CRC Perak Bulletin Issue 05

BULLETIN
Issue
05
Recombinant SARS-CoV-2 Fusion Protein
Vaccine Booster
CRC HRPB Ipoh:
Dr. Philip Rajan
Dr. Lim Xin Jie
Suria Junus
CRC Hospital Seri Manjung:
Chiew Shoen Chuen
Norsarlizna Mat Sari
Dr. Ting Siew Ying
RCT of Ivermectin For Post-Exposure
Prophylaxis For COVID-19 Infection Among
Close Contacts (I-CPEP)
Research Grant
MOH Research Grant (MRG)
Ministry of Science,
Technology and Innovation
(MOSTI) Grant
Other Malaysian Research
Grants
Clinical Research Centre
Perak Networks
Perak Networks
e-ISSN 2682-7867
Premature death due to road traffic
accidents
CRC Hospital Taiping:
Prema Muninathan
Advisors:
Perak State Health Director
Dr. Sirajuddin bin Hashim
Hospital Raja Permaisuri Bainun, Ipoh
Director
Dr. Megat Iskandar bin
Megat Abdul Hamid
Hospital Taiping Director
Dr. Hjh Narimah Yusof
Hospital Seri Manjung Director
Dr. Nordin bin Nasir
Editorial Committee:
In Focus
Page 1
© 2023 Clinical Research Centre Hospital Raja Permaisuri Bainun. All Rights Reserved
Inside this issue:
Contents
Perak State Research Meeting 2022
CRC's Research Performance
Meet The Team
Summary Event
of 2022
Upcoming Event
In Year 2023

Perak State Research
Meeting 2022
24
NOVEMBER
2022
On November 24th, 2022, the Perak State Research
Meeting was held at Jabatan Kesihatan Negeri (JKN)
Perak. Dr. Sirajuddin bin Hashim, Pengarah Kesihatan
Negeri, presided over the meeting, which was attended
by 67 representatives from the JKN, Pejabat Kesihatan
Daerah (PKD), heads of services, hospitals, Klinik
Kesihatan (KK), and CRCs. During the meeting, the
chairperson congratulated all Perak health
professionals for their contributions to research in
2022. He emphasized the importance of evidence-
based decision-making in health care and
encouraged all attendees to participate in research
despite their hectic work schedules.
Jabatan
Kesihatan
Negeri
Perak
Subsequently, the heads of CRCs shared their
accomplishments in 2022 and goals for 2023. Dr. Philip
Rajan, the Head of CRC HRPB, shared the updated
standard of practice for tracing electronic medical
records for research use in HRPB. In order to overcome
workplace limitations in CRC HRPB, it was highlighted
by Dr. Philip that there is a proposal together with CRM
in place to restore an old building for the CRM HRPB
team to use. In regards to future plans, he disclosed
that there will be more collaborative research and
training in partnership with Taylor's University in 2023.
Moving on to CRC Taiping, Dr. Cheah
Wee Kooi, the Head of CRC Taiping,
highlighted the issue of inadequate
manpower support from the hospital
and shared the exciting news of a
possible collaborative work between
CRC Taiping with the Institute of Medical
Research (IMR) and Pantai Group on an
axiom genotyping project. Turning
attention to CRC Seri Manjung, the
emphasis was on that the current
infrastructure of CRC Seri Manjung will be
substantially improved, according to Dr.
Ngah Shih Hang, the Head of CRC Seri
Manjung. Following that, Mr. Venoo
Kuppusamy (Associate Regional
Manager of Clinical Research Malaysia)
shared CRM Perak's accomplishments
and praised CRM Seri Manjung and CRM
Taiping for enrolling the world's first
patients in several projects. He
emphasized the need for GCP
certification for physicians interested in
doing industrial sponsored research.
After all the sharing sessions, the meeting was open to the
floor for participants to address any concerns or express
any thoughts in regards to research. Clinicians took the
opportunity to raise questions and seek clarification on
matters related to research like funding for publication
fees. In addition, clinicians also used the opportunity to
encourage others to conduct research by sharing their own
experiences with it. Furthermore, Dr S. Sivanandarajah,
Director of Hospital Slim River also grab the chance to
explore the prospects and process of establishing a CRC in
Hospital Slim River.
Page 2

I-CPEP TRIAL
Randomized, Double Blind, Placebo Controlled Clinical
Trial of Ivermectin For Post Exposure Prophylaxis For
COVID-19 Infection Among Close Contacts
Hospital
Taiping
Ivermectin is an antiparasitic drug and has been used as a treatment for
COVID-19 in a few countries. However, the I-TECH study findings do not
support the use of ivermectin for patients with COVID-19 in Malaysia. I-CPEP
was then designed to assess the efficacy of Ivermectin as post-exposure
prophylaxis in asymptomatic adults (≥18 years of age) who had close-contact
exposure to a confirmed case of COVID-19 patient.
The study was initiated by Dr. Cheah
Wee Kooi as PI and supported by 10
health clinics; 7 in Perak, 1 each in
Penang, Kedah, & Perlis. The
investigational product (IP) was
supplied by Hovid Sdn. Bhd. It was
approved by MREC on 17th November
2021.
Read More
Page 3
NMRR-21-1371-60569
IN FOCUS

The flow of study starts with
screening for eligible subjects.
Ivermectin (0.4 mg/kg/day -
maximum 24 mg) was given orally
on Day 1 and Day 3 after the
nasopharyngeal swab was
confirmed negative for Covid-19.
Follow-ups were through phone
calls until day 14. The subject
needed to be present at the health
clinic twice; at screening and on
day 8. The drug safety was
monitored through blood
parameters and adverse effects
reported by the subjects.
In late April 2022, the government
had announced that quarantine is
no more mandatory for
asymptomatic close contact. Five
months into the study, total
recruitment was far from target.
After discussion with Hovid and
interim data analysis, the study
was terminated on 8th November
2022 due to recruitment
challenges with only 50 subjects
made it to the final list.
Page 4
5 month study durations Total subject to be recruited is 300 10 health clinics
Total subject to be recruited is 300; 30 from each site with 15 on each arm. First
patient was randomized on 17th February 2022. However, subsequent
recruitment was hindered by changes of policy in managing close contact
although thousands were screen for eligibility. Protocol was amended twice
tailored to the situational Covid-19 management to ensure enough sample size
from each site.
Principal Investigator: Dr. Cheah Wee Kooi

RECOMBINANT SARS-COV-2 FUSION
PROTEIN VACCINE (V-01) BOOSTER
Hospital Seri Manjung NMRR-21-1565-61053
Principal Investigator: Dr. Lee Li Yuan
Protocol No.: TG2102V01
Study Objective:
Vaccine (V-01) efficacy
was 47.8%
This study aims to evaluate the
relative efficacy of recombinant
SARS-CoV-2 fusion protein
vaccine (V-01) as a booster to
prevent symptomatic infection
and RT-PCR positive COVID-19
compared with the placebo
control group.
This study is conducted at multiple sites in Malaysia and Pakistan, with total recruitment
of 10 218 subjects. V-01 vaccine efficacy was 47.8% (95%CI: 22.6 to 64.7) as per the
principle of intention-to-treat. Most common adverse events include transient, mild-to
moderate injection site pain, fever, headache and fatigue. Serious adverse events are
almost equal in both V-01 vaccine and placebo groups (0.12% versus 0.16%). These
interim results are published in an international journal with Dr. Lee Li Yuan as the co-
author.
PHASE III - RCT
Hospital Seri Manjung team, led by Dr. Lee Li Yuan has
recruited a total of 114 subjects for this COVID -19
vaccine booster trial, namely: A Global, Multi-Center,
Randomized, Double-Blind, Placebo-Controlled, Phase
III Clinical Study to Evaluate the Efficacy, Safety and
Immunogenicity of Sequential Immunization of
Recombinant SARS-CoV-2 Fusion Protein Vaccine
(V-01) Against Covid-19 in Healthy Adults aged 18
years and Older after the Vaccination of 2 Doses
of Inactivated Vaccines.
Findings:
Page 5

AGE-FRIENDLY CITY?
IS IPOH AN
Introduction: In response to the world's rapidly ageing
population, the World Health Organization (WHO)
launched the "Age-friendly Cities" programme in 2005.
According to the WHO initiative, a "age-friendly" city is one
that encourages active ageing; it maximises opportunities
for health, involvement, and security in order to improve
people's quality of life as they age.
The data were analyzed descriptively with frequencies and
percentages, while gap score analysis was performed for 32
items of the 8 age-friendly domains. The gap scores were
generated by comparing the importance and availability
scores. Of the 8 domains, housing (55.4%) and transportation
(50.7%) reported the highest mean perceived gap scores. Out of
the 32 elements, the highest mean gap percent scores were
observed in elderly priority parking bays (83.8%), home visits by
healthcare professionals (78.9%), financial assistance for home
modification and purchase (66.3%), and affordable housing
options (63.6%).
CRC HRPB used an exploratory
sequential mixed-method design to
explore older residents' perceptions
of the importance, availability, and
perceived gap of the features
specified under each domain to
determine if Ipoh is an age-friendly
city, and systematically integrated
quantitative and qualitative findings.
In Malaysia, only Ipoh
and Taiping are
members of the WHO
Global Network of
Age-Friendly Cities
and Communities
(GNAFCC).
In particular, 16.7% of Ipoh's 739,700 residents are over the
age of 60. In collaboration with JKN Perak and MBI, CRC
HRPB conducted a study in Ipoh to evaluate the baseline
characteristics of eight domains of Age-Friendly Cities,
namely housing, outdoor spaces and buildings,
transportation, job opportunities and civic participation,
social participation, respect and social inclusion,
communication and information, and community
support and health services.
Quantitative study:
Page 6
Clinical Research Centre, Hospital Raja Permaisuri Bainun, Ipoh
[NMRR-19-3191-51748]
The mean percent gap scores were compared between the city center and non-city center
respondents. Significantly higher gap scores were observed among the city center respondents in
4 elements, including modified rest-rooms for people with disabilities (40.3% in the city center vs.
30.0% in non-city center); well-maintained parks and facilities (26.8% vs. 16.5%), a range of
volunteer activities (29.9% vs. 22.2%) and free access to computers and the internet (56.0% vs.
49.0%). In contrast, respondents in the non-city center reported a significantly higher mean gap
percent score in nursing homes for older people (28.3% in the non-city center vs. 16.4% in the city
center), a variety of healthcare professionals (34.7% vs. 27.2%) and the variety of cultural
celebrations (35.9% vs. 24.0%).

Qualitative approach:
Page 7
CONT.
“We can't even use
the field. You can't
even play football
with your
grandchildren...
You can’t play.”
(P03)
Exercise,
sports and
recreation
facilities;
Affordability;
Accessibility
Digital divide: Inability to learn
about information technology
due to financial constrain.
01
“Unmet needs" are gaps between
an individual's self-assessment of
long-term care needs and the
actual resources available to
address those needs. A framework
analysis approach guided by the 5P
Ecological Model of Ageing was
adopted. The term 5P is refer to five
distinct domains: person (micro),
process (meso), place (macro),
and policymaking (macro), and it is
based on the (prime) relationship
with the health environment.
Theme 1:
Person
“We don't know much about IT
(information technology) ... Of
course, we can (join online classes),
but not at such a high cost.” (P06)
Theme 2:
Process
Economic security: I
receive a small pension
each month, which is
clearly insufficient for me.
That is one of the main
reasons I must continue
working on it. (P05)
02
Theme 3:
Place
03
“They want us to
use Grab, but it's
too expensive for
us.” (P04)
“They may want to be
creative and become
cashless, so hopefully
you will comply, but you
must recognize that
many people are still
older persons.” (P03)
Note: P: Older adult, C: Caregiver, K: Key-informant
MORE INFO AVAILABLE IN THE PUBLISHED ARTICLE:
Chang CT, Lim XJ, Supramaniam P, Chew CC, Ding LM, Rajan P. Perceived Gap of Age-
Friendliness among Community-Dwelling Older Adults: Findings from Malaysia, a Middle-
Income Country. Int J Environ Res Public Health. 2022 Jun 11;19(12):7171.
doi: 10.3390/ijerph19127171. PMID: 35742420; PMCID: PMC9223156.

