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Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Birth Control, Big Money
and Bad Medicine
A Deadly Trif...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
How do we know what we think we
know?
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Generations of Marketing
For $1 in R&D, $19 in marketin...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
More Sophisticated Advertising
67.4% of retractions wer...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Big Influence
Center for Responsive Politics.
https://w...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Big Money
Top 20 health products for women in the U.S. ...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Almost every woman uses
hormonal contraceptives
88.2%
3...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
For years on end
n = 924
Age OC use
begins:
Average Len...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Provided she survives the
side-effects
Percentage of U....
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Political tug-of-war
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
What do we really know?
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
A Foundation for
Understanding
Hormones.
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
A persistent notion in contraceptive research is that
p...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Disconnected
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Compartmentalized
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Everything is
connected
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Pregnancy Prevention
http://sitn.hms.harvard.edu/flash/...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Beyond Reproduction
Steroid hormones regulate everythin...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Beyond the Ovaries
Where steroids are synthesized
Perip...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Where there are receptors…
Hormones act.
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormones are Promiscuous
• Never one-to-one
relationshi...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Metabolites Matter
4-methyl-2,4-bis(4-
hydroxyphenyl)pe...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Operate within exceedingly complex
feedback systems
Fig...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Under Hormonal Control
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormones and the Brain
• Hormone receptors co-localized...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Front. Neurosci., 20 February 2015 | http://dx.doi.org/...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
GABAA Receptors
• Primary inhibitory
neurotransmitter
•...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Morphological Changes
• Hippocampal neurons
• Estradiol...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Engines within our cells
• Mitochondria
• Convert food ...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormones and Mitochondria
• Steroidogenesis
begins in t...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Mitochondria on Estradiol
Schematic
representation
of p...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
We need endogenous hormones
Estradiol regulates metabol...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
So far
• Steroid hormones synthesized pretty much every...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Affect more than reproduction
• CNS
• Synaptogenesis
• ...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Overly simplistic notion
http://sitn.hms.harvard.edu/fl...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Exogenous vs Endogenous
Hormones
Are they the same?
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Synthetic steroids are similar but not identical
to end...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Similar but not identical
• Shape
• Binding
• Patterns,...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Progestin Shape ►Receptor
Activity ► Side Effect Profil...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Side Note: Progesterone & Blood
Pressure
• Gain-of-func...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
What happens to
endogenous hormones
while on synthetics...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Estradiol and Estriol
0.6
0.9
1.2
1.5
1.8
2.1
2.4
2.7
3...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Progesterone and Testosterone
5.0
15.0
25.0
35.0
45.0
5...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
DHEAS and Cortisol
6.0
8.0
10.0
12.0
14.0
16.0
18.0
20....
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Long Term Changes in
Endogenous Hormones
Significantly ...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
What happens to innate systems that rely on
endogenous ...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Side Effects
Or perhaps, if we’re honest, the just effe...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormonal Contraceptive Side
Effects
• Depend upon
• Cha...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Delivery Method
Determines bioavailability.
Affects rap...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Evaluating Dose-Response
• Hormonal reactions are:
• no...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Contraceptive Side Effects
• Systemic changes
• Where t...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Mood and Cognitive Changes
• Great animal research on h...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Altered Immune Function
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Deficient, Reactive, or
Exhausted Immune System
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Cost/Benefit
If hormonal contraceptives override innate...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormonal Contraceptives Alter
Nutrient Concentrations
•...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Nutrients are Critical for
Mitochondrial & Cellular Fun...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Blood Clots
Drugs exert a pro-thrombotic
state by a var...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Medical Misuse
Menstrual normalization, endometriosis, ...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Pill withdrawal bleeds are not
periods.
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Endometriosis, PCOS, Fibroids
• Induces tissue growth
•...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Hormonal contraceptives more likely to
• Evoke depressi...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Contraceptives in the Real World
• Hormonal contracepti...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Final thoughts
Adverse events and side effects do not h...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
“You did then what you knew how to do,
And when you kne...
Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Reach out
o Websites
o LucineHealthSciences.com I Busin...
