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Gynecology part
BSc Nurse
By Alemu Guta (Ass.t prof)
4/5/2023 Alemu G 1
Early pregnancy bleeding
4/5/2023 Alemu G 2
Cause of Early pregnancy bleeding
 Abortion
 Ectopic pregnancy
 GTD
3
4/5/2023 Alemu G
Abortion
4/5/2023 Alemu G 4
Outline
 Overview of maternal mortality
 Define abortion
 Discuss different classification of abortion
 Discuss etiologies of abortion
 Discuss clinical types of spontaneous abortion
 Outline the management of abortion
5
4/5/2023 Alemu G
MATERNAL MORTALITY-
MORBIDITY,
UNWANTED PREGNANCY AND
UNSAFE ABORTION:
CAUSE, MAGNITUDE,
PREVENTION
4/5/2023 Alemu G 6
Brainstorming
• Q1. Define maternal mortality?
4/5/2023 Alemu G 7
Maternal mortality: definition
 The death of a woman while pregnant or
within 42 days of termination of
pregnancy, irrespective of duration and site
of pregnancy, from any cause related to or
aggravated by pregnancy or its
management but not from accidental or
incidental causes.
(ICD-10, Tenth Revision,1992, WHO. ICD-MM, 2012)
4/5/2023 Alemu G 8
Causes of Maternal Death
1. Direct obstetric deaths:
Hemorrhage
Sepsis
Eclampsia/HPN
Unsafe abortion
Obstructed Labor
2. Indirect obstetric deaths:
 Cardiac/renal diseases (existing)
 Adolescent pregnancy
 HIV among pregnant women
 Malaria
 Malnutrition
 Harmful traditional practices
4/5/2023 Alemu G 9
Causes of Maternal Death in 2013: Global
Abortion,
15%
Haemorrhage,
15%
Gestational
HPN, 10%
Obstructed
Labor, 6%
Sepsis,
8%
Late, 15%
Other Direct,
19%
Indirect,
11%
HIV, 0.7%
4/5/2023 Alemu G 10
Unwanted Pregnancy
4/5/2023 Alemu G 11
Unwanted Pregnancy
Unwanted pregnancy is a pregnancy that a woman is not
actively trying to have (@ the time of conception).
It could be:-
Unintended
Unplanned
A mistake or
Not at the right time
4/5/2023 Alemu G 12
Why unwanted pregnancy happened?
Main reasons include
o Failure of family planning (contraceptive) delivery systems:
Lack of information
Lack of access
o Social/cultural/religious barriers
o Sexual violence: rape/incest
4/5/2023 Alemu G 13
Why unwanted pregnancy happened…
Main reasons include
o The method they were using failed
o Stigmatization/discrimination of unmarried women using
contraceptives
o Lack of knowledge on sexuality and reproduction
4/5/2023 Alemu G 14
Who is at Risk of Unwanted
Pregnancy?
4/5/2023 Alemu G 15
Who is at risk of Unwanted pregnancy?
 Married women
 Single women
 Adolescents and school girls
 Rich and poor
 From Urban/Rural
All women are at risk!!!
4/5/2023 Alemu G 16
Fate of women with unwanted
pregnancies
4/5/2023 Alemu G 17
Why women resort to unsafe abortion?
4/5/2023 Alemu G 18
Why women resort to unsafe abortion?
o Restrictive laws
o Unavailability of the service (despite liberal law)
o Lack of awareness
o Privacy (lack of facility)
o Providers attitude towards safe abortion
4/5/2023 Alemu G 19
What are the factors contributing
for maternal death?
The three delays
4/5/2023 Alemu G 20
 Lack of information and inadequate
knowledge about danger signals
during pregnancy and labor,
 Cultural/ traditional practices that
restrict women from seeking health
care, and
 Lack of money
The 1st delay: Delay in deciding to seek care at
household
4/5/2023 Alemu G 21
 Out of reach of health facilities,
 Poor roads and communication
network, and
 Poor community support
mechanisms.
 Most important barrier to seek
service (DHS 2011)
The 2nd delay: inability to access health facilities
4/5/2023 Alemu G 22
 Inadequate skilled attendants,
 Poorly motivated staff,
 Inadequate equipment and
supplies, and
 Weak referral system.
The 3rd delay: Delay between arriving and receiving
care at the health facility
4/5/2023 Alemu G 23
• Access to Comprehensive FP
• Access to legal Safe Abortion/CAC
• Skilled birth attendance
• Improvement in access & quality of Emergency
Obstetric Care (EmOc)
• Gender equality, Women’s empowerment
• Improvement in legal & policy framework.
What is the Magic/Secret?
4/5/2023 Alemu G 24
Thank You!!!
NO MORE…
4/5/2023 Alemu G 25
Define Abortion ?
