Diese Präsentation wurde erfolgreich gemeldet.
Wir verwenden Ihre LinkedIn Profilangaben und Informationen zu Ihren Aktivitäten, um Anzeigen zu personalisieren und Ihnen relevantere Inhalte anzuzeigen. Sie können Ihre Anzeigeneinstellungen jederzeit ändern.
Introduction, Review of
Biomolecules
Lecture 1, Medical Biochemistry
Lecture 1 Outline
• Review some basic chemical nomenclature
and concepts
• Review the structural and functional
features o...
Common Functional Groups
Common Condensation
Reactions
Common Enzymatic Conversions
Oxidation-Reduction
Phosphorylation Phosphatase
Terms/Concepts to Review
• Hydrophobicity and hydrophilicity
• Aromatic and aliphatic
• Ionic, or electrostatic, interacti...
Major Causes of Disease
(from Table 1.1 in text)
• Physical Agents: mechanical trauma,
temperature extremes, radiation, el...
Disease Causes (cont.)
• Immunologic Reactions: anaphylaxis,
autoimmune disorders
• Nutritional Imbalances: deficiencies,
...
Two-Way Street: Medicine and
Biochemistry
Sugars/Carbohydrates
Membrane Lipids
Sterols
Fatty Acids
Saturated and Unsaturated
Which Compound Would be
Found in a Membrane?
Nucleic Acids: Components of
RNA and DNA
DNA:
double helix
Adenosine Triphosphate - ATP
Amino Acids:
Protein Building Blocks
Levels of Protein Structure
Human Genome Project
• A rough draft is complete, >90% sequenced
• Represents approximately 75,000 human genes
(estimated ...
Proteomics
• Proteomics – the study of how all proteins
interact with each other in a cell
• Estimate 50,000 to 2,000,000 ...
The Next 40 years in Medicine
• Predictions made by Francis Collins
M.D./Ph.D., director of the National Human
Genome Rese...
Predictions - 2010
• Primary care providers will practice genetic
medicine
• Preimplantation diagnoses of fertilized
embry...
Predictions - 2020
• Gene-based designer drugs will be marketed for
some diseases
• Cancer therapies will target the molec...
Predictions - 2030
• Human aging genes will be fully
catalogued; clinical trials designed to
increase life span will be in...
Predictions - 2040
• Comprehensive genomics-based healthcare will be
standard.
• Individualized preventive treatments will...
Sie haben dieses Dokument abgeschlossen.
Lade die Datei herunter und lese sie offline.
Nächste SlideShare
What to Upload to SlideShare
Weiter
Nächste SlideShare
What to Upload to SlideShare
Weiter
Herunterladen, um offline zu lesen und im Vollbildmodus anzuzeigen.

Teilen

Introduction to Medical Biochemistry

Herunterladen, um offline zu lesen

Lecture 1. Medical Biochemistry,
Review of Biomolecules

Ähnliche Bücher

Kostenlos mit einer 30-tägigen Testversion von Scribd

Alle anzeigen

Ähnliche Hörbücher

Kostenlos mit einer 30-tägigen Testversion von Scribd

Alle anzeigen

Introduction to Medical Biochemistry

  1. 1. Introduction, Review of Biomolecules Lecture 1, Medical Biochemistry
  2. 2. Lecture 1 Outline • Review some basic chemical nomenclature and concepts • Review the structural and functional features of different biomolecules • Discuss the human genome project and the future of molecular medicine
  3. 3. Common Functional Groups
  4. 4. Common Condensation Reactions
  5. 5. Common Enzymatic Conversions Oxidation-Reduction Phosphorylation Phosphatase
  6. 6. Terms/Concepts to Review • Hydrophobicity and hydrophilicity • Aromatic and aliphatic • Ionic, or electrostatic, interactions • Hydrogen bonds • van der Waals interactions • Covalent bonds
  7. 7. Major Causes of Disease (from Table 1.1 in text) • Physical Agents: mechanical trauma, temperature extremes, radiation, electric shock • Chemical Agents: toxic compounds, drugs • Biologic Agents: viruses, bacteria, fungi, parasites, biochemistry professors • Genetic Disease • Oxygen Lack: loss of blood, decreased oxygen-carrying capacity of blood, mitochondrial poisoning
  8. 8. Disease Causes (cont.) • Immunologic Reactions: anaphylaxis, autoimmune disorders • Nutritional Imbalances: deficiencies, excesses • Endocrine Imbalances: hormonal deficiencies/excesses
  9. 9. Two-Way Street: Medicine and Biochemistry
  10. 10. Sugars/Carbohydrates
  11. 11. Membrane Lipids
  12. 12. Sterols
  13. 13. Fatty Acids Saturated and Unsaturated
  14. 14. Which Compound Would be Found in a Membrane?
  15. 15. Nucleic Acids: Components of RNA and DNA
  16. 16. DNA: double helix
  17. 17. Adenosine Triphosphate - ATP
  18. 18. Amino Acids: Protein Building Blocks
  19. 19. Levels of Protein Structure
  20. 20. Human Genome Project • A rough draft is complete, >90% sequenced • Represents approximately 75,000 human genes (estimated range: 30,000 to 120,000) • Based on the DNA from six individuals; thus provides little information regarding genetic diversity within the population • Estimated that 95% of our DNA content is not important; represents evolutionary “baggage” • Highlights the need for continued sequencing of genomes from other organisms to identify essential genes and their functions
  21. 21. Proteomics • Proteomics – the study of how all proteins interact with each other in a cell • Estimate 50,000 to 2,000,000 human proteins • The amino acid sequence of a protein can be determined from the gene sequence, but in most cases, this cannot be used to predict overall 3D- structure or function; usually this is done by X- ray crystallography • Only about 1% of proteins have had their 3D structures determined
  22. 22. The Next 40 years in Medicine • Predictions made by Francis Collins M.D./Ph.D., director of the National Human Genome Research Institute
  23. 23. Predictions - 2010 • Primary care providers will practice genetic medicine • Preimplantation diagnoses of fertilized embryos will be widely available • Gene therapy will be routinely used for a few conditions
  24. 24. Predictions - 2020 • Gene-based designer drugs will be marketed for some diseases • Cancer therapies will target the molecular fingerprint of each tumor type • Drug susceptibility will be determined before a prescription is written • Genomic intervention via homologous recombination will be used to insert genes without interfering with neighboring genes
  25. 25. Predictions - 2030 • Human aging genes will be fully catalogued; clinical trials designed to increase life span will be initiated • Computer models of human cells will be available for research • Complete genome sequencing will cost less than $1,000 per person
  26. 26. Predictions - 2040 • Comprehensive genomics-based healthcare will be standard. • Individualized preventive treatments will be available and effective. • Gene therapies and gene-based drug therapies will be available for most diseases. • Newborn testing for disease pre-disposition in adulthood will be feasible. • The average lifespan will reach 90 yrs.
  • elizabethogunyo

    Jun. 1, 2021
  • BettyKiarie

    Mar. 3, 2021
  • MartynCharles

    Jan. 22, 2021
  • RobiulislaRaihan

    Jun. 8, 2020
  • DishaPandya4

    Jan. 11, 2020
  • NawabAli29

    Dec. 10, 2018

Lecture 1. Medical Biochemistry, Review of Biomolecules

Aufrufe

Aufrufe insgesamt

2.544

Auf Slideshare

0

Aus Einbettungen

0

Anzahl der Einbettungen

0

Befehle

Downloads

89

Geteilt

0

Kommentare

0

Likes

6

×