1.
The ultimate pain monitoring system.
RAYE YEOW LIU YUCHUN SHRUTHI SURESH JOHN SHI-NASH
Principal Investigator
Assistant Professor
Biomedical Engineering
NUS
Entrepreneurial Lead
Research Fellow
Dept of Medicine
NUS
Technical Lead
Research Engineer
Biomedical Engineering
NUS
Mentor
Assoc. Director
Alliance Management
NUS-ILO

2.
First Business Model Canvas
•Doctors
•Designers
•Manufacturers
• Loyalty / referral points
• Freemium / premium
use of device
• Advertising at medical
conferences
• Good customer service
• Technical evaluation
• Device manufacturing
& design
• Regulatory approval
• Capital for product
validation
• Human resources
(Technical, clinical,
sales, marketing)
• Intellectual resources
(IP, databases)
• Distributors
• Online store
• Web and email
• Retail store
• Personal networks
• Device manufacturing & design
• R&D costs
• Technology development
• Manpower (technical, marketing, sales)
• Platform maintenance
• Objective quantification
& verification of pain
intensities
• Remote pain
monitoring in real-time
• Test efficacy of
treatment
• Self-monitoring of pain
• Early pain detection /
prediction
• Hospital
- Doctors - Nurses
• Individuals
• Palliative (Hospices/
caregivers)
• Pharma Companies
• Telemedicine
• Sale of device and disposables
• Sale of info from pain database
• Service / usage subscription fees
• Adverts of pain data
• Licensing fee / royalties

3.
Unconscious / Non-
responsive Patients
Caregivers’
Loved Ones
Athletes
Baby-care
Pharma Companies /
Clinical Trial Centres
Medical Use Consumer Use
Responsive
Patients
Initial Assumptions: Anyone with Pain

4.
People we interviewed
Doctors
54%
Nurses
23%
Medtech
13%
Others
10%

5.
Doctors
Paediatrics
Neurology
Anaesthesia
Palliative
Pain Specialist
Dermatologist
Oncologist
Sports Medicine
ICU
Nurses
Senior
Nurses
Nurse
Clinician
Nurse
Manager
Private
Public
Hospital
Management

6.
Doctors Nurses
Patients
“I don’t always ask
patient for pain score.
“We monitor patients’ pain
scores every 1h for acute
pain in post-op patients….
Doctors Versus Nurses
To diagnosis, treat To monitor, provide comfort

7.
Doctors Nurses
Patients
Doctors Versus Nurses
To diagnosis, treat To monitor, provide comfort
• Pain locality
• Early dysfunction
• Malingering pain
• Drug dosage titration
• Progressive tracking
- Drug dosage titration
- Convenience, better patient care
- Form factor, integration, ease of use

8.
Doctors Nurses
Patients
Higher
Management
Objective monitoring
↓ Treatment variability
Remote monitoring
↑ Doctor/nurses’ burden
Legal implications

9.
Changes in Business Model Canvas
• Loyalty / referral points
• Freemium / premium
use of device
• Advertising at medical
conferences
• Good customer service
• Capital for product
validation
• Human resources
(Technical, clinical,
sales, marketing)
• Intellectual resources
(IP, databases)
• Distributors
• Online store
• Web and email
• Retail store
• Personal networks
• Device manufacturing & design
• R&D costs
• Technology development
• Manpower (technical, marketing, sales)
• Platform maintenance
• Objective quantification
& verification of pain
intensities
• Remote pain
monitoring in real-time
• Individuals
• Palliative (Hospices/
caregivers)
• Pharma Companies
• Telemedicine
• Test efficacy of
treatment
• Self-monitoring of pain
• Early pain detection /
prediction
• Sale of device and disposables
• Sale of info from pain database
• Service / usage subscription fees
• Adverts of pain data
• Licensing fee / royalties
• Hospital
- Doctors - Nurses
• Technical evaluation
• Device manufacturing
& design
• Regulatory approval
(ISO 13485)
• Distributors
• Suppliers
• Key Opinion Leaders
Network (ie local/
overseas hospitals)
• Medtech company
• Regulatory
Consultant
•Doctors
•Designers
•Manufacturers
• Consultancy fees
• IP maintenance
- Device rental fees, with sale of disposables
- Licensing fee (integration with other monitoring systems)
- Co-development fees with big players
- Bundled sales with complementary goods
Public hospital
(doctors / nurses)
Private hospitals
(doctors / nurses)
• Identify suitable distributors,
suppliers, manufacturers
• Collaborations with
hospitals/clinics Objective titration of
medication dosasge
• Direct sales to local hospitals
• Bundled with other products
• Tradeshow/conference
• Website
• Journal papers
• Key opinion leader
network
• Web, email, online forum
• Co-creation

10.
Unconscious / Non-
responsive Patients
Caregivers’
Loved Ones
Athletes
Baby-care
Pharma Companies /
Clinical Trial Centres
Medical Use Consumer Use
Responsive
Patients
From An Assumption of “Anyone with Pain”

11.
Unconscious / Non-
responsive Patients
Medical Use
Post-surgery acute
pain
Targeted Patient Population
25 million experience acute pain
due to injury/surgery per year
Assessment of pain in unconscious / non-
responsive patients is a critical problem!
43% of cases misdiagnosed due to
altered states of consciousness
Pain - most common reason for seeking medical
attention. 9/10 regularly suffer from pain.

12.
Competitive Analysis Chart

13.
Moving Forward…What Next?
Build up robust database
Clinical Partners to
conduct multiple Patient Trials
Utility and device form factor
VALIDATION needed! Apply for more grants
Proof of Concept
Device Pricing -
VALIDATION needed!
Patients
Influencers/
Decision-Makers
Overseas
Hospital Systems
VALIDATION needed!

14.
Thank You!