The document discusses the results of surveys of potential clinical trial participants across three medical conditions: HIV, overactive bladder (OAB), and psoriasis. Across all conditions, addressing potential side effects and allowing participants to discuss the study with family/doctors is important. Participants want ongoing communication and support through the study, as well as reimbursement for travel costs. Regardless of condition, developing effective recruitment strategies tailored to each study and learning from past experiences is key.

1. What is Most Important to Potential Participants Similarity of Patient Responses in Three Therapeutic Areas John Needham’s PatientQuest Surveys HIV >250 responses OAB >400 responses Psoriasis > 50 responses

2. How Long Did You Have Your Medical Condition Before You Participated in a Clinical Trial? 2008 Clinical Research Educational Conference Source: February 2005 Volunteer Survey Percent of Respondents N= 534 Recruitment Insights

3. From The Time You First Heard About The Clinical Trial, How Long Before You Decided To Participate? Source: February 2005 Volunteer Survey Percent of Respondents N= 534

4. Which would most likely affect your decision to participate in a trial? 2008 Clinical Research Educational Conference HIV Patients

5. Over Active Bladder Patients 2008 Clinical Research Educational Conference

6. Psoriasis Patients 2008 Clinical Research Educational Conference

7. Would you discuss trial participation with a partner, friend or family member?

8. If considering an OAB trial, who, other than the study doctor, would you discuss the decision with? 2008 Clinical Research Educational Conference OAB US responders

9. Psoriasis 2008 Clinical Research Educational Conference

10. If considering a trial, who, other than the study doctor, would you discuss the decision with? 2008 Clinical Research Educational Conference EU Results

11. Other than receiving a new medical treatment for OAB, what else would interest you in joining and remaining in a clinical research study? 2008 Clinical Research Educational Conference US Results

12. Other than receiving a new medical treatment for OAB, what else would interest you in joining and remaining in a clinical research study? 2008 Clinical Research Educational Conference EU Results

13. 11. Do you feel your regular doctor understands how you feel about having OAB? 2008 Clinical Research Educational Conference Internet responses Inner-city responses

14. Do you feel your regular doctor understands how you feel about having OAB? 2008 Clinical Research Educational Conference EU Results

15. 2008 Clinical Research Educational Conference Can you or do you prefer to discuss your OAB with the nurses in your doctor’s office? Internet responses Inner-city responses

16. Can you or do you prefer to discuss your OAB with the nurses in your doctor’s office? 2008 Clinical Research Educational Conference EU Results

17. Which of the following would keep you interested in participating in a study for a year or longer? 2008 Clinical Research Educational Conference HIV

18. Which of the following would keep you interested in participating in a study for 3 months or longer? USA OAB Patients

19. Which of the following would keep you interested in participating in a study for 3 months or longer? 2008 Clinical Research Educational Conference EU OAB Patients

20. Psoriasis Patients 2008 Clinical Research Educational Conference