4/5/2023 Alemu G 26
DEFINITION OF ABORTION
• Abortion is the termination of pregnancy before fetal viability,
Conventionally -less than 28 weeks from LNMP
If LNMP is not known, a birth weight of less than 1000gm
• WHO: define abortion as pregnancy termination or loss before 20 weeks’
gestation or with a fetus delivered weighing <500 g.
• It may occur either spontaneously or induced.
• Induced abortion can be safe or unsafe.
27
4/5/2023 Alemu G
Magnitude Abortion
 It is the most common complication of pregnancy
 About 15% of clinically recognized pregnancies end in abortion.
 More than 80% of spontaneous abortions occur within the first 12 weeks
of gestation.
4/5/2023 Alemu G 28
Magnitude of abortion in Ethiopian
 In 2014, an estimated 620,300 abortions were performed
every year in Ethiopia.
 Prevalence of induced abortion in
Wachamo University was 5.9% (Shimelis M, et al, 2015)
Hawassa University was 68.7% (አስደንጋጭ)
(Addisu Tadesse, et al, 2019)፣
https://doi.org/10.1155/2020/2856502.
4/5/2023 Alemu G 29
Classification of abortion
Classification of abortion based on:-
A. Method or onset:
 Spontaneous and Induced
B. Clinical staging of Abortion
1. Threatened
2. Inevitable
3. Incomplete
4. Complete
5. Missed
6. Septic
7. Recurrent
C. Legality:
 Legal and Illegal
D. Trimester:
 1st and 2nd
E. Service type
 Safe Abortion & Post abortion care
F. Safety
 Safe and unsafe
4/5/2023 Alemu G 30
Types of abortion
Based on onset:-
1. Spontaneous– happen on its own or without any deliberate
intervention.
2. Induced – caused by deliberate intervention
 Safe or unsafe
 Induced abortion is one of the mechanisms to deal with
unwanted pregnancy.
4/5/2023 Alemu G 31
Discuss -3Minute
Q. Abortion is legal or illegal in Ethiopia?
4/5/2023 Alemu G 32
Legality of abortion in Ethiopia
 Rape, (የተደፈረች)
 Incest or fetal impairment (እርግዝናዉ ከዜመድ ከሆነ)
 A woman can legally terminate a pregnancy if her life or her
child's life is in danger, or if continuing the pregnancy or giving
birth endangers her life.
 A woman may also terminate a pregnancy if she is unable to bring
up the child, owing to her status as a minor (aged under 18 years)
or to a physical or mental infirmity or illness.
4/5/2023 Alemu G 33
Based on service type: -
 Safe Abortion care: is a comprehensive termination of pregnancy that
is offered to clients as permitted by the law
 Post abortion care: is a comprehensive service to treat women that
present to a health care facility after abortion has occurred
spontaneously or after attempted termination.
4/5/2023 Alemu G 34
Etiology
A. First trimester abortion :(the first 12 wk) #1
1. Fetal chromosomal abnormalities –
 is commonest cause
 particularly Trisomy, Polyploidy.
50– 70 % of the first trimester abortions
the incidence increased with the increase in the maternal age.
4/5/2023 Alemu G 35
Etiology
2. Anembryonic pregnancy - Blighted ovum.
3. Infections: genital tract infection , systemic infection with pyrexia
& ToRCH syndrome.
4. Uterine disorders: Uterine anomalies, sub mucus fibroid & Asher
man's syndrome.
5. Psychological disorders.
6. Cigarette smoking ,alcohol, anesthetic agents & chemical agents .
4/5/2023 Alemu G 36
Etiology…
B. Second trimester abortion:
1. Multiple pregnancy
2. Cervical incompetence (congenital & acquired )
3. Uterine anomalies and sub mucous fibroid
4. Genital tract infection and PROM
5. Systemic infections: HIV, Malaria, syphilis, Rubella
6. Maternal health: Diabetes, Renal disease, Hypertension.
4/5/2023 Alemu G 37
4/5/2023 Alemu G 38
Threatened abortion
 Painless vaginal bleeding
 Minimal/mild suprapubic discomfort, mild cramps, pelvic pressure, or
persistent low backache
 On examination:
Uterine size is appropriate for gestational age and
Cervix is long and closed.
4/5/2023 Alemu G 39
Threatened abortion..
 Fetal cardiac activity is detectable by ultrasound or Doppler.
 Even if miscarriage does not follow threatened abortion, rates of later
adverse pregnancy outcomes are increased.
 Of these, highest risks are for preterm delivery.
4/5/2023 Alemu G 40
Threatened abortion (Management)
1. Reassurance: If fetal heart activity is present
2. Advice the woman to avoid strenuous activity and sexual intercourse.
3. ANC as high risk patients
Because those patients are liable to late pregnancy complications such
as APH and preterm labour .
4/5/2023 Alemu G 41
Inevitable abortion
 Bleeding increases,
 Painful uterine cramps/contractions reach peak intensity,
 Membrane is ruptured
 The cervix is dilated to variable extent
 The gestational tissue can often be felt or visualized through the internal
cervical os.
