarix
Description of Vaccines in Development
TG 4001/R3484
HspE7
Lovaxin C
VGX-3100
CA-9
Market Summary
Current and Potential Competitors and Analysis, 2012
CHAPTER FOUR: COLON/RECTAL CANCER VACCINES
Overview
Description of Vaccines on the Market
OncoVAX
Description of Vaccines in Development
OncoVAX
TroVAX
Avicine
CEA VRP Vaccine
Collidem
IMA910
Lapuleucel-T
Oncophage

5. CDX-1307-01
Tumor Associated Antigen Therapeutic Vaccine - CEA DNA Cancer Vaccine
MKC1106-PP
Market Summary
Potential Competitors and Analysis, 2012
CHAPTER FIVE: LUNG CANCER VACCINES
Overview
Description of Vaccines in Development
Lucanix
MAGE-A3 Peptide
Stimuvax
EGF Cancer Vaccine
GV-1001
HyperAcute Lung
IDM 2101 (EP-2101)
Oncophage
INGN 225
TG 4010
LungVAX
Tumor Associated Antigen Therapeutic Vaccine - CEA DNA Cancer Vaccine
DC Vax
L523S
Market Summary
Potential Competitors and Analysis, 2012
CHAPTER SIX: LYMPHOMA VACCINES
Overview

6. Description of Vaccines in Development
MyVax
BiovaxID
FavId
TG 1042
Market Summary
Potential Competitors and Analysis, 2012
CHAPTER SEVEN: MELANOMA VACCINES
Overview
Description of Vaccines on the Market
Description of Vaccines in Development
M-VAX
GMK
Allovectin-7
MDX-1379 with Combination Treatment MDX-010
Oncophage
MAGE-A3 ASCI 3
Uvidem
AGI-101H Vaccine
ALVAC Vaccine
HyperAcute Melanoma
Market Summary
Potential Competitors and Analysis, 2012
CHAPTER EIGHT: PROSTATE CANCER VACCINES
Overview
Description of Vaccines in Development

7. Provenge
DCVax-Prostate
GVAX
ProstAtak
TroVAX
Telomerase Cancer Vaccine
MVA-BN Prostate
HyperAcute Prostate
MKC1106-PP
Market Summary
Potential Competitors and Analysis, 2012
CHAPTER NINE: BREAST CANCER VACCINES
Overview
Description of Vaccines in Development
INGN 225
CEA VRP Vaccine
MVA-BN HER2
Lapuleucel-T
PX 104.1
CDX-1307-02
Tumor Associated Antigen Therapeutic Vaccine - CEA DNA Cancer Vaccine
MKC1106-PP
Market Summary
CHAPTER TEN: GASTROINTESTINAL CANCER VACCINES
Overview
Description of Vaccines in Development

8. GV 1001
GI-4000
Avicine
GVAX
HyperAcute Pancreas
Oncophage
CDX-1307-01
CRS-100
CRS-207
DC Vax
MKC1106-PP
Market Summary
CHAPTER ELEVEN: RENAL CANCER VACCINES
Overview
Description of Vaccines on the Market
Oncophage
Description of Vaccines in Development
Oncophage
Reniale
TroVAX
IMA901
AGS-003
MDX-1106
MKC1106-PP
Market Summary
Potential Competitors and Analysis, 2012

9. CHAPTER TWELVE: BRAIN CANCER VACCINES
Overview
Glioblastoma
Neuroblastoma
Description of Vaccines in Development
DCVax-Brain
CDX-110
GliAtak
Oncophage
Market Summary
CHAPTER THIRTEEN: BLADDER CANCER VACCINES
Overview
Description of Vaccines on the Market
BCG Therapy (OncoTICE- Organon Teknika) (Immucyst-Sanofi Pasteur)(Pacis-Shire Pharmaceuticals)
Description of Vaccines in Development
Bexidem
CG0070
MDX-1307-01
Market Summary
CHAPTER FOURTEEN: OVARIAN CANCER VACCINES
Overview
Description of Vaccines in Development
OVax Autologous Cell Vaccine
Lapuleucel-T
Tumor Associated Antigen Therapeutic Vaccine - CEA DNA Cancer Vaccine
MKC1106-PP

10. Market Summary
CHAPTER FIFTEEN: LEUKEMIA VACCINES
Overview
Description of Vaccines in Development
GVAX
PR1 Peptide Vaccine
AGS-005
Market Summary
CHAPTER SIXTEEN: ISSUES AND TRENDS AFFECTING THE CANCER VACCINE MARKET
Introduction
Early Detection and Screening
Monoclonal Antibodies and Therapeutic Vaccines
Political and Social Pressure
Insurance and Reimbursement Issues
Personalized Medicine
Pharmacogenomics
Vaccine Strategies
New Genetic Technique
Future Growth in Vaccines
CHAPTER SEVENTEEN: THE CANCER VACCINE MARKET: MARKET FORECASTS
Overview
Total Market Size and Forecast
Market and Competitor Analysis
CHAPTER EIGHTEEN: CANCER VACCINE CORPORATE PROFILES
Introduction
Antigenics, Inc

