1. Kumar Organic Products Limited
Product Information
Antidandruff Active Ingredient
Zinc Pyrithione 50% FPS
Contents
• Introduction
• Product Data
• Anti-microbial properties
• Clinical Study
• Benefits of Zinc Pyrithione
• Our Export Destinations
• Product Specification
Kumar Organic Products Limited
Usha Krishan Centre, No.819/C, 13th Cross, 7th Block (West)
J.S.S. College Circle, Jayanagar, Bangalore 560082, Karnataka, India.
Ph : 00 91 80 – 41525960, 080-41425832 Fax : 91 80 -26715688
Email : sales_india1@kumarorganic.net

2. INTRODUCTION
The first antidandruff shampoo containing Zinc Pyrithione was launched
almost four decades ago. Since then Zinc Pyrithione bactericide-fungicide has
become the worlds leading antidandruff agent. It also used as an antibacterial
agent in Dermatological creams and ointments.
It effectively does the job any antidandruff agent is expected to do i.e.
relieving the flaking and itching symptoms of dandruff. Its lasting
properties make Zinc Pyrithione a superior one, meaning it sticks and
remains active on the scalp, so it’s effectiveness lasts from one use to the
next.
Combination of efficacy and safety has made it most effective antidandruff
agent for several decades.

3. PRODUCT DATA
Structural Formula
N S
O Zn O
S N
Zinc-2-Pyridinethiol-1-Oxide
Zinc Pyrithione is actually Zinc complex of Pyrithione which
is 2-Pyridine thiol-1-oxide. Under chemical abstracts registry
it is named as bis[1-hydroxy-2(1H)-Pyridinethionato-O,S]-(T-
4)Zinc (CAS No: 13463-41-7). The molecular and structural
formulae are C10H8N2O2S2Zn and

4. Physical Properties
Description : Off – White color, stable aqueous dispersion
free from sign of impurities
Odor : Mild, Characteristic odor
Assay ( % ZPT ) : 48% - 50%
Zinc Content : 09.3 to 11.3 %
pH ( 5% Slurry in pH 7 water ) : 6.5 to 9.0
Particle size : 90% < 1 Micron
Solubility Properties
Water : 0.01% Max
Ethanol : 0.02% Max
Methanol : 0.03% Max
Chloroform : 0.10% Max
Ether : 0.01% Max

5. Stability Study
Heat Stability :
It is stable at 100°c for at least 120hrs. Around 240°c it undergoes decomposition.
pH : Stability :
Zinc Pyrithione is quite stable over the pH range from 4 – 10. Below 4.5 the
Zinc complex starts dissociating, forming free Pyrithione. Above pH 9.5 the
Zinc complex undergoes hydrolysis to give ionized Pyrithione
Light Stability :
Zinc Pyrithione undergoes gradual decomposition when exposed to light

6. Anti-microbial properties of ZPT:
Data shows very low concentrates of Zinc Pyrithione inhibits
the growth of many micro-organisms
Minimum Inhibitory
Concentration(mcg/gm)
Microorganisms
Staphylococcus aureus 6.3
Escherichia Coli 12.6
Bacillus Subtillus 6.3
Pytyrosporum Ovale 6.3
Trichophyton 12.5
Zinc Pyrithione, an effective biocide with anti Pityrosporum
activity, eliminates P.ovale the causative organism of dandruff
and maintains good personal hygiene.

