This dinner short course is sponsored by Chemical Computing Group and will be held on June 19, 2013 at the Revere Hotel in Boston, MA. The course takes place at the conclusion of day one of CHI's 13th Annual Structure-Based Drug Design conference (June 19-21).

1. A Uniform Framework for Computer-Aided
Biologics Design
***** A Dinner Short Course Announcement *****
with Chris Williams, Ph.D., Principal Scientist, Chemical Computing Group
June 19, 2013 – The Revere Hotel – Boston, MA
Protein engineering plays a pivotal role in modulating the function, activity and physical properties
of biologics. Representative strategies employed in protein engineering include rationale protein
design and directed evolution. In general, disparate work has been done in applying computer-
aided biologics design (CABD) to protein engineering for the development of novel biological
therapeutics. Here, we describe a unified framework of in silico protein engineering tools and
investigate its applicability to the modulation of protein properties such as affinity and stability.
The course will cover current in silico technologies used in protein engineering and biologics
design. More specifically, applications for visualizing, and analyzing mutations will be
described. Tools for calculating surface properties such as electrostatic hot-spots or patches, as
well as physicochemical properties will be presented. A number of case studies will be used to
describe how residue scanning technology can be used to address challenges in species cross-
reactivity, stability, and aggregation.
This course will be held from 6:00 pm – 8:00 pm which starts immediately after the
conclusion of day one of CHI’s Structure-Based Drug Design conference (June 19-21).
WAYS TO REGISTER:
Online: https://chidb.com/register/2013/sbd/reg.asp
Call: 781-972-5400
Email: reg@healthtech.com
http://www.healthtech.com/sbd