This document is the first produced by the Strategic Technology Monitoring & Prospective Studies Unit. Thanks to a reactive observation system, this unit plays a lead role in supporting Inria to develop its strategic and scientific orientations. It also enables the institute to anticipate the impact of digital sciences on all social and economic domains. It has been coordinated by Bertrand Braunschweig with contributions from 45 researchers from Inria and from our partners. Special thanks to Peter Sturm for his precise and complete review.