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HCF 2019 Panel 2: Andrew Turley

Panel 2: Grouping of chemical substances and how to avoid regrettable substitution

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HCF 2019 Panel 2: Andrew Turley

  1. 1. © Copyright 2019 Chemical Watch (CW Research Ltd) Grouping of chemical substances and regrettable substitution Chair: Andrew Turley, Science Editor, Chemical Watch
  2. 2. © Copyright 2019 Chemical Watch (CW Research Ltd) Panelists Ninja Reineke, Chemtrust Jack de Bruijn, ECHA Maggie Saykali, Cefic Kerry Nugent, IMAP, NICNAS
  3. 3. © Copyright 2019 Chemical Watch (CW Research Ltd) Grouping ● For overcoming the data deficit problem ● Enables extrapolation of hazard properties from a data-rich substance to a data-poor substance that is ‘similar’ (read-across) ● When an unsafe substance is substituted for...another unsafe substance Regrettable substitution
  4. 4. A recent example ● Request made by regulatory authority ● Independent expert committee recommends grouping (to some extent…) for assessment of organohalogen flame retardants ● 16 groups ● “The alternative – individual assessments of hundreds of chemicals – is unrealistic"
  5. 5. Opening questions ● Is everyone using the same approaches to grouping? ○ Minimise duplication of work globally; provide greater certainty for industry; but ○ Challenging given diversity of legislative constraints and diversity of chemicals ● In each case, should the approach be: ○ General (IE, agnostic with respect to chemical structure, use, exposure route, etc); ○ Tailored to the chemicals under consideration; or ○ Something in between? ● How should risk assessors define groups?

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