Qualitative approach
CONT.
Inclusiveness: “I'm not OKU. It's ridiculous that senior citizens are
not allowed to drive, as recently reported in the media (at the time
this study took place) ... So, you instil fear in people like us.” (P04)
Conclusion: The findings served
as a baseline input for local city
councils to make improvements
to Ipoh city not only to meet the
benchmark of GNAFCC but also
to plan for short- and long-term
intervention in creating an age-
friendly environment. A
multifaceted approach is
recommended to specifically
address the unmet needs among
older adults in the local context.
In the global context, the
information from this study adds
knowledge to existing aging
research that allows researchers
to make comparisons among the
age-friendly cities.
Governance: “I cannot find one
(a nursing home) that is good
enough for me to send my loved
ones to.” (K01)
04
Page 8
Theme 4:
Policy making
Multidisciplinary collaboration: “A geriatrician,
for example, will serve as the coordinator, so we will
hold a multi-disciplinary team meeting” (K01)
Theme 5:
Prime
05
Health promotion: "Even starting
in schools, taking enough calcium
and vitamin D would have prevented
the 20 to 30-year-old ladies from
osteoporosis. But, many people don't
know about that.” (K01)
Respite care: "It is not the popular respite care, like
giving the caregivers a break. The family caregivers
said they can't afford (RM) 500 a day for home
private nursing. (C1)
Note: P: Older adult, C: Caregiver, K: Key-informant

A total of 184 COVID-19 patients who were suspected to
have PTE disease were included in this study. CTPA
examinations revealed a total of 150 patients (81.5%)
suffered from concomitant PTE disease. Among the PTE
cohort, the commonest comorbidities were diabetes
mellitus (n=78), hypertension (n=66) & dyslipidemia
(n=25). They were generally more ill than the non-PTE
cohort as they reported a significantly higher COVID-19
disease category during CTPA examination with
p=0.042.
CLINICAL AND COMPUTED TOMOGRAPHICAL PATTERNS OF PULMONARY
THROMBOEMBOLIC DISEASE ASSOCIATED WITH COVID-19 INFECTION:
A TERTIARY HOSPITAL ANALYSIS
This study aims to study the
clinical characteristics, computed
tomographical features of
pulmonary thromboembolic
disease associated with COVID-19
infection.
81%
52%
16%
COVID-19 patients suffered
from concomitant PTE disease
have diabetes mellitus
diagnosed with
hypertension
Page 9
NMRR-21-1732-61096 (IIR)
Hospital Seri Manjung
This is a retrospective cohort study in
which we retrospectively review all
hospitalized patients with confirmed
COVID-19 infection who had undergone
CT pulmonary angiogram (CTPA)
examinations for suspected PTE disease
between April 2021 and May 2021 in
Hospital Tengku Ampuan Rahimah.
Expectedly, the length of both intensive care unit stays
(median number of days 8 vs. 3; p=0.021) and hospital
stays (median number of days 14.5 vs. 12; p=0.006) were
significantly longer. Intriguingly, almost all the subjects
had received either therapeutic anticoagulation or
thromboprophylactic therapy prior to CTPA
examination (n=173, 94.0%).
44%
were dyslipidemia
Besides, laboratory data analysis
identified a significantly higher peak
CRP (median 124.1 vs. 82.1; p=0.027)
and ferritin levels (median 1469 vs.
1229; p=0.024) among them.
Overall, PTE disease remains prevalent
among COVID-19 patients despite
timely administration of
thromboprophylactic therapy. The
presence of hyperinflammatory
activities, unique thrombotic locations
as well as concurrent pulmonary
parenchyma and vasculature
aberrations in our PTE cohort implicate
immunothrombosis as the principal
mechanism of this novel phenomenon.
We strongly recommend future
researchers to elucidate this important
clinical disease among our post-COVID
vaccination populations.
Evaluation of CT features showed that COVID-19
pneumonia pattern (p<0.001) & pulmonary angiopathy
(p<0.001) were significantly more profound among the
PTE cohort. To note, the most proximal pulmonary
thrombosis was located in the segmental (n=3, 2.0%) &
subsegmental pulmonary arteries (n=147, 98.0%). Also,
the thrombosis predominantly occurred in bilateral
lungs with multilobar involvement (n=95, 63.3%).

This study aims to explore the survival patterns among hospitalized COVID-19 cases
complicated with pulmonary thromboembolic disease. This is a retrospective cohort
study in which we retrospectively review all hospitalized Covid-19 cases complicated
with pulmonary thromboembolic disease admitted to Hospital Tengku Ampuan
Rahimah between 1st April 2021 and 31st May 2021. Demographic, clinical &
laboratory data were retrieved, whilst CTPA images were analyzed by a senior
radiologist.
NMRR-21-1558-59028
SURVIVAL ANALYSIS OF PULMONARY THROMBOEMBOLIC DISEASE ASSOCIATED WITH COVID-
19 INFECTION: A COMPARISON BETWEEN GERIATRIC AND NON-GERIATRIC POPULATIONS
A total of 150 patients were recruited,
comprising 45 geriatric patients and 105 non-
geriatric patients. The prevalence rate of
hypertension, diabetes mellitus and
dyslipidaemia were higher among the geriatric
cohort. Interestingly, the percentage of
patients with fever and diarrhoea were
significantly higher among the non-geriatric
cohort. The geriatric cohort also recorded a
significantly lower absolute lymphocyte count
at presentation and albumin level during
admission. Despite earlier presentation, the
geriatric cohort suffered from more severe
disease.
Analysis of the CT features
demonstrated that the most
proximal pulmonary thrombosis
specifically limited to the
segmental and subsegmental
pulmonary arteries in both
cohorts. The elderly suffered
from a significantly higher in-
hospital mortality rate and their
cumulative probability of
survival was significantly lower.
In conclusion, typical COVID-19 symptoms may
be absent among the elderly, prompting a
lower threshold of suspicion during the COVID-
19 pandemic. Additionally, the elderly
demonstrated a higher probability of adverse
outcomes despite earlier presentation and
treatment.
Hospital Seri Manjung
Page 10

Background of the study:
The rate of road traffic death is considerably
high in South-East Asia with 20.7 deaths per
100,000 people. In Malaysia, transport accident
has been reported as one of the five principle
causes of death in year 2020 with 3.8% died
due to road traffic accidents (DOSM, 2021).
Hospital Raja Permaisuri Bainun
The impact of the COVID-19 pandemic on premature death due to
road traffic accidents in Perak State
The novel coronavirus (COVID-19) outbreak has been
declared as a pandemic on March 2020. Various
methods to prevent the spread of the COVID-19
infection through stay-at-home orders, social
distancing as well as temporary closures of
businesses and services have been implemented. The
Movement Control Order (MCO) was established in
the country on 18 March 2020 and was followed by
the Conditional Movement Control Order (CMCO),
Recovery Movement Control Order (RMCO) and the
MCO by states which all ended in June 2021 through
the implementation of the National Recovery Plan
(NRP). COVID-19 has changed the pattern of life
regardless of geographical, age-group and gender
distribution on the globe.
Life expectancy in Malaysia in 2021 is 75.6
years. Meaning, a newborn baby in the year
2021 is expected to live until the age of 75.6
years. How many years will be lost due to road
traffic fatalities? Premature death especially
due to road traffic accidents is preventable loss
of life (Aragón T. J., et. al, 2008, Murray C.J, et.
al, 1996).
Objectives:
The standard expected YLL measure has been
reported as valuable analytic tool as the foundation of
the measurement is based on the comparison of the
age at death and the standard life expectancy curve
(Aragón, T. J., et. al, 2008, Murray CJ, et. al, 1996).
Furthermore, the spatial patterns of the trends and
characteristics of fatal road accidents can be
visualized using Geographical Information System
(GIS). Visualization of the incidence of accidents and
deaths on the geographical mapping layers against the
infrastructure and facilities could facilitate planning
and prevention strategies by the stakeholders.
Mortality indicators like incidence, prevalence,
mortality and case fatality rate were often used
to signify the mortality due to road traffic
accidents. However, the impact of the
premature death can be measured using Years
of Life Lost (YLL).
Page 11
To explore the shift in trend patterns and
spatial distribution of the road traffic
fatalities as an impact of the COVID-19
pandemic in Perak State, Malaysia.
To determine the burden of premature death
using YLL in Perak State, Malaysia

Expected outcomes:
Trend patterns
1.
NMRR ID-22-00218-FQQ
Current status:
Analyses on the trend patterns and YLL
estimation: - Completed and manuscript
draft in progress.
Analyses on the spatial mapping and
models: - Study team is collaborating with
PerakGIS and analysis is in progress.
Aragón, T. J., Lichtensztajn, D. Y., Katcher, B. S., Reiter, R., &
Katz, M. H. (2008). Calculating expected years of life lost for
assessing local ethnic disparities in causes of premature
death. BMC public health, 8(1), 1-12.
Department of Statistics Malaysia. (2021, July 29). Press
Release Abridged Life Tables, Malaysia, 2019-2021.
Murray, C. J., Lopez, A. D., & World Health Organization. (1996).
The global burden of disease: a comprehensive assessment of
mortality and disability from diseases, injuries, and risk factors
in 1990 and projected to 2020: summary. World Health
Organization
Study References:
1.
2.
3.
Overview:
Fatal road traffic accident/crash fatality cases (n=2207) were obtained from all 14 Forensic Departments
in the government hospitals in Perak. Death Registration Book, Autopsy Request Form Pol.61 (revision
4/86), and post-mortem report were reviewed for eligible cases by trained research assistants. This study
was partially sponsored by MedRSI.
Cont.
Page 12
2. YLL estimates
3. Spatial mapping:
Reference sources: Premaa Supramaniam,
Suria Junus, Lina Hashim, Chiew Shoen
Chuen, Philip Rajan Devesahayam: The
impact of the COVID-19 pandemic on
premature death due to road traffic
accidents in Perak State, Malaysia.
Unpublished manuscript: Clinical Research
Centre (CRC), Hospital Raja Permaisuri
Bainun, Ministry of Health Malaysia, 2022,
NMRR-ID22-00218-FQQ.
Reference sources: Example of mapping by PerakGIS (Village@Perak):

AttitudesandBeliefs
toUseofMedical
Cannabisamong
Malaysian'sDoctors
HOSPITAL SERI MANJUNG
This study aims to determine the beliefs of
medical doctors towards medical cannabis
usage for the treatment of patients,
including its perceived benefits and risks,
as well as doctors’ willingness to prescribe
medical cannabis.
Page 13
This study is conducted at multiple sites in Malaysia. All doctors including Medical
Officer, Specialist and Consultants, registered with Malaysian Medical Council are
invited to answer an online questionnaire.
NMRR ID-22-02260-DHZ (IIR)
Medical cannabis or medical marijuana uses the marijuana plant or chemicals in it to
treat diseases or conditions. It's basically the same product as recreational marijuana,
but it's taken for medical purposes.
The marijuana plant contains more than 100 different chemicals called cannabinoids.
Each one has a different effect on the body. Delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) are the main chemicals used in medicine. THC also produces the
"high" people feel when they smoke marijuana or eat foods containing it.
Researchers are studying whether medical marijuana can help treat a number of
conditions including; Alzheimer's disease, Appetite loss, Cancer, Crohn's disease,
Diseases affecting the immune system like HIV/AIDS or Multiple Sclerosis (MS), Eating
disorders such as anorexia, Epilepsy, Glaucoma, Mental health conditions like
schizophrenia and posttraumatic stress disorder (PTSD), Multiple sclerosis, Muscle
spasms, Nausea, Pain, Seizures, Wasting syndrome (cachexia).
The greatest amount of evidence for the therapeutic effects of cannabis relates to its
ability to reduce chronic pain, nausea, and vomiting due to chemotherapy, and
spasticity (tight or stiff muscles) from Multiple Sclerosis.
Definition of Medical Cannabis
© 2021 WebMD, LLC. All rights reserved.

