CV

1. CURRICULUM VITAE
Date Prepared: 03/29/2016
Name: Gokhan Baris Ozdener
Office Address: Department of Molecular & Cell Biology,
700 Albany Street; W-216
Boston, MA 02118
Home Address: 21 Walnut Street Apt #8
Quincy, Ma 02171, U.S.A
E-mail: ozzbaris@gmail.com
Place ofBirth: Denizli, TURKEY
CareerObjective:Seeking a research fellow role where I can
integrate my scientific, clinical skills and team work
skills for cancer research, drug discovery and delivery.
Award/Prices: High SchoolResearch Project Competition Award 1st prize
in Physics and Energy Efficiency Categories Scientific and
Technological Research Council of Turkey
(TUBITAK), 1993.
Departmental Fellowships Award (Boston University
Molecular and Cell Biology Department), 2010-2011.
Graduate Fellowships Award (Boston University),
2011-2013.
Graduate Research Assistant Scholarship/Stipend Award
(Boston University), 2013-2014.

2. 2016 Science Day at BostonUniversity GSDM Poster
Competition/ PostdoctoralFellows 1st Place Award, 2016.
PersonalProfile: Experience in biology research and dentistry enhanced wide
range of transferable skills-problem solving, self-motivation,
independent work and team working-that equip me for a
career in a research environment combined with clinical
applications in medical field. My aim is to work in a
challenging, team based multiple projects that enable
personal development.
Languages:
Turkish: Native proficiency
English: Full professional proficiency
Italian: Elementary proficiency
Certifications:
Professional Association of Diving Instructors (PADI) Open
Water Diver
American Heart Association Basic Life Support(BLS) Health
Care Provider (CPR and AED)
Education:
ExpectedGraduation, 2018:
Henry M. Goldman Schoolof Dental Medicine at Boston
University, Boston, USA.
Advanced Standing for Internationally Trained Dentists
(AS), DMD
2014-2015: Molecular and Cell Biology Department, Boston University,
Boston, USA.
Diploma Dissertation: “Macropinocytosis and Caveola-
Dependent Endocytosis are Major Uptake Pathways for
Lysyl Oxidase Propeptide”

3. 2010-2014: Boston University, Boston, USA.
Doctorof Science (D.Sc.)in Molecularand Cell Biology
-Design, synthesis and fluorescent labeling of a
recombinant protein lysyl oxidase propeptide (rLOX-PP) as a
cancer therapeutic.
-Studied the cellular/nuclear entry and pH buffering
mechanism of rLOX- PP to further tune-up its accumulation
in cancer cell lines.
-Studied rLOX-PP interaction with DNA repair pathway
on prostate cancer xenograft growth.
-Studied endosomal escape, recycling and enhanced
delivery of rLOX-PP by employing pH sensitive nano-
particles.
-Developed dark quencher compound usage for Flow
Cytometry and ConfocalMicroscopy.
-Studied pH modulation effect of rLOX-PP on
macropinocytosis and developing an efficient cytoplasmic
delivery for its intra-cellular targets.
-Studied rLOX-PP interaction with its extra-cellular targets
Syndecan 4 and 1 in cancer cell lines.
-Developed networking, presentation and interpersonal skills
through the attendance of conferences.
-Worked independently to design and plan nature of work,
overcome problems and manage workload.
2001-2002: Ege University Schoolof Dental Medicine, Izmir, Turkey.
Diploma Dissertationand Masterof Science Degree(MSc)
“Comparison of the Advantages of Magnetic Resonance (MR),
Computerized Tomography (CT), and Diagnostic Sonography
As Visualization Techniques for Cancer Diagnosis in
Maxillofacial Area.” directed by Prof. Dr. Nesrin Dundar.
1994-2002: Ege University School of Dental Medicine, Izmir, Turkey.
Doctorof Dental Surgery (DDS)
-Enhanced problem solving skills and interpersonal skills
through theoretical classes and dental clinics.
-Acquired clinical skills in scientific environment.
-Gained knowledge for intensive case-based problem solving.

4. 1991-1993: Erzurum Science High School, Erzurum, Turkey.
-National First Prize for Physics Projectin NationalScience
ProjectCompetition for High Schools (TUBITAK), 1993.
-Gained theoretical and experimental problem solving skills.
-Built self-discipline for studying strategies.
ResearchInterests:
Molecular Biology of Cancer, Gene Therapy, Targeting
Cellular Signaling Pathways, Drug Discovery, Molecular
Neuroscience, Biological Therapeutics for Cancer,
Dental Research, Delivery and Nanoparticles.
ResearchExperiences:
January 2015-Present:
Post-DoctoralAssociate
Department of Molecular and Cell
Biology at BostonUniversity’s Henry M. Goldman Schoolof
Dental Medicine (GSDM), directed by Prof. Philip C.
Trackman.
September 2010-January2015:
D.Sc. Student and ResearchAssistant
Department of Molecular and Cell
Biology at BostonUniversity’s Henry M. Goldman Schoolof
Dental Medicine (GSDM), directed by Prof. Philip C.
Trackman.
March 2009-August2010:
ResearchAssistant
Massachusetts General Hospital/Harvard Medical School
(MGH) Neurogenetics Unit, directed by Prof. Xandra O.
Breakefield (Dr. Okay Saydam’s group).

