2. Topics
Introduction
Dietary sources
Biochemical functions
Absorption storage transport
RDA of vitamin E
Diseases
Deficiency symptoms
Toxicity
References
3. Introduction
It is a fat soluble vitamin and heat labile.
The term vitamin E describes a family of 8
antioxidants , 4 tocopherols (a,b, g, & d) and 4
tocotrienols.
a-tocopherol is the active form of vitamin E in the
human body.
The tocopherols are derivatives of 6-hydroxy
chromane (tocol) ring with isoprenoid (3 units) side
chain.
The antioxidant property is due to the hydroxyl
group of chromane ring.
6. FUNCTIONS
It is a membrane antioxidant .
Vit E prevents lipid peroxidation.
There is continuous production of free radicals in our
body . This free radicals can Damage PUFA ,Vitamin E
excepts free radicals and itself gets converted to
quinone form.
Vitamin E is important for the maintainence of RBC
membrane prevents hemolysis
It is important in maintainence of reproduction and
germinal epithelium in gonads.
7. It prevents sterility
It helps to prevents oxidized LDL formation
Selenium is important constituent of glutathione
peroxidase . Vitamin E along with Selenium functions as an
antioxidant.
Immune response
It prevents oxidation of vitamin A
It helps to prevent cataract along with vitamin A and C.
It is important in heme synthesis because it activates
(aminolevulinic acid )ALA synthase and ALA dehydratase.
8. It is important in nucleic acid synthesis.
It is required for proper storage of creatine in skeletal
muscle.
Vitamin E prevents massive hepatic necrosis produced
in diet deficient of amino acids .
11. Vitamin E is absorbed along with fat in the small intestine.
Bile salts are necessary for the absorption. In the liver, it is
incorporated into lipoproteins (VLDL and LDL) and
transported.
Vitamin E is stored in adipose tissue, liver and muscle. The
normal plasma level of tocopherol is less than 1 mg/dl.
12.
13. DISEASES
Myopathy(skeletal muscle pain)and weakness
Ceroid pigment accumulation (fat accumulation)
Hemolytic Anaemia
Degenerative neuropathy
Ataxia
Loss of vibratory sense
Loss of coordination of limbs
15. Toxicity
Vitamin e is least toxic among other fat soluble vitamins.
Doses above 1000mg /day leads to toxicity.
Headache
Fatigue
Nausea
Double
vision
Muscular
weakness
Creatinuria
Gastrointestinal
distress
Vit E
intoxication
16. NOTES
Although there is no direct relation vitamin E in
disease .
That’s why it is also known as insearch of disease
vitamin. But so many disease occur due to oxidation
of cells.
It prevents in coronary artery disease
Dilates the bloodvessels for easy bood flow.
It is mainly known for its antioxidant role .