RESEARCH GRANT
Introduction
1.
Planning Monitoring
Budget
The Ministry of Health (MOH) Malaysia
Research Grant or MRG is a research
fund that supports health research
and development (R&D) activities
based on the priority areas (research
that will benefit the MOH-return of
investment (ROI)) set by the MOH with
the aim to improve population health
and health delivery services.
Page 14
The objectives of MRG are to:
i. provide funding to generate new scientific knowledge and discoveries,
ii. to improve health delivery services, and
iii. to encourage the development of innovative technologies among the
MOH investigators.
RESEARCH SCOPE:

MRG applications can be submitted throughout the year
via National Medical Research Register (NMRR).
Submissions must be made together with research
registration, application to NIH Research Review Panel
(Jawatankuasa Penilaian Penyelidikan; JPP-NIH), and
Medical Research and Ethics Committee (MREC).
2. Mode of Application
Page 15
Cont.
3. Criteria of Application
i. The Principal Investigator (PI) must be a MOH personnel;
ii. The research funding period shall not exceed three (3) years;
iii. PI is allowed to apply and submit only two (2) research submissions at a time;
iv. Investigators who are on study leave are not allowed to be PI. However, he/she can be a
Sub-Investigator;
v. PI who has changed department/affiliation/resigned/on study leave must not continue
his role as a PI. However, can still remain as a member of the research group. The PI
must notify MRG Secretariat in writing and nominate a new PI whenever such a situation
occurs. An amendment must be submitted to MREC under such circumstances (as per
post ethical approval submission).
4. MRG Review Panel
The MRG Review Panel is chaired by the Deputy Director-
General of Health (Research and Technical Support),
MOH. Research that has been evaluated by the JPP-NIH
Panel and has received MREC approval will be brought to
the MRG Review Panel for evaluation. The decision made
by the panel is final.
5. Priority in Research Evaluation
i. Research that can support and improve an existing policy, methodology, and solution model
according to the needs of the MOH; or
ii. Research covering health issues for the purpose of increasing the value of life in the country and
globally; or
iii. Research must identify and obtain the support of MOH stakeholders; or
iv. Research that has the potential to contribute to the national strategic plan.
i. Approval letters will be sent to the PI and a copy of the approval letter will be forwarded to the
respective head of the department.
ii. Allocation will be disbursed to the PI through the relevant department.
6. Result Notification in the MRG Application

In brief, the funding categories are as follows:
i. Travel and transportation - expenses on all domestic travels
and transportations related to research;
ii. Utilities - all charges related to postage (excluding parcel
post), telephone, telex, telegraph, cable, and others;
iii. Rental - rental for equipment, transportation and other
items related to research activities;
iv. Food and beverages - expenses for purchasing food and
beverages for research purposes;
v. Raw materials - expenses on oil and petrol for research
purposes;
vi. Research supply and materials - expenses related to
research-related supplies and materials (such as reagents, kits,
consumables, animal bedding, stationeries, and others).
vii. Minor repair and modifications - expenses for minor repair
and modifications of equipment, vehicles or other items
related to research activities. The cost of maintaining the
existing equipment during the implementation of the
research is allowed;
viii. Services - covers printing, hospitality, honorarium,
reimbursement to the research participants or subjects,
service-based input, and others; training costs related to
research such as workshops and others should be provided
with strong justification to be supported by the JPP-NIH
review panel and approved by the Grant Review Panel;
**Funding must not be used to pay for expenses incurred to attend
seminars or conferences and publication fee.
ix. Contract Personnel - salary and allowance for short-term
personnel, which will be hired based on the research; and
x. Equipment and accessories - the amount allocated for this
category should not exceed 40% of the approved total budget.
Should any application exceed this limit, PI must provide
strong justifications, specifications, quotations, and
estimations for the purchase to the grant committee.
**For the purchasing of any ICT software and equipment, PI is
required to seek professional advice from the ICT department at their
locality prior to the JPP-NIH panel review meeting. The technical
input from the ICT Department needs to be sent together with the
application as supporting documents. Their evaluation must cover
the plan and maintenance for related software and equipment
during and after the completion of the research.
Page 16
i. PI is responsible for carrying out approved
research.
ii. PI is required to sign the “Surat Akujanji”.
iii. PI must ensure that the research is carried
out effectively to achieve the objectives and
milestones within the stipulated period as
well as the approved allocation;
iv. PI must present the research results to the
stakeholders upon completion of the
research;
v. Research progress reports must be
submitted every 6 months to MRG
Secretariat, NIH no later than July 15th and
January 15th.
vi. A monthly research expenditure report
must be submitted to the MRG Secretariat,
NIH no later than the 15th of the following
month.
7. Responsibility of
Principal Investigator (PI) Further details on the categories and scopes of
funding will be made available based on the current
financial circulars applicable for that particular year.
*For collaborative research between MOH and non-MOH
organisations, funding distribution will be made available only to
the MOH department.
8. Funding Scope
Any amendment to the allocation must be
approved by the Deputy Director-General of
Health (Research and Technical Support)
who is also the Chairman of the MRG Review
Panel. The completed form must be sent to
the MRG Secretariat, NIH for approval.
9. Amendment to Grant
Allocation
All research must be carried out based on
the approved methodology and allocation
within the stipulated time. Approved research
will be monitored by the MRG Secretariat
based on the following aspects:
i. Financial performance;
ii. Research performance; and
iii. Outcome or Output.
10. Implementation and
Research Conduct

For further questions and inquiries,
investigator may contact the MRG
Secretariat at:
Research and Grant Management Unit,
Level 4, Block A,
National Institutes of Health,
No.1, Jalan Setia Murni U13/52,
Seksyen U13, Setia Alam, 40170,
Shah Alam, Selangor
Phone: +603 -3362 8888 ext
8405/8316
Email: nihmrg@moh.gov.my
Any violation of these
codes of conduct may
lead to the termination of
the grant.
Find Us
Page 17
PI is responsible for completing and submitting
the financial reports and performance of
research under his/her supervision as follows:
i. Research financial report - must be sent to
the MRG Secretariat every month no later than
the 15th of the following month;
ii. Research progress report - reports must be
submitted semi-annually (on the 15th July and
15th January of the following year);
iii. Research findings monitoring report - reports
must be submitted every fourth quarter before
15th January of the following year.
iv. End of project report - the final research
report must be submitted within three (3) months
after the completion of the research.
**PI needs to adhere to the deadline. Failure to submit
any required report by the due date will affect the
consideration for next year’s funding.
11. Research Monitoring
Application for extension of research period
must be submitted to the MRG Secretariat,
NIH before the research end date through
the utility of relevant forms.
12. Extension of Research
Each PI must ensure the implementation of
the research is in accordance with the
Declaration of Helsinki, Malaysia Good
Clinical Practice (GCP), Malaysian Code of
Responsible for Conduct in Research
(MCRCR), and other local regulatory
requirements and guidelines.
13. Termination of Grant

OBJEKTIF
Ministry of Science, Technology and Innovation (MOSTI) Grant
MOSTI Grant
inistry of Science, Technology
and Innovation (MOSTI) is the
Malaysian ministry in charge of
research, telecommunication and
information technology.
MOSTI is tasked to championing scientific
discovery and transforming innovation through
efficient, ethical and professional management of
funds for Research and Development and
Commercialisation (R&D&C); increasing the
quantity and quality of human capital in Science,
technology and innovation (STI); and wider
dissemination and application of technology for
the benefit of grassroots.
M
Meningkatkan kesejahteraan hidup masyarakat
keutamaan kepada golongan B40 dan kumpulan yang
terkesan akibat selepas pandemik COVID-19 melalui
pelaksanaan projek aplikasi teknologi tempatan yang
berinovatif yang telah dibangunkan dan sedia
dilaksanakan secara mampan.
MAKLUMAT PROGRAM
(MYIS KOMUNITI)
MOSTI Grant
KELAYAKAN
i) Warganegara Malaysia.
ii) Terdiri daripada Agensi Kerajaan, Badan
Berkanun, University Awam, Syarikat
Berkaitan Kerajaan (GLC), Syarikat
Berhad dengan Jaminan (CLG), Syarikat
pemula perniagaan (start-up company)
yang beroperasi tidak melebihi 5 tahun,
Pertubuhan bukan kerajaan (NGO).
iii) Hanya projek yang mempunyai aplikasi
teknologi tempatan berinovatif dan misi
sosial yang jelas layak memohon.
iv) Projek mesti dilaksanakan di Malaysia.
Program Inisiatif Inovasi Sosial Malaysia (MyIS Komuniti) merupakan
inisiatif dibawah Kementerian Sains, Teknologi dan Inovasi (MOSTI)
dan Yayasan Inovasi Malaysia (YIM) sebagai agensi pelaksana yang
menjurus kepada penjanaan pendapatan untuk meningkatkan
kesejahteraan masyarakat di kawasan bandar dan luar bandar.
YIM melaksanakan inisiatif yang
selari dengan dasar Kerajaan untuk
memastikan negara mempunyai modal
insan yang berpengetahuan tinggi,
berkemahiran pelbagai, berdaya
kreatif dan inovatif bagi memenuhi
keperluan negara menjelang 2050
terutama untuk mencapai Wawasan
Kemakmuran Bersama, selain
menghadapi ledakan IR 4.0.
SKOP PEMBIAYAAN
Pembiayaan merangkumi perkara-perkara yang berikut:
i) Bahan mentah dan peralatan
ii) Dokumentasi projek (seperti rakaman video
perjalanan program, gambar beresolusi tinggi dan
sebagainya) [Maksimum RM2,000.00]
iii) Perbelanjaan perkhidmatan (perundingan dan
pengujian)
iv) Kajian impak projek [Maksimum RM5,000]
Page 18
PERMOHONAN
Permohon hendaklah memohon melalui laman web
YIM menggunakan sistem Innomap seperti berikut:
https://www.mysi.innomap.my
Sebarang pertanyaan:
Sekretariat Inovasi Sosial Malaysia
Yayasan Inovasi Malaysia
L3-E-1A & L3-E-1B, Level 3, Enterprise 4
Technology Park Malaysia
57000 Bukit Jalil
Kuala Lumpur
Tel: 03 – 8996 1714
Faks: 03 – 8996 1715
Emel : sekretariat.mysi@yim.my