4/5/2023 Alemu G 42
Incomplete abortion
 The membrane ruptured & often the fetus passed
 Part of the placenta may be retained
 On physical exam: cervix usually open, conceptus tissue in the
vagina/cervix
 Small for date uterus
 Amount of bleeding varies
 Often they have painful cramp
4/5/2023 Alemu G 43
Complete abortion
• Is complete expulsion of the entire pregnancy.
• A history of heavy bleeding, cramping, and passage of tissue is typical.
• The uterus is small for GA and well contracted
• Closed cervix,
• Scant vaginal bleeding
• US may indicate a minimally thickened endometrium without a gestational
sac.
4/5/2023 Alemu G 44
4/5/2023 Alemu G 45
Missed abortion
 Is in-utero death of the embryo or fetus prior to the 28th week of
gestation with retention of the pregnancy for 1 wk and above.
 Regression of symptoms associated with early pregnancy and they don't
"feel pregnant" any more;
 Vaginal bleeding may occur.
 The cervix is usually closed
4/5/2023 Alemu G 46
Transvaginal sonography displays an anembryonic gestation
4/5/2023 Alemu G 47
Septic abortion
Definition: Any
of the stage of
abortion
complicated by
pelvic infection.
Etiology
Polymicrobial
• E.Coli
• Bacteroid
• Enterococi
• B-hemolytic
streptococci
• C.Perferenges &
tetani
• Klebsiella, proteus
Symptoms:
• Fever, chills,
malaise,
• abdominal pain,
• vaginal bleeding,
and
• foul smelling
vaginal
discharge.
Physical
examination
may reveal
• Tachycardia,
• Tachypnea,
• Lower abdominal
tenderness, and
• Boggy, tender uterus
with dilated cervix.
4/5/2023 Alemu G 48
4/5/2023 Alemu G 49
Septic Abortion…
The infection may spread, leading to salpingitis, generalized
peritonitis, and septicemia.
Most spontaneous abortions are not septic.
Is, however, a common complication of illegally performed induced
abortion.
4/5/2023 Alemu G 50
Treatment of Septic Abortion
Antibiotics :
 Ampicillin 2gm IV QID,
 gentamicin 3-5mg/kg IV TID
 Metronidazole 500mg IV TID
Removal of infected tissue within an hour of antibiotics.
Administered until the patient has improved and been afebrile for 48
hours.
4/5/2023 Alemu G 51
Recurrent abortion
 Definition: Occurence of >3 consecutive spontaneous aboritions.
 Etiology
1. Immunologic
2. Anatomic
3. Endocrinology
4. Microbiology
5. Genetic
6. Thrombophilia
7. Vitamin deficiency
8. Unknown
4/5/2023 Alemu G 52
Management of abortion
4/5/2023 Alemu G 53
Management of Abortion
The choice of management approach depends on
 Gestational age
 Clinical diagnosis
 Availability of methods of uterine evacuation
 The skill of the providers
4/5/2023 Alemu G 54
Methods for evacuation of uterine content
Medical
methods:
• Mifepristone + misoprostol
• Misoprostol
• High dose oxytocin
Surgical
methods
• MVA- preferred method
• Suction dilation and curettage or suction curettage
4/5/2023 Alemu G 55
Expect
ant
Reassurance, Advice, Rest, ANC follow-up, counseling
1. EXPECTANT MANAGEMENT
• In cases of threatened abortion, pregnancy can continue till
term and clients can be managed expectantly.
• Medical treatment is not usually required.
• Avoid strenuous activity and sexual intercourse.
4/5/2023 Alemu G 56
2. MEDICAL ABORTION
4/5/2023 Alemu G 57
Definition and the drugs
• Medication abortion (MA) is termination of pregnancy using drugs
• There are different types of drugs used for abortion
• Currently, the commonly used MA agents are mifepristone and
misoprostole.
4/5/2023 Alemu G 58
4/5/2023 Alemu G 59
Fig. Mifepristone + Misoprostol tablets
4/5/2023 Alemu G 60
The Drugs
4/5/2023 Alemu G 61
Mifepristone
Is a synthetic anti-progesterone
Is developed as RU-486- Roussel-Uclaf plus a serial number.
 Leads to
 detachment of the pregnancy from the uterine wall;
 it also dilates the cervix
It is teratogenic if pregnancy continues after use
It is given orally!
4/5/2023 Alemu G 62
Misoprostole
• Is a prostaglandin E analogue
• Originally manufactured for treatment of PUD
• Works by causing uterine contraction and cervical
dilatation
• Can be used for prevention and/or treatment of PPH
• Is given in different roots (oral, vaginal, buccal, sublingual).
4/5/2023 Alemu G 63
Mechanism of Action: Mifepristone + Misoprostol
Rhythmic
Uterine
Contractions
Progesterone Blockade
Decidual
Necrosis
Cervical
Ripening
Detachment Expulsion
Abortion
© Lisa Penalver
Source: NAF
4/5/2023 Alemu G 64
Effectiveness of MA
Combination of two drugs more effective than either used
alone.
