Startup Health Insights provides an in-depth analysis of digital health funding and trends. It is promoting Startup Health's mission to transform global health and wellbeing through 10 "moonshot" goals within their 25-year vision. The document summarizes digital health funding trends in 2016, showing continued growth in funding rounds and deals particularly in patient/consumer experience technologies. It provides an overview of the most active subsectors and largest deals of the year to date.

1. CONFIDENTIAL INFORMATION. NOT FOR DISTRIBUTION.JOIN THE HEALTH TRANSFORMER MOVEMENT
STARTUP HEALTH INSIGHTS
Katya Hancock
Director of Strategic Partnerships
katya@startuphealth.com
@katyahancock
In Depth Analysis of Digital Health Funding & Trends

2. 25YEARS
5YEARS
LAUNCH
2CONFIDENTIAL INFORMATION. NOT FOR DISTRIBUTION. 2
5 YEARS INTO OUR 25-YEAR MISSION
Transform the Health & Wellbeing of Everyone in the World

3. WHEN WE DO THIS
Achieve 10 Moonshots Essential to Improving Global Health
1 Access to Care Moonshots
Deliver quality care to everyone, regardless of
location or income
2
Cost to Zero Moonshots
Radically reduce the cost of care by a factor of a
million
3 Cure Disease Moonshots
Cure disease using data, technologies and
personalized medicine
4
Cancer Moonshots
End cancer as we know it
5
Women’s Health Moonshots
Prioritize women’s health, including preventive
care and new research
6 Children’s Health Moonshots
Ensure every child has access to quality care,
particularly in underserved areas
7
Nutrition Moonshots
Ensure everyone has access to high quality,
healthy food and water
8 Brain Health Moonshots
Unlock the mysteries of the brain to improve
health
9
Mental Health Moonshots
De-stigmatize mental health and connect mind,
body and spirit
10
Longevity Moonshots
Add 50 healthy years to every human life
JOIN THE HEALTH TRANSFORMER MOVEMENT ™ & © 2016 StartUp Health Holdings, Inc. All rights reserved. 3

4. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
LIFETIME
COACHING
PARTNER
ACCESS
MEDIA
PLATFORM
DATA-DRIVEN TECH PLATFORM
COACHING FROM “UNIQUE ABILITY” TEAM
4JOIN THE HEALTH TRANSFORMER MOVEMENT ™ & © 2016 StartUp Health Holdings, Inc. All rights reserved.
Based on The Health Transformer Mindset™

5. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
5
350+ Entrepreneurs from 169 Companies and 16 Countries
A GLOBAL COMMUNITY OF TRANSFORMERS
5
NEW YORK
3,000+ Companies Have Applied, Tracking 7,500+ Companies Globally

6. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
6
Academy Companies Acquired
10
by
by
by
by
by
Female Founders
30%
by
Serial Entrepreneurs
34%
MDs and PhDs
43%
Total Raised by All Companies*
$617M
*$300M raised by HLI
ACADEMY PORTFOLIO AT-A-GLANCE
by
by
by
0
30
60
90
120
150
180
'11 '12 '13 '14 '15 '16
YTD
169StartUp Health
Companies
6
by

7. 1 US and Global Growth
2 Digital Health's First Wave
3 An Active Investor Ecosystem
4 Unique Collaborations
5 The Rise of the Rest
TAKEAWAYS:
•Q3 was significant with almost $2.4B in
deals, nearly half of which were
international: supporting a continued
trend of global market expansion
•2016 on track to be the biggest year ever
for digital health funding
•2016 total deal volume on pace to
outstrip 2015
FUNDING INSIGHTS: 2016 YTD SUMMARY

8. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
8
•Digital health funding in Q3 2016 surpassed all previous third quarters
•We are on track for the strongest year yet, with funding to date already passing 2015’s total of $6.1B
YEAR OVER YEAR FUNDING SNAPSHOT
Funding($B)
$2
$4
$6
$8
2010 2011 2012 2013 2014 2015 2016 (YTD)
Q1 Q2 Q3 Q4
$1.1B
150
283
467
629
574
523
394
Deal Count
$1.91B
Q3
$2.37B
$1.90B
$811M
$619M
$ 6.5B (YTD)
$6.1B
$7.1B
$2.9B
$2.4B
$1.9B
$687M
$270M
TAKEAWAY: Digital Health startup ecosystem continues to grow and mature significantly