7. In – House Clinical Study
Clinical trial to study the efficacy and safety of Anti-dandruff shampoo containing
1.0% of Zinc Pyrithione was conducted on 20 male volunteers with moderate to
severe dandruff for 04 weeks
Results of Clinical Trials
Non of them complained of any adverse effects like pruritus, erythema, hair fall or local
discomfort
there was definite reduction in dandruff (White powder / flakes in the scalp) in all the volunteers
S.no No.of people Percentage Reduction in dandruff in %
1 16 80 90
2 2 10 80
3 1 5 75
4 1 5 60
After 04 weeks of product usage it was not possible to isolate P.ovale in culture
from all the volunteers.
Isolation of P.ovale Isolation of P.ovale
in culture before % in culture after %
S.No treatment treatment
1 20 100 NIL 0

8. World wide Clinical Study
This graphic shows the clinical studies success rates of SKIN
CARE in the treatment of severe skin disorders

9. Conclusion of different Clinical Research of ZPT Formulation
This therapy represents one of the best advances in the treatment of psoriasis.
- Abbott Northwestern Hospital, USA
Positive effects in 95.5% of the treated cases. Good anti-inflammatory effect. No
side effects. Disappearance of itches. No irritations. Very good results in dermatitis
and neurodermatitis.
- State University of Medicine of Siberia
Positive effects were observed, with decrease of inflammation, itching and flaking.
ZINC PYRITHIONE spray can be recommended for the treatment of psoriasis,
dermatitis, seborrhea rosacea and eczema.
Centre for the Medical and Social Rehabilitation of Children Affected by Allergodermatitis,
RUSSIA,
ZINC PYRITHIONE spray is a very effective and safe treatment, specially
reducing flaking and plate erythema in patients affected by common psoriasis
- University of Buenos Aires
Good and very good results from the 6th day of treatment. Very good results,
above all with spray and shampoo. Good absorption. Absence of side effects.
Effective alternative for the treatment of psoriasis.
University Hospital of Dermatology
- University Hospital of Dermatology

10. Benefits of Zinc Pyrithione
It produced dramatic healing effects on skin lesions produced
by psoriasis, dandruff, eczema, ringworm, fungus, athletes
foot, dry skin, atypical dermatitis, tinea etc.
An effective, practically nontoxic antidandruff active ingredient
Suitable for the manufacture of antidandruff shampoos
and hair care products such as hair tonics and cream rinses
with an antidandruff action
Low concentration is required.
No side effects : Safe and effective antidandruff agent

11. End Use / Formulations
• As an antidandruff agent in Shampoo
• Effective antibacterial – Anti fungal agent in derma – Cream
Spray and Soap.
• Highly effective in Dandruff control, Psoriasis,
Seborrheic Dermatitis, Other Dermatitis and Eczema

12. Our Export Destinations
America Europe
-USA -United Kingdom Asia
-Canada -France
-China
-Philippines
-Indonesia
-Thailand
-Taiwan
-U.A.E.
-Iran
Africa -Vietnam
-South Africa
Latin America -Kenya
-Brazil
-Argentina
-Venezuela
-Columbia
-Guatemala

13. Kumar Organic Products Limited
Product Specification - Zinc Pyrithione
Sl.No. Properties Limits
1 Description Off - White colour, Stable Aqueous dispersion free from signs of impurity.
2 Identity Confirms
3 Odour Mild, Characteristic odour.
4 Assay 48-50%
5 Zinc content 9.3 –11.3%
6 PH ( 5% Slurry in pH 7 water ) 6.5-9.0
7 Particle size by Malvern 90% < 1 Microns
8 Iron 10ppm max as Fe
9 Arsenic 5 ppm max as As
10 Lead 5 ppm max as Pb
11 Chromium 3 ppm max as Cr
12 Cobalt 3 ppm max as Co
13 Nickel 5 ppm max as Ni
14 Mercury 1 ppm max as Hg
15 Microbiological Test
1. Total plate count/g Less than 100
(Including yeast and mold)
2. E.coli/g Negative
3. S.Aureaus/g Negative
4. Pseudomonas/g Negative
5. Enterobacteria/g Negative

14. Kumar Organic Products Limited
Usha Krishan Centre, No.819/C, 13th Cross, 7th Block (West)
J.S.S. College Circle, Jayanagar, Bangalore 560082,
Karnataka, India.
Ph : 00 91 80 – 41525960, 080-41425832 Fax : 91 80
-26715688
Email : sales@kumarorganic.net