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dmt history.pdf
1. History of DMT
What is DMT Dimethyltryptamine
BUY DMT ONLINE DMT has been around for a very long time—thousands of years. It has frequently
been an element of sacred rites in indigenous societies. For instance, there is proof that it was in use in
Trinidad when Spanish colonists first arrived there. The substance is the main component of ayahuasca,
a traditional brewed tea from South America.
DMT is used illegally because of its psychotropic and psychedelic properties. Numerous users claim,
anecdotally, that they utilize the substance to experience spiritual enlightenment. According to scientific
evidence, it may have brain consequences that are similar to those of a near-death experience.
Human consumption
BUY DMT ONLINE According to data from the 2021 Global Drug Survey, DMT microdosing was reported
by 7.4% of participants. The practice of taking small dosages of a medicine to foster understanding and
original thought is known as microdosing. In many plants and animals, including humans, N,N-
Dimethyltryptamine (DMT or N,N-DMT, SPL026) is a substituted tryptamine that is both a derivative and
a structural analog of tryptamine.[3] As an entheogen, DMT is manufactured by many civilizations for
ritual usage as a hallucinogenic substance.[4] Many plant species generate DMT, frequently in
combination with its chemically related 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and
bufotenin (5-OH-DMT) compounds.[8] Indigenous Amazonian shamanic rituals frequently involve the
usage of plants that contain DMT. It is typically one of the primary active ingredients in ayahuasca;[9][4]
Ayahuasca, however, is occasionally made using herbs that don't contain DMT. Numerous plants,
including Mimosa tenuiflora, Diplopterys cabrerana, and Psychotria viridis, have it as the main
hallucinogenic alkaloid. In snuff prepared from Virola bark resin, where 5-MeO-DMT is the major active
alkaloid, DMT is present as a minor alkaloid.[8] QUICK FACTS ABOUT DMT
Here are some essential DMT facts.
2. The plant Psychotria viridis, which is found in Mexico, South America, and some regions of Asia,
produces DMT, a white, crystalline powder. It can be found in cohoba, a psychedelic made from
Piptadenia peregrina seeds.
Usual methods of consumption are as follows:
Ingested orally in brews like ayahuasca, evaporated or smoked in a pipe, occasionally snorted or injected
DMT functions as a non-selective agonist at most or all serotonin receptors, particularly at the serotonin
5-HT2a receptor, and shares a chemical root structure with the anti-migraine medication sumatriptan. A
neurotransmitter called serotonin has a significant impact on the majority of the brain cells in our
bodies. There is some proof that DMT is also produced naturally by the body (Reliable Source). This
implies that DMT is produced by the body, most likely in the brain's pineal gland.An average smoked
dosageDMT's Trusted Source (mg) dosage ranges from 40 to 100 milligrams, and it starts functioning
practically immediately. The effects last for a total of 30 to 60 minutes until reaching their peak and
plateau for 2 to 5 minutes.The dose of ayahuasca when drunk as a brew ranges from 0.6 to 0.85
milligrams for every kilogram of fluids. Effects start after 60 minutes, BUY DMT ONLINE reach their peak
after 90 minutes, and end after 4 hours.
The main article has additional information and supporting details.
DMT has been utilized by people for thousands of years, frequently in religious ceremonies.
In South America, the substance is frequently used in shamanic ceremony.
Strong hallucinations are among the side effects.
Some refer to DMT as the "spirit molecule" because of its unique properties.
Street names in DMT
DMT is known by several slang terms, including:
journey of the businessman Dimitri
Special fantasy of a businessman's 45-minute insanity
Negative effects
BUY DMT ONLINE The main psychological effects of DMT include euphoria, strong visual and aural
hallucinations, and a changed perception of space, body, and time.Many users speak of dramatic, life-
altering encounters including traveling to other planets, conversing with extraterrestrial beings known
as "DMT elves" or "machine elves," and radical changes in how they perceive themselves and the world
around them. DMT causes short-lived but vivid visual and audio hallucinations when smoked, which
some users compare to an alternate universe, the otherworld, or a near-death experience.
3. Users of DMT frequently assert that the substance has less side effects than other psychedelics,
however it is challenging to measure and quantify this claim.
The following are possible DMT adverse effects:
• Higher heart rate
• A higher blood pressure level
• Stiffness or pain in the chest
• Agitation
• Dilated eyes
• Dizzy quick rhythmic eye motions
• DMT can induce these side effects when consumed orally.
•
BUY DMT ONLINEThe DMT experience can be immensely thrilling or intensely terrifying depending on
the individual user. Because of how intense the experience can be, some people may find it difficult to
process and apply the "trip" to their everyday lives. Some individuals may endure trauma and upheaval
when using DMT since it can resemble a near-death experience.After taking the medication, mental
adverse effects may continue for several days or weeks.
Risks
DMT and the neurotransmitter serotonin share structural similarities. Serotonin syndrome, which can be
fatal, can be brought on by excessive use or use in combination with other medicines that contain
serotonin. The most vulnerable group to this problem is anyone taking antidepressants.When the body
produces an excessive amount of serotonin, serotonin syndrome develops. The illness is more prevalent
in those who take a variety of medicines together.
Symptoms of having too much serotonin in the body include:
• Agitation confusion
• Blood pressure is high.
• Headache and a loss of motor coordination
Interactions
BUY DMT ONLINE The most well-known and detrimental effect of DMT is its capacity to lead to
serotonin syndrome. People who take antidepressants or other medications that raise serotonin levels
are more prone to experience this. Its interactions with other medications have not often been
investigated in clinical research.DMT has the potential to intensify the effects of other psychedelic drugs
like LSD. It can alter heart rate, perceptions, and emotional states, which can alter how these processes
are affected by medicines.
Harm minimization
4. It might be challenging to get trustworthy information about the use and safety of DMT because it is
banned. Doctors are likely to advise against using it and may not be very knowledgeable about reducing
the danger. Several harm reduction tactics are as follows: not using DMT if a person has a history of
serious mental health issues, especially psychosis or dissociation, using DMT under the supervision of an
experienced user or practitioner starting with a very small dose and only increasing the dose based on
response
Clinical use studies
Systemic hypoxia is combated by dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors
(Sig-1Rs). Research shows that DMT promotes astrocyte survival in an ischemic environment and lowers
the amount of apoptotic and ferroptotic cells in mammalian forebrain. These findings suggest that DMT
could be used as an adjuvant pharmaceutical therapy for the treatment of acute cerebral ischemia.In a
Phase 1/2 clinical trial, DMT is being investigated as a potential treatment for Parkinson's disease.Phase
II clinical studies for SPL026 (DMT fumarate) are now being conducted to examine the drug's potential
for treating Major Depressive Disorder by combining it with supportive psychotherapy. A safety study is
also being conducted to look into the results of mixing SPL026 with SSRIs.
Neuropharmocology
BUY DMT ONLINE N,N-dimethyltryptamine has recently been identified as a powerful psychoplastogen,
a substance that can foster rapid and sustained neuroplasticity and may have a variety of therapeutic
benefits.In a psychiatric investigation, dimethyltryptamine and O-methylbufotenin were detected in
human CSF fluid in small amounts.
Summary
A powerful hallucinogen, DMT can significantly alter one's perception, awareness, and sensory
experiences. For some people, having this experience is transformational and life-affirming. It
traumatizes others.Anyone interested in using DMT should do their research and put harm reduction
techniques into practice. It can be risky to use DMT alone or in combination with other substances.
While it might have some positive effects on mental health, these effects are still hypothetical and
unproven.
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