Anterior Segment Company Showcase - Z lens at OIS@AAO 2016. Presenter: Paul Beer, MD, Founder & CEO Powered by: Healthegy For more ophthalmology innovation Visit us at www.ois.net

1. OIS, Chicago, October 13th 2016
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Paul Beer MD
Z Lens LLC
Founder & CEO

2.  Dr. Paul Beer (inventor)
 28 years as retinal surgeon
 Professor of Ophthalmology at Albany Medical
Center
 Founder, former President of the Retina
Research Foundation
 Merit and Senior Honor Awards from the
American Society of Retinal Specialists & AAO
 PI in >25 multicenter clinical trials in vitroretinal
therapies
 PI in multiple IST’s
 Edward Eveleth
 Multiple start-ups
 Founded CyclicsCorporation
▪ Purchased patents to unique
plastic fromGE
▪ Raised over $40M in equity
▪ Built plant in Germany
 MBA, Cornell University

3.  Rob Stupplebeen
 9+ years experience IOL and contact
lens engineering
 6 yrs at Bausch + Lomb
 Consulted for 5 IOL Co’s
 MEng, Cornell University
 Wisconsin Primate Center
 Dept. of Ophthalmol, UW-Madison
 Paul Kaufman MD
 Mary Ann Croft MA
 Greg Heatley MD
 Jarred McDonald
 Learner Research Institute-
Biomedical Engineering
Animal Experiments
Design
Prototyping
Advisors
 Tom Dunlap
 Tom McNicholas

4. Validation: Rhesus monkey animal studies (9 eyes, > 1 yr.) show results beating competition
Product: Accommodating Intraocular Lens
Protection: 2 foundational patents
Size: $500MM+ current market - $1B anticipated
Financing: NSF Phase I, Phase IB and Phase II SBIR;
NIH Phase I STTR, NEI high program relevance
Application: Cataract patients

5. To replicate the movement of the natural lens
We made the best single rigid optic accommodating IOL
-preclinical-

7. OPTICS CERTIFIED BY PHOTONGEAR INC., 245 DAVID PARKWAY, ONTARIO, NY 14514
Successfully captures & responds to zonular forces
• YAG laser activation & radial capsular sectioning
• Titration of radial capsular sectioning

8. EPPUR SI MOUVE!
“And yet it moves”
and moves
and moves

11. 1 year post implantation

12. Anterior Lens face shifts: 0.48mm
Anterior Optic face shifts: 0.47mm

13. Axial shift Ant. Lens face: 0.59mm
Axial shift Ant. Optic face: 0.80mm

14. Axial shift Optic: 0.8mm Flexion haptics: ~ 20 degrees
Biometricly Predicted Accommodation: 1D/1mm of axial shift
Observed accommodation: ~2D/0.5-8mm (1-3D EW, 4D Carb)
-objective=Hartinger Refractor
-meets FDA label requirements*

16. • Shape shifting optic provides more accommodation
• Driven by a haptic structure that works
• Dual Mode AD-IOL= shape & axial shifting
• Small, simple, easy to make optic vesicle

17. Small & simple fluid filled optic vesicle gets
thicker during accommodation

18. Current prototype will be ready for animal testing Q1 2017

19. FEA: ¼ lens in cross section

20. • Accommodation method
• U.S. Patent No. 9,220,590
• "ACCOMMODATIVE INTRAOCULAR LENS AND METHOD OF
IMPROVING ACCOMMODATION"
• Dissaccommodation Method
• U.S. Patent No. 9,364,318 B2
• "ACCOMMODATIVE-DISACCOMODATIVE INTRAOCULAR LENS“
• Devices:
• Divisional applications covering all device concepts and device in use
• Provisional Application covering Dual Mode IOL

21. 1. Finish development of prototypes
2. Round A
-2 MM to take Dual Mode AD-IOL to human trial
3. Explore Industry Partnership
Axial Shift AD-IOL Dual Mode AD-IOL
Human trials of best design Build and test prototype

22.  Novel, powerful IOL concepts
 Major Milestones achieved
 Expert team with proven success
 Patent protection
 Massive opportunity 500MM market
Dr. Paul M. Beer
Z Lens LLC
drbeer@zlensllc.com
We captured the movement!
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