Combined regimen is 92-98% effective in pregnancies ≤ 9
weeks since LMP (Von Hertzen et al., 2003).
Misoprostol alone = 85-90% effective
4/5/2023 Alemu G 65
Regimes for medication
abortion:
doses & route of administration
4/5/2023 Alemu G 66
MEDICALABORTION FOR FIRST TRIMESTER
SAFE ABORTION CARE
4/5/2023 Alemu G 67
Regimens
1. Mifepristone
200mg (1 tab) orally on day 1.
Most women will feel no change after taking mifepristone:
Some women will begin bleeding before taking the next pill
(misoprostol).
A few women will abort after the mifepristone alone.
4/5/2023 Alemu G 68
Regimens
2. Misoprostole
800 (4 tabs) microgram vaginal suppository after 36-48
hours.
There is a range of options in route, dosage and timing
After seven weeks LMP, vaginal doses are more
effective
Up to 90% of women will expel within six hours of
vaginal dose (WHO, 2003).
4/5/2023 Alemu G 69
4/5/2023 Alemu G 70
What to expect after MA
4/5/2023 Alemu G 71
Side effects vs. Complications
Side effects:
• Effects of the treatment, other than the intended outcome,
that might include physiological or psychological
consequences.
 Most are minor, and require little or no intervention
Complications:
• Effects of treatment with potentially serious clinical
consequences
 Require medical intervention
4/5/2023 Alemu G 72
Expected side effects following MA
 Pain
 Bleeding
 Fever, chills, sweating
 Nausea, vomiting
 Dizziness
 Diarrhea
 Skin rashes
 Headache
4/5/2023 Alemu G 73
How much bleeding is too much?
4/5/2023 Alemu G 74
Heavy bleeding Management
Aspiration (MVA) to stop bleeding (0.4 - 2%)
Transfusion required in approximately 0.2% cases
For early surgical abortion ~ 0.1%
No reports of hysterectomy for hemostasis after MA reported
4/5/2023 Alemu G 75
Steps taken before administering MA
• Clinical assessment
History and physical examination
+ Investigations
• Counselling and informed consent
• Discussion of contraceptive needs
4/5/2023 Alemu G 76
Medical abortion for first trimester post abortion care
(Missed and incomplete abortion)
4/5/2023 Alemu G 77
MA for Post-abortion Care
• Evidences show that misoprostole is equally effective to treat incomplete
abortion in the first trimester as MVA.
• MA for PAC is included in the Ethiopian procedural guideline
4/5/2023 Alemu G 78
4/5/2023 Alemu G 79
Misoprostol for Missed Abortion
 800 µgm vaginally
 Administered at home or in clinic
 Success rates: 80-90%
But diagnosis of “missed” abortion depends on access to
ultrasound
4/5/2023 Alemu G 80
MA for second trimester abortion
• MA can also be used for treatment of second trimester safe abortion
• The Ethiopian procedural guideline states
• Additionally trained personnel
• Should be done in hospital set-up having emergency back-up
• The risk of complication is higher than first trimester abortion
4/5/2023 Alemu G 81
3. Uterine Evacuation using
Manual Vacuum Aspiration
(MVA)
4/5/2023 Alemu G 82
Manual Vacuum Aspiration [MVA]
The following equipment for MVA procedure:
 Pelvic model
 High-level disinfected or sterile surgical gloves
 Personal protective barriers
 MVA syringes and cannula
 Vaginal speculum
 Single-toothed tenaculum or vulsellum forceps
4/5/2023 Alemu G 83
Parts Assembled
4/5/2023 Alemu G 84
Steps of the MVA Procedure
1. Prepare instruments.
2. Prepare the woman.
3. Perform cervical antiseptic prep.
4. Dilate cervix.
5. Insert cannula.
6. Suction uterine contents.
7. Inspect tissue.
8. Perform any concurrent procedures.
9. Process instruments.
Step 1: Prepare Instruments
Prepare all necessary equipments and instruments for
doing UE using MVA
Check that the aspirator retains a vacuum.
Have more than one aspirator available.
Create a Vacuum
Step 2: Prepare the Woman
Ask for consent (when appropriate)
Ensure pain medication is given at the appropriate time.
Ask the woman to empty her bladder.
Help her onto the table.
Wash hands and put on barriers.
Perform a bimanual exam.
Signs of complete evacuation
• Red or pink foam without tissue passing through cannula
• Gritty sensation over surface of uterus
• Uterus contracting around cannula
• Increased uterine cramping
• Cervix tightly gripping the cannula
Post Abortion Family Planning Counseling &
Services (PAFP)
• PAFP is one of the key quality indicators for CAC
• Ovulation can occur within 10 days following abortion and
the woman may risk subsequent unintended pregnancy
• PAFP thus prevent further unintended pregnancy and
abortion
• Remember that some women may desire another
pregnancy.