11. Avax Technologies, Inc
Biovest International, Inc
Cell Genesys, Inc
Dendreon Corporation
Genitope Corporation
GlaxoSmithKline plc
Merck & Company, Inc
Northwest Biotherapeutics, Inc
NovaRx
Oncothyreon
Vaccinogen
Vical, Inc
CHAPTER NINETEEN: COMPANY NAMES AND ADDRESSES
TABLE OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
• Table 1-1: Cancer Vaccines: Developing and Emerging Cancer Vaccine Markets, 2008-2012
• Figure 1-1: Cancer Vaccines: Developing and Emerging Cancer Vaccine Markets, 2008-2012
CHAPTER TWO: INTRODUCTION
• Table 2-1: Estimated and Projected World Cancer Incidence by Selected Types of Cancer, 2007
and 2020
• Figure 2-1: Estimated and Projected World Cancer Incidence by Selected Types of Cancer, 2007
and 2020
• Table 2-2: Total Cancer Incidence by Sex and Country, 2007 Estimates
• Figure 2-2: Total Cancer Incidence by Sex and Country
• Table 2-3: World Population by Selected Geographical Region, 2007-2050
• Figure 2-4: World Population by Selected Geographical Region, 2007-2050
• Table 2-4: Estimated World Population by Age and Geographical Region, 2007
• Figure 2-4: Estimated World Population by Age and Geographical Region, 2007
• Table 2-5: Percent Population Over 65 by Year and Region
• Figure 2-5: Estimated World Population by Age, 2007 and 2050
• Table 2-6: Life Expectancy at Birth by Selected Countries, 2006
• Table 2-6: United States Average Years of Life Lost Per Person Dying of Cancer, All Races, Both

12. Sexes, 2004
• Table 2-7: United States Estimated Person-Years of Life Lost Due to Cancer, All Races, Both
Sexes, 2004
CHAPTER THREE: CERVICAL CANCER VACCINES
• Table 3-1: Estimated World Incidence of Cervical Cancer by Country, 2007
• Figure 3-1: Estimated World Incidence of Cervical Cancer by Country, 2007
• Table 3-2: Cervical Cancer Vaccines Approved and in the Pipeline
• Table 3-3: The Developing Cervical Cancer Vaccine Market, 2008-2012
• Figure 3-2: The Developing Cervical Cancer Vaccine Market, 2008-2012
• Table 3-4: The Developing Cervical Cancer Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 3-3: The Developing Cervical Cancer Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 3-4: Anticipated Product Sales by Year for Cervical Cancer Vaccines, 2008-2012
CHAPTER FOUR: COLON/RECTAL CANCER VACCINES
• Table 4-1: Estimated World Incidence of Colon/Rectal Cancer by Country, 2007
• Figure 4-1: Estimated World Incidence of Colon/Rectal Cancer by Country, 2007
• Table 4-2: Colon/Rectal Cancer Vaccines in the Pipeline
• Table 4-3: The Emerging Colon/Rectal Cancer Vaccine Market, 2008-2012
• Figure 4-2: The Emerging Colon/Rectal Cancer Vaccine Market, 2008-2012
• Figure 4-3: Anticipated Product Sales by Year for Emerging Colon/Rectal Cancer Vaccines, 2008-
2012
CHAPTER FIVE: LUNG CANCER VACCINES
• Table 5-1: Types of Primary Lung Cancer
• Table 5-2: Estimated World Incidence of Lung Cancer by Country, 2007
• Figure 5-1: Estimated World Incidence of Lung Cancer by Country, 2007
• Table 5-3: Lung Cancer Vaccines in the Pipeline
CHAPTER SIX: LYMPHOMA VACCINES
• Table 6-1: Classification of Non-Hodgkin’s Lymphomas
• Table 6-2: Estimated World Incidence of Lymphoma by Country, 2007
• Figure 6-1: Estimated World Incidence of Lymphoma by Country, 2007
• Table 6-3: Lymphoma Vaccines in the Pipeline
• Table 6-4: The Emerging Lymphoma Vaccine Market, 2008-2012
• Figure 6-2: The Emerging Lymphoma Vaccine Market, 2008-2012
• Table 6-5: The Emerging Lymphoma Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 6-3: The Emerging Lymphoma Vaccine Market, Leading Suppliers Shares by Market

