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Integrated Breeding Platform
Breeding Management System
(BMS)
IBP Management Team
Presenter – Graham McLaren
January 2014
Rationale for the IBP




Large private seed companies have successfully
implemented extensive suites of integrated informatics
tools to turbocharge their breeding programs
Implementation of this integrated informatics in public
programs lags behind, especially in developing countries






Some tools have been developed at various CG centers, but
implementation has been uneven and they are not integrated into
a comprehensive system
Most NARS programs still rely on rudimentary tools, from pen
and paper to Excel spreadsheets
Small SMEs in developing countries typically do not have the
resources to acquire available commercial software or to
implement breeding IT systems on their own
https://www.integratedbreeding.net/
Breeding Management System
(BMS) – Product Concept







Simple and easy-to-use application containing all
informatics tools needed by a breeder
Seamless flow of data between applications
Accumulation, sharing and re-use of breeding data
Targets routine breeding activities and will not replace
research tools
Will allow integration of users own tools into the system
Implementable as a standalone system




Access central and local DB, as well as the BMS on a local PC

Will also be implementable as a cloud-based system via
iPlant cyber-infrastructure


For computationally intensive analyses or large data storage
needs
List Manager Functionality
The List Manager is at the center of all activities in the Breeding
Management System:






First screen you arrive at after opening your Breeding Program
New left navigation menu provides direct access to all tools
Easily build and work with the lists that are used in each stage of
the breeding cycle

Key List Manager Features:






Ability to browse and modify existing lists
Ability to search for lists and germplasm entries
Ability to create a new list dynamically by pulling from existing
lists or germplasm search results
Expanded ability to modify list contents
Ability to export lists for use outside of the Breeding Management
System
Breeding Logistics
Once the strategy and parental material have
been identified, the breeder wants to:


make crosses,



develop populations,



track pedigrees,



track inventory,



characterize lines
Nursery and Trial Management


Breeding Manager configured for different crops






IB Fieldbook





Crossing manager, nursery manager, pedigree recording
Focuses on population development and line selection
Nursery advance and seed inventory tracking
Focuses on field trial management for germplasm evaluation
Trait selection, field design, labels and sample tracking

Android-based hand-held device




Optimized for use with Samsung Galaxy tablet for field data
collection
Other Android devices can be used if preferred

Breeding manager and Field books fully integrated into
BMS workbench
Field Testing
Once populations are developed, the breeder
wants to:


select traits,



make lists of germplasm,



generate designs,



produce fieldbooks,



collect data,



check and store data.
Breeding Management
Trait Dictionaries

Reporting
units or scale
Measurement
method

Trait property

Measurement
Variate
Breeding Management
Trait Selector
Breeding Management
Germplasm List Manager
Breeding Management
IBP Fieldbook
Breeding Management
Bar Code labels
Breeding Management
Tablet Devices

Fieldbook
connects to
Androidbased tablet
devises for
data
collection in
the field and
laboratory
Integrated Breeding Database



Genealogy Management System (GMS)





Phenotypeing Data Management System (DMS)





Germplasm nomenclature, chronology, IP and passport data
Pedigrees and breeding history
Germplasm characterization and evaluation data
Annotated with Crop Research and Crop Trait Ontologies

Genotypic Data Management System (GDMS)




Medium density fingerprinting data
Genotyping data for MAS and MABC
Genotyping data for Marker-trait association analysis

Databases fully integrated into BMS workbench
Query Tools
At the outset of a breeding cycle users want to:


browse all germplasm information



review existing characterization and evaluation



search for adapted germplasm



perform head to head comparisons
Statistical Analysis of Phenotyping Data









Breeding View provides easy access to the high
throughput analyses routinely required by breeders
The same interface can be used to access procedures in
Genstat or R-scripts and allows analyses to be configured
Single site analysis is available for complete and
incomplete block designs as well as row-column designs
and spatial analysis. New designs are being added at
each update,
Analyses can be run in batches over environments and
traits,
Two-stage multi-site analysis is available for GxE and
stability analysis with or without grouping of
environments,
Single pass meta analysis of unbalanced site by season
data is being incorporated.
Tools to be fully integrated into the BMS by June 2014
Genotyping
To use molecular technologies, the breeder
wants to:


select population,



select markers,



genotype population,



check and store genotyping data.
Genotyping Data Management
Breeding View - QTL analysis



Single trait linkage analysis (QTL)












Quality control phenotypes (summary
statistics)
Quality control marker data
QTL detection – genome wide scan
using single and composite IM
Output includes profile plots and tables
Results available for automatic viewing
in Flapjack
HTML report of QTL results

Multiple trait sequential analysis



QTL results for each trait combined
Single Flapjack view for all traits
Decision support for
Marker implementation




OptiMAS
Developed at INRA, Le
Moulon
Implementation of
markers in a MARS
breeding scheme
Identify and track
favorable alleles through
cycles of recombination
and selection
Molecular Breeding
Decision Tool (MBDT)
Developed by team at
ICRISAT
Implementation of
markers in a MAS and
MABC context
Future Directions







Continuous improvement of UI based on user
feedback
Additional analysis methods for expanded
experimental designs and genetic analysis
Seed inventory management system
LAN based deployment available in January, cloud
based deployment available in June
Data will be stored in a single shareable database
with user access roles
Off-line capability will be supported by a data cache
which will synchronize when a connection is
available