OTHER MALAYSIAN RESEARCH GRANTS
MALAYSIA TORAY SCIENCE FOUNDATION
(MTSF): SCIENCE & TECHNOLOGY RESEARCH
GRANT
Scaling Solutions for the community. The innovative
& Intelligent City Cluster’s main intent is to bridge
the industry, policy makers and universities with a
common interest in developing impactful and
sustainable solutions for the ecosystem through
R&D and technology applications.
Objective: To create an innovative test bed to
demonstrate and test the latest solutions for
Smart Living Applications.
Contact Us:
CREST (Collaborative Research in Engineering, Science &
Technology) (950906-A) sains@usm,
Block C, Ground Floor No 10 Persiaran Bukit Jambul, 11900
Bayan Lepas, Penang.
Email: info@crest.my
Tel: +60 (0)4 652 0088
COLLABORATIVE RESEARCH IN
ENGINEERING, SCIENCE AND TECHNOLOGY
(CREST)
Energetic and creative researcher, Malaysian citizen
aged below 40, residing in Malaysia, engaged in a
basic fundamental scientific research field
excluding mathematics and clinical medicine at a
research facility in Malaysia, whose work has
thepotential to contribute greatly to the
advancement of science and technology.
Contact Us:
Malaysia Toray Science Foundation
c/o Penfabric Sdn. Berhad
Block B, Prai Free Industrial Zone 1, 13600 Prai, Penang.
Tel: (+604) 385 4151
Fax: (+604) 385 4194
Email : mtsf.tml.mb@mail.toray
Website : www.mtsf.org
FRGS, TRGS AND PRGS
ANNUAL GRANTS AWARDED BY THE
MALAYSIAN MINISTRY OF EDUCATION
Fundamental Research Grant Scheme (FRGS),
Prototype Development Research Grant Scheme
(PRGS), Trans Disciplinary Research Grant Scheme
(TRGS).
Contact Us:
Malaysian Technical Standards
Forum Bhd (MTSFB)
(200401016865 (655368-P))
Level 3A, MCMC Tower 2,
Jalan Impact, Cyber 6,
63000 Cyberjaya,
Selangor Darul Ehsan
Email: admin@mtsfb.org.my
Tel: +603 8680 9950
Fax: +603 8680 9940
MALAYSIA DIGITAL ECONOMY
CORPORATION (MDEC)
Malaysia Digital is a national strategic initiative by
the Malaysian Government to encourage and
attract companies, talents and investment while
enabling Malaysian businesses and Rakyat to play
a leading part in the global digital revolution and
digital economy. To provide opportunity and
platform for digital creative content creators in
developing and creating digital creative content.
Contact Us:
Malaysia Digital Economy
Corporation (MDEC) Sdn Bhd
2360 Persiaran APEC
63000 Cyberjaya
Tel: 1-800-88-8338
Email: clic@mdec.com.my
MALAYSIAN COMMUNICATIONS AND
MULTIMEDIA COMMISSION
The Industry Promotion and Development Grant,
also known as the ‘MTSFB Project Grant’ was
initiated by MCMC in 2012. MTSFB is entrusted by
MCMC to manage the Grant and projects
implemented by Grant recipients. The MTSFB
Project Grant was conceived for the purpose of
enhancing knowledge, Research & Development
(R&D), and establishing competitiveness in
technology innovation by creating a Proof-of-
Concept (PoC) project that contributes to the
communications and multimedia industry.
Contact Us:
Malaysian Technical Standards
Forum Bhd (MTSFB)
Level 3A, MCMC Tower 2,
Jalan Impact, Cyber 6,
63000 Cyberjaya,
Email: admin@mtsfb.org.my
Tel: +603 8680 9950; Fax: +603 8680 9940
Other Malaysian Research Grant Page 19
Projek Malaysia Greater Research Network System
(MyGRANTS) merupakan inisiatif BKPI dalam usaha untuk
meningkatkan kecemerlangan penyelidikan negara dengan
membangunkan dan menyediakan sebuah sistem
pengurusan geran-geran penyelidikan secara dalam talian.
Penggunaan MyGRANTS telah memudahkan pengurusan
dan pelaksanaan Dana Penyelidikan Kementerian Pengajian
Tinggi (DP KPT) yang lebih teratur, cekap dan berkesan.

A. Number of staff in CRC/CRM Hospital Raja Permaisuri Bainun
Staff Designation 2020 2021 2022
CRC staff
Medical officer (MO) 4 6 10
Pharmacist 2 2 1
Research officer (RO) 1 1 1
Assistant research officer 1 1 1
Allied health 1 1 -
Temporary staff (PSH)/MySTEP
available until Dec
5 8 5
CRM staff Study coordinator 6 7 7
PERFORMANCE
THE CRC's RESEARCH
CLINICAL RESEARCH CENTRE,
HOSPITAL RAJA PERMAISURI BAINUN
CRC HRPB available staff
(as of 31st Dec 2022):
Head of Dept.:
Dr. Philip Rajan Devesahayam
-10 Medical officers
-1 Pharmacist
-2 Research officers
-1 Associate research officer
-7 CRM study coordinators
-5 Personel MySTEP staffs
Summary Report: Research Performance of CRC HRPB, Ipoh
Page 20
CRC, HRPB Ipoh
"In this office... we do Teamwork, we do Help, we do Respect,
Punctuality, and Laughter, We do Friendship. We do Coffee and
Cake. We Communicate and Listen. We do Motivation.
We do Great Things."

B. Type of Research Services provided 2020 2021 2022
NMRR
registration
No. of research/Case studies/Clinical audit registered
No. of research/Case studies/Clinical audit
projects with ethical approval
228
142
108
56
106
53
Consultation No. of consultations (episodes) provided 638 342 663
Proposal review
No. of proposals reviewed by Hospital Research
Review Committee (HRRC)
106 32 75
Publication &
presentation
submitted to CRC
No. of application of publication in local/ int. journals
No. of application of oral/poster presentation
26
5
25
5
31
5
Registry No. of patient registries supported 14 14 14
Training /
Conference
No. of training workshops organised
No. of Ministry of Health staff trained
18
719
7
449
16
1135
C. Investigator Initiated Research (IIR) Projects and Output 2020 2021 2022
IIR projects
No. of research projects initiated by CRC and/ or in
collaboration with other institutions
39 38 47
Publications
No. of published articles in local/ int. journals
No. of manuscripts pending publication
16
9
21
15
26
7
Reports No. of research reports completed 8 17 9
Presentation
No. of oral presentations
No. of poster presentations
1
8
3
7
3
2
Awards No. of awards received 5 5 2
D. Industry Sponsored Research (ISR) 2020 2021 2022
Feasibility No. of feasibility studies conducted 59 65 114
Clinical trials
No. of on-going clinical trials
No. of upcoming clinical trials
36
8
35
17
35
7
CRC, Hospital Raja Permaisuri Bainun, Ipoh
No. Name Award/achievement details in 2022
1. Dr. Philip Rajan Devesahayam Best Editor Award of Medical Journal of Malaysia 2021/22
2. Chang Chee Tao
Best Poster Award in15th National Conference for Clinical Research (NCCR) 2022 for
study title Perceived unmet needs of age-friendly environment: Qualitative exploration of
older adults' perception in a Malaysian city [NMRR-19-3191-51748]
Page 21

No. Publication Details
1.
Lee FS, Sararaks S, Yau WK, Ang ZY, Jailani AS, Abd Karim Z, Naing L, Krishnan T, Chu AR, Junus S, Ahmad MS,
Sapiee N, Veloo VW, Manoharan S, A Hamid M. Fall determinants in hospitalized older patients: a nested case-
control design - incidence, extrinsic and intrinsic risk in Malaysia. BMC Geriatr. 2022 Mar 3;22(1):179.
doi:10.1186/s12877-022-02846-6.
2.
C KW Wong, Chii-Chii Chew, E-Li Leong, LH Chia, BH Lee, AP Anthonysammy, M Gobalan, KS Thong, SR Sulaiman,
KW Foong. The Challenges and Strategies in Managing Intensive Care Units for COVID-19 Pandemic in Malaysia.
Malaysian Journal of Medicine and Health Sciences 18(1): 331-336, Jan 2022.
3.
IZ Mohamad, C KW Wong, Chii-Chii Chew, E-Li Leong, BH Lee, CK Moh, K Chenasammy, S CL Lim, HB Ker. The
landscape of antibiotic usage among COVID-19 patients in the early phase of pandemic: a Malaysian national
perspective. Journal of Pharmaceutical Policy & Practice 15, 4 (2022). https://doi.org/10.1186/s40545-022-00404-4
4.
Ju‑Ying Ang, E‑Li Leong, HK Chan, AA Shafe, SQ Lee, P Mutiah,R VM Lim, CM Loo, R US Rajah, M M.Ahmad Shah, Z J.
Osman, LC Yeoh, D Krisnan, K Bhojwani. Health-Related Quality Of Life Of Malaysian Patients With Chronic Non-
Malignant Pain And Its Associated Factors: A Cross-Sectional Study. BMC Musculoskeletal Disorders (2022) 23:400.
https://doi.org/10.1186/s12891-022-05354-1
5.
Chii-Chii Chew, Xin-Jie Lim, LL Low, KM Lau, M Kari, UK Shamsudin, Philip Rajan. The challenges in managing the
growth of indigenous children in Perak State, Malaysia: A qualitative study. PLoS ONE 17(3): e0265917.
https://doi.org/10.1371/journal.pone.0265917.
6.
Lim Xin Jie, Philip Rajan, Teh HM, Raja FB, Tan JN. Analysis of pediatric cochlear implant candidacy: Single center,
retrospective observational study. Med J Malaysia. 2022 Mar; 77(2):143-149. PMID: 35338619.
7.
Aie Yen Tan, Chee Tao Chang, Yong King Yu, Yi Xin Low, Najah Fatehah Mohd Razali, Sui Yan The, Shaun Wen Huey
Lee. Adverse Events Following BNT162b2 mRNA COVID-19 Vaccine Immunization among Healthcare Workers in a
Tertiary Hospital in Johor, Malaysia. Vaccines. 2022; 10(4):509. https://doi.org/10.3390/vaccines10040509.
8.
Shea Jiun Choo, Chun Zheng Ng, Yi Jing Ong, Kamariah Shamsinar Kamarul Baharin, Chee Tao Chang. Intravenous
human immunoglobulin utilization patterns and cost analysis in a Malaysian tertiary referral hospital. J of Pharm
Policy and Pract 15, 31 (2022). https://doi.org/10.1186/s40545-022-00430-2.
9.
Fun Wee Hoo, Chee Tao Chang, Mohd Haz Hairul Amran. Home parenteral nutrition during the COVID-19
pandemic: Experience in a tertiary referral hospital in Malaysia. Clin Nutr. 2022 Mar;41(3):630-631. doi:
10.1016/j.clnu.2022.01.013.
10.
Chee Tao Chang, Xin Jie Lim, Premaa Supramaniam, Chii Chii Chew, Lay Ming Ding, Philip Rajan. Perceived Gap of
Age-Friendliness among Community-Dwelling Older Adults: Findings from Malaysia, a Middle-Income Country. Int J
Environ Res Public Health 2022; 19(12):7171. https://doi.org/10.3390/ijerph19127171.
11.
Shea Jiun Choo, Chee Tao Chang, Balamurugan Tangiisuran, Mohd Faiz Abdul Latif, Nor Aida Sanusi, Sabariah
Noor Harun. Abstinence Rate, Adverse Events and Withdrawal Symptoms after Varenicline Use and Predicting
Factors of Smoking Abstinence: A Multicentre Single-State Study in Malaysia. Int J Environ Res Public Health. 2022
Jun 24;19(13):7757. doi: 10.3390/ijerph19137757
12.
Lim SCL, Hor CP, Tay KH, Anilawati MJ, Tan WH, Ker HB, Chow SC, Masliza Z, Cheah WK, Lim HH, Khalid KE, Cheng
JT, Mohd-Unit H,AN N, Nasruddin AZ, Low LL, Khoo SW, Loh JH, Zaidan NZ, Ab-Wahab S, Song Li Herng, Koh HM,
King TL, Lai NM, Chidambaram SK, M. Peariasamy K. Efficacy of Ivermectin Treatment on Disease Progression
Among Adults with Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial. JAMA
Intern Med. 2022182(4):426-435. doi:10.1001/jamainternmed.2022.0189
13.
Chang, C.T., Ong, S.Y., Lim, X.J., Chew, L.S. and Rajan, P. Managing nirmatrelvir/ritonavir during COVID-19:
pharmacists’ experiences from the Perak state of Malaysia. Journal of Pharmaceutical Policy and Practice15
(1).doi:10.1186/s40545-022-00469-1.
PUBLICATION
CRC, HRPB Ipoh
Page 22
List of Publication CRC HRPB 2022

