The presentation describes an adaptive approach to explaining the broadest spectrum of pharmacological activity of a course of systemic ozone therapy. This approach is based on the idea of systemic ozone therapy as a form of activation therapy. The difference between ozone therapy and other types of activation therapy is that ozone fixes a specific conditioned-unconditioned reflex of the adaptation system   for the pharmacological activity of ozone.

1. “Adaptive rejuvenation as the basis
of the therapeutic effect of the
systemic ozone therapy”
E.I.Nazarov, Odessa

2. Slide 1
• My report is devoted to a new approach to the
mechanism of the course of systemic ozone therapy.
This approach was the result of attempts to find an
answer to the two questions:
• First: Why during the course of ozone therapy the
patient's condition periodically improves and worsens
and
• Second question: Why does the therapeutic effect of
ozone therapy if achieved persist for 3 to 6 months?
• The modern theory of ozone therapy can not explain
these features of ozone. Let us consider two examples.

3. The correct course of ozone therapy !
Dissatisfied with the treatmentWithout changesGood health Bad feeling
Before
course
After
course
Slide 2

4. Slide 2
• This slide shows schematically the dynamics
of patient's psycho-somatic state throughout
the six AHT- O3 procedures and during the
next eight months after the completion of the
course. This slide represents a successful
course of therapy because for 6 months the
patient enjoys the result of treatment.

5. Wrong course of ozone therapy
What is the reason that some courses of treatment result in a steady
improvement in the patient's condition and psycho-emotional
upsurge, and other courses are ineffective?
Dissatisfied with the treatmentWithout changesGood health Bad feeling
Before
course
After
course
Slide 3

6. Slide 3
• On this slide the unsuccessful course of ozone
therapy is schematically shown. The course failed
because the patient received only a minor and
short-term improvement at his health.
• What is the reason for achieving the different
effectiveness from the standard course of
systemic ozone therapy and how do we make the
course results predictable? To study this we use
the generally accepted quality of life
questionnaire Medical Outcomes Study-Short
Form, SF-36.

7. Health related quality of life was studied in random sample
of 2156 men and 2769 women aged 45-69 years,
according with SF-36 is an indicator of overall health
status. (Manchuk VT, Nadtochiy LA Condition and tendencies of health formation of the
indigenous population of the North and Siberia // Siberian Scientific Medical Journal. - 2010. - V. 30. -
No. 03.)
Slide 4

8. Slide 4
• After a successful course of ozone therapy,
patients oftenly say "I am 10 or 20 years
younger." This led us to the idea of assessing
the subjective age of the patient during
treatment. In order to the this we use the
results of a statistical analysis of the
dependence of the quality of life on age. We
chose the parameter of physical role
functioning (PRF).

9. 30
40
50
60
70
80
90
100
0 4 8 12 16 20 24
PSYICALROLEFUNCTIONSF-36
WEEKS
The dynamics of the physical role function (PRF) of the SF-36
questionnaire during the AHT-O3 course and after the course
completion. The study involved six patients with stage 2 hypertension
(men aged 64 to 72 years)
course of
AHT-O3
Slide 5

10. Slide 5
• In this slide you can see that during the
course of ozone therapy there is a fluctuation
at the physical well-being of patients. Then
throughout the 18 weeks after therapy the
achieved value of the studied parameter is
preserved. After then spontaneous worsening
of the patients' condition takes place.

11. 30
40
50
60
70
80
90
100
0 5 10 15 20
AGE
WEEKS
rejuvenationcourse of
AHT-O3
withdrawal
syndrome
Dynamics of the average calculated age of a group of
patients during the course of ozone therapy and after
the completion of the course
Slide 6

12. Slide 6
• If we calculate the subjective age of the
patients we get the following graphic. In fact
this is the patient's adaptive age graphic. In
this graph we can distinguish three periods:
1) fluctuations in the adaptive age during the
course of procedures, 2) the period of
adaptive rejuvenation, and 3) the period of
development of the ozone withdrawal
syndrome

13. Dependence of the remission time on age after the course of ANT-O3
(6-10 procedures, ozone dose 27 μg / kg). The calculation is based on
a medical history of 58 patients suffering from hypertension,
diabetes, rheumatoid arthritis, hepatitis C. The age of patients is 47-
84 years.
2.00
3.00
4.00
5.00
6.00
7.00
8.00
40 50 60 70 80 90
Remissiontime,months
AGE
Slide 7

14. Slide 7
• The duration of remission caused by the
course of ozone therapy depends on the age
of the patient. The duration of remission is
about 6 months at 50 years and about 3
months at 80 years.