4/5/2023 Alemu G 90
Post Abortion care (PAC)
 PAC- is a global initiative in response to the problem of maternal
mortality and morbidity resulting from unsafe abortion.
 Essential elements of PAC services
1. Treatment of incomplete and unsafe abortion
2. Counseling to respond to women's needs
3. Contraceptive services
4. Link to other Reproductive services
5. Community and provider partnerships
4/5/2023 Alemu G 91
GOOD LUCK
4/5/2023 Alemu G 92

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Causes and Management of Early Pregnancy Bleeding

  • 1. Gynecology part BSc Nurse By Alemu Guta (Ass.t prof) 4/5/2023 Alemu G 1
  • 3. Cause of Early pregnancy bleeding  Abortion  Ectopic pregnancy  GTD 3 4/5/2023 Alemu G
  • 5. Outline  Overview of maternal mortality  Define abortion  Discuss different classification of abortion  Discuss etiologies of abortion  Discuss clinical types of spontaneous abortion  Outline the management of abortion 5 4/5/2023 Alemu G
  • 6. MATERNAL MORTALITY- MORBIDITY, UNWANTED PREGNANCY AND UNSAFE ABORTION: CAUSE, MAGNITUDE, PREVENTION 4/5/2023 Alemu G 6
  • 7. Brainstorming • Q1. Define maternal mortality? 4/5/2023 Alemu G 7
  • 8. Maternal mortality: definition  The death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of duration and site of pregnancy, from any cause related to or aggravated by pregnancy or its management but not from accidental or incidental causes. (ICD-10, Tenth Revision,1992, WHO. ICD-MM, 2012) 4/5/2023 Alemu G 8
  • 9. Causes of Maternal Death 1. Direct obstetric deaths: Hemorrhage Sepsis Eclampsia/HPN Unsafe abortion Obstructed Labor 2. Indirect obstetric deaths:  Cardiac/renal diseases (existing)  Adolescent pregnancy  HIV among pregnant women  Malaria  Malnutrition  Harmful traditional practices 4/5/2023 Alemu G 9
  • 10. Causes of Maternal Death in 2013: Global Abortion, 15% Haemorrhage, 15% Gestational HPN, 10% Obstructed Labor, 6% Sepsis, 8% Late, 15% Other Direct, 19% Indirect, 11% HIV, 0.7% 4/5/2023 Alemu G 10
  • 12. Unwanted Pregnancy Unwanted pregnancy is a pregnancy that a woman is not actively trying to have (@ the time of conception). It could be:- Unintended Unplanned A mistake or Not at the right time 4/5/2023 Alemu G 12
  • 13. Why unwanted pregnancy happened? Main reasons include o Failure of family planning (contraceptive) delivery systems: Lack of information Lack of access o Social/cultural/religious barriers o Sexual violence: rape/incest 4/5/2023 Alemu G 13
  • 14. Why unwanted pregnancy happened… Main reasons include o The method they were using failed o Stigmatization/discrimination of unmarried women using contraceptives o Lack of knowledge on sexuality and reproduction 4/5/2023 Alemu G 14
  • 15. Who is at Risk of Unwanted Pregnancy? 4/5/2023 Alemu G 15
  • 16. Who is at risk of Unwanted pregnancy?  Married women  Single women  Adolescents and school girls  Rich and poor  From Urban/Rural All women are at risk!!! 4/5/2023 Alemu G 16
  • 17. Fate of women with unwanted pregnancies 4/5/2023 Alemu G 17
  • 18. Why women resort to unsafe abortion? 4/5/2023 Alemu G 18
  • 19. Why women resort to unsafe abortion? o Restrictive laws o Unavailability of the service (despite liberal law) o Lack of awareness o Privacy (lack of facility) o Providers attitude towards safe abortion 4/5/2023 Alemu G 19
  • 20. What are the factors contributing for maternal death? The three delays 4/5/2023 Alemu G 20
  • 21.  Lack of information and inadequate knowledge about danger signals during pregnancy and labor,  Cultural/ traditional practices that restrict women from seeking health care, and  Lack of money The 1st delay: Delay in deciding to seek care at household 4/5/2023 Alemu G 21
  • 22.  Out of reach of health facilities,  Poor roads and communication network, and  Poor community support mechanisms.  Most important barrier to seek service (DHS 2011) The 2nd delay: inability to access health facilities 4/5/2023 Alemu G 22
  • 23.  Inadequate skilled attendants,  Poorly motivated staff,  Inadequate equipment and supplies, and  Weak referral system. The 3rd delay: Delay between arriving and receiving care at the health facility 4/5/2023 Alemu G 23
  • 24. • Access to Comprehensive FP • Access to legal Safe Abortion/CAC • Skilled birth attendance • Improvement in access & quality of Emergency Obstetric Care (EmOc) • Gender equality, Women’s empowerment • Improvement in legal & policy framework. What is the Magic/Secret? 4/5/2023 Alemu G 24