Cont. Publication
CRC, HRPB Ipoh
Page 23
No. Publication Details
14.
Chii‑Chii Chew, Hasni‑Adha Ibrahim, Venugopalan K. Balan, Nor‑Azizah Abd‑Aziz, Hooi‑Meng Puah And Amar‑Singh
HSS. Growth management and prevalence of underweight of indigenous children (Orang Asli) in Peninsular
Malaysia: a clinical audit. BMC Pediatrics (2022) 22:481. https://doi.org/10.1186/s12887-022-03532-7.
15.
Lai, Q.X., George Visuvasam D., Loh C.L., Satday Singh A.K., Ang J.Y. Serum Concentration and Clinical Outcomes of
Weight-Based and Conventional One-Gram Loading Dose of Vancomycinin in End-Stage Kidney Disease Patients.
Perak Medical Journal, 2(1), Pp. 43. Available at: https://myjms.mohe.gov.my/index.php/pmj/article/view/7096Date
accessed: 10 Oct 2022. NMRR-13-1049-17806.
16.
Low, L.L., Tong, S.F., Ang, J.Y., Abdullah, Z., Hamid, M.A., Risman, M.S., Wong, Y.T., Jamalul-lail, N.I., Chelladorai, K.,
Tan, Y.P., Tay, Y.L., Nordin, A.A. and HSS, A.-S. Social responsibility perspective in public response to the COVID-19
pandemic: a grounded theory approach. BMC Public Health, 22(1). doi:10.1186/s12889-022-12819-4.
17.
Ashamuddin N.A., Mohd Noor S., Dzulkafli A., Daywipragas S., Balakrishnan T., Osman A., Ang J.Y. HIV among Blood
Donors in Perak, Malaysia: A Review from 2015 to 2019. Asian Journal of Medicine and Health Sciences, 5(1), pp.13-
24. NMRR -20-1427-55339.
18.
Chee Tao Chang, Chern Choong Thum, Xin Jie Lim, Chii Chii Chew, Philip Rajan. Monkeypox outbreak: Preventing
another episode of stigmatisation. Tropical Medicine & International Health, 27(9), pp.754–757.
doi:10.1111/tmi.13798.
19.
SH Lee, ZX Yeoh, IS Sachlin, N Gazali, SA Soelar, CY Foo, LL Low, SB Syed Alwi, TM Izam Tengku K, J S, M Zaid, CY
Wong, HH Chua, S Yusuf, D Muhamad, Philip Rajan Devesahayam, HB Ker, Z Salahuddin, M Mustafa, H Sawali, HG
Lee, S Din, NA Misnan, A Mohamad, MN Ismail, C Periasamy, TS Chow,EK Krishnan, CL Leong, PF Lim, NZ Zaidan,
MZ Ibrahim, SA Wahab, SS Mohd Hashim & Malaysian, COVID-19 Anosmia Research Group. Self‑reported
symptom study of COVID‑19 chemosensory dysfunction in Malaysia. Sci Rep. 2022 Feb 8;12(1):2111. doi:
10.1038/s41598-022-06029-6.
20.
Noryantimarlina Abdullah, and Basyariatul Fathi Othman, and Kartini Ahmad, and Philip Rajan Devesahayam, and
Yazmin Ahmad Rusli, (2022) Perkembangan bahasa dan pertuturan kanak-kanak Melayu pengguna implan koklea
di bawah Program Implan Koklea Kebangsaan, Kementerian Kesihatan Malaysia. Jurnal Sains Kesihatan Malaysia,
20 (1). pp. 37-50. http://dx.doi.org/10.17576/JSKM-2022-2001-04.
21.
Yee Ho Hwee, Philip Rajan Devesahayam. Skull Base Osteomyelitis: A rare case. Perak Medical Journal, 2(1).
Available at: https://myjms.mohe.gov.my/index.php/pmj/article/view/7096Date accessed: 10 June 2022.
22.
Kugan V, Purushotman R, Philip Rajan Devesahayam. An Atypical Presentation of Nasopharyngeal Carcinoma – A
Case Report. 2022 Perak State Health Department Technical Report, pg 70. MOH/P/PK 24:22 (TR). ISSN 2785-9428.
23.
Chii‑Chii Chew, Chee‑Tao Chang, Xin‑Jie Lim, Wai‑Yin Yong, Doris George, Pathma Letchumanan, Philip Rajan, Chee
Ping Chong. The management of allergic rhinitis by pharmacists in public services: a proposed PhaRmacISt‑led
Education Model (AR‑PRISE). Journal of Pharmaceutical Policy and Practice (2022) 15:80.
https://doi.org/10.1186/s40545-022-00477-1.
24.
Chee Tao Chang, Xin-Jie Lim, Chii-Chii Chew, Philip Rajan, Huan-Keat C, Muhammad Radzi AH, Asrul Akmal S,
Shaun Wen Huey L. Preferences and willingness of accepting COVID-19 vaccine booster: Results from a middle-
income country. 2022 Dec 12; 40(52): 7515–7519. https://doi.org/10.1016/j.vaccine.2022.10.057.
25.
Chang Chee Tao, Xin‑Jie Lim, Awatef Amer Nordin, Chern Choong Thum, Sondi Sararaks, Kalaiarasu Periasamy and
Philip Rajan. Health system preparedness in infectious diseases: perspective of Malaysia, a middle‑income
country, in the face of monkeypox outbreaks. Tropical Medicine and Health (2022) 50:87.
https://doi.org/10.1186/s41182-022-00479-4
26.
Arvinder Singh HS, Pei-Ling Foo, Chii-Chii Chew, Simarjeet-Singh Dhillon. Prevalence and barriers of reporting
needle-stick injures amongst government pharmacists working in Perak, Malaysia. Med J Malaysia Vol 77 No 6
November 2022.

CRC HRPB families 2022
The
Charismatic
Physician
Dr. Sharon Linus Lojikip
Dr. Leong E Li
Dr. Lim Xin Jie
Dr. Chow Lai
Yeng
Dr. Nur Sabrina
Abd Rahim
Dr. Josephine
Paul Durai
Dr. Devin Kumar
Dr. Siti Nabilah
Mohamad Zaini
Dr. Muhd Nuh
Idy Razlan THE APOTHECARIES
ACE
Ang Ju Ying
Datin Dr. Harpreet
Kaur Harbans Singh
The Number
Maniacs
Premaa
Supramaniam
The Pillar
Lina Hashim
Ooi Siew Har
The ISR Consul
THE STEP-ING'S STARS
Revathe Rajendran
Norharjiana
Surianti
Wan Ainor Syahdah
Wan Hassan
Gregory Domnic
Swarnaletchumi
Kanapathy
NoorSyamimi
Mhd Akhir
Choong Jing Wei
Aisyah Ahmad
Shadzili Suria Junus
Thinessha
Muruthi
Ruth Merry
Chang Chee Tao
Chew Chii Chii
Good Luck in your study
D'Boss
Dr. Philip Rajan
Dr. Philip Rajan
Dr. Philip Rajan
Devesahayam
Devesahayam
Devesahayam
Page 24
Chin Ei Wei
Hasni
Adha
Dr. Billy Song
Thian
Zu
Juin
Suniljeet
Singh
Nor Aizura
Zulkifli
The
Numerophile
Sis

A. Number of staff in CRC/CRM Hospital Taiping
CRC staff
Pharmacist 2 2 2
Research officer (RO) 1 1 1
Assistant research officer - - -
Allied health 1 1 1
Temporary staff (PSH)/MySTEP
available until Dec
0 1 1
NMRR
registration
No. of research/Case studies/Clinical audit registered 16 20 17
No. of research/Case studies/Clinical audit projects with ethical
approval
16 19 17
Research
consultation
No. of consultations (episodes) provided 57 57 58
Proposal
review
No. of proposals reviewed by the Hospital Research Review
Committee (HRRC)
17 9 26
Publication &
presentation
submitted to
CRC Taiping
No. of application of publication in local/international journals 9 6 4
No. of application of oral/poster presentation 3 3 16
Training /
Conference
No. of training workshops organised 11 3 11
No. of Ministry of Health staff trained 241 32 311
Clinical Research Centre,
Hospital Taiping
"Coming together is a beginning.
Keeping together is progress. Working
together is a success". - Henry Ford
Summary Report: Research Performance of
CRC Hospital Taiping
CRC Hosp. Taiping available staff
Head of Dept.:
Dr. Cheah Wee Kooi
-2 Medical officers
-2 Pharmacist
-1 Research officers
-1 Allied Health
-2 CRM study coordinator
Page 25
C. Industry Sponsored Research (ISR) 2020 2021 2022
Clinical
trials
10
1
14
1
11
2
~The expert in everything was one a beginner~
CRC, Hospital Taiping

D. Investigator Initiated Research (IIR) Projects and Output 2020 2021 2022
IIR projects
No. of research projects initiated by CRC and/or in
4 2 5
Publications
No. of published articles in local/international journals
9
0
6
1
7
3
Presentation
0
3
1
2
2
0
No. Article details
1.
Ng, L.Y.; Chin, C.J.; Danial, M.; Albart, S.A.; Suppiah, P.D.; Ganasegeran, K.; Tan, W.T.; Hoo, H.E.; Teh, E.E.;
Karupiah, G.; et al. Validation of the Visual Cognitive Assessment Test (VCAT) for the Early Diagnosis of
Cognitive Impairment in Multilingual Population in Malaysia.Psych2022,4, 38–48.
2.
Lim SCL, Hor CP, Tay KH, et al. Efficacy of Ivermectin Treatment on Disease Progression Among Adults
With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial. JAMA Intern
Med.
3.
Tay CL, Ng WL, Beh HC, Lim WC, Hussin N. Screening and management of osteoporosis: a survey of
knowledge, attitude, and practice among primary care physicians in Malaysia. Arch Osteoporos. 2022
Apr 26;17(1):72. doi:10.1007/s11657-022-01111-y.
4.
Wang XY, Mahmood SF, Jin F, Cheah WK, Ahmad M, Sohail MA, Ahmad W, Suppan VK, Sayeed MA,
Luxmi S, Teo AH, Lee LY, Qi YY, Pei RJ, Deng W, Xu ZH, Yang JM, Zhang Y, Guan WX, Yu X. Efficacy of
heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein
vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial. Emerg Microbes
Infect. 2022 Jun 10:1-44.
5.
Tan MP, Leong CL, Pang YK, Razali RM, Ismail AI, Sam I-C, Abdul Rani R, Chong J, Mohd Zim MA, Musa
AN, Leong JH, Idris S, Khor J, Cheong A, El Guerche-Séblain C, Hasmukharay K, Arumugam M, Khalid KE,
Ismail I and Cheah WK. (2022). Dearth of influenza among older adults admitted with respiratory
symptoms in Malaysia during the coronavirus disease 2019 pandemic in 2021.Front. Med. 9:977614.
6.
Narwani H, Sreevali M, Chan W.S., Nurul N.J. Diabetic Control among Type 2 Diabetes Mellitus (T2DM)
Patients before and after the Implementation of Movement Control Order (MCO) due to COVID-19
Pandemic. Asian Journal of Medicine and Health Sciences Vol 5 Issue 2 November 2022.
7.
Mohammad M.A.A., Narwani H., Chng X. Y., Osman A. Timeliness of Interhospital Patient Transfer (IHT)
within Hospital Kluster Perak Utara, Malaysia. Asian Journal of Medicine and Health Sciences Vol 5
Issue 2 November 2022.
It is always the simple that produces the marvelous by Amelia Barr
List of Publication January – December 2022
Page 26