15. The dynamics of the level of Cortisol in the blood of six
patients (41-64 years old) in control, during the course
of AHT-O3 procedures (dose 27μg/kg, every other day)
and within five months after completion of the course.
Slide 8

16. Slide 8
• We use the term adaptive rejuvenation in order to
emphasize the generalized nature of the processes in
the patients' body. Depending on the nature of the
underlying disease of the patient we observe a
reduction in blood pressure for hypertensive patients
or a decrease in glucose concentration for diabetics
and so on. It is obvious that we are dealing with the
effect of ozone on some integrating system of the
body. The real candidate for this role is the hormonal
system. This is evident from the dramatic dynamics of
the level of cortisol during the course of ozone therapy.

17. The normalized level of Cortisol in the blood of six
patients (41-64 years old) in control, during the course
of AHT-O3 procedures (dose 27μg/kg, every other day)
and within five months after completion of the course.
Slide 9

18. Slide 9
• The same results are presented in a
normalized form. Normalization is carried out
to average level of the control. It can be seen
that the course of ozone therapy initiates
abrupt changes in the level of cortisol in all
patients. One month after the completion of
the course the level of the hormone stabilizes
at a new level. The concentration of cortisol in
the blood returns to the baseline level for
several months.

19. The normalized level of Cortisol in the blood of six
patients (41-64 years old) in control, during the course
of AHT-O3 procedures (dose 27μg/kg, every other day)
and within one months after completion of the course.
Slide 10

20. Slide 10
• The following slide shows the dynamics of
cortisol in the blood in a more detailed form. The
arrows mark the end of the course of AHT- O3
procedures. It can be seen that the influence of
the course of procedures on the concentration
of the hormone is highly individual. The micro-
quantity of ozone introduced into the blood
causes a pronounced change in the hormonal
status of the patient's body. How does ozone
affect the level of the hormone and how does
the body maintain a new hormonal status for
several months?

21. Ozone as a physiotherapeutic agent
According to the widely used terminology, study of natural or
preformed natural factors (for example: mud, mineral waters as well
as electric and magnetic fields and so on) is a subject of a separate
section of medicine the - physiotherapy. From this point of view,
ozone is the preformed form of the natural factor - oxygen.
Slide 11

22. Slide 11
• In order to give an answer to this question
we must think about the existing theoretical
basis of physiotherapy. Why physiotherapy?
Because this medical specialty is focused on
the study of natural and preformed natural
factors. Ozone is a preformed natural oxygen
factor. On this basis in a number of countries
ozone therapy is accepted as a kind of
physiotherapy.

23. In accordance with the theoretical views of physiotherapy, ozone, like other natural
factors, causes a systemic compensatory-adaptive reaction in the body, the
basis of which is a conditioned-unconditioned reflex with its neurohumoral
component. As can be seen from the illustration, the structures of the intermediate
brain and brain stem play the leading role in the organization of the compensatory-
adaptive reaction. The most important of these is the hypothalamic-pituitary complex
integrating the influence of external and internal factors on the organism and forming
an adaptive response.
Novelty
factor Slide 12

24. Slide 12
• Physiotherapy teaches us that under the
influence of curative natural factors a
compensatory-adaptation reaction develops.
This reaction based on conditioned
unconditioned reflexes with neurohumoral
component

25. O3
Slide 13

26. Slide 13
• . That is the organism behaves like a Pavlov’s dog. First
we develop a conditioned reflex to ozone during ozone
therapy and then the role of a reinforcing factor is
played by the products of ozonolysis of the blood.
Over time the conditioned reflex decays and a new
course of ozone therapy is needed to resume it.
Physiotherapy teaches us also that the formation of a
conditioned reflex occurs in the hypothalamic-pituitary
complex. Thus the course of systemic ozonotherapy
can be considered completed if the hypothalamic-
pituitary complex stops the formation of a conditioned
reflex to ozone.

27. How to control the dynamics of
the compensatory-adaptive
reaction of the body during the
course of ozone therapy?
Slide 14

28. Slide 15

29. Slide 15
• Let us turn to a simplified scheme for the
functioning of the hormonal system. The
central element of this system is the
hypothalamic-pituitary complex which
through the feedback system controls the
activity of the adrenal thyroid and gonads
glands. In the posterior and anterior part of
the hypothalamus there are nuclei regulating
the activity of the sympathetic and
parasympathetic nervous system respectively.

30. Slide 16
The sympathetic
nervous system
increases the
rhythm of the
heart

31. Slide 17
sympathetic nervous system increases the
rhythm of the heart
The parasympathetic
nervous system slows
down the rhythm of
the heart

32. Slide 18
In real conditions
the work of these
systems together
makes the heart
rhythm unstable.

33. Slide 18
• Thus analyzing changes in the rhythm of the
heart we obtain indirect information about
the work of the hypothalamic-pituitary
complex.

