1.
GtoImmuPdb Data: Targets and Ligands
The GtoP database has been enriched by tagging targets & ligands of
immunological relevance and by linking these to immunological processes, cell
types and relevant diseases.
S. D. Harding1
, E. Faccenda1
, A. J. Pawson1
, J. L. Sharman1
, C. Southan1
, S. P. Alexander2
,
S. Anderton3
, C. Bryant4
, A. P. Davenport5
, C. Doerig6
, D. Fabbro7
, F. Levi-Schaffer8
, M. Spedding9
, J. A. Davies1
1Centre for Discovery Brain Sciences, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UNITED KINGDOM, 2Life Sciences, University of Nottingham, Nottingham, UNITED KINGDOM,3MRC Centre for Inflammation Research, QMRI,
University of Edinburgh, Edinburgh, UNITED KINGDOM, 4
Veterinary Medicine, University of Cambridge, Cambridge, UNITED KINGDOM,5
Clinical Pharmacology Unit, University of Cambridge, Cambridge, UNITED KINGDOM, 6
Department of Microbiology,
Monash University, Clayton, AUSTRALIA, 7PIQUR Therapeutics AG, Basel, SWITZERLAND, 8School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, ISRAEL, 9Spedding Research Solutions SARL, Le Vesinet, FRANCE.
Introduction
Immune/inflammatory/infection responses and disorders are a major focus of
pharmacological R&D. Chronic diseases, aspects of ageing and progress of infection all
have, or depend strongly on, an immune, or inflammatory, component. Being able to
modulate these more effectively with better drugs would be immensely valuable.
Development of these drugs will benefit from improved data exchange between the
immunology expert and pharmacology expert communities.
What is the Guide to IMMUNOPHARMACOLOGY
Our Wellcome Trust-funded project to produce the IUPHAR Guide to
IMMUNOPHARMACOLOGY (GtoImmuPdb) addresses this need by providing a new
portal to the existing IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb), that is both
'immunologist-friendly' for pharmacological information and 'pharmacologist-friendly'
for accessing immunological agents and targets. GtoImmuPdb will be a freely-available,
regularly updated and richly annotated resource. Curated by expert NC-IUPHAR*
sub-committees, including additional contributors with expertise in immunity,
inflammation and kinase biology.
The 2018.3 GtoPdb release contain over 16,000 curated interactions across 2,875
human targets and 9,336 ligands.
GtoImmuPdb Immunological Data Types
www.guidetoimmunopharmacology.org
Slideshare: http://ow.ly/AbSe30jVume Twitter: @GuidetoPHARM
References
* International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification
1. Harding SD, et al. (2018) The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion
to encompass the new Guide to IMMUNOPHARMACOLOGY. Nucl. Acids Res. 46(D1):D1091-D1106
PMID: 29149325
GtoImmuPdb presents a set of top-level immunological process and cell type
categories against which targets in the database can be annotated and which
form the basis of organising, navigating and searching for immunological
process and cell type associations.
Immuno Processes
Antigen presentation
Barrier integrity
B cell (activation)
Cellular signalling
Chemotaxis & migration
Cytokine production & signalling
Immune regulation
Immune system development
Inflammation
T cell (activation)
Tissue repair
Targets Ligands
Cell types Processes
Disease
IUPHAR Guide to
IMMUNOPHARMACOLOGY
●
A unique access-
point to
immunological data
in GtoPdb
●
An expert-curated
database containing
immunological
information
●
Develop new pages
and extend search
mechanism for
immunological data
●
Assist in the
identification of
novel therapeutic
targets
●
Assist in identifying
small-molecules for
experimental
investigation
Detailed view pages display
associations between targets
and immunological data
These include detailed curator
comments and links to
external references
Displaying
GtoImmuPdb
data in detailed
view of BTK
As of 9 May 2017
GtoImmuPdb held
525 protein targets
and 993 ligands
tagged as being of
immunological
relevance.
Ligand lists highlight
immuno relevant ligands
with new icons.Here
showing inhibitors of BTK
Disease summary pages
highlight target and ligands
relevant to immunological
disease. Here, a snapshot of
some ligands linked to
Psoriasis – includes drug
approval status, curatorial,
clinical use and bio-activity
comments
GtoImmuPdb uses ontologies
(Cell, Gene & Disease) as
controlled vocabularies against
which to annotate.
Browse via immune system cell type for
associated drug targets
Showing snapshot of Enzyme targets
asssociated with cytokine production &
signalling. Includes GO annotations and curator
comments