MEET THE CREW:
CRC HOSPITAL TAIPING
No. Name Award/achievement details in 2022
1. Chua Kin Wei
3rd place CRC oral presentation in Perak Research Conference 2022 for study title
Evaluation of the Tolerability and Effectiveness of Tenecteplase in Patients with ST-Segment
Elevation Myocardial Infarction in A Secondary Hospital in Malaysia: A Retrospective Case Series
Page 27
C
R
C
Dr Narimah Bt Yusof
Dr Cheah Wee Kooi,
Head of CRC
Dr Narwani Hussin,
Deputy Head
Chan Wai Seong
Christopher
Prema Muninathan,
Research Officer
H
o
s
p
it
a
l
D
ir
e
c
t
o
r
Pharmacist
Chua Kin Wei,
Pharmacist
Dr Rosilawatii Abdul Rani,
Medical Officer
Nur Fatin Raihanah,
CRM SC
Siti Suraya, CRM SC
Sreevali Muthuvadivelu,
Registered Nurse

CRC Hospital Seri
Manjung available staff
Head of Dept.:
Dr. Nga Shih Hang
-1 Medical officers
-1 Pharmacist
-1 Allied Health
-2 CRM study coordinator
SUMMARY REPORT: RESEARCH PERFORMANCE
OF CRC HOSPITAL SERI MANJUNG
Hospital
Seri
Manjung
CLINICAL RESEARCH CENTRE
A. Number of staff in CRC/CRM Hospital Seri Manjung
CRC staff
Pharmacist 1 1 1
Research officer (RO) - - -
Assistant research officer - - -
Allied health 1 1 1
Temporary staff (PSH)/
MySTEP available until
Dec
1 1 0
"It always seems
impossible until it's
done" - Nelson Mandela
Page 28
NMRR
registration
No. of research/Case studies/Clinical audit registered 10 18 27
No. of research/Case studies/Clinical audit projects with ethical
approval
11 11 11
Research
consultation
No. of consultations (episodes) provided 432 499 489
Proposal
review
No. of proposals reviewed by the Hospital Research Review
Committee (HRRC)
6 16 18
Publication &
presentation
submitted to
CRC Taiping
No. of application of publication in local/international journals 8 8 7
No. of application of oral/poster presentation 0 2 10
Training /
Conference
No. of training workshops organised 2 4 9
No. of Ministry of Health staff trained 103 133 589

C. Investigator Initiated Research (IIR) Projects and Output 2020 2021 2022
IIR projects
No. of research projects initiated by CRC and/or in
19 21 23
Publications
No. of published articles in local/international journals
3
3
4
1
1
4
Presentation
0
4
3
4
5
5
D. Industry Sponsored Research (ISR) 2020 2021 2022
Clinical trials
9
2
11
2
12
9
No. Publication details
1.
Idris, I., Mafauzy, M.M., Baharuddin, K.A., Alwi, F., Mohamad, W.S., 2022. Localized tetanus
mimics acute perforated viscus: A diagnostic challenge and review of case reports. Turk J
Emerg Med, 22(4), pp. 226-229.
CRC Hospital
Seri Manjung
Page 29
2
0
2
2
Award
Ms. Chiew Shoen Chuen
has won the Best
Presentation Award
(among the CRC's Oral
presentation) in the
Perak Annual Medical
Research Conference
2022, for the study title
of Are Malaysian
Children Aware of Their
Rights?

CRC H. Seri Manjung
Consultation
Research Training
Publication
"Success is best
when it's shared"
Page 30
Hospital Seri Manjung Squad
Moving
Moving
Moving
forward
forward
forward
together
together
together
Dr Nordin b. Nasir
Hospital Director
D
r
N
g
a
Shih Hang
(
H
O
D
)
Azirah Osman,
SC CRM
Dr Farah Alwi
Deputy CRC
Dr Zarina Fuad
Deputy Director
Sn. Norsarlizna
Mat Sari
(CRC Manager)
Chiew Shoen Chuen
(Pharmacist)
Lailye Zuraida Abu
Bakar, SC CRM
Dr Ting Siew Ying
(Medical Officer)
The strength of the team is
each individual member.
The strength of each member is
the team.~ Phil Jackson

FUTURE PLAN
CRC HRPB, Ipoh
Future Plans Issues Updates [Year 2022]
Research
Infrastructure
and Space
Hospital Director agreed to let CRC HRPB to
take over the old nursing college administrative
block.
Meeting with Hospital director, CRM and
CRC on the application for funds from CRM
for refurbish works.
We had put up application for RMK,
unfortunately till today we have not received
any feedback.
Request for renovation of old nursing
college to set up ISR facilities for
allocation from CRM.
Early of 2021, CRC HRPB also submitted to Unit
Pembangunan to apply for Pembangunan
warrant to renovate the building but we have
not received any update from them.
No further updates.
Total allocation RM324,740.00 applied through
Pemohonan Peruntukan BP06000 (naiktaraf,
ubahsuai dan pembaikan)
Need to perform budgeting estimation due
increase of cost.
Large-scale
Nationwide
Research
Projects
Investigator Initiated Research (IIR):
i. Ageing Friendly City Project (within Perak State):
Ipoh has been successfully registered as a
member the WHO’s Global Network for Age-
friendly Cities and Communities in Dec 2019.
A mixed method study exploring the view of
elderly and their caregivers was initiated in Feb
2020. Quantitative baseline survey started in
Health clinics in Kinta District, social events in
Ipoh since Feb 2020. Awarded with NIH grant.
2020: Data collection expected to resume after
hiring temporary staffs (Pekerja Sambilan
Harian - PSH).
2021: Quantitative baseline survey: Manuscript
writing & Qualitative telephone interviews were
conducted
Presentation to stakeholders:
• The Mayor, Ipoh City Council (April 2022 &
September 2022)
• The Perak State Health Director (April
2022)
Publication:
Published 1 article in International Journal
of Environmental Research and Public
Health
DOI: 10.3390/ijerph19127171.
Presentation:
1.Oral:
• Bengkel Pembangunan Keupayaan ke
Arah
Bandar dan Komuniti Mesra Usia di
Malaysia
(April 2022)
• The National Conference on Ageing 2022
(October 2022)
2.Poster:
Best poster Award – 15th NCCR (National
Conference for Clinical Research 2022)
ii. Pneumococcal surveillance study:
A collaborative study was initiated between CRC
HRPB and Paediatrics Department of HRPB to
study on the Invasive Pneumococcal Vaccine
Program among children 5 years old and below
admitted into Malaysian Public Hospitals.
Commenced in Dec 2020, thus the multi-sites
surveillance study was carried out. Expected
year of completion is 2026. The study received
funding from GSK.
Current status:
Still on-going. Monitoring Phase.
iii. Clinical audit on Malnourished Orang Asli Children:
Currently, the intervention is in progress to
identify the root-causes via qualitative Focus
Group Discussion (FGD) and in-Depth interview
(IDI) among healthcare providers of Mobile
Team Orang Asli Services.
2020 & 2021: Qualitative FGD and IDI
Presentation to stakeholders:
• Nutrition Department, Ministry of Health
Malaysia (Bahagian Pemakanan, Jabatan
Kesihatan Awam) September 2022
Publication:
1 article published in PLoS One
DOI: 10.1371/journal.pone.0265917
A L L C R C ' S
S U M M A R Y O F I S S U E S A N D F U T U R E P L A N S F O R C R C H R P B
Page 31

CRC HRPB, Ipoh
Large-scale
Nationwide
Research
Projects
Investigator Initiated Trial (IIT):
Randomized Control Trial - VICSEL (Vitamin C):
Collaboration between CRC HRPB, Medical
and Anaesthesiology & Intensive Care
Department of HRPB involving multicentre
in Peninsular Malaysia.
2020: Protocol development
2021: MREC approval, CTX and Grant
application in progress
Current status:
Pending MREC approval
Registry:
Drowning registry:
On-going registry for the paediatric
population (<18 years). There is a plan to
include adult population in the registry.
2021:
• Suspended plan to include adult
population in the registry
• Plan to collate 2 years for report
Current status:
• The inclusion of adult population into the
registry did not materialise because there is
a lack of funding for dedicated system and
human resource from VIP Unit, MOH.
• Still on-going. Data collection and analysis
to produce report by early next year 2023.
Investigator Sponsored Research (ISR) - Hybrid / Collaboration:
i. Randomized, Double -Blinded, Placebo
Controlled Phase III Clinical Trial for the
Evaluation of Efficacy and Safety of SARS-
CoV-2 Vaccine, Inactivated (Vero Cell) in
Healthy Population Aged 18 Years and
Above in Malaysia
Extended:
A Multi-centre, Randomized, Double-blind,
Placebo-controlled Phase III Clinical Trial
to Evaluate the Efficacy, Immunogenicity
and Safety of COVID-19 Vaccine (Vero Cell),
Inactivated Booster Dose in Adults Aged 18
Years and above
Current status:
Study document sent for archive.
ii. Ivermectin Treatment Efficacy in Covid-
19 High Risk Patients (I-TECH Study): A
Multicentre Open-label Randomized
Controlled Clinical Trial
1 article published in JAMA Internal Medicine
DOI: 10.1001/jamainternmed.2022.0189
Covid-19 related studies by CRC staffs:
Published 16 Covid-19 related articles in
year 2020-2021
A total of 21 Covid-19 related studies were
conducted:
• Published – 3
• Data analysis – 6
• Data collection – 10
• NMRR registration - 2
Dissemination of
Research
Findings and
Translation into
Practice
i. CRC bulletin:
CRC bulletin was published electronically to
publicize the past, present and future
research activities and updates in Perak by
CRC HRPB, CRC Taiping and CRC Seri
Manjung.
Bulletin was produced quarterly since 2019.
Plan to produce biannual bulletins starting
2020.
2021: Published Issue 04
Current status:
• Plan to produce annual bulletins starting
2022.
• Current issue in progress with added
features:
1) To promote Perak Annual Medical Research
Centre Conference.
2) To promote article submission to ePMJ.
F U T U R E P L A N C O N T .
Page 32

