3D printed models of biological structures in Hackuarium

1. Bacteriophage Project
@Hackuarium
By
Jonathan Sobel

2. 3D modeling
• Small molecules
• Protein
• Virus
• Other biological structures (root of Arabidopsis)

3. 3D Printing Technology
Plastic laser-sintering system
Fused deposition modeling

4. • Educational purpose
• Ergonomic
• Buildable
• Low-cost
• Open Source
Bacteriophage Project

5. • In house competence for 3D model
development
• Phage model available
• Development of a bacterial model
• Model usable for educational purpose
• Phage therapy represents an alternative to
antibiotics (especially for multi-resistant
bacteria)
• Phages are extensively used in research
(antibody engineering)
Conclusions

6. Bacteriophage Biology
Phage T7 genome
40Kbp dsDNA
55 proteins encoded

7. Bacteriophage Biology

8. Phage Display
Antibody engineering

9. Phage Therapy

10. 3D Printing Working Group
• Hackuarium: Guy, Jonathan S., Anne-Laure,
Marco
• Fab Lab Chêne 20: Richard, Jonathan F., Olivier
• L’Eprouvette: Severine, Mathilde
• Musée de la main: Roxanne
• STI EPFL: Roland