5. 2001-2002:
Graduate ResearchAssistant
Ege University Schoolof Dental Medicine: Diploma
Dissertation Studies directed by Prof. Dr. Nesrin Dundar.
ProfessionalExperiences:
April 2006-December2006:
Doctor of Dental Surgery (DDS), Didim Estetica Ağız ve Dis
Sagligi Poliklinigi,Aydin, Turkey.
Phone: 00 90 256 813 63 85, 00 90 256 813 64 00
E-mail: info@esteticadental.com.tr
October2004-March2006:
DDS, Self-employed Dental Office,
Izmir,Turkey.
April 2003-October2004:
DDS, Izmir Can Tip Merkezi, Izmir,
Turkey.
Phone: 00 90 232 264 32 19, 00 90 232 264 69 69
Publications: Peerreviewed articles:
-Gokhan Baris Ozdener, Manish V. Bais, Philip C. Trackman.
“Determination of Cell Uptake Pathways for Tumor Inhibitor
Lysyl Oxidase Propeptide.” Molecular Oncology. 2015 Aug 6.
pii: S1574-7891(15)00145-3.
-Manish Bais , GokhanOzdener , Gail E. Sonenshein and
Trackman PC. “Effects of Tumor SuppresorLysyl Oxidase
Propeptide on Prostate Cancer Xenograft Growth and Its Direct
Interactions with DNA Repair Pathways.” Oncogene.
Dec 2013; ONC-2013-01199.
-Mizrak A, Bolukbasi MF, Ozdener GB, Brenner GJ,
Madlener S, Erkan EP, StröbelT, Breakefield XO, Saydam O.
“Genetically Engineered Microvesicles Carrying Suicide

6. mRNA/Protein Inhibit Schwannoma Tumor Growth.”
Mol Ther. 2013 Jan;21(1):101-8.
-Mehmet Fatih Bolukbasi, Arda Mizrak, Ozdener GB,
Sibylle Madlener, Thomas Ströbel, Erdogan Pekcan Erkan,
Jian-Bing Fan, Xandra O. Breakefield, and Okay Saydam
“miR-1289 and ‘Zipcode’-like Sequence Enrich mRNAs in
Microvesicles” Mol Ther Nucleic Acids. 2012 February; 1(2):
e10.
-Saydam O, Senol O, Würdinger T, Mizrak A, Ozdener GB,
Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky
AM, Saydam N,Brenner GJ, Breakefield XO. “miRNA-7
attenuation in Schwannoma tumors stimulates growth by
upregulating three oncogenic signaling pathways.” Cancer Res.
2011 Feb 1;71(3):852-61.
- Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar S,
Stemmer-Rachamimov AO, Breakefield XO, Brenner GJ.“A
novel imaging-compatible sciatic nerve schwannoma model.”
J Neurosci Methods. 2011 Jan 30;195(1):75-7.
Book Chapter:
-Arda Mizrak, Ozlem Senol, Baris GokhanOzdener, Okay
Saydam. “miR-200a Regulation of the Wnt Signaling in
Meningioma Tumorigenesis.” Tumors of the Central Nervous
System Volume 7, pp 59-67 (2012).
Presentations (Oraland PosterPresentations atConferences):
- GokhanBaris Ozdener, Philip C. Trackman.
Lysyl oxidase propeptide (LOX-PP) inhibits oral cancer
metastasis and tumor growth by interacting with Stromal cell-
derived factor 1 (SDF-1), syndecan-4 (SDC-4) and syndecan-1
(SDC-1). International Conference on Periodontics and
Prosthodontics/June, 2016 New Orleans, USA (Organizing
Committee Member).
- GokhanBaris Ozdener, Philip C. Trackman.
Vacuolar/Cytoplasmic pH Gradient by Inhibitors of ATP and
Ionophores Increase Cell Uptake and Endosomal Escape of the

