Dermatology - Intracellular Signal Transducers and Cytokine Signaling Molecules Dominate Pipeline

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Category : Pharma & Healthcare
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Introduction to Report
 Launch Date: June 1, 2017
 Number of Pages: 98
 Geography Coverage: Global
 Available Format: PDF
Price For Single User License: USD 6,995
Price For Site User License: USD 13,990
Price For Global User License: USD 20,985
Delivery Time: Within 24 Hours (During Working
Days)

About the Report
Dermatology is a highly diverse therapy area that
deals with diseases of the skin, hair and nails.
Over 3,000 distinct dermatological conditions are
thought to exist, ranging from rare autoimmune
disorders such as scleroderma, to very common
conditions such as acne vulgaris and atopic
dermatitis.
For the past decade the majority of the therapeutic
dermatology market has been saturated and
highly genericized, and strongly dominated by
small molecules.

Key Highlights:
There is a significant unmet need for more efficacious
and safer treatment options, as physicians often cite
poor efficacy, low patient compliance and problematic
safety profiles as issues with the long-term use of many
available treatments.
Although the scope of dermatological disorders is
diverse in terms of severity, clinical presentation, and
key patient demographics, there is a degree of
crossover between many indications in terms of their
underlying pathophysiology.
Increased inflammation and aberrant immune response
resulting in skin barrier dysfunction are commonly
shared causes.
Infections and dysfunctions in wound healing are also
common causes of dermatological diseases.

Key Highlights: Continues…
Scientific advancements over the course of recent
decades have revealed a broad range of novel potential
molecular targets, enabling the advancement of a
previously stagnant field.
This is reflected in the high number of products being
developed, with 961 pipeline products currently in the
dermatology therapy area pipeline.
Analysis indicates that the current pipeline is following
a trend of focusing on innovative biologic therapies,
following the clinical and commercial success of such
therapies in the treatment of psoriasis.
There are various biologics in the pipeline for major
skin disorders - including atopic dermatitis, acne
vulgaris and rosacea - for which there is a significant
unmet need in patients with moderate-to-severe
conditions.

Scope:
With 961 products in active development, the
pipeline is considerably large. How will pipeline
innovation affect the future dermatology market?
There are 197 first-in-class products in the
dermatology pipeline. Which of these hold the
greatest potential to improve future disease
treatment with regard to their molecular target?
The majority of first-in-class products are in
development for indications involving
inflammation.
Which first-in-class targets are most promising,
and how does the ratio of first-in-class targets to
first-in-class products differ by stage of
development and molecular target class?

Scope: Continues…
A significant number of first-in-class products
have been identified with no prior involvement in
deals.
How do deal frequency and value compare
between target families and molecule types, and
which first-in-class programs have not yet been
involved in a licensing or co-development deal?

Reasons to buy:
Understand the current clinical and commercial
landscape. The report includes a comprehensive
study of disease pathogenesis, diagnosis,
prognosis and the treatment options available.
Visualize the composition of the dermatology
market in terms of dominant molecule types and
targets, highlighting what the current unmet needs
are and how they can be addressed. This
knowledge allows a competitive understanding of
gaps in the market.
Analyze the dermatology pipeline and stratify by
stage of development, molecule type and
molecular target. There are strong signs in the
pipeline that the industry is seeking novel
approaches to treating dermatological diseases,
including rare conditions.

Reasons to buy: Continues…
Assess the therapeutic potential of first-in-class
targets. Using proprietary matrices, first-in-class
products have been assessed and ranked
according to clinical potential.
The matrices have been split into three
categories: inflammatory diseases, infectious
diseases, and wounds/scars. Promising targets
have been reviewed in greater detail.
Identify commercial opportunities in the
dermatology deals landscape by analyzing trends
in licensing and co-development deals, and
producing a list of first-in-class therapies with no
prior involvement in licensing or co-development
deals.

Report Coverage:
1. Executive Summary
2. The Case for Innovation
3. Clinical and Commercial Landscape
4. Assessment of Pipeline Product Innovation
5. Signaling Network, Disease Causation and
Innovation Alignment
6. First-in-Class Target and Pipeline Program
Evaluation
7. Strategic Consolidations
8. Appendix
For more details regarding Report coverage see the last slide
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Dermatology - Intracellular Signal Transducers and Cytokine Signaling Molecules Dominate Pipeline

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