9. Highest Seed-Series B deal counts: Patient / consumer experience, wellness, workflow
SUB-SECTOR MATURITY MAP (2010-2016)
Seed Series A Series B Series C Series D-H
TAKEAWAY: Big focus on empowering the consumer & providing tools for wellbeing & self-care
Patient/Consumer
Experience
163 109 50 22 19
Wellness 113 63 28 11 11
Workflow 92 109 59 24 0
Medical Device 63 65 42 31 19
Big Data/Analytics 49 78 48 20 6
Clinical Decision
Support
50 53 31 10 2
Personalized Health/QS 42 45 33 18 23
Population Helth 37 40 31 29 8
E-Commerce 39 38 15 6 4
Research 24 33 20 8 10
Education/Training 17 10 4 5 8
EMR 14 10 8 5 26
50Plus 5 4 4 1 15

10. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
10
47%
45%
Oncology 12 25 17 6 6
Mental Health 16 20 9 3 1
Chronic Disease 17 18 7 4 8
Diabetes 12 17 11 9 9
Cardiology 9 11 9 8 5
Dermatology 10 5 2 0 0
Autism 5 3 3 3 0
Pulmonology 10 8 4 2 0
Ophthalmology 7 2 2 1 1
Immunology 2 2 3 1 0
Rare Disease 3 0 0 0 0
Seed Series A Series B Series C Series D-H
Oncology, Mental Health & Chronic Disease Related Deals
Have Led Seed, Series A & B Funding Deal Counts
MARKET MATURITY MAP (2010-2016)

11. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
11
Total investment tends to spike in May and September
FUNDING SNAPSHOT MONTH OVER MONTH
TAKEAWAY: Five out of nine months this year have record-setting funding numbers.
$0
$250,000,000
$500,000,000
$750,000,000
$1,000,000,000
$1,250,000,000
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
2013 2014 2015 2016 YTD

12. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
12
The two $500M deals, Ping An Good Doctor, focused on bringing medical services to the Chinese market
via mobile & Onduo, focused on solving one of America’s chronic disease challenges vary significantly.
THE TOP 10 LARGEST DEALS OF 2016 (YTD)
Company $ Invested Subsector Notable Investor
1 $500M Patient / Consumer Experience Undisclosed
1 $500M Patient / Consumer Experience
3 $448M Patient / Consumer Experience
4 $400M Wellness
5 $220M Personalized Health
6 $175M Personalized Health
7 $160M Wellness
8 $151M Patient / Consumer Experience
9 $120M Patient / Consumer Experience
10 $100M Personalized Health
10 $100M Medical Device
TAKEAWAY: Largest deals in 2016 going towards Patient / Consumer Experience

13. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
13
The top-funded subsector shows a continued push towards patient/consumer experience, with almost
triple the total funding of the second-most active focus area.
THE TOP 10 MOST ACTIVE SUBSECTORS OF 2016 (YTD)
Subsector Total Raised YTD Deal Count Average Deal Size
1 Patient / Consumer Experience $2.53B 101 $25.1M
2 Wellness $918M 33 $27.8M
3 Personalized Health / Quantified-Self $634M 26 $24.4M
4 Big Data / Analytics $564M 40 $14.1M
5 Medical Device $478M 40 $12.0M
6 Workflow $419M 59 $7.1M
7 Clinical Decision Support $309M 20 $15.4M
8 Population Health $248M 31 $8.0M
9 E-commerce $242M 13 $18.6M
10 Research $107M 15 $7.1M
TAKEAWAY: Patient / Consumer Experience has been the most active subsector in 2016

14. Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only through September 30, 2016. © 2016 StartUp Health LLC
This year, StartUp Health has joined regulars GE Ventures and Khosla Ventures as one of the most active
venture investors in digital health
THE TOP VENTURE INVESTORS OF 2016 (YTD)
TAKEAWAY: New entrants & “Non-traditional” healthcare investors are taking the lead
Firm 2016 YTD Deals 2015 Deals Stage
Early Mid Late
1 10 9
1 10 2
3 9 10
4 6 3
5 5 6
5 5 -
5 5 4
5 5 1
5 5 6

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Katya Hancock, Director of Strategic Partnerships
katya@startuphealth.com
@katyahancock
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