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PAG XXII 2014 – The Breeding Management System (BMS) of the Integrated Breeding Platform (IBP) – G McLaren

  • 1. Integrated Breeding Platform Breeding Management System (BMS) IBP Management Team Presenter – Graham McLaren January 2014
  • 2. Rationale for the IBP   Large private seed companies have successfully implemented extensive suites of integrated informatics tools to turbocharge their breeding programs Implementation of this integrated informatics in public programs lags behind, especially in developing countries    Some tools have been developed at various CG centers, but implementation has been uneven and they are not integrated into a comprehensive system Most NARS programs still rely on rudimentary tools, from pen and paper to Excel spreadsheets Small SMEs in developing countries typically do not have the resources to acquire available commercial software or to implement breeding IT systems on their own
  • 4. Breeding Management System (BMS) – Product Concept       Simple and easy-to-use application containing all informatics tools needed by a breeder Seamless flow of data between applications Accumulation, sharing and re-use of breeding data Targets routine breeding activities and will not replace research tools Will allow integration of users own tools into the system Implementable as a standalone system   Access central and local DB, as well as the BMS on a local PC Will also be implementable as a cloud-based system via iPlant cyber-infrastructure  For computationally intensive analyses or large data storage needs
  • 5.
  • 6. List Manager Functionality The List Manager is at the center of all activities in the Breeding Management System:     First screen you arrive at after opening your Breeding Program New left navigation menu provides direct access to all tools Easily build and work with the lists that are used in each stage of the breeding cycle Key List Manager Features:      Ability to browse and modify existing lists Ability to search for lists and germplasm entries Ability to create a new list dynamically by pulling from existing lists or germplasm search results Expanded ability to modify list contents Ability to export lists for use outside of the Breeding Management System
  • 7.
  • 8. Breeding Logistics Once the strategy and parental material have been identified, the breeder wants to:  make crosses,  develop populations,  track pedigrees,  track inventory,  characterize lines
  • 9. Nursery and Trial Management  Breeding Manager configured for different crops     IB Fieldbook    Crossing manager, nursery manager, pedigree recording Focuses on population development and line selection Nursery advance and seed inventory tracking Focuses on field trial management for germplasm evaluation Trait selection, field design, labels and sample tracking Android-based hand-held device   Optimized for use with Samsung Galaxy tablet for field data collection Other Android devices can be used if preferred Breeding manager and Field books fully integrated into BMS workbench
  • 10.
  • 11. Field Testing Once populations are developed, the breeder wants to:  select traits,  make lists of germplasm,  generate designs,  produce fieldbooks,  collect data,  check and store data.
  • 12. Breeding Management Trait Dictionaries Reporting units or scale Measurement method Trait property Measurement Variate
  • 17. Breeding Management Tablet Devices Fieldbook connects to Androidbased tablet devises for data collection in the field and laboratory
  • 18. Integrated Breeding Database  Genealogy Management System (GMS)    Phenotypeing Data Management System (DMS)    Germplasm nomenclature, chronology, IP and passport data Pedigrees and breeding history Germplasm characterization and evaluation data Annotated with Crop Research and Crop Trait Ontologies Genotypic Data Management System (GDMS)    Medium density fingerprinting data Genotyping data for MAS and MABC Genotyping data for Marker-trait association analysis Databases fully integrated into BMS workbench
  • 19. Query Tools At the outset of a breeding cycle users want to:  browse all germplasm information  review existing characterization and evaluation  search for adapted germplasm  perform head to head comparisons
  • 20. Statistical Analysis of Phenotyping Data       Breeding View provides easy access to the high throughput analyses routinely required by breeders The same interface can be used to access procedures in Genstat or R-scripts and allows analyses to be configured Single site analysis is available for complete and incomplete block designs as well as row-column designs and spatial analysis. New designs are being added at each update, Analyses can be run in batches over environments and traits, Two-stage multi-site analysis is available for GxE and stability analysis with or without grouping of environments, Single pass meta analysis of unbalanced site by season data is being incorporated. Tools to be fully integrated into the BMS by June 2014
  • 21.
  • 22. Genotyping To use molecular technologies, the breeder wants to:  select population,  select markers,  genotype population,  check and store genotyping data.
  • 24. Breeding View - QTL analysis  Single trait linkage analysis (QTL)        Quality control phenotypes (summary statistics) Quality control marker data QTL detection – genome wide scan using single and composite IM Output includes profile plots and tables Results available for automatic viewing in Flapjack HTML report of QTL results Multiple trait sequential analysis   QTL results for each trait combined Single Flapjack view for all traits
  • 25.
  • 26. Decision support for Marker implementation   OptiMAS Developed at INRA, Le Moulon Implementation of markers in a MARS breeding scheme Identify and track favorable alleles through cycles of recombination and selection Molecular Breeding Decision Tool (MBDT) Developed by team at ICRISAT Implementation of markers in a MAS and MABC context
  • 27. Future Directions       Continuous improvement of UI based on user feedback Additional analysis methods for expanded experimental designs and genetic analysis Seed inventory management system LAN based deployment available in January, cloud based deployment available in June Data will be stored in a single shareable database with user access roles Off-line capability will be supported by a data cache which will synchronize when a connection is available