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Bubpha techapattaraporn equal partnership case studies from biotec

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IFPMA Technical Briefing, Making Natural Product Research Work, Dr Bubpha Techapattaraporn, Research Assistant, Bioresource Technology Unit, BIOTEC National Center for
Genetic Engeneering and Biotechnology, Thailand (Geneva, 5 February 2013)

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Bubpha techapattaraporn equal partnership case studies from biotec

  1. 1. Equal Partnership: case studies from BIOTEC Bubpha Techapattaraporn BioLaw Research Unit, Bioresources Technology Unit, BIOTEC, Thailand
  2. 2. OUTLINES1. Thai Biodiversity;2. Thailand and ABS regulation;3. BIOTEC: the introduction;4. ABS case studies at BIOTEC5. Conclusion
  3. 3. Biodiversity for bioresources Thailand accounts for ca. 7-10 % of the world’s species richness Seed and Leaf-litter Fungi Marine and Mangrove Fungi Freshwater Fungi Basidiomycota
  4. 4. Overview of Thai ABS rules and regulations 2012 2011 Enactment of Signing the NP - The National -Under 2004 Committee on consideration Conservation and Ratifying the Sustainable Use of preparation of CBD1999 Biodiversity’s ratifying; Enactment of Regulation on -More of ABS - Thai PVPA Act Criteria and Rules and Methods for ABS Regulation?? -The Protection and from the Use of BR Enhancement of Thai (Thai ABS Traditional Medicinal Regulation) Wisdom Act
  5. 5. BIOTEC at a glanceStatus: Established in 1983 A member of the National Science and Technology Development Agency . NSTDA is a quasi-government agency, affiliated to Ministry of Science and TechnologyLocation: Headquarter at Thailand Science Park, 30 kilometers north of BangkokPersonnel: 570 (470 research and scientific staff and approx. 170 Ph.Ds)Budget: Approx 20 million USD (from government and revenue from service provision and commercialization)5 Research Units at Thailand Science Park & 10 Satellite Labs at various universities andgovernment agencies
  6. 6. NSTDA Organization NSTDA Board chaired by Minister of Science and Technology established by Sci. & Tech. Dev. Act. in 1991 1983 1985 1985 2006 2003NSTDA : National Science and Technology Development AgencyBIOTEC : National Center for Genetic Engineering and BiotechnologyMTEC : National Metal and Materials Technology CenterNECTEC : National Electronics and Computer Technology CenterNANOTEC : National Nanotechnology Center 1TMC : Technology Management Center
  7. 7. B TE R & C F IO C oles ore unctionsCore FunctionsRDE(Conduct research on basic science, platform technology, applied science)TT(Technology transfer to industry and public sector)InfrastructureDevelop and maintain (support the establishment and maintenance of specializedunits at universities, conduct policy research, support and subsidize service labsand maintain public databases)HRD(Provide scholarships, organize training, support the establishment of new graduateprogram in universities)Support Functions- Create public relations and provide science awareness- Seek and maintain international relations
  8. 8. Cordyceps sp.
  9. 9. BIOTEC
  10. 10. Hirsutella nivea on hopperBCC 2594, collected from Homopteraleaf-hopper, Khao Yai National Park,
  11. 11. Hirsutella nivea BCC 2594(MeOH extract of mycelia) Hirsutellones A-E H O OH OH H O O NH O NH O O O O NH H H H H H H H H O O O HH R HH R HHH3 C H3 C H3C 1 : R = H (A) 2 : R = H (B) 3 (C) 4 : R = CH3 (D) 5 : R = CH3 (E) Compound Anti-TB Cytotoxicity MIC; µg/mL vero; IC50 µg/mL 1 0.78 >50 2 0.78 >50 3 0.78 12 4 3.13 not tested Isaka, M., et al., Tetrahedron Lett. (2005), 61, 5577-5583
  12. 12. Research at Bioresources Technology Unit, BIOTEC Culture-dependent Conservation approach and microbial identification Academics Utilization of Microbes Industry BiocontrolBioactive compounds Enzymes ConservationHigh-value products Culture-independent approach Management of microbes Bioresources Screening Value-added products
  13. 13. BIOTEC-NOVARTISObjective: to find potential use ofmicroorganisms and natural compounds assources of potential new medicines.3 Phases of collaboration: 1st: 2005-2008 2nd: 2008-2011 3rd : 2011-2014
  14. 14. The contributions BIOTEC NOVARTIS• Diversity of microbes in • Technology transfer Thailand; via training• Expertise in knowledge (internship, experts, of microorganisms, i.e. and seminar); collection, • Consultant identification, preservation, isolation and elucidation of pure natural compound;
  15. 15. The achievement BIOTEC NOVARTIS• Capacity building via • Diversity of compounds technology transfer (able (7,200 microbial isolates to automate and improve and 115 pure its extraction and compounds have been chemical screening evaluated against a system, actenomycetes battery of drug targets). expert);• Enable BIOTEC to accumulate more strains;• Able to set different research directions.
  16. 16. ABS mechanisms Equal partnership (based oncomplementary expertise of both parties) Agreement: negotiation (based on theconcept of Mutually Agreed Terms)
  17. 17. Conclusion: Factors for the success of equal partnership• Organisation’s vision and policy;• Expertise of organisation;• Trust between involved parties;• Simple ABS rules and regulation (Mutually agreed terms)
  18. 18. Acknowledgement1. Dr. Kanyawim Kirtikara2. Dr. Lily Eurwilaichitr3. Ms. Sronkanok Tangjaijit4. Ms. Suwanee Chunhametha5. Dr. Vanicha Vichai
  19. 19. Thank you very much