7. Tumor SuppressorLysyl Oxidase Propeptide (rLOX-PP).
Science Day 2016 at Boston University GSDM.
-Gokhan Baris Ozdener, Manish V. Bais, Philip C. Trackman.
“Determination of Cell Uptake Pathways for Tumor Inhibitor
Lysyl Oxidase Propeptide.” Etiology and Pathogenesis of Oral
Cancer the Affinity Research Collaboratives (EPOC ARC)
Symposium, October, 2015
- GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman.
“Macropinocytosis Uptake Pathways for the Lysyl Oxidase
Propeptide(rLOX-PP). Head & Neck Cancer Symposium at
BostonUniversity GSDM and Dana-Farber (September, 2015).
- GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman.
“Macropinocytosis Uptake Pathways for the Lysyl Oxidase
Propeptide(rLOX-PP).” The 93rd General Session & Exhibition
of the International Association for Dental Research (IADR) and
the 44th of the AADR (March, 2015).
- GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman.
“Macropinocytosis and Caveola - dependent Endocytosis Are
Major Cell Uptake Pathways for the Tumor Inhibitor Lysyl
Oxidase Propeptide” Science Day 2015 at Boston University
GSDM.
- GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman.
“Cellular Uptake of rLOX-PP Involves Phosphatidylinositol 3-
kinase (PI3K) Dependent, HSPG Mediated Macropinocytosis,
Caveola - dependent Endocytosis.rLOX- PP alkalizes endosomes
via modulating endosomal pH.” Science Day 2014 at Boston
University GSDM.
- Mehmet Fatih Bolukbasi, Arda Mizrak, GokhanBaris Ozdener,
Sibylle Madlener, Thomas Ströbel, Erdogan Pekcan Erkan, Jian-
Bing Fan, Xandra O. Breakefield and Okay Saydam. “miR-1289
and “zipcode”-like sequence enrich mRNAs in microvesicles.”
Scientific Program, International Society of Extracellular Vesicles
(ISEV) meeting 2012.

8. Articles in preparation:
-Ozdener G.B., Trackman Philip C. “Developing BSA-QSY9
quencher for flow cytomety and confocalmicroscopyto quench
red fluorescent emiting dyes”. (Manuscript writing)
-Ozdener GB, Bais M., Trackman Philip C. “Syndecan 1 and 4
involved ras-dependent macropinocytosis and caveola- dependent
pathways are major pathway for cellular uptake of LOX-PP in
various cell lines and their cancerous partners”.
-Ozdener G.B., Trackman Philip C. “rLOX-PP stimulates
macropinocytosis by increasing submembranous pH and activating
Rac1 and Cdc42signaling.”
-Ozdener G.B., Trackman Philip C. “The uptake of LOX-PP from
cytoplasm to nucleus is KPNA4 and KPNB1 dependent in
DU1453 and PC-3 cell lines.”
-Ozdener G.B., Trackman Philip C. “Cholesterol sequestration by
filipin enhances the uptake and activity of rLOX-PP in cancer cells
via activating clathrin-dependent uptake pathway.”
References:
Xandra O. Breakefield, PhD.
Professorof Neurology,
Molecular Neurogenetics Unit Massachusetts General Hospital-
East Building 149, 6th floor 13th Street Charlestown, MA 02129,
USA
Phone: 617-726-572
Fax: 617-724-1537
Email: breakefield@hms.harvard.edu

9. Philip C. Trackman, PhD.
Director, Graduate Programs in the Department of Molecular &
Cell Biology, Professor, Department of Molecular & Cell
Biology, At Boston University
700 Albany Street. Boston, MA 02118, USA
Phone: 617-638-4076
Email: trackman@bu.edu
Okay Saydam, PhD.
ProfessorofNeuro-Oncology,
Molecular Neuro-Oncology Research Unit, Division of Neuro-
Oncology, Department of Pediatrics, Medical University of
Vienna, Vienna,AUSTRIA
Phone: 01-40400-2146 or -3485
Email: okay.saydam@meduniwien.ac.at
Manish Bais, PhD.
Assistant Professorin the Department of Molecular &
Cell Biology, Boston University
700 Albany Street. Room # 216
Boston, MA 02118, USA
Phone: 617-638-4004
Email: manish.bais@bu.edu
Darrell J. Irvine, PhD
ProfessorofMaterials Science & Engineering and Biological
Engineering, MIT
Koch Institute for Integrative Cancer Research at MIT
Room76-261
Phone (617) 452-4174
Email: djirvine@mit.edu
Serge Dibart, DDS, DMD.
Chair of Periodontology, Director of the Advanced Specialty
Education Program in Periodontics at GSDM,
Professor, Department of Periodontology
100 East Newton Street Boston, MA 02118, USA
Phone: 617-638-4762
Email: sdibart@bu.edu

10. Celal Artunc, PhD.
Dean and ProfessorofDental Medicine,
Ege Univesity Schoolof Dental Medicine
Ege University, EU Bornova Izmir 35040, TURKEY.
Phone: 90 232 388- 6432 ext: 2801-102.
E-mail: celal.artunc@ege.edu.tr
JeffreyW. Hutter, BS, DMD, MEd
Dean and Spencer N. Frankl Professorin Dental Medicine,
Dean’s Office (G-317), Boston University Schoolof Dental
Medicine,
100 East Newton Street, Boston MA 02118 USA
Phone: 617-638-4780
Email: jhutter@bu.edu
David E. Levin, Ph.D.
Professorand Chair of Molecular and Cell Biology, BUGSDM
ProfessorofMicrobiology
72 East Concord Street, E430
Phone: 617-414-1057
Email: delevin@bu.edu
Gary Jay Brenner, M.D., PH.D.
Associate Professorof Anesthesia, Massachusetts General Hospital
MGH Center for Pain Medicine, WAC 334, 15 Parkman Street
Boston MA 02114
Phone: 617/726-9223
Email: gjbrenner@partners.org