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Die HIV-Infektion: ein Überblick zum Welt-AIDS-Tag 2015

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Zum Welt-AIDS-Tag am 1. Dezember 2015 hat IMS Health einen Überblick über die HIV-Infektion zusammengestellt. Von der Zahl der Infizierten weltweit und in Deutschland, über wichtige Meilensteine der Therapie, Umsatzentwicklung der Virustatika sowie deren Generika, führende Präparate bis zu einem Ausblick - das alles finden Sie in dieser Infografik.

Veröffentlicht in: Gesundheit & Medizin
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Die HIV-Infektion: ein Überblick zum Welt-AIDS-Tag 2015

  1. 1. @IMSHealthDE IMS Health | www.imshealth.de | info@de.imshealth.com © 2015 IMS Health Incorporated or its affiliates. All rights reserved. Die HIV-Infektion: ein Überblick zum Welt-AIDS-Tag 2015 Weltweit gab es Ende 2014 rund 36,9 Mio. HIV-Infizierte, und noch immer kommen neue Fälle hinzu: 2014 gab es ca. 2 Mio. neue Infizierte.1 Quellen: 1 Fact sheet 2015 der UNAIDS, http://www.unaids.org/en/resources/campaigns/HowAIDSchangedeverything/factsheet, abgerufen am 26.11.2015 2 Robert Koch-Institut: Epidemiologisches Bulletin Nr. 45 / 9.11.2015 3 Infektion erfolgte über kontaminierte Blutkonserven und Gerinnungsfaktorenkonzentrate überwiegend in der Zeit vor 1986 4 Unter Inland wird ausgewiesen: HIV-Infektionen bei Personen mit Herkunftsland Deutschland und bei Personen mit in Deutschland erworbener HIV-Infektion 5 Deutsche AIDS-Hilfe, http://www.aidshilfe.de/de/faq/chronik, abgerufen am 26.11.2015 6 IMS PharmaScope®; Umsatz zum Apothekenverkaufspreis (AVP) ohne Abzug jeglicher Rabatte 7 WHO -Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV; http://www.who.int/hiv/pub/guidelines/earlyrelease-arv/en/, abgerufen am 26.11.2015 8 IMS Institut for Healthcare Informatics: Global Medicines in 2020. Outlook and Implications. November 2015. Abrufbar: http://www.imshealth.de/de_DE/thought-leadership/ims-institute/reports/global-medicines-use-in-2020; IMS Therapy Prognosis™: Beinhaltet Umsatz-Prognosen für Haupt-Therapiegebiete in 14 Kernmärkten, 8 davon entwickelt (USA, Japan, Deutschland, Frankreich, Italien, Spanien, U.K., Kanada und Südkorea) und 6 pharmerging (China, Brasilien, Russland, Indien, Türkei und Mexiko) 57.600 der Personen mit HIV-Diagnose in Deutschland erhalten eine antiretrovirale Therapie.2 Antivirale Mittel im Apothekenmarkt; Umsatz in Tausend Euro zu AVP Jahr 1987 Erstes Arzneimittel (Retrovir) gegen HIV wird zugelassen Mittlerweile stehen 34 Präparate als Einzelwirkstoffe oder fixe Kombinationen von bis zu 4 Wirkstoffen für die HIV-Therapie zur Verfügung. Ziel ist es, die Viruslast im Körper der Patienten so weit zu senken, dass der Virus nicht mehr nachweisbar ist und die Erkrankung an AIDS verhindert wird. Der Umsatz mit Virustatika gegen HIV in Deutschland seit 2005:6 Die nach Umsatz führenden Präparate im Jahr 2014:6 68.400 Männer 15.100 Frauen Es gibt verschiedene Infektionswege. Innerhalb Deutschlands birgt der sexuelle Kontakt zwischen Männern das größte Ansteckungsrisiko.2 In Deutschland lebten 2014 etwa 83.400 Personen mit HIV/AIDS. Deutlich mehr Männer sind betroffen als Frauen.2 Jahr 1995 Kombinationstherapie mit 2 Wirkstoffen wird neuer Therapiestandard Jahr 1996 Zulassung neuer Präparateklasse der Proteasehemmer markiert Beginn von Kombinations- therapie aus 3 (oder 4) antiretroviralen Wirkstoffen Jahr 2006 Erste fixe Kombination von 3 Wirkstoffen in einer Tablette wird verfügbar 2013 994 2014 1.059 2008 201120102009 2012 922 853 788 687 587 2007 487 2006 429 2005 377 Antivirale Mittel im Apothekenmarkt; Umsatz in Tausend Euro zu AVP (links); Wachstum in Prozent (rechts) 7% 92% 1% 1.059 Jahr 2014 Geschützte Präparate GENERIKUM ORIGINAL NICHT MEHR GESCHUETZT 212 -20 9 Ausblick: In Deutschland gilt offiziell die Regel, dass Menschen mit HIV-Infek- tion mit einer Behandlung beginnen sollten, sobald die T-Helferzellzahl im Blut unter den Wert von 350 pro Mikroliter sinkt. Mediziner wissen aber schon länger, dass ein früher Therapiebeginn bei einer Infektion sinnvoll ist und auch die Ausbreitung des Virus eindämmen kann. Nach neusten Empfehlungen der WHO soll eine Therapie sofort nach Erhalt der Diagnose starten.7 Diese Empfehlung könnte das Marktwachstum zukünftig beeinflussen. Die Sterblichkeitsrate von HIV geht zwar zurück, aber dennoch bleibt es eine schwerwiegende Krankheit, besonders in Ländern mit niedrigem Einkommen. IMS Health prognostiziert den folgenden spezialtherapeutischen Gebieten den größten Umsatz in 2020:8 ● Onkologie: 100-120 ● Autoimmunerkrankung: 55-65 ● Virushepatitis: 45-55 ● Immunsuppressiva: 20-30 ● Antivirals/HIV: 20-30 450 7.90010.500 53.800 Drogengebrauch Blutprodukte3Heterosexuelle Kontakte Sex zwischen Männern Es gibt 15 neue HIV-Therapien in späteren Stadien klinischer Studien. Viele davon werden voraussichtlich im Jahr 2020 verfügbar sein.8 Erste Generika gibt es in Deutschland seit 2011. Ihr Marktanteil liegt aktuell bei 1% bei einem Wachstum im dreistelligen Bereich (+212%).6 Wichtige Meilensteine in der Behandlung von HIV:5 Umsatz in Mrd. US-Dollar Ansteckung im Inland4 (nach Infektionsweg); ungefähre Fallzahlen ● Truvada ● Atripla ● Isentress ● Eviplera ● Prezista

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