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Birth Control, Big Money and Bad Medicine: A Deadly Trifecta in Women’s Health

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Veröffentlicht am

Keynote address for Contraceptive Conundrum Conference, August 8, 2015.

Veröffentlicht in: Gesundheit & Medizin
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Birth Control, Big Money and Bad Medicine: A Deadly Trifecta in Women’s Health

  1. 1. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Birth Control, Big Money and Bad Medicine A Deadly Trifecta in Women’s Health Chandler Marrs, PhD Lucine Health Sciences Hormones Matter Heal with Friends
  2. 2. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends How do we know what we think we know?
  3. 3. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Generations of Marketing For $1 in R&D, $19 in marketing and advertising (BMJ 2012;345:e4348)
  4. 4. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends More Sophisticated Advertising 67.4% of retractions were attributable to misconduct, including fraud or suspected fraud “Journals have devolved into information laundering operations for the pharmaceutical industry." Richard Horten, Editor-in-Chief – Lancet, 2004
  5. 5. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Big Influence Center for Responsive Politics. https://www.opensecrets.org/ Lobbying dollars spent 1998-2015 FDA funded by fees from drug companies • FY 2010: $573,258,400 (http://blogs.plos.org/workinprogress/2012/01/25/how-much- money-do-drug-companies-pay-the-fda/) • ~80% of all filed applications will eventually be approved • Consumer Reports (2006), 12 types of drugs sold in 140 prescription medications had "rare but serious side effects" that went unnoticed prior to their market approval from the Food and Drug Administration (FDA). • CDC foundation funding from drug companies (BMJ 2015;350:h2362) • Pharma single largest government lobbyist
  6. 6. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Big Money Top 20 health products for women in the U.S. based on revenue in 2013 Total oral contraceptive market expected to reach $17B annually 2015 (reported in Financial Times, citing GIA)
  7. 7. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Almost every woman uses hormonal contraceptives 88.2% 35.4% 69.1% 89% 97.7%99.1% 97.5% 99.6% 99% 99.2% 0.0% 20.0% 40.0% 60.0% 80.0% 100.0% 120.0% All women, 15-44 years 15-17 years 18-19 years 20-24 years 25-44 years Percentageofwomen All women Sexually experienced women Percentage of sexually experienced U.S. woman aged 15-44 who ever used contraception in the period 2006-2010
  8. 8. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends For years on end n = 924 Age OC use begins: Average Length of time used: 9.41 years, SD 6.33
  9. 9. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Provided she survives the side-effects Percentage of U.S. women aged 15-44 years who discontinued the use of selected contraceptive methods in 2006-2010
  10. 10. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Political tug-of-war
  11. 11. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends What do we really know?
  12. 12. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends A Foundation for Understanding Hormones.
  13. 13. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends A persistent notion in contraceptive research is that progesterone and estradiol are singularly involved with reproduction. What follows is a presumption that these hormones have no impact on other tissues and altering them affects nothing but the intended target.
  14. 14. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Disconnected
  15. 15. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Compartmentalized
  16. 16. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Everything is connected
  17. 17. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Pregnancy Prevention http://sitn.hms.harvard.edu/flash/2014/the-risks-of-control-assessing-the-link-between-birth-control-pills- and-breast-cancer/
  18. 18. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Beyond Reproduction Steroid hormones regulate everything.
  19. 19. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Beyond the Ovaries Where steroids are synthesized Peripheral Tissue In man and higher primates active sex steroids are in large part or wholly synthesized locally in peripheral tissues. Labrie, 2005
  20. 20. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Where there are receptors… Hormones act.
  21. 21. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Hormones are Promiscuous • Never one-to-one relationship • Cross bind with multiple receptors, different affinities and different activities • Metabolites bind and cross bind, sometimes more strongly than the original hormone
  22. 22. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Metabolites Matter 4-methyl-2,4-bis(4- hydroxyphenyl)pent-1-ene (MBP) has about 1000-fold higher estrogenic activity than BPA.
