Unified Software Suite for NGS and Microarray Data Analysis and Interpretation.

1. iOMICS
Unified Software Suite for NGS and Microarray Data Analysis and Interpretation

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Multi-omics Multi-scale data management, analysis, and interpretation
software.
Developed for composite analysis needs and tested with numerous
data sets,
this robust platform addresses the complexities of Life Sciences “Big
Data”
for driving actionable insights with unprecedented ease.
iOMICS: Omics Software Solution
Apps for every data (omics) type
Intuitive Analysis
Dynamic Visualization
Support proprietary and 3rd
party softwares and databases

3. RESTful
iOMICS
dbNSFP, dbSNP, Uniref100,
Uniprot, HumDiv, HumVar,
Ensemble, RefSeq, miRBase
KEGG, Interactome, etc
Annotated Variations
Enriched Pathways
Peaks and Motifs
Known and putative genes
Differential Gene Expression
Known and Putative miRNA
Potential Drug Targets
Phenotype-specific Biomarkers
Stratified Patient Groups
Off-target effects
App Store
DNA RNA ChIP miRNA
Exome MicroArray
Meta
Genome
Integrative
Biology
Ion Torrent, Illumina,
Affymetrics, Agilent
Phenotype
Modeling
iOMICS: High Level Architecture
FASTQ
CEL
SAM/BAM
CSV/TSV
VCF
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Drug Target
Identification
Patient
Stratification

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5. iOMICS: Scalable, Customizable, Flexible
Flexible and easy to use user interface (UI)
Raw data to results in three steps
– Create
– Analyze
– Visualize
Checkpoint and Re-start
Fast and efficient workflows to process hundred's of samples
Data store to manage high-through put data 6

6. iOMICS: Visualization
Heatmap for significantly
expressed genes
Clustering of samples based on
significant genes
Enriched peaks based on
epigenetic data
Karyotype plot representing the
significant genes and peaks
Gene-Pathway Interaction
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Integrative Biology: Overview
ChIP-RNA
Input Inference
DNA-RNA
miRNA-RNA
 Called peaks
 Differential gene
expression
Gene Expression alterations
due to epigenetic factors
 Variants associated
with phenotype
 Gene expression
Impact of mutations on gene
expression associated wih
phenotype
 Differential miRNA
expression
 Differential gene
expression
miRNA target association
and validation based on
gene expression changes
Analytics
LASSO, IDA Causal
Inference, Mutual
Information
Linear Regression,
ANOVA
Likelihood Test,
Bayesian Mixture
Models

8. iOMICS 4.0: Significant Features
Indepth Pathway
Analysis
Knowledge Base
(Omnia)
Multi-Omics Data
Integration
Advanced Biological
Filters
 High to low level visualization of all types of biological pathways
based on the experiment
 Visualization includes genes, proteins, metabolites, reactions, and
complexes
 Curated disease centric knowledge base, constructed using text and
data mining techniques
 Structured data from multiple high-throughput genomic and
transcriptomic experiments, and open-databases
 Integration of multi-omics datasets to simulate the genetic flow of
information associated with the phenotypes
 Powerful statistical tools such as LASSO, Linear regression, Anova
etc are used for integrative analysis
 User defined filters on all results for easier biological interpretation
 Built in biologically relevant filters for variant prioritization using
annotated information
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9. Wide range of biological networks
– Protein Interaction Networks
– Metabolic Networks
– Gene Co-expression Networks
– Gene Regulatory Networks
– Pathway-Gene Networks
Sophisticated network analysis
– Network topology
– Clustering
– Bayesian Networks
– Constraint based modeling
– In-silico knockout models
Top-down and bottom-up approach for biomarker
iOMICS 4.0: Network Analysis
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10. JNCASR
Some Of Our Customers
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11. Corporate Office: India Corporate Office: USA
InterpretOmics India Pvt. Ltd., InterpretOmics, Inc.
#15 Shezan Levelle, Walton Road #5 Parker Street, Lexington
Bangalore – 560 001 MA 02421, USA
Email : prahalad@interpretomics.co Email: info@interpretomics.co
Telephone: +91 80 46623 800 Telephone: 415-800-4515
URL: www.interpretomics.co URL: www.interpretomics.co
Genomic Sequencing Lab: India
InterpretOmics Center for Next Generation Sequencing
#329 7th Main, 80 Ft Road,
Indiranagar, HAL II Stage
Bangalore – 5600 08/
Thank
You