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Proteins, medical
   utility, diagnosis
   and treatment in
  Alzheimer disease
              
Juan Sebastian Marin Cardenas.
Medicine student, III Semester.
Molecular Biology.
BOOKLET
BOOKLET
BOOKLET
BOOKLET
BOOKLET
 DIFFERENTIAL PROCESSING OF
 AMYLOID PRECURSOR PROTEIN
       IN BRAIN AND IN
PERIPHERALBLOOD LEUKOCYTES.

 
BOOKLET

    DIFFERENTIAL PROCESSING OF
    AMYLOID PRECURSOR PROTEIN
          IN BRAIN AND IN
   PERIPHERALBLOOD LEUKOCYTES


• The reaction between APP and
  methaloproteases is an important
  mecanism for preventing the APP
  deposit and cell damage.

• The expresión of methaolproteases
  by the cells is different in tissues,
BOOKLET

     DIFFERENTIAL PROCESSING OF AMYLOID
      PRECURSOR PROTEIN IN BRAIN AND IN
        PERIPHERALBLOOD LEUKOCYTES.

     •The cell has a Lot of molecular
     mecanisms to regulate the homeostasis of
     its extracell matrix, one of them is
     expresing some proteins that protects the
     cell and reguates the initial equilibrium
BOOKLET

    OBSERVATION

     The advanced knowledge of
      the Alzheimer disease and
    investigation will aproach us
   to an early treatment that can
   improve the quality of life that
    the people with this patology
                yearn.
BOOKLET
BOOKLET

   ADAM10 as a Biomarker for
                                    • Molecular signaling and proteins plays
Alzheimer’s Disease: A Study with     an important role in Amyliod protrein
        Brazilian Elderly.            degradation involved in AD.

                                    • Neurodegenerative process.

                                    • ADAM10 is an important
                                      methaolprotease that catalyzes
                                      reacctions depending of some co-
                                      factors, degrading APP.
BOOKLET

   ADAM10 as a Biomarker for
  Alzheimer’s Disease: A Study
      with Brazilian Elderly.

•ADAM10 activity decreased in AD. That gives
some clues for understanding the
pathogenesis.
BOOKLET




 The lack of ADAM10 and other proteins like
 neprilisin can boost the acumulation of this
 APP, that is caracteristly in AD in the brain.
BOOKLET

     OBSERVATION
   I think we must guide new studies about
   the impact of the AD in Colombia, for
   knowing the comportment of this
   pathology and corroborate the previous
   results and information we have about
   this disease related to the proteins
   expression         and       molecular
   phisiopathology.
BOOKLET

The proteins and the medical utility has
been growing up the last days, binding the
diagnosis to the molecular dianas of the
principally proiteins involved in the
Alzheimer disease and others neurological
pathologies.
BOOKLET

• The caracterization of this
  proteins will help us to
  dilucidate the importance
  of this proteins in several
  pathologies that will guide
  the diagnosis and the
  treatment of the people
  with Alzheimer disease.
BOOKLET

.             Specific biomarkers to
              make a correct
.             diagnosis can be
              formulated concrete
              ways to prevent and
              treat in a better way
              this type of pathology
BOOKLET

• Today we have a very wide range
  of laboratory tests. These are
  now essential tools in basic and
  clinical research, the study and
  explanation of various functions
  and cellular processes and even
  in research of diseases such as
  Alzheimer's diseases and cancer.
BOOKLET

                             REFERENCES.

•Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD, Differential processing of amyloid
precursor protein in brain and in peripheral blood leukocytes.Neurobiol.Aging 2013 Jan 5. 21:89-97.

•Manzine R, França JM, Barham E, Assis J, Vale C, Sobreiro H, et al.ADAM10 as a Biomarker for
Alzheimer Disease: A Study with Brazilian Elderly. Dement Geriatr Cogn Disord 2013;35:58–66.

•Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E: Alzheimer disease. Lancet 2011;
377: 1019–031.
BOOKLET




     Alzheimer with his co-workers
     Nervenklinik Munich 1909-1910
     .

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Proteins, medical utility, diagnosis and treatment in Alzheimer disease

  • 1. Proteins, medical utility, diagnosis and treatment in Alzheimer disease   Juan Sebastian Marin Cardenas. Medicine student, III Semester. Molecular Biology.
  • 6. BOOKLET DIFFERENTIAL PROCESSING OF AMYLOID PRECURSOR PROTEIN IN BRAIN AND IN PERIPHERALBLOOD LEUKOCYTES.  
  • 7. BOOKLET DIFFERENTIAL PROCESSING OF AMYLOID PRECURSOR PROTEIN IN BRAIN AND IN PERIPHERALBLOOD LEUKOCYTES • The reaction between APP and methaloproteases is an important mecanism for preventing the APP deposit and cell damage. • The expresión of methaolproteases by the cells is different in tissues,
  • 8. BOOKLET DIFFERENTIAL PROCESSING OF AMYLOID PRECURSOR PROTEIN IN BRAIN AND IN PERIPHERALBLOOD LEUKOCYTES. •The cell has a Lot of molecular mecanisms to regulate the homeostasis of its extracell matrix, one of them is expresing some proteins that protects the cell and reguates the initial equilibrium
  • 9. BOOKLET OBSERVATION The advanced knowledge of the Alzheimer disease and investigation will aproach us to an early treatment that can improve the quality of life that the people with this patology yearn.
  • 11. BOOKLET ADAM10 as a Biomarker for • Molecular signaling and proteins plays Alzheimer’s Disease: A Study with an important role in Amyliod protrein Brazilian Elderly. degradation involved in AD. • Neurodegenerative process. • ADAM10 is an important methaolprotease that catalyzes reacctions depending of some co- factors, degrading APP.
  • 12. BOOKLET ADAM10 as a Biomarker for Alzheimer’s Disease: A Study with Brazilian Elderly. •ADAM10 activity decreased in AD. That gives some clues for understanding the pathogenesis.
  • 13. BOOKLET The lack of ADAM10 and other proteins like neprilisin can boost the acumulation of this APP, that is caracteristly in AD in the brain.
  • 14. BOOKLET OBSERVATION I think we must guide new studies about the impact of the AD in Colombia, for knowing the comportment of this pathology and corroborate the previous results and information we have about this disease related to the proteins expression and molecular phisiopathology.
  • 15. BOOKLET The proteins and the medical utility has been growing up the last days, binding the diagnosis to the molecular dianas of the principally proiteins involved in the Alzheimer disease and others neurological pathologies.
  • 16. BOOKLET • The caracterization of this proteins will help us to dilucidate the importance of this proteins in several pathologies that will guide the diagnosis and the treatment of the people with Alzheimer disease.
  • 17. BOOKLET . Specific biomarkers to make a correct . diagnosis can be formulated concrete ways to prevent and treat in a better way this type of pathology
  • 18. BOOKLET • Today we have a very wide range of laboratory tests. These are now essential tools in basic and clinical research, the study and explanation of various functions and cellular processes and even in research of diseases such as Alzheimer's diseases and cancer.
  • 19. BOOKLET REFERENCES. •Delvaux E, Bentley K, Stubbs V, Sabbagh M, Coleman PD, Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes.Neurobiol.Aging 2013 Jan 5. 21:89-97. •Manzine R, França JM, Barham E, Assis J, Vale C, Sobreiro H, et al.ADAM10 as a Biomarker for Alzheimer Disease: A Study with Brazilian Elderly. Dement Geriatr Cogn Disord 2013;35:58–66. •Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E: Alzheimer disease. Lancet 2011; 377: 1019–031.
  • 20. BOOKLET Alzheimer with his co-workers Nervenklinik Munich 1909-1910 .