  • 27. DEFINITION OF ABORTION • Abortion is the termination of pregnancy before fetal viability, Conventionally -less than 28 weeks from LNMP If LNMP is not known, a birth weight of less than 1000gm • WHO: define abortion as pregnancy termination or loss before 20 weeks’ gestation or with a fetus delivered weighing <500 g. • It may occur either spontaneously or induced. • Induced abortion can be safe or unsafe. 27 4/5/2023 Alemu G
  • 28. Magnitude Abortion  It is the most common complication of pregnancy  About 15% of clinically recognized pregnancies end in abortion.  More than 80% of spontaneous abortions occur within the first 12 weeks of gestation. 4/5/2023 Alemu G 28
  • 29. Magnitude of abortion in Ethiopian  In 2014, an estimated 620,300 abortions were performed every year in Ethiopia.  Prevalence of induced abortion in Wachamo University was 5.9% (Shimelis M, et al, 2015) Hawassa University was 68.7% (አስደንጋጭ) (Addisu Tadesse, et al, 2019)፣ https://doi.org/10.1155/2020/2856502. 4/5/2023 Alemu G 29
  • 30. Classification of abortion Classification of abortion based on:- A. Method or onset:  Spontaneous and Induced B. Clinical staging of Abortion 1. Threatened 2. Inevitable 3. Incomplete 4. Complete 5. Missed 6. Septic 7. Recurrent C. Legality:  Legal and Illegal D. Trimester:  1st and 2nd E. Service type  Safe Abortion & Post abortion care F. Safety  Safe and unsafe 4/5/2023 Alemu G 30
  • 31. Types of abortion Based on onset:- 1. Spontaneous– happen on its own or without any deliberate intervention. 2. Induced – caused by deliberate intervention  Safe or unsafe  Induced abortion is one of the mechanisms to deal with unwanted pregnancy. 4/5/2023 Alemu G 31
  • 32. Discuss -3Minute Q. Abortion is legal or illegal in Ethiopia? 4/5/2023 Alemu G 32
  • 33. Legality of abortion in Ethiopia  Rape, (የተደፈረች)  Incest or fetal impairment (እርግዝናዉ ከዜመድ ከሆነ)  A woman can legally terminate a pregnancy if her life or her child's life is in danger, or if continuing the pregnancy or giving birth endangers her life.  A woman may also terminate a pregnancy if she is unable to bring up the child, owing to her status as a minor (aged under 18 years) or to a physical or mental infirmity or illness. 4/5/2023 Alemu G 33
  • 34. Based on service type: -  Safe Abortion care: is a comprehensive termination of pregnancy that is offered to clients as permitted by the law  Post abortion care: is a comprehensive service to treat women that present to a health care facility after abortion has occurred spontaneously or after attempted termination. 4/5/2023 Alemu G 34
  • 35. Etiology A. First trimester abortion :(the first 12 wk) #1 1. Fetal chromosomal abnormalities –  is commonest cause  particularly Trisomy, Polyploidy. 50– 70 % of the first trimester abortions the incidence increased with the increase in the maternal age. 4/5/2023 Alemu G 35
  • 36. Etiology 2. Anembryonic pregnancy - Blighted ovum. 3. Infections: genital tract infection , systemic infection with pyrexia & ToRCH syndrome. 4. Uterine disorders: Uterine anomalies, sub mucus fibroid & Asher man's syndrome. 5. Psychological disorders. 6. Cigarette smoking ,alcohol, anesthetic agents & chemical agents . 4/5/2023 Alemu G 36
  • 37. Etiology… B. Second trimester abortion: 1. Multiple pregnancy 2. Cervical incompetence (congenital & acquired ) 3. Uterine anomalies and sub mucous fibroid 4. Genital tract infection and PROM 5. Systemic infections: HIV, Malaria, syphilis, Rubella 6. Maternal health: Diabetes, Renal disease, Hypertension. 4/5/2023 Alemu G 37
  • 39. Threatened abortion  Painless vaginal bleeding  Minimal/mild suprapubic discomfort, mild cramps, pelvic pressure, or persistent low backache  On examination: Uterine size is appropriate for gestational age and Cervix is long and closed. 4/5/2023 Alemu G 39
  • 40. Threatened abortion..  Fetal cardiac activity is detectable by ultrasound or Doppler.  Even if miscarriage does not follow threatened abortion, rates of later adverse pregnancy outcomes are increased.  Of these, highest risks are for preterm delivery. 4/5/2023 Alemu G 40
  • 41. Threatened abortion (Management) 1. Reassurance: If fetal heart activity is present 2. Advice the woman to avoid strenuous activity and sexual intercourse. 3. ANC as high risk patients Because those patients are liable to late pregnancy complications such as APH and preterm labour . 4/5/2023 Alemu G 41
  • 42. Inevitable abortion  Bleeding increases,  Painful uterine cramps/contractions reach peak intensity,  Membrane is ruptured  The cervix is dilated to variable extent  The gestational tissue can often be felt or visualized through the internal cervical os. 4/5/2023 Alemu G 42