  23. 23. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Operate within exceedingly complex feedback systems Figure 3 Human steroidogenic and steroid-inactivating enzymes in peripheral intracrine tissues. 4-DIONE, androstenedione; A-DIONE, 5-alpha- androstane-3,17-dione; ADT, androsterone; epi-ADT, epiandrosterone; E1, estrone; E1-S, estrone sulfate; 5-DIOL-FA, androst-5-ene-3alpha,17beta- diol fatty acid; 5-DIOL-S, androst-5-ene-3alpha,17beta-diol sulphate; HSD, hydroxysteroid dehydrogenase; TESTO, testosterone; RoDH-1, Ro dehydrogenase 1; ER, estrogen receptor; AR, androgen receptor; UGT2B28, uridine glucuronosyl transferase 2B28; Sult2B1, sulfotransferase 2B1; UGT1A1, uridine glucuronosyl transferase 1A1. F Labrie et al. J Endocrinol 2005;187:169-196
  24. 24. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Under Hormonal Control
  25. 25. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Hormones and the Brain • Hormone receptors co-localized on neurons • GABAA, DA, 5HT, NE, Glutamate • Regulate mood, cognition, and other functions The brain is a major target for and source of steroid hormones.
  26. 26. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Front. Neurosci., 20 February 2015 | http://dx.doi.org/10.3389/fnins.2015.00037 Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Claudia Barth1, Arno Villringer1,2,3,4,5 and Julia Sacher1,2*
  27. 27. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends GABAA Receptors • Primary inhibitory neurotransmitter • Progesterone: agonist (↑ inhibition/sedation) • Prog sulfate antagonist (↓ inhibition↑ anxiety) • DHEA: antagonist • DHEAS: 1000X stronger
  28. 28. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Morphological Changes • Hippocampal neurons • Estradiol (E2): excitatory • Mediates dendritic growth • Elicits DA hypersensitivity • E2 + PROG = ↑growth • When both removed abrupt retraction of new dendrites Woolley, C. S., and McEwen, B. S. (1993). Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J. Comp. Neurol. 336, 293–306. doi: 10.1002/cne.903360210
  29. 29. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Engines within our cells • Mitochondria • Convert food fuel to cell fuel (ATP) • Bi-product ROS • Regulate immune signaling • Apoptosis • Control steroidogenesis Cycle of Ill-Health Toxicants ± insufficient nutrients ► dysfunctional mitochondria ► ↓ATP ► ↑ROS ► mitochondrial damage ► cell damage ► disease
  30. 30. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Hormones and Mitochondria • Steroidogenesis begins in the mitochondria • Ends there too with membrane receptors • Mitochondria are dependent upon estradiol Front Neuroendocrinol. 2014 Jan; 35(1): 8–30.; Published online 2013 Aug 29. doi: 10.1016/j.yfrne.2013.08.001; Estrogen: A master regulator of bioenergetic systems in the brain and body; Jamaica R Rettberg, a Jia Yao, b and Roberta Diaz Brinton a,b,c
  31. 31. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Mitochondria on Estradiol Schematic representation of presynaptic mitochondria in the mammalian brain and their effect on synaptic remodelling. Martin Picard, and Bruce S. McEwen PNAS 2014;111:7-8 ©2014 by National Academy of Sciences
  32. 32. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends We need endogenous hormones Estradiol regulates metabolic flexibility – the ability to utilize different fuel sources when needed.
  33. 33. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends So far • Steroid hormones synthesized pretty much everywhere • Not just in the gonads and adrenals • Bind to all sorts of different receptors to modulate health • Cognate receptor • Receptors of other steroids • Neurotransmitters • Immune cells • Hormones fluctuate across the lifecycle, menstrual cycle, pregnancy/postpartum • Sensitive to endocrine disrupting chemicals, environmental and pharmaceutical
  34. 34. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Affect more than reproduction • CNS • Synaptogenesis • Dendritic growth • Neurotransmitters • Nerve myelination • Vascularization • Vasoconstriction • Dilation • Tumorogenesis • Metabolic flexibility • Mitochondrial fuel usage, structure and function • Insulin signaling • Immune function • Cytokine cross talk • Connective tissue, muscle, bone • GI Motility
  35. 35. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Overly simplistic notion http://sitn.hms.harvard.edu/flash/2014/the-risks-of-control-assessing-the-link- between-birth-control-pills-and-breast-cancer/ We cannot override one system by substituting two synthetic hormones and not impact everything else.