13. Revenues, Projected 2012
• Figure 6-4: Anticipated Product Sales by Year for Emerging Lymphoma Vaccines, 2010-2012
CHAPTER SEVEN: MELANOMA VACCINES
• Table 7-1: Malignant Condidtions of the Skin
• Table 7-2: Estimated World Incidence of Melanoma by Country, 2007
• Figure 7-1: Estimated World Incidence of Melanoma by Country, 2007
• Table 7-3: Melanoma Vaccines in the Pipeline
• Table 7-4: The Developing Melanoma Vaccine Market, 2008-2012
• Figure 7-2: The Developing Melanoma Vaccine Market, 2008-2012
• Table 7-5: The Developing Melanoma Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 7-3: The Developing Melanoma Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 7-4:Anticipated Product Sales by Year for Developing Melanoma Vaccines, 2010-2012
CHAPTER EIGHT: PROSTATE CANCER VACCINES
• Table 8-1: Estimated World Incidence of Prostate Cancer by Country, 2007
• Figure 8-1: Estimated World Incidence of Prostate Cancer by Country, 2007
• Table 8-2: Prostate Cancer Vaccines in the Pipeline
• Table 8-3: The Emerging Prostate Cancer Vaccine Market, 2008-2012
• Figure 8-2: The Emerging Prostate Cancer Vaccine Market, 2008-2012
• Table 8-4: The Emerging Prostate Cancer Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 8-3: The Emerging Prostate Cancer Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 8-4: Anticipated Product Sales by Year for Emerging Prostate Vaccines, 2010-2012
CHAPTER NINE: BREAST CANCER VACCINES
• Table 9-1: Estimated World Incidence of Breast Cancer by Country, 2007
• Figure 9-1: Estimated World Incidence of Breast Cancer by Country, 2007
• Table 9-2: Breast Cancer Vaccines in the Pipeline
CHAPTER TEN: GASTROINTESTINAL CANCER VACCINES
• Table 10-1: Estimated World Incidence of Gastrointestinal Cancer by Country, 2007
• Figure 10-1: Estimated World Incidence of Gastrointestinal Cancer by Country, 2007
• Table 10-2: Gastrointestinal Cancer Vaccines in the Pipeline
CHAPTER ELEVEN: RENAL CANCER VACCINES
• Table 11-1: Estimated World Incidence of Renal Cancer by Country, 2007

14. • Figure 11-1: Estimated World Incidence of Renal Cancer by Country, 2007
• Table 11-2: Renal Cancer Vaccines in the Pipeline
• Table 11-3: The Developing Renal Cancer Vaccine Market, 2008-2012
• Figure 11-2: The Developing Renal Cancer Vaccine Market, 2008-2012
• Table 11-4: The Developing Renal Cancer Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 11-3: The Developing Renal Cancer Vaccine Market, Leading Suppliers Shares by Market
Revenues, Projected 2012
• Figure 11-4: Anticipated Product Sales by Year for Renal Cancer Vaccines, 2008-2012
CHAPTER TWELVE: BRAIN CANCER VACCINES
• Table 12-1: Estimated World Incidence of Brain Cancer by Country, 2007
• Figure 12-1: Estimated World Incidence of Brain Cancer by Country, 2007
• Table 12-2: Brain Cancer Vaccines in the Pipeline
CHAPTER THIRTEEN: BLADDER CANCER VACCINES
• Table 13-1: Estimated World Incidence of Bladder Cancer by Country, 2007
• Figure 13-1: Estimated World Incidence of Bladder Cancer by Country, 2007
• Table 13-2: Bladder Cancer Vaccines in the Pipeline
CHAPTER FOURTEEN: OVARIAN CANCER VACCINES
• Table 14-1: Estimated World Incidence of Ovarian Cancer by Country, 2007
• Figure 14-1: Estimated World Incidence of Ovarian Cancer by Country, 2007
• Table 14-2: Ovarian Cancer Vaccines in the Pipeline
CHAPTER FIFETEEN: LEUKEMIA VACCINES
• Table 15-1: TYPES OF LEUKEMIA
• Table 15-2: Estimated World Incidence of Leukemia by Country, 2007
• Figure 15-1: Estimated World Incidence of Leukemia Cancer by Country, 2007
• Table 15-3: Leukemia Vaccines in the Pipeline
CHAPTER SIXTEEN: ISSUES AND TRENDS AFFECTING THE CANCER VACCINE MARKET
• Table 16-1: Cancer Detection Tests
CHAPTER SEVENTEEN: THE CANCER VACCINE MARKET: MARKET FORECASTS
• Table 17-1: Cancer Vaccines: Developing and Emerging Cancer VaccineMarkets, 2008-2012
• Figure 17-1: Cancer Vaccines: Developing and Emerging Cancer Vaccine Markets, 2008-2012
• Figure 17-2: Cancer Vaccines: Developing and Emerging Cancer Vaccine Markets by Percent

15. and Vaccine Indication, 2012
CANCER VACCINE CORPORATE PROFILES
COMPANY NAMES AND ADDRESSES
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