3. Systemic Lupus Erythematosus (SLE)
• Chronic inflammatory disease, Associated withChronic inflammatory disease, Associated with
abnormalities of immune systemabnormalities of immune system
• Results from interactions among genetic, hormonal,Results from interactions among genetic, hormonal,
environmental, immunologic factorsenvironmental, immunologic factors
• Autoimmune reactions directed against constituents ofAutoimmune reactions directed against constituents of
cell nucleus and DNAcell nucleus and DNA
• Ranges from disorders, most commonly affects the skin,Ranges from disorders, most commonly affects the skin,
muscles, joints, lungs, heart, nervous system, andmuscles, joints, lungs, heart, nervous system, and
kidneyskidneys
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