  36. 36. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Exogenous vs Endogenous Hormones Are they the same?
  37. 37. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Synthetic steroids are similar but not identical to endogenous steroids.
  38. 38. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Similar but not identical • Shape • Binding • Patterns, affinities, interactions with other cells • Potency • Metabolites (and their actions) • Elimination Differences between synthetic and endogenous hormones
  39. 39. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Progestin Shape ►Receptor Activity ► Side Effect Profile • Most are derived from testosterone or progesterone • Bind to AR, GR, PR, MR to varying degrees • Most more strongly than endogenous progesterone (10-100X) • Androgenic side effects: hair, acne, BP, lipid changes • Glucocorticoid side effects: BP, weight gain • Drospirenone derived from spirolactone (anti- mineralocorticoid) • No androgenic effects (why it’s prescribed for acne) • Blocks, mineralocorticoid receptors, reduce swelling, BP (not in all women) • Binds 500X to AR than progesterone
  40. 40. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Side Note: Progesterone & Blood Pressure • Gain-of-function mineralocorticoid receptor mutation • Increased progesterone binding • Constitutively activated • Early onset, high BP relative to cycle, pregnancy and contraceptives, especially drospirenone • Possible epigenetic and functional changes too
  41. 41. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends What happens to endogenous hormones while on synthetics? A mixed response.
  42. 42. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Estradiol and Estriol 0.6 0.9 1.2 1.5 1.8 2.1 2.4 2.7 3.0 Follicular Mid-Cycle Luteal Estradiol(pg/mL) Phase in Cycle Control High EE Low EE 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 Follicular Mid-Cycle Luteal Estriol(pg/mL) Phase in Cycle Control High EE Low EE Guillermo C, Marrs C, unpublished data.
  43. 43. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Progesterone and Testosterone 5.0 15.0 25.0 35.0 45.0 55.0 65.0 75.0 Follicular Mid-Cycle Luteal Progesterone(pg/mL) Phase in Cycle Control High EE Low EE 15.0 20.0 25.0 30.0 35.0 40.0 45.0 50.0 Follicular Mid-Cycle Luteal Testosterone(pg/mL) Phase in Cycle Control High EE Low EE Guillermo C, Marrs C, unpublished data.
  44. 44. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends DHEAS and Cortisol 6.0 8.0 10.0 12.0 14.0 16.0 18.0 20.0 Follicular Mid-Cycle Luteal DHEAS(ng/mL) Phase in Cycle Control High EE Low EE 3.0 4.0 5.0 6.0 7.0 8.0 9.0 10.0 Follicular Mid-Cycle Luteal Cortisol(ng/mL) Phase in Cycle Control High EE Low EE Guillermo C, Marrs C, unpublished data.
  45. 45. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Long Term Changes in Endogenous Hormones Significantly lower endogenous hormones.
  46. 46. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends What happens to innate systems that rely on endogenous hormones for adaptive regulation?
  47. 47. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Side Effects Or perhaps, if we’re honest, the just effects.
  48. 48. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Hormonal Contraceptive Side Effects • Depend upon • Characteristics of the drug • Shape • Binding affinity to hormone receptors • Actions at those receptors • Metabolites • Dose and duration of use • Route of administration • Inter-individual variability • Genetic, epigenetic, environmental, nutritional, medical and pharmaceutical interactions
  49. 49. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Delivery Method Determines bioavailability. Affects rapidity with which acute side effects develop and, to some degree, the location. Order of bioavailability of EE Patch, Ring, Oral
  50. 50. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Evaluating Dose-Response • Hormonal reactions are: • not always linear • time dependent
  51. 51. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Contraceptive Side Effects • Systemic changes • Where there are receptors, the drug will evoke an effect • Compensatory reactions • Short-term • Acute and emergent reactions • Longer-term • Changes in enzymes, binding proteins and hormone concentrations • Epigenetic changes • Potentially transgenerational
  52. 52. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Mood and Cognitive Changes • Great animal research on hormones and learning • Contradictory finding with the human studies • Vast methodological differences • Must measure symptom changes across the menstrual cycle relative to each hormone individually and to the hormone pathway • Patterns differ with oral contraceptives • Would be great to measure synthetic concentrations relative to symptoms • Cannot test symptoms at cycle phase We know hormones affect the brain, how do hormonal contraceptives affect mood or cognition?
