Autophagy: implications in neurodegeneration, fitness exercise and beyond
Proteins, medical utility, diagnosis and treatment in Alzheimer disease
1. Proteins, medical
utility, diagnosis
and treatment in
Alzheimer disease
Juan Sebastian Marin Cardenas.
Medicine student, III Semester.
Molecular Biology.
7. BOOKLET
DIFFERENTIAL PROCESSING OF
AMYLOID PRECURSOR PROTEIN
IN BRAIN AND IN
PERIPHERALBLOOD LEUKOCYTES
• The reaction between APP and
methaloproteases is an important
mecanism for preventing the APP
deposit and cell damage.
• The expresión of methaolproteases
by the cells is different in tissues,
8. BOOKLET
DIFFERENTIAL PROCESSING OF AMYLOID
PRECURSOR PROTEIN IN BRAIN AND IN
PERIPHERALBLOOD LEUKOCYTES.
•The cell has a Lot of molecular
mecanisms to regulate the homeostasis of
its extracell matrix, one of them is
expresing some proteins that protects the
cell and reguates the initial equilibrium
9. BOOKLET
OBSERVATION
The advanced knowledge of
the Alzheimer disease and
investigation will aproach us
to an early treatment that can
improve the quality of life that
the people with this patology
yearn.
11. BOOKLET
ADAM10 as a Biomarker for
• Molecular signaling and proteins plays
Alzheimer’s Disease: A Study with an important role in Amyliod protrein
Brazilian Elderly. degradation involved in AD.
• Neurodegenerative process.
• ADAM10 is an important
methaolprotease that catalyzes
reacctions depending of some co-
factors, degrading APP.
12. BOOKLET
ADAM10 as a Biomarker for
Alzheimer’s Disease: A Study
with Brazilian Elderly.
•ADAM10 activity decreased in AD. That gives
some clues for understanding the
pathogenesis.
13. BOOKLET
The lack of ADAM10 and other proteins like
neprilisin can boost the acumulation of this
APP, that is caracteristly in AD in the brain.
14. BOOKLET
OBSERVATION
I think we must guide new studies about
the impact of the AD in Colombia, for
knowing the comportment of this
pathology and corroborate the previous
results and information we have about
this disease related to the proteins
expression and molecular
phisiopathology.
15. BOOKLET
The proteins and the medical utility has
been growing up the last days, binding the
diagnosis to the molecular dianas of the
principally proiteins involved in the
Alzheimer disease and others neurological
pathologies.
16. BOOKLET
• The caracterization of this
proteins will help us to
dilucidate the importance
of this proteins in several
pathologies that will guide
the diagnosis and the
treatment of the people
with Alzheimer disease.
17. BOOKLET
. Specific biomarkers to
make a correct
. diagnosis can be
formulated concrete
ways to prevent and
treat in a better way
this type of pathology
18. BOOKLET
• Today we have a very wide range
of laboratory tests. These are
now essential tools in basic and
clinical research, the study and
explanation of various functions
and cellular processes and even
in research of diseases such as
Alzheimer's diseases and cancer.
19. BOOKLET
REFERENCES.
•Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD, Differential processing of amyloid
precursor protein in brain and in peripheral blood leukocytes.Neurobiol.Aging 2013 Jan 5. 21:89-97.
•Manzine R, França JM, Barham E, Assis J, Vale C, Sobreiro H, et al.ADAM10 as a Biomarker for
Alzheimer Disease: A Study with Brazilian Elderly. Dement Geriatr Cogn Disord 2013;35:58–66.
•Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E: Alzheimer disease. Lancet 2011;
377: 1019–031.
20. BOOKLET
Alzheimer with his co-workers
Nervenklinik Munich 1909-1910
.