Ultimate goal of nanomedicine is to integrate disease detection, diagnostics, treatment and prevention into a single personalized platform. Nanoparticles can be used for targeted drug delivery and detection of pathogens and cancer. For example, gold nanoparticles have been functionalized with oligonucleotides to detect specific RNA sequences through fluorescence. Nanoparticles less than the size of cancer cell pores can pass through tumor interstitial spaces, delivering therapeutic payloads directly inside tumors. While promising applications are under development, regulatory issues around safety, ethics, and artificial intelligence must be addressed for nanomedicine to realize its potential for widespread health improvements.

1. Medical Science Using
Nano Technology
Mahfuzur Rahman
CSE 04406150
Stamford University Bangladesh

2. What is Nano Technology ?
 Nanotechnology are the study and application of
extremely small things and can be used across all the
other science fields, such as chemistry, biology,
physics, materials science, and engineering.
Properties:
• Small size;
• Unique properties
• Control the properties.

3. Introduction
 What is nanomedicine?
 It is nanotechnology used for the treatment, diagnosis, monitoring
and control of biological systems
 It includes the delivery and targeting of pharmaceutical, therapeutic,
and diagnostic agents using nanoparticles to cancer and other cells
 It includes nanomaterial for bone, cartilage,
vascular, bladder and neural applications
Flesh eating/repairing nanorobots

4. Introduction–Goals of Nanomedicine
 End goal of nanomedicine is improved diagnostics, treatment and prevention
of disease

5. Introduction
Ultimate goal is to integrate detection, diagnostics, treatment and prevention of disease
into a personalized single platform

6. Nanotechnology holds key to a number of recent
and future breakthroughs in medicine

7. Nanoparticles for Pathogen
Detection
Nanoparticle Targeted RNA Fluorophore Release
• Gold nanoparticles can be functionalized with thiolated oligonucleatides.
• When the targeted RNA (H2N2, HIV or a cancer) bindes to the oligonucleatide, the
fluorophore is released and becomes fluorescence.
• The fluorescence can be detected in a BioMEMS device.
• Challenge is developing oligonucleatides with high selectivity for the target RNA.

8. Nanoparticles for Targeted
Detection of Cancer
Breast Cancer Cells Healthy Cells
•As an example, nanoparticle probes were developed at Northwestern Univ. that
target the surviving RNA sequence known to exist in a certain breast cancers.
•On the left, cancer cells fluoresce.
•On the right, healthy cells show minimal fluorescence.

9. Nanoparticles At Interfaces
nm
mm to
mm
oil-nanoparticle
suspension,
w/ droplets
water droplet:
• Nanoparticles can be functionalized, cross linked or
sintered to make shell permanent, strengthen shell or
change shell permeability.

10. Nano-Encapsulation for Drug Delivery
• By making the holes between nanoparticles approximately the same size as the
drug you want to administer you can get a constant release rate – avoids spikes in
dosage.
• Can also allow encapsulation of hydrophobic drugs which are difficult to get into
you mostly water body.
DrugConcentrationinPatient
Time
Nano-Encapsulated Drug Delivery
Standard Diffusion Based Drug Delivery

11. Targeted Delivery to Tumors
• Goal is to inject treatment far from tumor and
have large accumulation in tumor and minimal
accumulation in normal cells/organs.

12. Nanoparticle use in Cancer Treatments
• Because of their small size, nanoparticles
can pass through interstitial spaces
between necrotic and quiescent cells.
• Tumor cells typically have larger
interstitial spaces than healthy cells
• Particles collect in center bringing
therapeutics to kill the tumor from inside
out.

13. Application of nanomedicine
 Drug Delivery:
 Drug Discovery :
 Tissue Repair and Replacement
 Structural Implant
 Sensory Aids
 Surgical Robotics
 The daVinci Surgical Robotics System
Some Common Application

14. Regulatory and Risk Issues
Genetic alteration
Environmental and workplace impact
Possibly heightened toxicity of free nanoparticles
Manage the product supply chain

15. Will medical nanorobots possess a
humanlike artificial intelligence
 Quit Impossible for
today
 May be in far
future

16. Estimation
under development or nearing commercialization
New nanotechnologies may offer the only hope for systematic,
affordable, and long term improvements to the health status of
our population. This is because nano therapies may in action in
the long run.

17. Thank you