CRC HRPB, Ipoh
Dissemination of
Research
Findings and
Translation into
Practice
ii. Electronic Perak Medical Journal (e-PMJ):
Electronic Perak Medical Journal (e-PMJ)
was an initiative to capture studies
conducted by Perak state researchers and
to increase the visibility of researches
conducted in the region
Two conference proceedings were
published:
• 11th ASEAN & 8th Perak Health Congress
on Primary Health Care, June 2019; Volume
1, Special Issue 1 (20 abstracts)
• Perak Research Conference, August 2019;
Volume 1, Special Issue 2 (53 abstracts)
Published the first issue of full articles
Volume 2, Issue 1 (14 articles), August 2022:
One conference proceeding was published:
• 12th Annual Malaysian Rehabilitation
Medicine Conference, July 2022; Volume 2,
Supplement 1 Conference Proceedings of 24
abstracts
Two conference proceedings will be published:
• 12th ASEAN & 9th Perak Health Congress on
Primary Health Care, August 2022; Volume 2,
Supplement 2 Conference Proceedings of 28
abstracts
• Perak Research Conference, October 2022;
Volume 2, Supplement 3 Conference
Proceedings of 19 abstracts
On-going acceptance and peer-review of new
articles submitted to ePMJ.
iii. Request from Dewan Bahasa & Pustaka (DBP):
Use of infographic from research output
for the publication of the revised Primary
School Standard Curriculum (KSSR)
textbook, revision 2017 for use starting in
2022.
[Study: Is Our Child Safe on the Escalator?
NMRR-16-2191-33056]
Not related
Staff
Development and
Training
Current in-house human capacity:
• Completed Master – 2 staffs
• Pursuing Master – 3 staffs
• CRM – 6 staffs
• Completed PHD – 1
• Pursuing PHD – 2
• Completed Masters – 3
• Pursuing Masters – 3
• Completed Degree – 1
• CRM staffs – 7 staffs
Training & workshop:
• Successfully conducted virtual trainings
using Google Classroom & Zoom platform in
year 2021.
• External trainer for research
brainstorming for Institut Latihan
Kementerian Kesihatan Malaysia (ILKKM)
Sultan Azlan Shah for undergraduates.
• More workshops with external experts to
be conducted on health economics,
advanced statistical analyses, EQ5D,
questionnaire validation, outcome
translation & qualitative thematic analysis.
• Successfully conducted thematic analysis,
pharmacoeconomics, NMRR, research and
statistics trainings / workshops.
• Invited Prof. Dr. Adi Negara for
Questionnaire Validation & Sample Size
Calculation Workshops.
• Co-organiser for Clinical Audit workshop
series with Paediatric Dental.
• External trainer for proposal writing
workshop – Hospital Slim River and Hospital
Teluk Intan.
• External reviewer for the Dental Health
Systems Research Review Meeting.
• Conducted a series of 15 in-house CREs.
Staff
Requisition
• Request for additional hospital posts as
listed below:
i. Pembantu Tadbir (N19) to assist in CRC
daily administrative activities.
ii. Contract Research Officer posts.
• Due to insecurity of PSH and MySTEP
positions and turnover of CRC HRPB well-
trained staffs left the organization to
obtain secure post.
No further updates. Currently hiring contract
staff (MySTEP) to facilitate CRC HRPB
administrative tasks.
To accelerate the application and approval
for MySTEP staffs due to the need to
conduct research projects.
Identify an in-charge person in JKN Perak
to work with CRC Hospital pertaining
MySTEP hiring process.
No further updates.
Page 33

CRC HRPB, Ipoh
Issues
i. Research focus & consultation:
CRC HRPB is emphasizing in the transition
in a new direction to achieve the units’
mission and vision. Below are the
strategies:
• Involvement in collaborative research
projects with clinicians especially with
Public Health and/or Dental (Research
Camps).
• Consultative services limited to segmental
consultation and committed involvement
through collaborative studies with
clinicians.
• Focus more on the translational studies so
that research findings can be translated
into the services.
• Involved in Covid-19 studies (public
health).
• Invited as facilitators for Bengkel
pembentangan Kertas Kerja Health System
Research, Perak State Oral Health Division,
2021.
Initiation of research projects through
collaboration:
• Research collaboration with departments in
Hospital.
• Research collaboration between CRCs in
Perak State.
Initiation of Health System Research projects
at Perak State level.
ii. Clinical audit:
Clinical audit is not under CRC HRPB.
Clarified with HRPB QA unit, that Clinical
Audit should be handled by the Hospital
Quality Unit.
CRC HRPB committed to assist as
trainer/facilitators for clinical audit
workshops and trainings.
Co-organised Clinical Audit 3-series workshop
with Perak State Paediatric Dental
Department.
iii. Calibration and maintenance of ISR related equipment:
Discussed the calibration matters with
CCRN ICR.
Feedback from KSU: all equipment under
CRC Hospital should be maintained and
calibrated using the organisation
operational budget.
KSU agreed to provide more allocation for
calibration if necessary.
No further update.
iv. Research census in Perak:
• To identify the mechanism to capture
research conducted in Perak:
i. To capture research conducted in Perak
via NMRR
ii. Feedback from District & Health Clinics
iii. ISR through CRM
iv. Others
• The research activities to be captured for
the following:
i. New research
ii. On-going research
iii. Completed research
iv. Dissemination of research findings
through publication & presentation
The upgraded version 2 of the NMRR system,
disabled the generation of census reports
through the system. Thus, research report
was generated using conventional data
collection via departments, internal records
and KPI reporting.
Page 34
"Planning Is Bringing The Future Into The Present So That You Can Do Something About It Now"
~ Alan Lakein

FUTURE PLAN
CRC Hospital Taiping
Future Plans CRC Hospital Taiping CRC Hospital Seri Manjung
Research
Infrastructure
and Space
Purchasing of -80 Degree
Celsius freezer
To apply for budget for purchasing of the following:
i. ECG Machine, Model CR150 Brand: Welch Allyn
ii. Mindray Beneheart D3 With Pacer Defibrillator
Machine with Emergency Trolley
iii. Centrifuge (Refrigerated), Brand: Eppendorf
iv. Mini Centrifuge (Non-Refrigerated), Brand:
Hettich
v. -40 PHCbi Biomedical Plasma Freezer
vi. Spot Vital Sign (NIBP) Mediana
vii. Heartsine Samaritan Defibrillator AED
viii. 2 laptops
ix. 2 laser printers
Large-scale
Nationwide
Research
Projects
• Collaboration with Public
Health in environmental health
• Collaboration with ILKKM on
research projects
To publish the following research projects in journal:
i. Clinical and Computed Tomographical Patterns of
Pulmonary Thromboembolic Disease associated with
COVID-19 Infection: A Tertiary Hospital Analysis.
ii. Survival Analysis of Pulmonary Thromboembolic
Disease associated with Covid-19 Infection: A
Comparison between Geriatric and Non-geriatric
Populations.
iii. Are Malaysian children aware of their rights?
iv. Moral Distress among Healthcare Professionals in
Malaysia during the COVID-19 Pandemic.
To involve in the following nationwide research:
i. Knowledge, Attitude and Practice Regarding
Clinical Research Among Researchers from
Government Hospitals and Institute for Clinical
Research, Malaysia.
ii. The rate of blood culture contamination and
common organisms isolated in Malaysian Public
Hospitals.
Dissemination
of Research
Findings and
Translation
into Practice
• ICPEP - pending sponsor
approval
• Burnout among nurses -
pending publication
• 10 on 10 - pending publication
To sponsor publication of good quality research
papers in journal for CRC staffs.
Staff
Development
and Training
TGP Training - 1
Application for Masters - 2
Application for PhD - 2
Training on audit MSQH/ ISO - 1
Training for Clinical Trial
Management - 1
Training for Qualitative
Research - 1
Attending research related
training as needed.
To sponsor and facilitate research-related training
for CRC and hospital staffs (virtual and physical).
To conduct the routine workshops as planned in 2023.
Staff
Requisition
2 Medical Officer
1 MyStep Personnel
NIL
A L L C R C ' S
S U M M A R Y O F I S S U E S A N D F U T U R E P L A N S F O R
C R C H O S P I T A L T A I P I N G A N D S E R I M A N J U N G
Page 35
CRC Hospital Seri Manjung
"The future Does Not Get Better By Hope, It Gets Better By Plan. And To Plan
For The Future We Need Goals" ~ Jim Rohn

2 0 2 2 S U M M A R Y O F E V E N T
C L I N I C A L R E S E A R C H C E N T R E , H O S P I T A L S E R I M A N J U N G
P A G E 3 6
2 0 2 2 E V E N T
C R C , H O S P I T A L S E R I M A N J U N G
A) PROPOSAL WRITING WORKSHOP B) BASIC BIO-STATISTICS WORKSHOP
C) INTRODUCTION TO CLINICAL
RESEARCH WORKSHOP
Date: 21st February 2022
Time: 2.00 pm - 5.00 pm
Place/Platform: Zoom Meeting
Speaker:
Dr. Ting Siew Ying &
Total Participants: 33
Date: 7th – 8th March 2022
Time: 8.00 am - 5.00 pm
Speaker:
Dr. Ting Siew Ying,
Ms. Chiew Shoen Chuen,
Dr. Leong E Li (CRC HRPB),
Ms. Premaa Supramaniam (CRC HRPB),
Ms. Suria Junus (CRC HRPB).
Date: 28th – 29th March 2022
Time: 2.00 pm - 5.00 pm
Speaker:
Dr. Nga Shih Hang (CRC HSM),
Dr. Chang Meng Lee (Medical Dept. HSM),
Dr. Ting Siew Ying (CRC HSM),
Ms. Chiew Shoen Chuen (CRC HSM),
Mr. Gobi Hariyanayagam Gunasekaran
(Pharmacy Dept. HSM),
Ms. Lailye Zuraida Bte Abu Bakar (CRM, HSM).
Date: 25th April 2022
Time: 2.15 pm - 4.30 pm
Speaker:
Dr. Ting Siew Ying,
D) NMRR REGISTRATION WORKSHOP
E) GOOD CLINICAL PRACTICE
WORKSHOP - HYBRID
Zoom Meeting (Lecture)
Open University Malaysia (OUM) Manjung
Date: 23rd – 25th May 2022
Time:
8.00 am - 5.00 pm (Day 1 & 2) - Lecture
8.00 am - 10.30 am (Day 3) - Lecture
2.00 pm - 3.00 pm (Day 3) - Exam
Place/Platform:
Learning Centre (Exam)
Speaker:
Dr. Nga Shih Hang (CRC HSM)
Dr. Chang Meng Lee (Medical department, HSM)
Ms. Aarti Devi Ram Dev (Clinical Management, PPD Malaysia)
Dr. Cheah Wee Kooi (CRC Hospital Taiping)
Dr. V Paranthaman a/l P. Vengadasalam (PKD Kinta)
Ms. Safiya Mohd Razif (NPRA)
Mr. Ahmad Izwan Abdul Rani (NPRA)

2 0 2 2 E V E N T
C R C , H O S P I T A L S E R I M A N J U N G
Date: 16th –17th August 2022
Time: 8.00 am - 5.00 pm
Speaker:
Professor Dr. Adinegara Bin Lutfi Abas
(Manipal University College, Malaysia)
H) SAMPLE SIZE CALCULATION FOR
RESEARCH WORKSHOP
Date: 6th September 2022
Time: 8.00 am - 5.00 pm
Place/Platform: Auditorium, Hospital
Raja Permaisuri Bainun, Ipoh
Detail:
Jointly organized with CRC HRPB, CRC
Hospital Taiping, JKN Perak and
Sponsored by PGMES
I) PERAK ANNUAL MEDICAL RESEARCH
CONFERENCE
YEAR 2023
F E B M A R A P R M A Y J U N J U L
7
23 feb
29
13
30
8 mar 9 may
25
12
apr
24
12 apr
9 mar
6 - 8 JUN
26 JUN
11 JUL
4
27
12 JUL
9
11
apr
31
A U G
16 AUG
12
5
U P C O M I N G E V E N T
CLINICAL RESEARCH CENTRE, HOSPITAL SERI MANJUNG
Basic Bio-
statistics
Workshop
Proposal
Writing
Workshop
Introduction
to
Clinical
Research
Workshop
O C T
Basic Bio-
statistics
Workshop
1
NMRR
Registration
Workshop
G
o
o
d
C
l
i
n
i
c
a
l
P
r
a
c
t
i
c
e
W
o
r
k
s
h
o
p
1
/
2
0
2
3
Pubmed
Search and
Referencing
Scientific
Writing
Workshop
Scientific
Writing
Workshop
Sample Size Calculation
for Research
To be announced
Perak Annual
Medical
Research
Conference
28
23 - 25
oCT
G
o
o
d
C
l
i
n
i
c
a
l
P
r
a
c
t
i
c
e
W
o
r
k
s
h
o
p
2
/
2
0
2
3
Date: 25th – 26th July 2022
Time: 1.50 pm - 5.00 pm
Speaker:
Dr. Cheah Wee Kooi (CRC Hospital Taiping)
Mr. Chan Huan Keat (CRC Hospital Sultanah
Bahiyah, Alor Star)
G) SCIENTIFIC WRITING WORKSHOP
P A G E 3 7
*Note: This is a tentative events. Any update or changes will be announced by the organizer.
Date: 4th July 2022
Time: 9.00 am - 4.00 pm
Speaker:
Dr. Narwani Hussin
(CRC Hospital Taiping)
F) PUBMED SEARCH & REFERENCING
WORKSHOP