  53. 53. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Altered Immune Function
  54. 54. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Deficient, Reactive, or Exhausted Immune System
  55. 55. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Cost/Benefit If hormonal contraceptives override innate and adaptive immunity, increasing susceptibility to STDs, autoimmune disease processes, cancers, is the tradeoff worth it?
  56. 56. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Hormonal Contraceptives Alter Nutrient Concentrations • ↓riboflavin, pyridoxine, folate, vitamin B12, ascorbic acid, zinc • ↓ CoQ10, vitamin E, antioxidants • +/- vitamin K, iron and copper, vitamin A
  57. 57. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Nutrients are Critical for Mitochondrial & Cellular Functioning Nutrient deficiency damage the mitochondria Impair steroidogenesis Increase inflammation (oxidative and cytokine) Increase disease processes
  58. 58. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Blood Clots Drugs exert a pro-thrombotic state by a variety of mechanisms--those affecting the vessel wall, the blood flow, and/or different blood constituents. Cumulative, additive or synergistic; immediate or delayed reaction. Genetic/epigenetic predisposition • Clotting factors • Endothelial damage Pharmacological/medical • Hormonal contraceptives (HRT too) • Contrast media • SSRIs, haloperidol • Fluoroquinolones • NSAIDs (PGI2 inhibition, AFIB) • Med/vax induced vasculitis • Lupron (E2/mito damage) Lifestyle • Smoking • Diet (mito dysfunction) • Intense exercise or prolonged sitting
  59. 59. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Medical Misuse Menstrual normalization, endometriosis, PCOS, fibroids, menorrhagia, depression, anxiety, bloating, fatigue.
  60. 60. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Pill withdrawal bleeds are not periods.
  61. 61. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Endometriosis, PCOS, Fibroids • Induces tissue growth • Impairs glucose tolerance • Induces chronic inflammation
  62. 62. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Hormonal contraceptives more likely to • Evoke depression and/or anxiety • Induce negative metabolic changes (weight gain, insulin resistance, ↑ BP) • Induce endometrioitic and fibroid growth • Induce or exacerbate autoimmune conditions Why then do we prescribe them for these conditions?
  63. 63. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Contraceptives in the Real World • Hormonal contraceptive • Monthly NSAIDs • SSRI (21% of females >20 on SSRIs) • Periodic antibiotics, regular vaccines, asthma or allergy medication • Western diet • Low nutrient content • Athletic • Trains hard • Injuries (contrast media) • Travels – long periods of sitting  Impaired mitochondrial functioning by multiple mechanisms  Oxidative stress  Inflammation  Impaired immune function  Increased risk of • Autoimmune disease • Thrombosis • Metabolic dysfunction • Injury (athletic) Polypharmacy – even in ‘healthy’ women
  64. 64. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Final thoughts Adverse events and side effects do not happen in a vacuum, and thus, cannot be evaluated singularly. We underestimate the risks of synthetic hormones significantly by ignoring the vast reach hormones have on health. Reproductive health is but one component of women’s health.
  65. 65. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends “You did then what you knew how to do, And when you knew better, You did better.” Maya Angelou
  66. 66. Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends Reach out o Websites o LucineHealthSciences.com I Business o HormonesMatter.com I online journal, medication adverse events surveys o HealwithFriends.com I Social health o Social Media o Facebook pages: Hormones Matter, Lucine Women Community o Twitter: @chanatlucine, @lucinewoman, @hormonesmatter, @healwithfriends

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