  • 43. Incomplete abortion  The membrane ruptured & often the fetus passed  Part of the placenta may be retained  On physical exam: cervix usually open, conceptus tissue in the vagina/cervix  Small for date uterus  Amount of bleeding varies  Often they have painful cramp 4/5/2023 Alemu G 43
  • 44. Complete abortion • Is complete expulsion of the entire pregnancy. • A history of heavy bleeding, cramping, and passage of tissue is typical. • The uterus is small for GA and well contracted • Closed cervix, • Scant vaginal bleeding • US may indicate a minimally thickened endometrium without a gestational sac. 4/5/2023 Alemu G 44
  • 46. Missed abortion  Is in-utero death of the embryo or fetus prior to the 28th week of gestation with retention of the pregnancy for 1 wk and above.  Regression of symptoms associated with early pregnancy and they don't "feel pregnant" any more;  Vaginal bleeding may occur.  The cervix is usually closed 4/5/2023 Alemu G 46
  • 47. Transvaginal sonography displays an anembryonic gestation 4/5/2023 Alemu G 47
  • 48. Septic abortion Definition: Any of the stage of abortion complicated by pelvic infection. Etiology Polymicrobial • E.Coli • Bacteroid • Enterococi • B-hemolytic streptococci • C.Perferenges & tetani • Klebsiella, proteus Symptoms: • Fever, chills, malaise, • abdominal pain, • vaginal bleeding, and • foul smelling vaginal discharge. Physical examination may reveal • Tachycardia, • Tachypnea, • Lower abdominal tenderness, and • Boggy, tender uterus with dilated cervix. 4/5/2023 Alemu G 48
  • 50. Septic Abortion… The infection may spread, leading to salpingitis, generalized peritonitis, and septicemia. Most spontaneous abortions are not septic. Is, however, a common complication of illegally performed induced abortion. 4/5/2023 Alemu G 50
  • 51. Treatment of Septic Abortion Antibiotics :  Ampicillin 2gm IV QID,  gentamicin 3-5mg/kg IV TID  Metronidazole 500mg IV TID Removal of infected tissue within an hour of antibiotics. Administered until the patient has improved and been afebrile for 48 hours. 4/5/2023 Alemu G 51
  • 52. Recurrent abortion  Definition: Occurence of >3 consecutive spontaneous aboritions.  Etiology 1. Immunologic 2. Anatomic 3. Endocrinology 4. Microbiology 5. Genetic 6. Thrombophilia 7. Vitamin deficiency 8. Unknown 4/5/2023 Alemu G 52
  • 54. Management of Abortion The choice of management approach depends on  Gestational age  Clinical diagnosis  Availability of methods of uterine evacuation  The skill of the providers 4/5/2023 Alemu G 54
  • 55. Methods for evacuation of uterine content Medical methods: • Mifepristone + misoprostol • Misoprostol • High dose oxytocin Surgical methods • MVA- preferred method • Suction dilation and curettage or suction curettage 4/5/2023 Alemu G 55 Expect ant Reassurance, Advice, Rest, ANC follow-up, counseling
  • 56. 1. EXPECTANT MANAGEMENT • In cases of threatened abortion, pregnancy can continue till term and clients can be managed expectantly. • Medical treatment is not usually required. • Avoid strenuous activity and sexual intercourse. 4/5/2023 Alemu G 56
  • 58. Definition and the drugs • Medication abortion (MA) is termination of pregnancy using drugs • There are different types of drugs used for abortion • Currently, the commonly used MA agents are mifepristone and misoprostole. 4/5/2023 Alemu G 58
  • 60. Fig. Mifepristone + Misoprostol tablets 4/5/2023 Alemu G 60
  • 62. Mifepristone Is a synthetic anti-progesterone Is developed as RU-486- Roussel-Uclaf plus a serial number.  Leads to  detachment of the pregnancy from the uterine wall;  it also dilates the cervix It is teratogenic if pregnancy continues after use It is given orally! 4/5/2023 Alemu G 62
  • 63. Misoprostole • Is a prostaglandin E analogue • Originally manufactured for treatment of PUD • Works by causing uterine contraction and cervical dilatation • Can be used for prevention and/or treatment of PPH • Is given in different roots (oral, vaginal, buccal, sublingual). 4/5/2023 Alemu G 63
  • 64. Mechanism of Action: Mifepristone + Misoprostol Rhythmic Uterine Contractions Progesterone Blockade Decidual Necrosis Cervical Ripening Detachment Expulsion Abortion © Lisa Penalver Source: NAF 4/5/2023 Alemu G 64
  • 65. Effectiveness of MA Combination of two drugs more effective than either used alone. Combined regimen is 92-98% effective in pregnancies ≤ 9 weeks since LMP (Von Hertzen et al., 2003). Misoprostol alone = 85-90% effective 4/5/2023 Alemu G 65
  • 66. Regimes for medication abortion: doses & route of administration 4/5/2023 Alemu G 66
  • 67. MEDICALABORTION FOR FIRST TRIMESTER SAFE ABORTION CARE 4/5/2023 Alemu G 67