34. 1 2 3 4
minutes
HEART RATE
100
50
HEART RATE
100
50
Slide 19

35. Slide 19
• This slide shows the appearance of the
cardio-intervalogram characteristic for the
young and the elderly. Spectral analysis of the
cardio-intervalogram allows us to evaluate
the parameters of activity of the sympathetic
parasympathetic and hormonal systems.

36. Screenshot of the working program O3Test. Left
intervalogram, right spectrum of intervalogram and
calculated adaptive characteristics of the patient's
state of health. Slide 20
We have created a hardware-software complex called O3Test which allows non
invasive rapid monitoring of the patient's adaptive age during the course of
ozone therapy. The data collection time is only 5 minutes and can be performed
during the AHT- O3 procedure. O3Test is integrated with O3Navigator.

37. Original records of cardio intervals during the course
of AHT-O3 (dose 30 mkg/kg). That is the course of
procedures leads to a patient's rejuvenation.
Slide 21

38. Original records of cardio intervals (left) dynamics of
the normalized level of monocytes, eosinophils,
basophils, neutrophils and calculated adaptive age
(right) during the course of AHT-O3 (dose 30 mkg/kg)
Slide 22

39. Slide 22
• The quantitative adaptation at age can be
determined by the O3Test program. The
dashed line indicates the dynamics of the
calculated adaptive growth during the course
of procedures. As we have already said
adaptive rejuvenation reflects a generalized
process of activation of the patient's
homeostasis. For example, we have led the
dynamics of the parameters of white blood
to mean values of the norm.

40. Original records of cardio intervals (left) dynamics of
the normalized level of monocytes, eosinophils,
basophils, neutrophils and calculated adaptive age
(right) during the course of AHT-O3 (dose 30 mkg/kg)
Slide 23

41. Slide 23
• The O3Test program allows demonstrating
the characteristics of the adaptation system
to the patient thereby making him a
conscious participant in the treatment
process.

42. late repeated
course
The slide shows a screen shot of the running program. This is a
usual dynamics of the patient's adaptation age during the course
of ozone therapy and for several months after the completion of
the course. Demonstration of this example should motivate the
patient to resume the course of ozone therapy. Slide 24

43. 43
40
40
In conclusion we will demonstrate the mechanical
metaphor of the ozone therapy course in the form of a
pendulum oscillation. Health is balance. Disease is a
deviation from balance.
Slide 25

44. 44
40
First procedure.The procedure of ozone therapy
removes the system of homeostasis from the state
of the disease.

45. 45
40
40
The pendulum moves

46. 46
40
40
Second procedure

47. 47
40
40
This is a state of health. But the
pendulum has inertia and can not stop in
this state

48. 48
40
40
The pendulum, by inertia, moves to the
opposite side. This is also a disease.

49. 49
40
40
Third procedure of ozone therapy

50. 50
40
40
The pendulum moves

51. 51
40
40
Fifth procedure of ozone therapy

52. 52
40
40
The pendulum, in balance
state, but by inertia, moves to
the opposite side

53. 53
40
40
It is illness too

54. 54
40
40
Sixth procedure of ozone therapy

55. 55
40
40
course of treatment completed
Treatment of the patient is strictly individual. For another patient, you
may need 10-16 oscillations of the pendulum until it stops. If the
doctor stops the treatment before pacifying the pendulum, then the
goal of treatment is not achieved.

56. conclusions
1) Ozone is an preforming natural factor and in accordance with the
theoretical basis of physiotherapy is the factor that causes the
conditioned-unconditioned adaptive reflex. This reflex decays for
several months and requires a repeated course of ozonotherapy for
resumption.
2) Fluctuations in the state of health of the patient during the course of
ozone therapy are associated with the restructuring of the hormonal
system.
3) The restructuring of the hormonal system is normotropic and leads to
an adaptive rejuvenation of the patient.
4) The duration of the compensatory-adaptive reaction is determined by
the duration of the conditioned reflex to ozone and decreases with age
from 6 months in 50 years to 3 months in 80 years.
5) For a successful course of systemic ozone therapy, constant
monitoring of the status of the patient's adaptation system should be
carried out. Criterion for the completion of the course of procedures is a
sharp decrease in the patient's adaptable age.

57. We must remember the Latin proverb.
MEDICINA CURATA,
NATURA PROCURA
Our task is only to shift, with the help of
ozone, the system of homeostasis to a
state of balance. Everything else will be
done by the body itself

58. 58
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33
Thanks for attention
23
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