UPCOMING EVENT 2023
Clinical Research Centre, Hospital Taiping
2022,
CRC Taiping
Events Summary
Roadshow to Nearest
MOH Facilities
Protocol
Writing
Workshop,
22-24 March
2022
Intermediate
SPSS
Workshop,
14-15 June
2022
Good Clinical
Practice
Workshop,
21-23 June 2022
Taiping
Research Day,
29 September 2022
Roadshow to
PKD Kerian,
2 June 2022
Roadshow to
PKD LMS,
7 June 2022
P A G E 3 8

TENTATIVE EVENT
FOR THE YEAR
2023
Clinical Research Centre, Hospital Taiping
1 Pubmed Short Training
18 Jan
2023
Event on
2 Introduction to Clinical
Research
20 - 21 Feb
3 Proposal Writing Workshop
To be announced
4 Good Clinical Practice
Workshop
15 - 17 May
5 Basic SPSS Workshop
13 - 15 Jun
6 Google e-form short
Training
22 Jun
7 Manuscript Writing
Workshop
12 - 13 Jul
8 Qualitative Research
Workshop
22 - 23 Aug
9 Intermediate SPSS
Workshop
20 - 21 Sep
P A G E 3 9

Clinical Research Centre, Hospital Raja Permaisuri Bainun
Summary List of CRC HRPB Key Activities in 2022
No Date
Training Offered
& Content
Number of
Participants
Outcomes
Jointly
Organised
1.
11 – 12 Jan
2022
Qualitative Data
Analysis With
ATLAS.ti 9
29
Virtual and Hands-on Training – This course
demonstrates the main functions of ATLAS.ti
for understanding qualitative data through
integration and reporting, practice on how to
analyse different data formats (textual,
images, audio, video, maps) using thematic
coding and learn how to write the findings
based on the visual, textual & numerical
reports of ATLAS.ti.
University
Utara Malaysia
2. 27 Jan 2022
CME Paediatric
department
25
Virtual - Sharing knowledge on how to do a
critical appraisal of the published article
Paediatric
Department
3.
7 – 8 Feb
2022
Basic Bio-
statistics
Workshop
22
Virtual and Hands-on Training –Introduction
to basic statistical methods and data analysis,
Data entry, Data transformation, Descriptive
statistics, Inferential statistics, Strategy in
choosing appropriate statistical test and test
of comparisons.
CRC Seri
Manjung
4. 18 Feb 2022
CME Hospital
Bahagia Ulu
Kinta
30
Virtual – Introduction to clinical research,
Overview of research process, Formulating a
research question, Objective & hypothesis,
Literature review, Ethical issues & IRB, study
designs, Data collection – tool & data
management, basic Statistical analysis –
descriptive & inferential, Measure of effect,
Proposal writing & NIH guidelines.
HBUK
5.
15 Mar 2022
CME Kolej Sains
Kesihatan
Bersekutu
65
Virtual – NMRR Registration with post-basic
student batch 2022
KSKB Ulu Kinta
6.
11 – 12 Apr
2022
Basic Research
Methodology
Workshop
50
Virtual and Hands-on Training -Introduction
to health research, Identification and
prioritization of research problems/areas,
Formulation of objectives, research questions
& hypotheses, Planning the measurements,
Study design options in medical and health
research, Variables, Determination of sample
size, Sampling methods, Data collection
methods and techniques, Ethical issues in
health research and Writing a research
proposal and research registration
CRC HRPB
7.
27 – 28 Apr
2022
Pharmacoecono
mics workshop
47
Virtual and Hands-on Training – Introduction
and principles of pharmacoeconomics,
costings and evaluation, measuring outcome,
type of outcome validity and realibility of EQ-
5D, HUI3, SF-36, Analysis CEA and CUA,
decision tree modelling, markov modelling,
evaluation reporting
National
Pharmaceutical
Regulatory
Agency
8. 29 Apr 2022
CME Hospital
Raja Permaisuri
Bainun
360
Virtual – Introduction to NMRR website.
Update on the new version of NMRR V2.0.
Sharing on the guideline research
registration and ethical submission in NMRR
website. Document required for the
submission and lastly the timeline for
approval.
ICT HRPB
9. 19 May 2022
NMRR hands-on
online course
57
Virtual – Introduction to NMRR registration.
Update on the new version of NMRR V2.0.
Hands-on training for register NMRR account
and research registration.
CRC HRPB
P A G E 4 0

Clinical Research Centre, Hospital Raja Permaisuri Bainun
Cont. Summary List of CRC HRPB Key Activities in 2022
No Date
Training Offered &
Content
Number of
Participants
Outcomes Jointly Organised
10. 1 Jun 2022
Clinical Audit
Workshop
26
Virtual – Introduction to Clinical Audit,
How to Perform Clinical Audit: 5 stages
approach – Stage 1: Plan for the audit,
Stage 2: Select standard and criteria,
Stage 3: Measuring performance, Stage
4: Making improvements and Stage 5:
Sustain improvements. Do’s and don’ts
in Clinical Audit, NMRR Registration,
Proposal presentation by Groups
Paediatric Dental &
State Dental
11.
29 – 30 Jun
2022
Questionnaire
Validation For
Research
36
Virtual – Introduction to questionnaire
validation. To learn and acquire basic
skills in designing questionnaires. To
understand the principles & apply
appropriate tools in dealing with validity
and reliability. Hands on training in
questionnaire’s design and validation.
Manipal University
College Malaysia
12. 20 Jul 2022
Proposal Writing
Workshop
26
Introduction to research, Identification
and prioritization of research
problems/areas, Formulation of
objectives, Hands-on protocol
development and group presentation.
Hospital Slim River
13. 27 Jul 2022
Basic Biostatistics
Workshop
33
Hands-on Training on Introduction to
basic statistical methods and data
analysis, Data entry, Data
transformation, Descriptive statistics,
Inferential statistics, Strategy in
choosing appropriate statistical test and
test of comparisons.
CRC HRPB
14.
16 – 17 Aug
2022
Sample Size
Calculation for
Research
30
Hands-on Training on basic skills of the
utilization and application of sample size
calculation in research and manuscript
writing. The workshop also covers basic
knowledge of types of research
methodology and statistical tools to
assist in determining the appropriate
sample size calculation technique.
CRC Hospital Seri
Manjung
15. 23 Aug 2022
Dental Health
Systems Research
Review
36
Virtual – Introduction to health system
research by CRC HRPB and reviews of 8
new dental health research proposal for
year 2022. The update of 13 on-going
dental health research study by the
participants.
Dental Health
State Department,
16. 6 Sep 2022
Perak Annual
Medical Research
Conference
263
Virtual conference - 20 research projects
conducted in Perak were presented
orally
CRC HRPB, JKN
Perak, HRPB Ipoh,
PGMES Ipoh, CRC
Hospital Taiping,
CRC Hospital Seri
Manjung
17. 24 Nov 2022
Perak State
Research
Committee
Meeting
67
Update on CRC / research activities and
procedures, discussion on the future
plans and needs for research and CRC
development in Perak State
JKN Perak
P A G E 4 1

2023 Upcoming Events
Basic
Research
Methodology
Introduction to
R, Systematic
Review and
Meta-analysis
NMRR
Registration
Workshop
Introduction
to
Epidemiology
28 FEB - 1 MAR 14 - 16 MAR 8 MAY 8 - 9 JUN
FEB MAR MAY JUN
CLINICAL RESEARCH CENTRE, HOSPITAL RAJA PERMAISURI BAINUN
Manuscript
Writing
Basic
Bio-statistics
Workshop
Perak Annual
Medical
Research
Conference
Perak
Research
State Meeting
15 JUN 10 - 11 JUL 16 AUG 26 OCT
JUN JUL AUG 04
P A G E 4 2

ePMJ
We are grateful to the Director-General,
Ministry of Health Malaysia for permission to
publish the articles in the e-PMJ.
ELECTRONIC-
PERAK MEDICAL
JOURNAL
We encourage readers to sign up for the
publishing notification service for this journal.
Use the Register link at the top of the home
page for the journal. This registration will result
in the reader receiving the Table of Contents
by email for each new issue of the journal. This
list also allows the journal to claim a certain
level of support or readership. See the
journal's Privacy Statement, which assures
readers that their name and email address will
not be used for other purposes.
About the e-PMJ
The e-PMJ is a joint effort between the Postgraduate
Medical Education Society (PGMES) of Hospital Raja
Permaisuri Bainun (HRPB) and Clinical Research
Centre (CRC) HRPB. The PGMES was first started in
1991 and officially registered in 1993.
Conference Proceedings of 11th ASEAN &
8th Perak Health Congress on Primary Health Care
Volume 1 (Supp 01) 2019
Conference Proceedings of Perak Research
Conference 2019
Volume 1 (Supp 02) (2019)
e-PMJ Articles
Volume 2 (Issue 01) (2022)
Conference Proceedings of 12th Annual Malaysian
Rehabilitation Medicine Conference
12th ASEAN & 9th Perak Health Congress on
Primary Health Care
Perak Annual Medical Research Conference 2022
https://myjms.mohe.gov.my/index.php/pmj
In 1992, in support of promoting educational activity
in HRPB (formerly known as Hospital Ipoh), the first
edition of Medical Practice Hospital Ipoh was
published, which was a compilation of full text
research articles from HRPB. In 2007, Medical
Practice Ipoh was renamed as Perak Medical Journal,
reflecting a wider scope of the journal coverage.
In 1997, the journal was first indexed with the
National Library of Malaysia. In 2019, the
electronic version was published as e-PMJ. All
articles published, including editorial and
letters, represent the views of the authors and
not necessarily those of the Editorial Board or
the Ministry of Health.
Acknowledgement
Milestones For readers:
For authors:
Interested in submitting to this journal? We
recommend that you review the About the
Journal page for the journal's section policies,
as well as the Instructions for Authors (May
2022). Authors need to register with the
journal prior to submitting or, if already
registered, can simply log in and begin the
five-step process.
For more info, visit us at:

Ipoh
Disclaimer:
Bulletin
© 2023 Clinical Research Centre Hospital Raja Permaisuri Bainun. All Rights Reserved
Level 4, Ambulatory Care Centre (ACC),
Hospital Raja Permaisuri Bainun,
Jalan Raja Ashman Shah,
30450 Ipoh,
Perak Darul Ridzuan.
T: 05-208 5146
VISIT US:
THE HOSPITAL CRC NETWORK NEAREST TO YOU.
Clinical Research Centre (Pusat
Penyelidikan Klinikal)
Hospital Seri Manjung,
32040 Seri Manjung Perak.
Tel: 05 - 689 6639 / 05- 688 2245
Fax: 05 - 688 4013 / 05 - 688 2245
Hospital Taiping
Jalan Taming Sari
34000 Taiping, Perak
Tel. No.: 05-820 4000
ext.:8400
Taiping
Seri Manjung
The materials and information on
this bulletin have been prepared or
assembled by the organisation and
are intended for informational
purposes only. The pictures showed
are for general information and not
meant to be invasive.
Special thanks to Prema Muninathan,
Dr. Ting Siew Ying, Chiew Shoen Chuen,
Norsarlizna Mat Sari, Dr. Lim Xin Jie, Dr.
Leong E Li, Ang Ju Ying, Premaa
Supramaniam, Thinessha Muruthi for
the support and contribution in
preparing this bulletin.
Acknowledgement:

CRC Perak Bulletin Issue 05

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