  • 68. Regimens 1. Mifepristone 200mg (1 tab) orally on day 1. Most women will feel no change after taking mifepristone: Some women will begin bleeding before taking the next pill (misoprostol). A few women will abort after the mifepristone alone. 4/5/2023 Alemu G 68
  • 69. Regimens 2. Misoprostole 800 (4 tabs) microgram vaginal suppository after 36-48 hours. There is a range of options in route, dosage and timing After seven weeks LMP, vaginal doses are more effective Up to 90% of women will expel within six hours of vaginal dose (WHO, 2003). 4/5/2023 Alemu G 69
  • 71. What to expect after MA 4/5/2023 Alemu G 71
  • 72. Side effects vs. Complications Side effects: • Effects of the treatment, other than the intended outcome, that might include physiological or psychological consequences.  Most are minor, and require little or no intervention Complications: • Effects of treatment with potentially serious clinical consequences  Require medical intervention 4/5/2023 Alemu G 72
  • 73. Expected side effects following MA  Pain  Bleeding  Fever, chills, sweating  Nausea, vomiting  Dizziness  Diarrhea  Skin rashes  Headache 4/5/2023 Alemu G 73
  • 74. How much bleeding is too much? 4/5/2023 Alemu G 74
  • 75. Heavy bleeding Management Aspiration (MVA) to stop bleeding (0.4 - 2%) Transfusion required in approximately 0.2% cases For early surgical abortion ~ 0.1% No reports of hysterectomy for hemostasis after MA reported 4/5/2023 Alemu G 75
  • 76. Steps taken before administering MA • Clinical assessment History and physical examination + Investigations • Counselling and informed consent • Discussion of contraceptive needs 4/5/2023 Alemu G 76
  • 77. Medical abortion for first trimester post abortion care (Missed and incomplete abortion) 4/5/2023 Alemu G 77
  • 78. MA for Post-abortion Care • Evidences show that misoprostole is equally effective to treat incomplete abortion in the first trimester as MVA. • MA for PAC is included in the Ethiopian procedural guideline 4/5/2023 Alemu G 78
  • 80. Misoprostol for Missed Abortion  800 µgm vaginally  Administered at home or in clinic  Success rates: 80-90% But diagnosis of “missed” abortion depends on access to ultrasound 4/5/2023 Alemu G 80
  • 81. MA for second trimester abortion • MA can also be used for treatment of second trimester safe abortion • The Ethiopian procedural guideline states • Additionally trained personnel • Should be done in hospital set-up having emergency back-up • The risk of complication is higher than first trimester abortion 4/5/2023 Alemu G 81
  • 82. 3. Uterine Evacuation using Manual Vacuum Aspiration (MVA) 4/5/2023 Alemu G 82
  • 83. Manual Vacuum Aspiration [MVA] The following equipment for MVA procedure:  Pelvic model  High-level disinfected or sterile surgical gloves  Personal protective barriers  MVA syringes and cannula  Vaginal speculum  Single-toothed tenaculum or vulsellum forceps 4/5/2023 Alemu G 83
  • 85. Steps of the MVA Procedure 1. Prepare instruments. 2. Prepare the woman. 3. Perform cervical antiseptic prep. 4. Dilate cervix. 5. Insert cannula. 6. Suction uterine contents. 7. Inspect tissue. 8. Perform any concurrent procedures. 9. Process instruments.
  • 86. Step 1: Prepare Instruments Prepare all necessary equipments and instruments for doing UE using MVA Check that the aspirator retains a vacuum. Have more than one aspirator available.
  • 88. Step 2: Prepare the Woman Ask for consent (when appropriate) Ensure pain medication is given at the appropriate time. Ask the woman to empty her bladder. Help her onto the table. Wash hands and put on barriers. Perform a bimanual exam.
  • 89. Signs of complete evacuation • Red or pink foam without tissue passing through cannula • Gritty sensation over surface of uterus • Uterus contracting around cannula • Increased uterine cramping • Cervix tightly gripping the cannula
  • 90. Post Abortion Family Planning Counseling & Services (PAFP) • PAFP is one of the key quality indicators for CAC • Ovulation can occur within 10 days following abortion and the woman may risk subsequent unintended pregnancy • PAFP thus prevent further unintended pregnancy and abortion • Remember that some women may desire another pregnancy. 4/5/2023 Alemu G 90
  • 91. Post Abortion care (PAC)  PAC- is a global initiative in response to the problem of maternal mortality and morbidity resulting from unsafe abortion.  Essential elements of PAC services 1. Treatment of incomplete and unsafe abortion 2. Counseling to respond to women's needs 3. Contraceptive services 4. Link to other Reproductive services 5. Community and provider partnerships 4/5/2023 Alemu G 91